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Study for the function of TCTP in spermatogenesis and analysis for the regulation of the expression of TCTP by androgen.

Research Project

Project/Area Number 18591817
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionHyogo College of Medicine

Principal Investigator

KOMORI Shinji  Hyogo College of Medicine, 医学部, 教授 (60195865)

Co-Investigator(Kenkyū-buntansha) TANAKA Hiroyuki  兵庫医科大学, 医学部, 講師 (80330447)
堀内 功  兵庫医科大学, 医学部, 講師 (70340974)
霞 弘之  兵庫医科大学, 医学部, 講師 (00289068)
Co-Investigator(Renkei-kenkyūsha) HORIUCHI Isao  兵庫医科大学, 医学部, 講師 (70340974)
KASUMI Hiroyuki  兵庫医科大学, 医学部, 講師 (00289068)
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,100,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥600,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2006: ¥1,500,000 (Direct Cost: ¥1,500,000)
Keywords精子形成 / TCTP / アンドロゲン / セルトリ細胞 / 精子形成過程
Research Abstract

アンドロゲンにより精巣のセルトリ細胞より分泌されるTCTPは減少することをin vitro及びin vivoにおいて明らかにした。さらにその発現調節に関連する部位も同定することに成功した。このことによりアンドロゲンのセルトリ細胞における機能の一旦を明らかにすることができ、今後の精巣でのアンドロゲン作用の解明に有益な結果を得ることができた。

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (12 results)

All 2008 2007 2006 Other

All Journal Article (3 results) (of which Peer Reviewed: 2 results) Presentation (8 results) Book (1 results)

  • [Journal Article] Upregulation of macrophage migaration inhibitory factor and calgizzarin by androgen in aTM4 mouse Sertoli cells.2006

    • Author(s)
      Kasumi H. Komori S. Sakata K. Yamamoto N. Yamasaki T. Kanemura Y Koyama K.
    • Journal Title

      Asian J Androl 8

      Pages: 549-554

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Upregulation of macrophage migaration inhibitory factor and calgizzarin by androgen in aTM4 mouse Sertoli cells.2006

    • Author(s)
      Kaumi H.Komori S.Sakata K.Yamamoto N.Yamasaki T.Kanemura Y.Koyama K.
    • Journal Title

      Asian Journal of Andrology 8巻・5号

      Pages: 549-554

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Analysis of effects of androgen on protein profiles in TM4 mouse Sertoli cells by SELDI-TOF mass spectrometry.

    • Author(s)
      Komori S. Sakata K. Kasumi H. Takenobu T. Yamasaki T. Kanemura Y Koyama K.
    • Journal Title

      Androgia submitted

      Pages: 0-0

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Presentation] セルトリ細胞株におけるアンドロゲンのTranslationally controlled tumor protein (TCTP)の発現調節に関する検討2008

    • Author(s)
      小森慎二
    • Organizer
      第27回日本アンドロロジー学会
    • Place of Presentation
      京都歌舞練場
    • Year and Date
      2008-07-05
    • Related Report
      2008 Annual Research Report
  • [Presentation] セルトリ細胞株におけるアンドロゲンのTranslationally controlled tumor protein (TCTP)の発現調節に関する検討2008

    • Author(s)
      小森慎二
    • Organizer
      第60回日本産科婦人科学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2008-04-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] andorogen downregulates the expression of translationally controlled tumor protein(TCTP) in mouse Sertoli cells2008

    • Author(s)
      Komori S, Kasumi H, Nakamura Y, Kinuta T, Tanaka H and Koyama K.
    • Organizer
      41^<rd> annual meeting of Society for Study of Reproduction
    • Place of Presentation
      Kailua-Kona Hawaii, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] Translationally controlled tumor protein(TCTP)の発現におけるアンドロゲンの作用の検討2007

    • Author(s)
      小森 慎二
    • Organizer
      第22回日本生殖免疫学会
    • Place of Presentation
      日本大学会館
    • Year and Date
      2007-11-30
    • Related Report
      2007 Annual Research Report
  • [Presentation] Sertoli細胞でのTranslationally controlled tumor protein(TCTP)の発現におけるアンドロゲンの影響についての検討2007

    • Author(s)
      小森 慎二
    • Organizer
      第59回日本産科婦人科学会
    • Place of Presentation
      京都国際会館
    • Year and Date
      2007-04-16
    • Related Report
      2007 Annual Research Report
  • [Presentation] Analysis of the androgen effect for the expression of translationally controlled tumor protein(TCTP) in mouse Sertoli cells.2007

    • Author(s)
      Komori S, Kasumi H, Uchida K, Nakamura Y and Koyama K.
    • Organizer
      63^<rd> annual meeting of the American Society for Reproductive Medicine
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] Studies on the androgen effect for the expression of macrophage inhibitory factor (MIF) and translationally controlled tumor protein (TCTP) in mouse Sertoli cells.2007

    • Author(s)
      Tanaka H, Komori S, Sakata K, Kasumi H and Koyama K.
    • Organizer
      10^<th> International congress of Reproductive immunology
    • Place of Presentation
      Opatija, Croatia
    • Related Report
      2008 Final Research Report
  • [Presentation] Analysis of effects of androgen on protein profiles in TM4 mouse Sertoli cells by SELDI-TOF mass spectrometry.2006

    • Author(s)
      Komori S, Sakata K, Kasumi H, Takenobu T, Uchida K, Fukuoka K and Koyama K.
    • Organizer
      26th anniversary meeting of American Society for Reproductive Immunology
    • Place of Presentation
      Nashville Tennessee
    • Related Report
      2008 Final Research Report
  • [Book] The role of androgens in spermatogenesis. Gamete Biology: Emerging frontiers in Fertility and Contraceptive Development (Edited by Gupta SK. Koyama K. and Murray JF)2007

    • Author(s)
      Komori S. Kasumi H. Sakata K. Koyama K.
    • Publisher
      Nottingham university press
    • Related Report
      2008 Final Research Report

URL: 

Published: 2006-04-01   Modified: 2016-04-21  

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