Etiology and teratment of acute tubular necrosis on peritubular capillary microcirculation

• Project/Area Number: 18591747
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Urology
• Research Institution: Nagoya University
• Principal Investigator: YAMAMOTO Tokunori Nagoya University, Graduate School of Meclicine, Lecturer (20182636)
• Co-Investigator(Kenkyū-buntansha): GOTOH Momokazu Nagoya University, Graduate School of Medicine, professor (10186900) ; HATTORI Ryohei Nagoya University, Graduate School of Medicine, associate professor (20324410) ; 小野 佳成 名古屋大学, 大学院医学系研究科, 助教授 (00301218)
• Project Period (FY): 2006 – 2007
• Project Status: Completed (Fiscal Year 2007)
• Budget Amount: ¥3,670,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥270,000); Fiscal Year 2007: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2006: ¥2,500,000 (Direct Cost: ¥2,500,000)
• Keywords: Acute tubular necrosis / PLCVM imaging / Trombomodulin / Oliprinone / Peritubular capillary / Microcirculation / Renal protect / 急性尿細管壊死 / 生体顕微鏡 / 腎微小循環

Research Abstract

We selected from clinical treatment drug with ability of prorecting vascular endthelial cells as treatment drug for acute tubular necrosis. Oliprinone as treatment drug of heart failure and thrombmodulin as treatment drug of disseminated inravascular coagulation were selected from evaluating on peritubular capillary flow of ischemic reperfusion rat model by pencil lens CCD video-microscopy(PLCVM) imaging technique adition to pathological and biochemical examinations resulting in having ability of renal protecting effect. It revealed that these clinical drugs have effect of protecting the microcirculation for rat repaerfusion model as acute tubular necrosis.
Near future, these clinical drugs with effect of renal microcirculatory protect will be used for patients with acute tubular necrosis.

