| Budget Amount *help |
¥2,510,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2006: ¥1,600,000 (Direct Cost: ¥1,600,000)
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| Research Abstract |
Because the incidence and mortality rates of prostate cancer have increased with westernized-social life spreading in Japan, it is urgently needed to investigate the relationship between progression of minimal occult prostate cancer and dietary environment factors in the molecular preventive research point of view. The present study measured remnant-like particles-cholesterol (RLP-C) and RLP-triglyceride (RLP-TG) using frozen serum as an index to westemization of life-style in Japanese males. Twenty five cases diagnosed with prostate cancer after at least 3 consecutive screening with baseline PSA levels lower than 4ng/ml (case group) and age-adjusted and baseline-PSA-adjusted 25 men without prostate cancer (control group), who participated in the population-based screening for prostate cancer between 1992 and 2005, were enrolled in the present study. RLP-C and RLP-TG were measured using serum samples at the time of initial screening visit for both groups, at the last screening visit fo
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r control group and at the time of diagnosis for case group. The mean RLP-C levels in case and control groups, respectively, were 33.9mg/dl and 26.8mg/ml at the initial screening, and 27.6mg/dl and 20.8mg/dl at the last screening. The mean serum RLP-Cs in case group were higher than those in the control group at both screening visits, but there was no significant difference. The mean RLP-TG in the case and control groups, respectively, were 46.2 mg/dl and 44.6 mg/dl at the initial screening, and 48.6 mg/dl and 39.1 mg/dl at the last screening. The mean serum RLP-TG levels increased from initial to last screening in the case groups, but not did in the control groups. However, there was no significant difference in the RLP-TG levels even at the last screening between the case and control groups. The present study did not show significant differences in the serum RLP-C and RLP-TG between the case and control group both at the initial and last screening visits, the present study may still show the possibility of relationship between continuous increase in serum remnant lipoprotein and developing prostate cancer. Less
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