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Elucidation of genetic-environmental interaction and prevention for pregnancy-induced hypertension

Research Project

Project/Area Number 18591789
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionNational Institute of Radiological Sciences

Principal Investigator

GEN Kobashi  National Institute of Radiological Sciences, Research Center for Charged Particle Therapy, Team Leader (60270782)

Co-Investigator(Kenkyū-buntansha) HATA Akira  Chiba University, Graduate School of Medicine, Department of Public Health, Professor (00244541)
MINAKAMI Hisanori  Hokkaido University, Graduate School of Medicine, Department of Obstetrics, Professor (40102256)
YAMADA Takahiro  Hokkaido University, Graduate School of Medicine, Department of Obstetrics, research associate (20419948)
IWATA Noboru  Hiroshima Kokusai University, Faculty of Human Environment, Professor (80203389)
OHTA Kaori  National Institute of Radiological Sciences, Research Center for Charged Particle Therapy, Researcher (20421985)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥4,010,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2006: ¥1,800,000 (Direct Cost: ¥1,800,000)
KeywordsPregnancv-Induced Hypertension / genotyping / stress / epidemiology / interview / 相互作用
Research Abstract

1. To clarify the interactions among the candidate gene polymorphisms for the occurrence of pregnancy-induced hypertension (PIH), we carried out genotyping of some kinds of genes associated with pressor/depressor mechanisms, the blood coagulation system, lipid metabolism, the intravascular system, the placenta. However we found no significant associations between these polymorphisms and PIH, performing subgroup analyses, in terms of genotypes of AGT, NOS3, and prepregnancy by body mass. Further studies should be carried out in terms of other kinds of genes using larger number of subjects in the future.
2. In order to develop a stress checklist for pregnant women to use examinations and interventions, we performed personal interview and focus group interview in obstetrical department. Emesis, body change by pregnancy, health control methods during pregnancy, economical burden, relationship to parents, child care in the near future, etc. were found to be the stress factors of the pregnant women.

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (30 results)

All 2008 2007 2006

All Journal Article (22 results) (of which Peer Reviewed: 8 results) Presentation (5 results) Book (3 results)

  • [Journal Article] Pulmonary thromboembolism in obstetrics and gynecology increased by 6.5-fold over the past decade in Japan.2008

    • Author(s)
      Kobayashi T, Nakabayashi M, et. al.
    • Journal Title

      Circ J 72

      Pages: 753-756

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Pulmonary thromboembolism in obstetrics and gynecology increased by 6.5-fold over the past decade in Japan2008

    • Author(s)
      Kobayashi T, Nakabayashi M, Ishikawa M, Adachi T, Kobashi G, Maeda M, Ikenoue T.
    • Journal Title

      Circ J 72

      Pages: 753-756

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Analysis of the geographical accessibility of neurosurgical emergency hospitals in Sapporo city using GIS and AHP.2007

    • Author(s)
      Ohta K, Kobashi G, Takano S, et. al.
    • Journal Title

      International Journal of Geographical Information Science 21

      Pages: 687-698

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 遺伝的因子.妊娠高血圧症候群の病態と管理.2007

    • Author(s)
      小橋 元、太田薫里、山田秀人, 他
    • Journal Title

      周産期医学 37

      Pages: 1091-1096

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 地域の健康づくりグループの発展を促進するための基礎的研究2007

    • Author(s)
      保田玲子、清水光子、照井レナ, 他
    • Journal Title

      高齢者問題研究 23

      Pages: 71-85

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Neurocognitive function of patients with brain metastasis who received either whole brain radiotherapy plus stereotactic radiosurgery or radiosurgery alone.2007

    • Author(s)
      Aoyama H, Tago M, Kato N, et. al.
    • Journal Title

      Int J Radiat Oncol Biol Phys 68

      Pages: 1388-1395

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Analysis of the geographical accessibility of neurosurgical emergency hospitals in Sapporo city using GIS and AHP.2007

    • Author(s)
      Ohta K, Kobashi G, Takano S, Kagaya S, Yamada H, Minakami H, Yamamura E.
    • Journal Title

      Int J Geogr Inf Sci 21

      Pages: 687-698

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Neurocognitive function of patients with brain metastasis who received either whole brain radiotherapy plus stereotactic radiosurgery or radiosurgery alone.2007

    • Author(s)
      Aoyama H, Tago M, Kato N, Toyoda T, Kenjyo M, Hirota S, Shioura H, Inomata T, Kunieda E, Hayakawa K, Nakagawa K, Kobashi G, Shirato H.
    • Journal Title

      Int J Radiat Oncol Biol Phys 68

      Pages: 1388-1395

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 遺伝的因子.妊娠高血圧症候群の病態と管理.2007

    • Author(s)
      小橋 元、太田 薫里、山田 秀人、水上 尚典
    • Journal Title

      周産期医学 37

      Pages: 1091-1096

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 地域の健康づくりグループの発展を促進するための基礎的研究2007

    • Author(s)
      保田 玲子、清水 光子、照井 レナ, 他
    • Journal Title

      高齢者問題研究 23

      Pages: 71-85

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neurocognitive function of patients with brain metastasis who received either whole brain radiotherapy plus stereotactic radiosurgery or radiosurgery alone.2007

    • Author(s)
      Aoyama H, Tago m, Kato N, et. al.
    • Journal Title

      Int J Radiat Oncol Phys 68

      Pages: 1388-1395

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multi-institutional Prospective Randomized Comparison of Stereotactic Radiosurgery plus Upfront Whole Brain Radiation Therapy versus Stereotactic Radiosurgery Alone for the Treatment of Solitary and Multiple Brain Metastases.2006

