Microcirculatory responses to phototherapy and angiogenesis during wound healing in rabbit ear chamber
| Project/Area Number |
18591727
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
KOMORI Makiko Tokyo Women's Medical University, School of Medicine, Associate Professor (60178332)
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| Co-Investigator(Kenkyū-buntansha) |
TAKADA Katsumi Tokyo Women's Medical University, School of Medicine, Associate Professor (20075609)
TOMIZAWA Yasuko Tokyo Women's Medical University, School of Medicine, Assistant Professor (00159047)
OZAKI Makoto Tokyo Women's Medical University, School of Medicine, Professor (30160849)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥3,420,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2006: ¥1,600,000 (Direct Cost: ¥1,600,000)
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| Keywords | phototherapy / angiogenesis / wound healing / rabbit ear chamber / microcirculation / bFGF / 創傷治癒 / 鍼 / REC / 直線偏光近赤外線 / 低出力レーザー / 組織血流 |
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| Research Abstract |
Treatment regimens used in pain clinics include oral drugs, nerve blocks, and physical therapy. Recently, phototherapy, a noninvasive treatment with minimal side effects, has been used for pain management in elderly patients in whom nerve blocks cannot be performed because of concurrent disease. We used the rabbit ear chamber method under direct vision to examine changes in the arteriolar microcirculation after phototherapy. Low-power laser light (laser group) and linearly polarized near-infrared light (near-infrared group) were used to measure the luminal diameter, blood-flow velocity, and blood volume of the arterioles. As compared with the values before treatment (100%), the arteriolar diameter increased to 101.9% f 5.9% in the control group, 130.1% ± 10.4% in the laser group, and 125.2% ± 16.9% in the near-infrared group. These increases in both the laser and near-infrared groups were significant as compared with the control value (p<0. 05). Blood-flow velocity increased from a baseline value of 100% to 101.3% t 3.6% in the control group, 126.3% ± 14.8% in the laser group, and 129.1% ± 16.8% in the near-infrared group. The increases in both the laser and near-infrared groups were significant as compared with that in the control group (p<0.05). Arteriolar blood volume showed a similar trend, and significantly increased after phototherapy (p<0.05). Phototherapy improved the microcirculation with minimal systemic and local side effects band can therefore be used as adjuvant therapy. Laser therapy is very often used in the field of pain management. Previous basic research, including our study, has suggested that the mechanism by which laser therapy relieves pain involves factors such as the selective inhibition of peripheral-nerve conduction, relaxation of vascular smooth muscle, and arteriolar dilation due to the inhibition of sympathetic-nerve activity. In addition to relieving pain, laser therapy can reduce inflammation and promote wound healing.
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Report
(3 results)
Research Products
(20 results)
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[Journal Article] Permissive range of hypercapnia for improved peripheral microcirculation and cardiac output in rabbits2007
Author(s)
Komori, M., Takada, K., Tomizawa, Y., Nishiyama, K., Kawamata, M., Ozaki, M
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Journal Title
Crit Care Med 35(9)
Pages: 2171-5
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Journal Article] Effects of treatment with oral prostaglandin E_1 on lumbar spinal canal stenosis2007
Author(s)
Komori, M., Nishiyama, K., Kondo, I., Sone Y., Fukuuchi, A., Mae, T., Kawamata, M., Ozaki, M
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Journal Title
Pain Clinic 19(1)
Pages: 37-39
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Journal Article] Milnacipran hydrochloride for the treatment of postherpetic neuralgia2006
Author(s)
Komori, M., Fukuuchi, A., Mae, T., Nishiyama, K., Mawamata, M., Ozaki, M
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Journal Title
Pain Clinic 18
Pages: 421-423
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Presentation] Microcirculatory Responses to Acupuncture Stimulation and Phototherapy2007
Author(s)
Makiko, Komori, Katsumi, Takada, Yasuko, Tomizawa, Miwako, Kawamata, Makoto, Ozaki
Organizer
Annual Meeting American Society Of Anesthesiologists
Place of Presentation
SanFranciso, CA
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Presentation] Oral Treatment with Prostaglandin E1 Improves Symptoms of Lumber Spinal Canal Stenosis2007
Author(s)
Makiko, Komori, Yoriko, Sone, Yasuko, Tomizawa, Katsumi, Takada, Makoto, Ozaki
Organizer
Annual Meeting American Society of Anesthesiologists (, October 13-17, 2007)
Place of Presentation
San Francisco, CA
Description
「研究成果報告書概要(欧文)」より
Related Report
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