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Discovery of epigenetically masked tumor suppressor genes in gyneoobgical cancer

Research Project

Project/Area Number 18591840
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionOita University

Principal Investigator

TAKAI Noriyuki  Oita University, Department of OB/GYN, Assistant Professor (50295185)

Co-Investigator(Kenkyū-buntansha) NARAHARA Hisashi  Oita University, Department of OB/GYN, Professor (60211447)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,810,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2006: ¥2,900,000 (Direct Cost: ¥2,900,000)
KeywordsEpigenetic / Histone / Microarray / Methvlation / Tumor suppressor gene / Gynecologic cancer / ヒストン修飾
Research Abstract

Realization that many tumor suppressor genes are silenced by epigenetic mechanisms has stimulated discovery of novel tumor suppressor genes. We used a variety of research tools to search for genes that are epigenetically silenced in human endometrial cancers. Changes in global gene expression of the endometrial cancer cell line Ishikawa was analyzed after treatment with the demethylating agent 5-aza-2'-deoxycytidine (5-Aza-CdR) combined with the histone deacetylase inhibitor, suberoyl anilide bishydroxamide (SAHA). By screening over 22,000 genes, candidate tumor suppressor genes were identified. Additional microarray analysis and real-time RTPCR of normal and cancerous endometrial samples, and search for CpG islands further refined the list. Tigl and C/ebpa were chosen for further study. Expression of both genes was low in endometrial cancer cell lines and clinical samples, but high in normal endometrial tissues. Bisulfite sequencing and restriction analysis revealed aberrant methylation of the CpG island in the Tigl gene of all 6 endometrial cancer cell lines examined, whereas the C/ebpa promoter remained unmethylated in endometrial cancers Chromatin immunoprecipitation showed increased acetylated histones H3 bound to both Tigl and C/ebpa genes after treatment with 5-Aza-CdR and/or SAHA. Forced expression of either TIG1 or C/EBPa led to significant growth reduction of Ishikawa cells. Immunoprecipitation and reporter gene assays demonstrated that C/EBPa bound to and suppressed transcriptional activity of E2F1, a key cell cycle regulator. Our data suggest that C/ebpa and Tigl function as tumor suppressor proteins in endometrial cancers and that their reexpression may be a therapeutic target.

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (150 results)

All 2008 2007 2006

All Journal Article (64 results) (of which Peer Reviewed: 31 results) Presentation (80 results) Book (6 results)

  • [Journal Article] Bufalin induces growth inhibition,cell cycle arrest and apoptosis in hu man endometrial and ovarian cancer cells2008

    • Author(s)
      Noriyuki Takai
    • Journal Title

      Int J Mol Med 21

      Pages: 637-643

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Histone deacetylase inhibitors induce growth inhibition,cell cycle arrest and apoptosis in human choriocarcinoma cells2008

    • Author(s)
      Noriyuki Takai
    • Journal Title

      Int J Mol Med 21

      Pages: 109-115

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] K252a is highly effective in suppressing the growth of human endometrial cancer cells,but has little effect on normal human endometrial epithelial cells2008

    • Author(s)
      Noriyuki Takai
    • Journal Title

      Oncol Rep 19

      Pages: 749-753

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Beta-hydroxyisovalerylshikonin has a profound anti-growth activity in human endometrial and ovarian cancer cells2008

    • Author(s)
      Noriyuki Takai
    • Journal Title

      Gynecol Oncol 109

      Pages: 107-114

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Tumorigenic effects of tamoxifen on the endometrium2008

    • Author(s)
      Kaei Nasu
    • Journal Title

      Curr Res in Cancer 2008;2:1-23 2

      Pages: 1-23

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Tumorigenic Effects of Tamoxifen on the Female Genital Tract2008

    • Author(s)
      Kaei Nasu
    • Journal Title

      Clinical Medicine:Pathology 1

      Pages: 1-18

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 過多月経・月経困難症に対するレボノルゲストレル徐放性IUSの有効性2008

    • Author(s)
      高井 教行
    • Journal Title

      産科と婦人科 75

      Pages: 223-224

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 過多月経2008

    • Author(s)
      高井 教行
    • Journal Title

      産科と婦人科増刊号 75(Suppl.)

