Development of nerve-sparing radical hysterectomy based on autonomic nerve ganglion mapping

• Project/Area Number: 18591821
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Tohoku University
• Principal Investigator: NAGASE Satoru Tohoku University, 病院, 講師 (00292326)
• Co-Investigator(Kenkyū-buntansha): NIIKURA Hitoshi 東北大学, 大学院・医学系研究科, 准教授 (80261634) ; YOSHINAGA Kousuke 東北大学, 病院, 助教 (40343058) ; MURAKAMI Gen 札幌医科大学, 病院, 教授 (30157747) ; YAEGASHI Nobuo 東北大学, 大学院・医学系研究科, 教授 (00241597)
• Co-Investigator(Renkei-kenkyūsha): MURAKAMI Gen 札幌医科大学, 病院, 教授 (30157747)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,000,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥600,000); Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2006: ¥1,400,000 (Direct Cost: ¥1,400,000)
• Keywords: 広汎子宮全摘出術 / 膀胱子宮靭帯 / 神経節 / 神経温存術式 / 骨盤腹膜 / 広汎子宮全摘術 / 骨盤筋膜 / 膀胱子宮靭帯後層

Research Abstract

膀胱子宮靭帯後層には神経節が多数存在することが初めて明らかになった(389~732個、中央値 : 561個)。48%の神経節は静脈群の内側または腟側にみられ、19.2%は静脈群間に、13%は静脈群の外側に、19.8%は背側に認めた。さらに、広汎子宮全摘出術を施行した40例(左右で75側)を対象に膀胱子宮靭帯後層を術中電気刺激し、骨盤内蔵神経の走行を確認した。神経の分布は、後層内と後層背側に認めたものが51例(69%)と最も多かった。

Research Products

• [Journal Article] Fetal development of the human gubernaculum with special reference to the fasciae and muscles around it (2008)
  • Author(s): Niikura H, Okamoto S, Nagase S, Takano T, Murakami G, Tatsumi H, Yaegashi N
  • Journal Title: Clin Anat Sep ; 21(6) Pages: 547-557
  • Peer Reviewed
• [Journal Article] Vesicouterine ligament contains abundant autonomic nerve ganglion cells : the distribution in histology concerning nnerve-sparing radical hysterectomy (2008)
  • Author(s): Katahira A, Niikura H, Ito K, Takano T, Nagase S, Murakami G, Yaegashi N.
  • Journal Title: Int J Gynecol Cancer 18 Pages: 193-198
  • Peer Reviewed
• [Journal Article] Fetal development of the human gubernaculum with special reference to the fasciae and muscles around it (2008)
  • Author(s): Niikura H
  • Journal Title: Clin Anat 6 Pages: 547-557
  • Peer Reviewed
• [Journal Article] Vesicouterine ligament contains abundant autonomic nerve ganglion cells: the distribution in histology concerning nerve-sparing radical hysterectomy. (2008)
  • Author(s): A Katahira
  • Journal Title: Int J Gynecol Cancer 18 Pages: 193-198
  • Peer Reviewed
• [Journal Article] Surgical anatomy of intrapelvicand vesico-uterine ligament in nerve-sparing radical hysterectomy with fresh cadaver dissections (2007)
  • Author(s): Niikura H, Katahira A, Utsunomiya H, Takano T, Ito K, Nagase S, Yoshinaga K, Tokunaga H, Toyoshima M, Kinugasa Y, Uchiyama E, Murakami G, Yabuki Y, Yaegashi N.
  • Journal Title: Tohoku J Exp Med. 212 Pages: 403-413
  • Peer Reviewed
• [Presentation] 膀胱子宮靭帯後層周辺における自律神経の走行と神経節の分布-術中自律神経電気刺激の利用と解剖学的検討- (2007)
  • Author(s): 新倉仁
  • Organizer: 第42回日本婦人科腫瘍学会教育シンポジウム骨盤の局所解剖と機能温存手術
  • Place of Presentation: 東京
  • Year and Date: 2007-06-30
• [Presentation] 教育シンポジウム「膀胱子宮靭帯後層周辺における自律神経の走行と神経節の分布〜術中自律神経電気刺激の利用と解剖学的検討〜 (2007)
  • Author(s): 新倉 仁
  • Organizer: 第42回日本婦人科腫瘍学会
  • Place of Presentation: 東京
  • Year and Date: 2007-06-30