Identification of responsible gene of bone metastasis in prostate cancer and its treatment using a recombinant HSV

• Project/Area Number: 18591778
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Urology
• Research Institution: Osaka Medical College
• Principal Investigator: KATSUOKA Yoji Osaka Medical College, 医学部, 教授 (10051757)
• Co-Investigator(Kenkyū-buntansha): AZUMA Haruhito 大阪医科大学, 医学部, 准教授 (40231914)
• Project Period (FY): 2006 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥660,000); Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2006: ¥1,300,000 (Direct Cost: ¥1,300,000)
• Keywords: HSV / 前立腺癌 / PSM / サバイビン / splice variants

Research Abstract

1) We have been developing the recombinant HSV, which has the promotor region targeted on prostate specific membrane (PSM).
2) We have found that one of the two splice variant of surviving, survivin-Ex3 has a positive, and the other splice variant survivin-2B has a negative correlation with histological grade.
3) We have been developing the recombinant HSV, which has the promotor region targeted on Survivin-Ex3.

Research Products

• [Journal Article] Conversion of Prostate Cancer from Hormone Independency to Dependency Due to AMACR Inhibition: Involvement of Increased AR Expression and Decreased IGF1 Expression. (2009)
  • Author(s): Takahara K, Azuma H, Sakamoto T, Kiyama S, Inamoto T, Ibuki N, Nishida T, Nomi H, Ubai T, Sagawa N, Katsuoka Y.
  • Journal Title: Anticancer Research 29 Pages: 2497-2506
• [Journal Article] Association of PPAR-gamma with BCG immunotherapy. (2009)
  • Author(s): Inamoto T, Azuma H, Ubai T, Katsuoka Y.
  • Journal Title: Medica Hypotheses. 72(2) Pages: 231-231
• [Journal Article] Association of PPAR- gamma with BCG immunotherapy (2009)
  • Author(s): Inamoto T, Azuma H, Ubai T, Katsuoka Y.
  • Journal Title: Medica Hypotheses 72 Pages: 231-231
  • Peer Reviewed
• [Journal Article] Conversion of Prostate Cancer from Hormone Independency to Dependency Due to AMACR Inhibition : Involvement of Increased AR Expression and Decreased IGF1 Expression (2009)
  • Author(s): Takahara K, Azuma H, Sakamoto T, Kiyama S, Inamoto T, Ibuki N, Nishida T, Nomi H, Ubai T, Sagawa N, Katsuoka Y.
  • Journal Title: Anticancer Research 29 Pages: 2497-2506
  • Peer Reviewed
• [Journal Article] Anticancer effect of combination therapy of VP16 and fosfesterol in hormone-refractory prostate cancer (2008)
  • Author(s): Azuma H, Sakamoto T, Kiyama S, Ubai T, Kotake Y, Inamoto T, Takahara K, Nishimura Y, Segawa N, Katsuoka Y
  • Journal Title: Am J Clin Oncol 31(2) Pages: 188-194
• [Journal Article] Anticancer effect of combination therapy of VP16 and fosfesterol in hormone-refractory prostate cancer (2008)
  • Author(s): Azuma H, Sakamoto T, Kiyama S, Ubai T, Kotake Y, Inamoto T, Takahara K, Nishimura Y, Segawa N, Katsuoka Y.
  • Journal Title: Am J Clin Oncol. 2 Pages: 188-194
  • Peer Reviewed
• [Journal Article] Marked regression of liver metastasis by combined therapy of ulrtasound-mediated NFkB-decoy transfer and transportal injection of paclitaxel, in mouse (2008)
  • Author(s): Azuma H, Tomita N, SakamotoT, Kiyama S, Inamoto T, Takahara K, Kotake Y, Segawa N, Morishita R, Taorie S, Tanigawa N, Katsuoka Y.
  • Journal Title: Int.J.Cancer 122 Pages: 1645-1656
  • Peer Reviewed
• [Journal Article] Humanized Anti-CD26 Monoclonal Antibody as a Treatment for Malignant Mesothelima Tumors (2007)
  • Author(s): Inamoto T, Yamada T, Ohnuma K, Kina S, Takahashi N, Yamochi T, Inamoto S, Katsuoka Y, Hosono O, Tanaka H, Dang NH, Morimoto C.
  • Journal Title: Clin Cancer Res 13 Pages: 4191-4200
  • Peer Reviewed
• [Journal Article] 神経伝達抑制物質gamma-aminobutryric acid(GABA)の前立腺転移癌転こおける役割-Neurotransmitter,gamma-aminobutyric acid as anoting factor of cancer metastasis (2007)
  • Author(s): 東 治人、勝岡 洋治
  • Journal Title: 日本臨床 65 Pages: 121-126
  • Peer Reviewed
• [Journal Article] 排尿日誌 (2006)
  • Author(s): 鈴木 俊明, 勝岡 洋治
  • Journal Title: 泌尿器科外科 19・1 Pages: 11-16
• [Journal Article] An Epidemiological Survey of Sexually Transmitted Diseases in the Hokusetu Area in Osaka (2006)
  • Author(s): Katsuoka Y, Kiura H, Azuma H, Kono K
  • Journal Title: Jpn J Urol Surg 19・2 Pages: 145-152
• [Journal Article] case of prostatic cancer discovered from lung metastatic lesions (2006)
  • Author(s): Segawa N, Abe H., Nishida T, Katsuoka Y
  • Journal Title: Hinyokika Kiyo 52・2 Pages: 147-149
  • NAID: 120002141577
• [Journal Article] Anti-CD26 Monoclonal Antibody-Mediated G1-S Arrest of Human Renal Clear Cell Carcinoma Caki-2 Is Associated with Retinoblastoma Substrate Dephosphorylation, Cyclin-Dependent Kinase 2 Reduction, p27kipl Enhancement, and Disruption of Binding to the Extracellular Matrix. (2006)
  • Author(s): T.Inamoto, T.Yamochi, K.Ohnuma, S, Iwata, S, Kina, S, Inamoto, M.Tachibana, Y.Katsuoka, Nam H.Dang, C, Morimoto
  • Journal Title: Clin Cancer Res 12・11 Pages: 3470-3477
• [Journal Article] Treatment for locally advanced prostate cancer : value of surgery (2006)
  • Author(s): Azuma H, Katsuoka Y
  • Journal Title: Hinyokika Kiyo 52・6 Pages: 459-467
  • NAID: 120002141649
• [Journal Article] 高齢者前立腺癌の臨床(序論) (2006)
  • Author(s): 勝岡 洋治
  • Journal Title: 泌尿器科外科 19・12 Pages: 1383-1384
• [Presentation] Transforming Growth Factor-beta Regulates Neuroendocrine Like Transdifferentiation of Human Prostate Cancer. (2009)
  • Author(s): Naokazu Ibuki, Kohei Koyama, Kazumasa Komura, Yutaka Fujisue1, Yatsugu Kotake, Takanobu Ubai, Haruhito Azuma, Yoji Katsuoka
  • Organizer: 5th Congress of Asia Pacific Society for the Study of Aging Male (APSSAM Osaka2009)
  • Place of Presentation: Osaka, Japan