      Pages: 219-223

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Bufalin induces growth inhibition, cell cycle arrest and apoptosis in human endometrial and ovarian cancer cells2008

    • Author(s)
      Noriyuki, Takai
    • Journal Title

      Int J Mol Med. 21

      Pages: 637-643

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Histone deacetylase inhibitors induce growth inhibition, cell cycle arrest and apoptoeis in human choriocarcinoma cells2008

    • Author(s)
      Noriyuki, Takai
    • Journal Title

      Int J Mol Med. 21(1)

      Pages: 109-115

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] K252a is highly effective in suppressing the growth of human endometrial cancer cells, but has little effect on normal human endometrial epithelial cells2008

    • Author(s)
      Noriyuki, Takai
    • Journal Title

      Oncol Rep 19(3)

      Pages: 749-753

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] beta-Hydroxyisovalerylshikonin has a profound anti-growth activity in human endometrial and ovarian cancer cells2008

    • Author(s)
      Noriyuki, Takai
    • Journal Title

      Gynecol Oncol 109(1)

      Pages: 107-114

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Tumorigenic effects of tamoxifen on the endometrium2008

    • Author(s)
      Kaei, Nasu
    • Journal Title

      Curr Res in Cancer 2

      Pages: 1-23

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Tumorigenic Effects of Tamoxifen on the Female Genital Tract2008

    • Author(s)
      Kaei, Nasu
    • Journal Title

      Clinical Medicine : Pathology 1

      Pages: 1-18

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] The use of intrauterine system with levonorgestrel.(Japanese)2008

    • Author(s)
      Noriyuki, Takai
    • Journal Title

      Obstet Gynecol(Jap) 75

      Pages: 223-224

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Hypermenorrhea.(Japanese)2008

    • Author(s)
      Noriyuki, Takai
    • Journal Title

      Obstet Gynecol(Jap) 75

      Pages: 219-223

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Histone deacetylase inhibitors induce growth inhibition, cell cycle arrest and apoptosis in human choriocarcinoma cells.2008

    • Author(s)
      Noriyuki Takai
    • Journal Title

      Int J Mol Med 21

      Pages: 109-115

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Beta-hydroxyisovalerylshikonin has a profound anti-growth activity in human endometrial and ovarian cancer cells.2008

    • Author(s)
      Noriyuki Takai
    • Journal Title

      Gynecol Oncol 109

      Pages: 107-114

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human endometrial and ovarian cancer cells:histone deacetylase inhibitors exhibit antiproliferative activity,potently induce cell cycle arrest,and stimulate apoptosis2007

    • Author(s)
      Noriyuki Takai
    • Journal Title

      Curr Med Chem 14

      Pages: 2548-2553

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Histone deacetylase inhibitor,suberoylanilide hydroxamic acid(Vorinostat,SAHA)profoundly inhibits the growth of human pancreatic cancer cells2007

    • Author(s)
      Takashi Kumagai
    • Journal Title

      Int J Cancer 121

      Pages: 656-665

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Application of the nuclear factor-kappaB inhibitor BAY 11-7085 for the treatment of endometriosis:an in vitro study2007

    • Author(s)
      Kaei Nasu
    • Journal Title

      Am J Physiol Endocrinol Metab 293

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Apicidin,a novel histone deacetylase inhibitor,has profound anti-growth activity in human endometrial and ovarian cancer cells2007

    • Author(s)
      Tami Ueda
    • Journal Title

      Int J Mol Med 19

      Pages: 301-308

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Granulosa cell tumor associated with secondary amenorrhea and serum luteinizing hormone elevation2007

    • Author(s)
      Kaei Nasu
    • Journal Title

      Int J Clin Oncol 12

      Pages: 228-230

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] The role of apoptotic dysfunction in the pathogenesis of endometriosis2007

