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Functional role of IDO, a novel prognostic marker for endometrial cancer, and development of the tailor-made IDO-targeted therapy

Research Project

Project/Area Number 18591831
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionNagoya University

Principal Investigator

INO Kazuhiko  Nagoya University, 大学院・医学系研究科, 准教授 (60303640)

Co-Investigator(Kenkyū-buntansha) YAMAMOTO Eiko  名古屋大学, 医学部附属病院, 助教 (10432262)
NOMURA Seiji  名古屋大学, 大学院・医学系研究科, 助教授 (20242860)
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,780,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2006: ¥1,700,000 (Direct Cost: ¥1,700,000)
Keywords子宮体癌 / 酵素 / 免疫寛容 / リンパ球 / NK細胞 / 標的治療 / 免疫療法 / IDO / 腫瘍免疫 / ヌードマウス / マイクロアレイ / 子後因子 / 腫瘍浸潤性リンパ球 / トリプトファン代謝酵素 / 予後因子 / オーダーメイド治療
Research Abstract

トリプトファン代謝酵素であるIDOは免疫抑制作用を有し、癌の宿主に対する免疫寛容に関与する.本研究では子宮体癌におけるIDOの発現とその意義について検討し以下の知見を得た.(1)IDOは子宮体癌の予後を規定する分子マーカーである.(2)IDOは局所腫瘍浸潤リンパ球を抑制する.(4)IDOを過剰発現した子宮体癌細胞は、マウスモデルにおいて腫瘍増殖が促進されるが、IDO阻害剤投与によりその増殖は抑制される.以上よりIDOは子宮体癌における新たな標的治療のターゲットとなる可能性が示された.

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (32 results)

All 2009 2008 2007 2006

All Journal Article (21 results) (of which Peer Reviewed: 5 results) Presentation (9 results) Book (2 results)

  • [Journal Article] Overexpression of indoleamine 2, 3-dioxygenase in human endometrial carcinoma cells induces rapid tumor growth in a mouse xenograft model2008

    • Author(s)
      Yoshida N, Ino K, et.al.
    • Journal Title

      Clin Cancer Res 14

      Pages: 7251-7259

    • Related Report
      2008 Final Research Report
  • [Journal Article] Inverse correlation between tumoral indoleamine 2, 3 dioxygenase expression and tumor-infiltrating lymphocytes in endometrial cancer : Its association with disease progression and survival2008

    • Author(s)
      Ino K, Yamamoto E, et.al.
    • Journal Title

      Clin Cancer Res 14

      Pages: 2310-2317

    • Related Report
      2008 Final Research Report
  • [Journal Article] Twist expression in patients with cervical cancer is associated with poor disease outcome2008

    • Author(s)
      Shibata K, Kajiyama H, Ino K, et.al.
    • Journal Title

      Ann Oncol 19

      Pages: 81-85

    • Related Report
      2008 Final Research Report
  • [Journal Article] Involvement of SDF-1α/CXCR4 axis in the enhanced peritoneal metastasis of epithelial ovarian carcinoma2008

    • Author(s)
      Kajiyama H, Ino K, et.al.
    • Journal Title

      Int J Cancer 122

      Pages: 91-99

    • Related Report
      2008 Final Research Report
  • [Journal Article] N-acetylglucosaminyltransferase V regulates extravillous trophoblast invasion through glycosylation of α5β1 integrin2008

    • Author(s)
      Yamamoto E, Ino K, et.al.
    • Journal Title

      Endocrinology 150

      Pages: 990-999

    • Related Report
      2008 Final Research Report
  • [Journal Article] 子宮体癌における新規予後規定分子IDOの発現とその意義 : 腫瘍浸潤リンパ球抑制による免疫寛容誘導2008

    • Author(s)
      井箟一彦
    • Journal Title

      日本婦人科腫瘍学会雑誌 26

      Pages: 125-129

    • NAID

      10021925260

    • Related Report
      2008 Final Research Report
  • [Journal Article] Overexpression of indoleamine 2, 3-dioxygenase in human endometrial carcinoma cells induces rapid tumor growth in a mouse xenograft model2008