Research Products

• [Journal Article] 腎後性のAMI (2008)
  • Author(s): 山本徳則
  • Journal Title: 臨床雑誌『内科学』 102(1)(掲載決定)
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Peritubular Ischemia Contributes More to Tubular Damage than Proteinuria in Immune-Mediated Glomerulonephritis. (2008)
  • Author(s): Wong MG, Yamamoto T, et. al.
  • Journal Title: JASN 19(2) Pages: 290-297
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Urine human L-FABP is a Potential Biomarker to predict COX-Inhibitor Induced Renal Injury. (2008)
  • Author(s): Tanaka T, Yamamoto T, et. al.
  • Journal Title: Nephron Experimental 108
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Acute Postreal Failure (2008)
  • Author(s): Yamamoto, T
  • Journal Title: clinical jounal : Internal Medicine 102(1)(in print)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Peritubular Ischemia Contributes More to Tubular Damage than Proteinuria in Immune-Mediated Glomerulonephritis (2008)
  • Author(s): Wong, MG, Suzuki, Y, Tanifuji, C, Akiba, H, Okumura, K, Sugaya, T, Yamamoto, T, Horikosh, S, Tan, SY, Pollock, C, Tomino, Y
  • Journal Title: JASN 19 Pages: 290-29
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Urine human L-FABP is a Potential Biomarker to predict COX-Inhibitor Induced Renal Injury (2008)
  • Author(s): Tanaka, T, Noiri, E, Yamamoto, T, Sugaya, T, Nugishi, K, Maeda, R, Nakamura, K, Portilla, D, Gotoh, M, Fujita, T
  • Journal Title: Nephron Experimental 108
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] 腎後性のAMI (2008)
  • Author(s): 由本徳則
  • Journal Title: 臨床雑誌『内科学』 102(1)(掲載決定)
  • Peer Reviewed
• [Journal Article] Novel treatment for nephrogenic diabetes insipidus using the Sendai-virusvector. (2008)
  • Author(s): Suga H, Yamamoto T, et
  • Journal Title: Endcrinology (in press)
  • Peer Reviewed
• [Journal Article] Peritubular Ischemia Contributes More to Tubular Damage than Proteinuria in Immune-Mediated Glomerulonephritis. (2008)
  • Author(s): Wong MG, Yamamoto T, et
  • Journal Title: JASN 19(2) Pages: 290-297
  • Peer Reviewed
• [Journal Article] Urine human L-FABP is a Potential Biomarker to predict COX-Inhibitor Induced Renal Injury. (2008)
  • Author(s): Tanaka T, Yamamoto T, et
  • Journal Title: Nephron Experimental 108
  • Peer Reviewed
• [Journal Article] Recombinant Human Soluble Thrombomodulin Ameliorates Ischemic Acute Renal Failure. (2007)
  • Author(s): Ozaki T, Yamamoto T, et. al.
  • Journal Title: Nephrol Gial Transpl 5(Epub ahead of print)
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Renal L-Type Fatty Acid:Binding Protein in Acute Ischemic Injury. (2007)
  • Author(s): Yamamoto T, et. al.
  • Journal Title: JASN 18 Pages: 2894-2902
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Effects of Olprinone, a phosphodiesterase III inhibitor, on Ischemic Acute Renal Failure. (2007)
  • Author(s): Anas C, Yamamoto T, et. al.
  • Journal Title: Int J Urol 14(3) Pages: 219-225
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Recombinant Human Soluble Thrombomodulin Ameliorates Ischemic Acute Renal Failure (2007)
  • Author(s): Ozaki, T, Anas, C, Maruyama, S, Yamamoto, T, Yasuda, K, Morita, Y, Ito, Y, Gotoh, M, Yuzawa, Y, Matsuo, S
  • Journal Title: Nephrol Gial Transpl 5(Epub ahead offprint)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Renal L-Type Fatty Acid : Binding Protein in Acute Ischemic Injury (2007)
  • Author(s): Yamamoto, T, Noiri, E, Ono, Y, Doi, K, Negishi, K, Kamijo, A, Kimura, K, Fujita, T, Kinugawa, T, Taniguchi, H, Nakamura, K,Goto, M, Shinozaki, N, Ohshima, S, Sugaya, T
  • Journal Title: JASN 18 Pages: 2894-2902
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effects of Olprinone, a phosphodiesterase III inhibitor, on Ischemic Acute Renal Failure (2007)
  • Author(s): Arms, C, Ozaki, T, Maruyama, S, Yamamoto, T, Gotoh, M, Ono, Y, Matsuo, S
  • Journal Title: Int J Urol 14(3) Pages: 219-225
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Recombinant Human Soluble Thrombomodulin Ameliorates Ischemic Acute Renal Failure. (2007)
  • Author(s): Ozaki T, Yamamoto T, et
  • Journal Title: Nephrol Gial Transpl 5(Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Renal L-Type Fatty Acid: Binding Protein in Acute Ischemic Injury. (2007)
  • Author(s): Yamamoto T, et
  • Journal Title: JASN 18 Pages: 2894-2902
  • Peer Reviewed
• [Journal Article] Effects of Olprinone, a phosphodiesterase III inhibitor, on Ischemic Acute Renal Failure. (2007)
  • Author(s): Anas C, Yamamoto T, et
  • Journal Title: Int J Urol. 14(3) Pages: 219-225
  • Peer Reviewed
• [Journal Article] The Effects of Olprinone, a phosphodiesterase III inhibitor on Ischemic Acute Renal Failure Internal (2007)
  • Author(s): Anas.C, Ozaki.T, Maruyama.S, Yamamoto.T, Gotoh.M, Ono.Y, Matsuo.S
  • Journal Title: Jounal of Urology (in press)
• [Journal Article] Autonomous Catheter Insertion System using Magnetic Mortion Capture Sensor for endvascular surgery. (2007)
  • Author(s): Terocero.C, Ikeda.S, Uchiyama.T, Fukuda.T, Arai.F, Okada.Y, Ono.Y, Hattori.R, Yamamoto.T, Negaro.M, Takahashi.I
  • Journal Title: The International Journal of Medical Robotics and Computer Assisted Surgery (in press)
• [Journal Article] Recombinant Human Soluble Thrombomodulin Ameliorates Ischemic Acute Renal Failure. (2007)
  • Author(s): Ozaki.T, Anas.C, Maruyama.S, Yamamoto.T, Yasuda.K, Morita.Y, Ito.Y, Ono.Y, Yuzawa.Y, Matsuo.S
  • Journal Title: Nephrol Gial Transpl (in press)
• [Journal Article] Does mica influence acute rejection in kidney transplantation? (2007)
  • Author(s): Kato.M, Kinukawa.T, Hattori.R, Tsuji.Y, Hirano.A, Horie.K, Tsuyuki.M, Mizutani.K
  • Journal Title: Clin Transplant (in press)
• [Journal Article] Effects of calcium channel blockade on angiotensin II-induced peritubular ischemia in rats. (2006)
  • Author(s): Kondo N, Yamamoto T, et. al.
  • Journal Title: J Pharmacol Exp Ther 316(3) Pages: 1047-1052
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Effects of calcium channel blockade on angiotensin II-induced peritubular ischemia in rats (2006)
  • Author(s): Kondo, N, Kiyomoto, H, Yamamoto, T, Miyatake, A, Sun, GP, Rahman, M, Hitomi H, Moriwaki, K, Hara, T, Kimura, S, Abe, Y, Kohno, M, Nishiyama, A
  • Journal Title: J Phannacol Exp Ther 316(3) Pages: 1047-1052
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] 急性虚血性腎不全に対する臍帯静脈血管内皮細胞移植治療 (2006)
  • Author(s): 山本徳則, 服部良平, 尾崎武徳, 小野佳成
  • Journal Title: Urology View 4 (4) Pages: 87-91
• [Journal Article] Effects of calcium channel blockade on angiotensin II-induced peritubular ischemia in rats. (2006)
  • Author(s): Kondo.N, Kiyomoto.H, Yamamoto.T, Miyatake.A, Sun.GP, Rahman.M, Hitomi.H, Moriwaki.K, Hara.T, Kimura.S, Abe.Y, Kohno.M, Nishiyama.A
  • Journal Title: J Pharmacol Exp Ther 316(3) Pages: 1047-1052