    • Author(s)
      Kaei Nasu
    • Journal Title

      Current Women's Health Reviews 3

      Pages: 113-122

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 選択的nuclear factor-kB阻害剤2007

    • Author(s)
      奈須 家栄
    • Journal Title

      HORMONE FRONTIER IN GYNECOLOGY 14

      Pages: 357-362

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Human endometrial and ovarian cancer cells : histone deacetylase inhibitors exhibit antiproliferative activity, potently induce cell cycle arrest, and stimulate apoptosis2007

    • Author(s)
      Noriyuki, Takai
    • Journal Title

      Curr Med Chem. 14(24)

      Pages: 2548-2553

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Histone deacetylase inhibitor, suberoylanilide hydroxamic acid(Vorinostat, SAHA) profoundly inhibits the growth of human pancreatic cancer cells2007

    • Author(s)
      Takashi, Kumagai
    • Journal Title

      Int. J. Cancer 121(3)

      Pages: 656-665

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Application of the nuclear factor-kappaB inhibitor BAY 11-7085 for the treatment of endometriosis an in vitro study2007

    • Author(s)
      Kaei, Nasu
    • Journal Title

      Am J Physiol Endocrinol Metab 293(1)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Apicidin, a novel histone deaoetylase inhibitor, has profound anti'growth activity in human endometrial and ovarian cancer cells.2007

    • Author(s)
      Tami, Ueda
    • Journal Title

      Int J Mol Med 19(2)

      Pages: 301-308

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Granulosa cell tumor associated with secondary amenorrhea and serum luteinizing hormone elevation2007

    • Author(s)
      Kaei, Nasu
    • Journal Title

      Int J Clin Oncol 12(3)

      Pages: 228-230

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] The role of apoptotic dysfunction in the pathogenesis of endometriosis2007

    • Author(s)
      Kaei, Nasu
    • Journal Title

      Current Women's Health Reviews 3

      Pages: 113-122

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Selective nuclear factor kB inhibitor.(Japanese)2007

    • Author(s)
      Kaei, Nasu
    • Journal Title

      Hormone Front Gynecol 14

      Pages: 357-362

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Human endometrial and ovarian cancer cells: histone deacetylase inhibitors exhibit antiproliferative activity, potently induce cell cycle arrest, and stimulate apoptosis.2007

    • Author(s)
      Noriyuki Takai
    • Journal Title

      Curr Med Chem 14

      Pages: 2548-2553

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Histone deacetylase inhibitor, suberoylanilide hydroxamic acid (Vorinostat, SAHA) profoundly inhibits the growth of human pancreatic cancer cells.2007

    • Author(s)
      Takashi Kumagai
    • Journal Title

      Int J Cancer 121

      Pages: 656-665

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Application of the nuclear factor-kappa B inhibitor BAY 11-7085 for the treatment of endometriosis: an in vitro study.2007

    • Author(s)
      Kaei Nasu
    • Journal Title

      Am J Physiol Endocrinol Metab 293

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Apicidin, a novel histone deacetylase inhibitor, has profound anti-growth activity in human endometrial and ovarian cancer cells.2007

    • Author(s)
      Tami Ueda
    • Journal Title

      Int J Mol Med 19

      Pages: 301-308

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Granulosa cell tumor associated with secondary amenorrhea and serum luteinizing hormone elevation.2007

    • Author(s)
      Kaei Nasu
    • Journal Title

      Int J Clin. Oncol 12

      Pages: 228-230

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of apoptotic dysfunction in the pathogenesis of endometriosis.2007

    • Author(s)
      Kaei Nasu
    • Journal Title

      Current Women's Health Reviews 3

      Pages: 113-122

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 選択的nuclear factor-kB阻害剤2007

    • Author(s)
      奈須家栄
    • Journal Title

      HORMONE FRONTIER IN GYNECOLOGY 14

      Pages: 357-362

    • Related Report
      2007 Annual Research Report
  • [Journal Article] A novel histone deacetylase inhibitor,Scriptaid,induces growth inhibition,cell cycle arrest and apoptosis in human endometrial cancer and ovarian cancer cells2006