    • Author(s)
      Yoshida N, Ino K, et al.
    • Journal Title

      Clin Cancer Res 14

      Pages: 7251-7259

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inverse correlation between tumoral indoleamine2, 3-dioxygenase expression and tumor-infiltrating lymphocytes in endometrial cancer : Its association with disease progression and survival2008

    • Author(s)
      Ino K, Yamamoto E, et al.
    • Journal Title

      Clin Cancer Res 14

      Pages: 2310-2317

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inverse correlation between tumoral indoleamine 2,3-dioxygenase expression and tumor-infiltrating lymphocytes in endometrial cancer:Its association with disease progression and survival2008

    • Author(s)
      Ino K, et. al.
    • Journal Title

      Clin Cancer Res 印刷中(印刷中)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Angiotensin II mimics the hypoxic effect on regulating trophoblast proliferation and differentiation in humanplacental explant cultures2008

    • Author(s)
      Araki-Taguchi M, Ino K, et. al.
    • Journal Title

      Life Sci 82

      Pages: 59-67

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of N-acetylglucosaminyltransferase V in endometrial cancer correlates with poor prognosis2007

    • Author(s)
      Yamamoto E, Ino K, et.al.
    • Journal Title

      Br J Cancer 97

      Pages: 1538-1544

    • Related Report
      2008 Final Research Report
  • [Journal Article] Expression of N-acetylglucosaminyltransferase V in endometrial cancercorrelates with poor prognosis2007

    • Author(s)
      Yamamoto E, Ino K, et. al.
    • Journal Title

      Br J Cancer 97

      Pages: 1538-1544

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of Twist increases the risk for recurrence and for poor survival in epithelial ovarian carcinoma patients2007

    • Author(s)
      Hosono S, et al.
    • Journal Title

      Br J Cancer 96

      Pages: 314-320

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Indoleamine 2, 3-dioxygenase is a novel prognostic indicator for endometrial cancer2006

    • Author(s)
      Ino K, Yoshida N, Kajiyama H, et.al.
    • Journal Title

      Br J Cancer 95

      Pages: 1555-1561

    • Related Report
      2008 Final Research Report
  • [Journal Article] Manipulating the angiotensin system--new approaches to the treatment of solid tumours2006

    • Author(s)
      Ino K, Shibata K, et.al.
    • Journal Title

      Expert Opin Biol Ther 6

      Pages: 243-255

    • Related Report
      2008 Final Research Report
  • [Journal Article] Angiotensin II type 1 receptor expression in ovarian cancer and its correlation with tumor angiogenesis and patient survival2006

    • Author(s)
      Ino K, Shibata K, et.al.
    • Journal Title

      Br J Cancer 94

      Pages: 552-560

    • Related Report
      2008 Final Research Report
  • [Journal Article] Indoleamine 2,3-dioxygenase is a novel prognostic indicator for endometrial cancer2006

    • Author(s)
      Ino K, et al.
    • Journal Title

      Br J Cancer 95

      Pages: 1555-1561

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Endoplasmic reticulum aminopeptidasel mediates leukemia inhibitory factor-induced cell surface HLA-G expression in JEG-3 choriocarcinoma cells2006

    • Author(s)
      Shido F, et al.
    • Journal Title

      Endocrinology 147

      Pages: 1780-1788

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Manipulating the angiotensin system-new approaches to the treatment of solid tumours2006

    • Author(s)
      Ino K, et al.
    • Journal Title

      Expert Opin Biol Ther 6

      Pages: 243-255

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Angiotensin II type 1 receptor expression in ovarian cancer and its correlation with tumor angiogenesis and patient survival2006

    • Author(s)
      Ino K, et al.
    • Journal Title

      Br J Cancer 94

      Pages: 552-560

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 子宮体癌における新しい予後規定分子マーカーIndoleamine 2,3-dioxygenase (IDO)の発現2006

