| Project/Area Number |
18591807
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Nagoya City University |
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Principal Investigator |
SUZUKI Yoshikatsu Nagoya City University, graduate School of Medical Sciences, Associate Professor (30254288)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Tamao Nagoya City University, graduate School of Medical Scipnoas, Research Associate (20405210)
ITOH Takeo Nagoya City University, graduate School of Medical Sciences, Professor (70159888)
WATANABE Yoshimasa Nagoya City University, graduate School of Medical Sciences, Assistant Professor (70381803)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥3,880,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥480,000)
Fiscal Year 2007: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2006: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | preeclampsoia / endothelial dysfunction / folic acid / L-arginine / prevention |
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| Research Abstract |
Preeclampsia, characterized as hypertension and proteinuria threatens to both maternal and fetal life. It causes to increase vascular tone and permeability due to the activation of endothelial function. There are two differ types of the disease. One is dependent on the placental disorder, which is caused by faulty of placentation at early pregnant time. The increases in production of cytokines and superoxide, and insulin resistance might be involved in the pathophysiology with and without placental disorder. Thus, it is important for the management of diet, including sodium and vitamin to treat and prevent it, being similar to metabolic syndrome. In the present study, we investigated whether or not an oral supplementation of L-arginine plus folic acid could improve endothelial dysfunction seen in preeclampsia.
The concentration of serum L-arginine had been increasing advancing gestational ages, however it was reduced in preeclamptic women. Furthermore, flow mediate vasodilatation (FMD), non-invasive evaluation of endothelial function using ultrasound was reduced in both preeclamptic and high risk women (previous preeclampsia). In preeclamptic women, the reduction could not be improved by profuse supplementation of L-arginine 9g plus folic acid 5 mg / day for a several days. In high risk women, the reduction could be improved by the profuse supplement as well as contentious administration of L-arginine lg plus folic acid 0.8mg/day from the second trimester. In conclusion, the supplementation of L-arginine plus folic acid might prevent the endothelial dysfunction seen in preeclampsia.
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