    • Author(s)
      Noriyuki Takai
    • Journal Title

      Int J Mol Med 17

      Pages: 323-329

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] M344 is a novel synthesized histone deacetylase inhibitor that induces growth inhibition,cell cycle arrest,and apoptosis in human endometrial cancer and ovarian cancer cells2006

    • Author(s)
      Noriyuki Takai
    • Journal Title

      Gynecol Oncol 101

      Pages: 108-113

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] CBHA is a family of hybrid polar compounds that inhibit histone deacetylase,and induces growth inhibition,cell cycle arrest and apoptosis in human endometrial and ovarian cancer cells2006

    • Author(s)
      Noriyuki Takai
    • Journal Title

      Oncology 70

      Pages: 97-105

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Anticancer activity of MS-275,a novel histone deacetylase inhibitor,against human endometrial cancer cells2006

    • Author(s)
      Noriyuki Takai
    • Journal Title

      Anticancer Res 26

      Pages: 939-945

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Expression of c-Ets1 protein in normal human placenta2006

    • Author(s)
      Noriyuki Takai
    • Journal Title

      Gynecol Obstet Invest 61

      Pages: 15-20

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] β-Hydroxyisovalerylshikonin induces apoptosis and G0/G1 cell-cycle arrest of endometriotic stromal cells:a preliminary in vitro study2006

    • Author(s)
      Masakazu Nishida
    • Journal Title

      Hum Reprod 21

      Pages: 2850-2856

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Magnetic resonance imaging findings in leiomyoma of the ovary:a case report2006

    • Author(s)
      Yasushi Kawano
    • Journal Title

      Arch Gynecol Obstet 273

      Pages: 298-300

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 子宮筋腫に対する薬物療法2006

    • Author(s)
      高井 教行
    • Journal Title

      日本産科婦人科学会九州連合地方部会雑誌 57

      Pages: 67-73

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 子宮体部に発生した悪性リンパ腫の一例2006

    • Author(s)
      平川 功二
    • Journal Title

      日本臨床細胞学会九州連合会雑誌 37

      Pages: 99-102

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] A novel histone deacetylase inhibitor, Scriptaid, induces growth inhibition, cell cycle arrest and apoptosis in human endometrial cancer and ovarian cancer cells2006

    • Author(s)
      Noriyuki, Takai
    • Journal Title

      Int J Mol Med 17(2)

      Pages: 323-329

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] M344 is a novel synthesized histone deacetylase inhibitor that induces growth inhibition, cell cycle arrest, and apoptosis in human endometrial cancer and ovarian cancer cells2006

    • Author(s)
      Noriyuki, Takai
    • Journal Title

      Gynecol Oncol 101(1)

      Pages: 108-113

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] CBHA is a family of hybrid polar compounds that inhibit histone deacetylase, and induces growth inhibition, cell cycle arrest and apoptosis in human endometrial and ovarian cancer cells2006

    • Author(s)
      Noriyuki, Takai
    • Journal Title

      Oncology 70(2)

      Pages: 97-105

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Anticancer activity of MS-275, a novel histone deacetylase inhibitor, against human endbmetrial cancer cells2006

    • Author(s)
      Noriyuki, Takai
    • Journal Title

      Anticancer Res 26(2A)

      Pages: 939-945

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Expression of c-Ets 1 protein in normal human placenta2006

    • Author(s)
      Noriyuki, Takai
    • Journal Title

      Gynecol Obstet Invest 61(1)

      Pages: 15-20

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] β-Hydroxyisovalerylshikonin induces apoptosis and G0/G1 cell-cycle arrest of endometriotic stromal cells : a preliminary in vitro study2006

    • Author(s)
      Masakazu, Nishida
    • Journal Title

      Hum Reprod 2(11)

      Pages: 2850-2856

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Magnetic resonance imaging findings in leiomyoma of the ovary : a case report2006

