Complex of Branched Cyclodextrin and Lidocain Prolonged the Duration of Peripheral Nerve Block

• Project/Area Number: 18591731
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Aichi Medical University
• Principal Investigator: ARAI Kenichi Aichi Medical University, 医学部, 講師 (50380316)
• Co-Investigator(Kenkyū-buntansha): 木村 智政 愛知医科大学, 医学部, 助教授 (50161568)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,880,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥480,000); Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2007: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2006: ¥1,800,000 (Direct Cost: ¥1,800,000)
• Keywords: 脳・神経 / 薬理学

Research Abstract

環状オリゴ糖構造のシクロデキストリンの緩徐な薬物放出特性に注目し、新たな薬物到達システムを開発した。シクロデキストリンと局所麻酔薬のリドカインを包接結合させ化合物を作成した。ラットの坐骨神経に、リドカイン、リドカイン+シクロデキストリン、シクロデキストリンを3群に分けて投与し、56℃の熱刺激を与え、後肢の局所麻酔作用時間を測定した。リドカイン+シクロデキストリンの局所麻酔効果がリドカイン単独のものより長いことを明らかにした。

Research Products

• [Journal Article] Complex of branched cyclodextrin and lidocaine prolonged the duration of peripheral nerve block
  • Author(s): Ryoko Suzuki, Young-Chang P. Arai, et. al.
  • Journal Title: Journal of Anesthesia (in press)
  • Peer Reviewed
• [Presentation] Complex of branched cyclodextrin and lidocaine prolonged the duration of peripheral nerve block (2007)
  • Author(s): Y-C. Arai, T. Ushida , S. Sasaguri
  • Organizer: Annual Congress of the European Society of Regional Anaesthesia & Pain Therapy
  • Place of Presentation: Valencia, Spain
• [Presentation] Complex of branched cyclodextrin and lidocaine prolonged the duration of peripheral nerve bl (2007)
  • Author(s): Y-C. Arai, T. Ushida, S. Sasaguri
  • Organizer: Annual Congress of the European Society of Regional Anaesthesia & Pain Th
  • Place of Presentation: Valencia, Spain