    • Author(s)
      Aoyama H, Shirato H, Kobashi G, et. al.
    • Journal Title

      JAMA 295

      Pages: 2483-2491

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Young Epidemiologists' Attitude towards Personal Data Protection.2006

    • Author(s)
      Kobashi G, Hoshuyama T, Ohta K, et. al.
    • Journal Title

      Journal of Epidemiology 16

      Pages: 90-92

    • NAID

      10017969840

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 妊娠高血圧症の遺伝因子2006

    • Author(s)
      小橋 元、太田薫里、山田秀人, 他
    • Journal Title

      血圧 13

      Pages: 845-850

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 生活習慣病としての習慣流産-特に遺伝学的要因について2006

    • Author(s)
      山田 秀人、小橋 元, 他
    • Journal Title

      産婦人科の実際 55

      Pages: 1389-1401

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Young Epidemiologists' Attitude towards Personal Data Protection2006

    • Author(s)
      Kobashi G, Hoshuyama T, Ohta K, Sugimori H, Oki I, Kanda H, Naito M, Takao S, Tamakoshi A.
    • Journal Title

      J Epidemiol 16

      Pages: 90-92

    • NAID

      10017969840

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Multi-institutional Prospective Randomized Comparison of Stereotactic Radiosurgery plus Upfront Whole Brain Radiation Therapy versus Stereotactic Radiosurgery Alone for the Treatment of Solitary and Multiple Brain Metastases.2006

    • Author(s)
      Aoyama H, Shirato H, Tago M, Nakagawa K, Toyoda T, Hatano K, Kenjyo M, Oya N, Hirota S, Shioura H, Kunieda E, Inomata T, Hayakawa K, Katoh N, Kobashi G.
    • Journal Title

      J AMA 295

      Pages: 2483-2491

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Analysis of the geographical accessibility of neurosurgical emergency hospitals in Sapporo city using GIS and AHP.2006

    • Author(s)
      Ohta K, Kobashi G, Takano S, et al.
    • Journal Title

      International Journal of Geographical Information Science (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Multi-institutional Prospective Randomized Comparison of Stereotactic Radiosurgery plus Upfront whole Brain Radiation Therapy versus Stereotactic Radiosurgery Alone foe the Treatment of Solitary and Multiple Brain Metastases.2006

    • Author(s)
      Aoyama H, Shirota H, kobashi G, et al.
    • Journal Title

      JAMA 295

      Pages: 2483-2491

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Young Epidemiologists' Attitude towards Personal Data Protection.2006

    • Author(s)
      Kobashi G, Hoshuyama T, Ohta K, et al.
    • Journal Title

      Epidemiol 16

      Pages: 90-92

    • NAID

      10017969840

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 妊娠高血圧症の遺伝因子2006

    • Author(s)
      小橋元, 太田薫里, 山田秀人, 水上尚典
    • Journal Title

      血圧 13

      Pages: 845-850

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 生活習慣病としての習慣流産・特に遺伝学的要因について2006

    • Author(s)
      山田秀人, 小橋元, 他
    • Journal Title

      産婦人科の実際 55

      Pages: 1389-1401

    • Related Report
      2006 Annual Research Report
  • [Presentation] 予防医学と疫学研究2006

    • Author(s)
      小橋 元
    • Organizer
      第30回大動物臨床研究会シンポジウム(基調講演)
    • Place of Presentation
      札幌市
    • Year and Date
      2006-11-25
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 妊娠高血圧症候群における遺伝子多型の交絡.日本人類遺伝学会第51回大会2006

    • Author(s)
      太田薫里、小橋 元、羽田 明, 他
    • Organizer
      日本人類遺伝学会第51回大会
    • Place of Presentation
      米子市
    • Year and Date
      2006-10-25
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] A confoundings of candidate single nucleotide polmorphisms for pregnancy-induced hypertention in Japan.2006

    • Author(s)
      Ohta K, Kobashi G, Yamada H, et. al.
    • Organizer
      American Society of Human Genetics 2006
    • Place of Presentation
      New Orleans, USA.
    • Year and Date
      2006-10-11
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 予防医学と疫学研究2006

    • Author(s)
      小橋 元
    • Organizer
      第11回大動物臨床教育セミナー(基調講演)
    • Place of Presentation
      江別市
    • Year and Date
      2006-05-30
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] PIH Epidemiological Study Group. A confoundings of candidate single nucleotide polmorphisms for pregnancy-induced hypertention in Japan.2006

    • Author(s)
      Ohta K, Kobashi G, Yamada H, Hata A, Minakami H, Fujimoto S, Kondo K, Hokkaido
    • Organizer
      American Society of Human Genetics 2006
    • Place of Presentation
      New Orleans, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] Sub Note保健医療論・公衆衛生学2008(母子保健部分)2007

    • Author(s)
      小橋 元, 他
    • Total Pages
      27
    • Publisher
      メディックメディア
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Book] Sub Note保健医療論・公衆衛生学2007(母子保健部分)2006

    • Author(s)
      小橋 元, 他
    • Total Pages
      27
    • Publisher
      メディックメディア
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] Sub Note 保健医療論・公衆衛生学 2007(母子保健部分)(担当部分)2006

    • Author(s)
      小橋元, 他
    • Total Pages
      27
    • Publisher
      メディックメディア
    • Related Report
      2006 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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