    • Author(s)
      Yasushi, Kawano
    • Journal Title

      Arch Gynecol Obstet 273

      Pages: 298-300

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Kole of Elf-1 in epithelial ovarian carcinoma : Immunohistochemistry. Handbook of immunohistochemistry and in situ hybridization of human carcinomas. Vol 4. Edited by MA Hayat2006

    • Author(s)
      Noriyuki, Takai
    • Journal Title

      Elsevier(USA)

      Pages: 487-492

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Medical treatment for uterine leiomyoma.(Japanese)2006

    • Author(s)
      Noriyuki, Takai
    • Journal Title

      Jpn J Obstet Gynecol(Kyushu) 57

      Pages: 67-73

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] A case of malignant lymphoma arising from endometrium.(Japanese)2006

    • Author(s)
      Koji, Hirakawa
    • Journal Title

      Jpn J Clin Cytol(Kyushu) 37

      Pages: 99-102

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Anticancer activity of MS-275, a novel histone deacetylase inhibitor, against human endometrial cancer cells.2006

    • Author(s)
      Noriyuki Takai
    • Journal Title

      Anticancer Res 26(2A)

      Pages: 939-945

    • Related Report
      2006 Annual Research Report
  • [Journal Article] CBHA is a family of hybrid polar compounds that inhibit histone deacetylase, and induces growth inhibition, cell cycle arrest and apoptosis in human endometrial and ovarian cancer cells.2006

    • Author(s)
      Noriyuki Takai
    • Journal Title

      Oncology 70(2)

      Pages: 97-105

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A novel histone deacetylase inhibitor, Scriptaid, induces growth inhibition, cell cycle arrest and apoptosis in human endometrial cancer and ovarian cancer cells.2006

    • Author(s)
      Noriyuki Takai
    • Journal Title

      Int J Mol Med 17(2)

      Pages: 323-329

    • Related Report
      2006 Annual Research Report
  • [Journal Article] M344 is a novel synthesized histone deacetylase inhibitor that induces growth inhibition, cell cycle arrest, and apoptosis in human endometrial cancer and ovarian cancer cells.2006

    • Author(s)
      Noriyuki Takai
    • Journal Title

      Gynecol Oncol 101(1)

      Pages: 108-113

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Expression of c-Ets1 protein in normal human placenta.2006

    • Author(s)
      Noriyuki Takai
    • Journal Title

      Gynecol Obstet Invest 61(1)

      Pages: 15-20

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Beta-hydroxyisovalerylshikonin induces apoptosis and G0/G1 cell-cycle arrest of endometriotic stromal cells : a preliminary in vitro study.2006

    • Author(s)
      Noriyuki Takai
    • Journal Title

      Hum Reprod 21(11)

      Pages: 2850-2856

    • Related Report
      2006 Annual Research Report
  • [Presentation] エピジェネティクスによる婦人科腫瘍への治療と新しい癌抑制遺伝子2008

    • Author(s)
      高井 教行
    • Organizer
      第60回日本産科婦人科学会総会・学術集会
    • Place of Presentation
      横浜市
    • Year and Date
      2008-04-14
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 多発肺転移を伴ったbenign metastasizing leiomyomaの一例2008

    • Author(s)
      津野 晃寿
    • Organizer
      第60回日本産科婦人科学会総会・学術集会
    • Place of Presentation
      横浜市
    • Year and Date
      2008-04-14
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 選択的nuclear factor-κB阻害剤BAY11-7085を用いた子宮内膜症の薬物療法2008

    • Author(s)
      奈須 家栄
    • Organizer
      第60回日本産科婦人科学会総会・学術集会
    • Place of Presentation
      横浜市
    • Year and Date
      2008-04-14
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 選択的nuclear factor-κB阻害剤BAY 11-7085による子宮内膜症の薬物療法2007

    • Author(s)
      奈須 家栄
    • Organizer
      第22回日本生殖免疫学会総会・学術集会
    • Place of Presentation
      東京都
    • Year and Date
      2007-11-30
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 選択的nuclear factor-κ B阻害剤BAY 11-7085による子宮内膜症の薬物療法2007