    • Author(s)
      井箆一彦
    • Journal Title

      日本婦人科腫瘍学会雑誌 24

      Pages: 6-11

    • Related Report
      2006 Annual Research Report
  • [Presentation] Role of the immunosuppressive enzyme indoleamine 2, 3-dioxygenase in the progression of ovarian carcinoma and its targeted therapy2009

    • Author(s)
      Ino K
    • Organizer
      Global Center of Excellence (COE) program 1st International Symposium
    • Place of Presentation
      Nagoya
    • Year and Date
      2009-01-23
    • Related Report
      2008 Final Research Report
  • [Presentation] 子宮体癌における免疫抑制酵素Indoleamine 2, 3-dioxygenase (IDO)の機能解析と新たな分子標的治療の開発2008

    • Author(s)
      井箟一彦
    • Organizer
      第44回日本婦人科腫瘍学会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-07-18
    • Related Report
      2008 Final Research Report
  • [Presentation] 子宮体癌における免疫抑制酵素Indoleamine 2, 3-dioxygenase (IDO)の機能解析と新たな分子標的治療の開発2008

    • Author(s)
      井箟一彦, 吉田憲生, et al.
    • Organizer
      第44回日本婦人科腫瘍学会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2008-07-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] Expression of the immunoregulatory enzyme indoleamine 2, 3-dioxygenase (IDO) in human normal and malignant invasive trophoblastic cells2008

    • Author(s)
      Ino K
    • Organizer
      14th IFPA Meeting 2008
    • Place of Presentation
      Graz, Austria
    • Related Report
      2008 Final Research Report
  • [Presentation] 子宮体癌における新規予後規定分子IDOの発現とその意義 : 腫瘍浸潤リンパ球抑制による免疫寛容誘導2007

    • Author(s)
      井箟一彦
    • Organizer
      第42回日本婦人科腫瘍学会
    • Place of Presentation
      東京
    • Year and Date
      2007-06-30
    • Related Report
      2008 Final Research Report
  • [Presentation] 子宮体癌における新規予後規定分子IDOの発現とその意義:腫瘍浸潤リンパ球抑制による免疫寛容誘導2007

    • Author(s)
      井箟一彦
    • Organizer
      第42回日本婦人科腫瘍学会
    • Place of Presentation
      東京
    • Year and Date
      2007-06-30
    • Related Report
      2007 Annual Research Report
  • [Presentation] 子宮体癌の新規予後規定分子Indoleamine 2, 3-dioxygenase (IDO)は腫瘍浸潤リンパ球の抑制による局所免疫寛容を誘導して腫瘍進展に関与する2007

    • Author(s)
      井箟一彦
    • Organizer
      第59回日本産科婦人科学会
    • Place of Presentation
      京都
    • Year and Date
      2007-04-16
    • Related Report
      2008 Final Research Report
  • [Presentation] 子宮体癌における新たな予後規定分子Indoleamine 2, 3-dioxygenase (IDO)の発現とその意義2006

    • Author(s)
      井箟一彦
    • Organizer
      第44回日本癌治療学会
    • Place of Presentation
      東京
    • Year and Date
      2006-10-19
    • Related Report
      2008 Final Research Report
  • [Presentation] Dual induction of indoleamine 2, 3-dioxygenase and HLA-G by interferon-gamma in human extravillous trophoblasts : its implication in tolerance at the fetal-maternal interface2006

    • Author(s)
      Ino K
    • Organizer
      12th IFPA Meeting 2006
    • Place of Presentation
      Kobe, Japan
    • Related Report
      2008 Final Research Report
  • [Book] Indoleamine 2, 3-dioxygenase. In : Schwab M (ed), Encyclopedia of Cancer, 2nd edition2008

    • Author(s)
      Ino K, Kikkawa F
    • Publisher
      Springer Science
    • Related Report
      2008 Final Research Report
  • [Book] 絨毛性疾患 in『婦人科がん標準化学療法の実際』(宇田川康博, 八重樫伸生(編))2008

    • Author(s)
      井箟一彦、吉川史隆
    • Publisher
      金原出版
    • Related Report
      2008 Final Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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