Relationship between sperm fertilizing ability and intracellular signal transduction.
| Project/Area Number |
18591796
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
KUBOTA Toshiro (2009) Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 教授 (50126223)
SHIMIZU Yasufumi (2006-2008) Tokyo Medical and Dental University, 医学部附属病院, 講師 (80242197)
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| Co-Investigator(Kenkyū-buntansha) |
HARADA Tatsuya 東京医科歯科大学, 医歯学総合研究科, 助教 (80376748)
ISIKAWA Tomonori 東京医科歯科大学, 医歯学総合研究科, 助教 (50447489)
久保田 俊郎 東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (50126223)
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| Co-Investigator(Renkei-kenkyūsha) |
SHIMIZU Yasufumi 田園都市レディースクリニック, 不妊センター長 (80242197)
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| Project Period (FY) |
2006 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,940,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥540,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2006: ¥1,600,000 (Direct Cost: ¥1,600,000)
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| Keywords | 生殖医学 / 精子 / 受精能 / 細胞内情報伝達系 / 体外受精 / 自動精子分析装置 / カルシウム / 受精 / プロゲステロン / hyperactivation |
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| Research Abstract |
The baseline and peak fluorescence of the spermatozoa with abnormal morphology was lower when compared with normal spermatozoa. Follicular fluid-induced [Ca^<2+>]i increase of morphologically normal spermatozoa from infertile couples was lower than that of morphologically normal spermatozoa from healthy donors. This study shows that spermatozoa with abnormal morphology have disorders of signal transduction in healthy donors, and normal shaped sperm from infertile patients have disorders of signal transduction comparing that from healthy donors.
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Report
(6 results)
Research Products
(30 results)
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[Journal Article] Methylation of the Calcium Channel-Related Gene, CACNA2D3, Is Frequent and a Poor Prognostic Factor in Gastric Cancer2008
Author(s)
Wanajo A, Sasaki A, Nagasaki H, Shimada S, Otsubo T, Owaki S, 清水康史, Eishi Y, Kojima K, Nakajima Y, Kawano T, Yuasa Y, Akiyama Y
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Journal Title
Gastroenterology 135
Pages: 580-590
Related Report
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[Journal Article] Methylation of the calcium channel-related gene, CACNA2D3, is frequent and a poor prognostic factor in gastric cancer2008
Author(s)
Wanajo A, Sasaki A, Nagasaki H, Shimida S, Otubo T, Owaki S, Shimizu Y, Eishi Y, Kojima K, Nakajima Y, Kawano T, Yuasa Y, Akiyama Y
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Journal Title
Gastroent erology 135
Pages: 580-590
Related Report
Peer Reviewed
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[Journal Article] Methylat ion of the calcium channel-related gene, CACNA2D3, is freouent and a poor prognostic factor in gastric cancer.2008
Author(s)
Wanajo A, Sasaki A, Nagasaki H, Shimida S, Otubo T, Owaki S, Shimizu Y, Eishi Y, Kojima K, Nakajima Y, Kawano T, Yuasa Y, Akiyama Y
-
Journal Title
Gastroenterology 135
Pages: 580-590
Related Report
Peer Reviewed
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