    • Author(s)
      奈須 家栄
    • Organizer
      第22回日本生殖免疫学会総会・学術集会
    • Place of Presentation
      東京都
    • Year and Date
      2007-11-30
    • Related Report
      2007 Annual Research Report
  • [Presentation] Histone deacetylase inhibitors induce growth inhibition,cell cycle arrest and apoptosis in human choriocarcinoma cells2007

    • Author(s)
      Noriyuki Takai
    • Organizer
      14th World Congress on Gestational Trophoblastic Diseases
    • Place of Presentation
      Fukuoka,Japan
    • Year and Date
      2007-11-11
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Histone deacetylase inhibitors induce growth inhibition, cell cycle arrest and apoptosis in human choriocarcinoma cells.2007

    • Author(s)
      Noriyuki, Takai
    • Organizer
      14th World Congress on Gestational Trophoblastic Diseases
    • Place of Presentation
      Fukuoka, Japan
    • Year and Date
      2007-11-11
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] ピストン脱アセチル化酵素阻害剤を用いた絨毛癌に対する新しい治療法の基礎的開発2007

    • Author(s)
      高井 教行
    • Organizer
      第45回日本癌治療学会総会
    • Place of Presentation
      京都府
    • Year and Date
      2007-10-26
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Histone deacetylase inhibitors induce growth inhibition, cell cycle arrest and apoptosis in human choriocarcinoma cells2007

    • Author(s)
      Noriyuki, Takai
    • Organizer
      45th Annual Meeting of the JSCO
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2007-10-26
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ヒストン脱アセチル化酵素阻害剤を用いた絨毛癌に対する新しい治療法の基礎的開発2007

    • Author(s)
      高井 教行
    • Organizer
      第45回日本癌治療学会総会
    • Place of Presentation
      京都府
    • Year and Date
      2007-10-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] 進行卵巣癌に対する拡大手術によるoptimal cytoreductionの達成と周術期合併症2007

    • Author(s)
      奈須 家栄
    • Organizer
      第45回日本癌治療学会総会
    • Place of Presentation
      京都市
    • Year and Date
      2007-10-24
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Optimal cytoreduction in ovarian cancer.2007

    • Author(s)
      Kaei, Nasu
    • Organizer
      45th Annual Meeting of the JSCO
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2007-10-24
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 進行卵巣癌に対する拡大手術によるoptimal cytoreductionの達成と周術期合併症2007

    • Author(s)
      奈須 家栄
    • Organizer
      第45回日本癌治療学会総会
    • Place of Presentation
      京都府
    • Year and Date
      2007-10-24
    • Related Report
      2007 Annual Research Report
  • [Presentation] Application of the nuclear factorkB inhibitor, BAY ll-7085, for the treatment of endometriosis2007

    • Author(s)
      Kaei, Nasu
    • Organizer
      22th Annual Meeting of the Japanes Society of Reproductive Immunology
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2007-09-30
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Polo like kinase(PLK)遺伝子と婦人科腫瘍2007

    • Author(s)
      高井 教行
    • Organizer
      第16回遺伝子診療ボーダレスカンファレンス
    • Place of Presentation
      大分県
    • Year and Date
      2007-09-04
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Polo lite kinase and gynecological cancer2007

    • Author(s)
      Noriyuki, Takai
    • Organizer
      16th Meeting of the Genetic Medicine in Oita
    • Place of Presentation
      Oita, Japan
    • Year and Date
      2007-09-04
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Polo like kinase (PLK)遺伝子と婦人科腫瘍2007

    • Author(s)
      高井 教行
    • Organizer
      第16回遺伝子診療ボーダレスカンファレンス
    • Place of Presentation
      大分県
    • Year and Date
      2007-09-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] 大分大学医学部のPBLチュートリアル事例内容の問題点について2007

    • Author(s)
      北野 敬明
    • Organizer
      第39回日本医学教育学会
    • Place of Presentation
      盛岡市
    • Year and Date
      2007-07-27
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] PBL tutolial education in Oita University Faculty of Medicine2007

    • Author(s)
      Takaaki, Kitano
    • Organizer
      39th Annual Meeting of the Japan Society for Medical Education
    • Place of Presentation
      Morioka, Japan
    • Year and Date
      2007-07-27
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 大分大学医学部のPBLチュートリアル事例内容の問題点について2007

    • Author(s)
      北野 敬明
    • Organizer
      第39回日本医学教育学会
    • Place of Presentation
      岩手県
    • Year and Date
      2007-07-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] 卵巣がんの治療2007

    • Author(s)
      高井 教行
    • Organizer
      第184回大分市医師会産婦人科臨床検討会
    • Place of Presentation
      大分市
    • Year and Date
      2007-07-24
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Treatment of ovarian cancer2007

    • Author(s)
      Noriyuki, Takai
    • Organizer
      184th Meeting of Obstetrics and Gynecology in Oita city
    • Place of Presentation
      Oita, Japan
    • Year and Date
      2007-07-24
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 卵巣がんの治療2007

    • Author(s)
      高井 教行
    • Organizer
      第184回大分市医師会産婦人科臨床検討会
    • Place of Presentation
      大分県
    • Year and Date
      2007-07-24
    • Related Report
      2007 Annual Research Report
  • [Presentation] Polo like kinase(PLK)の婦人科癌における発現とPLKの発現を抑制するβ-hydroxyisovalerylshikoninの婦人科癌に対する抗癌作用2007

    • Author(s)
      高井 教行
    • Organizer
      第6回日本婦人科がん分子標的研究会学術集会(阿蘇フォーラム)
    • Place of Presentation
      熊本県阿蘇市
    • Year and Date
      2007-07-21
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Tne utility of polo like kmase aml beta-HIVS in gynecological cancer2007

    • Author(s)
      Noriyuki, Takai
    • Organizer
      6th Annual Meeting of the Molecular Target Therapy
    • Place of Presentation
      Abo, Japan
    • Year and Date
      2007-07-21
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Polo like kinase (PLK)の婦人科癌における発現とPLKの発現を抑制するβ-hydroxyisovalerylshikoninの婦人科癌に対する抗癌作用2007

    • Author(s)
      高井 教行
    • Organizer
      第6回日本婦人科がん分子標的研究会学術集会(阿蘇フォーラム)
    • Place of Presentation
      熊本県
    • Year and Date
      2007-07-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] Application of the nuclear factor-B inhibitor,BAY 11-7085,for the treatment of endometriosis2007

    • Author(s)
      Kaei Nasu
    • Organizer
      23rd Annual Meeting of the European Society for Human Reproduction & Embryology
    • Place of Presentation
      Lyon,France
    • Year and Date
      2007-07-02
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Application of the nuclear factor-kB inhibitor, BAY 11-7085, for the treatmeat of endometriosis2007

    • Author(s)
      Kaei, Nasu
    • Organizer
      23rd Annual Meeting of the European Society for Human Reproduction & Embryology
    • Place of Presentation
      Lyon Convention Centre, Lyon, France
    • Year and Date
      2007-07-02
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Application of the nuclear factor-kB inhibitor, BAY 11-7085, for the treatment of endometriosis.2007

    • Author(s)
      Kaei Nasu
    • Organizer
      23rd Annual Meeting of the European Society for Human Reproduction & Embryology
    • Place of Presentation
      Lyon, France
    • Year and Date
      2007-07-02
    • Related Report
      2007 Annual Research Report
  • [Presentation] Erucylphosphocholineの子宮内膜癌に対する抗癌作用2007

    • Author(s)
      高井 教行
    • Organizer
      第42回日本婦人科腫瘍学会学術集会
    • Place of Presentation
      東京都
    • Year and Date
      2007-06-29
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 子宮頚癌の転移による癌性心外膜炎の1例2007

    • Author(s)
      吉良 尚子
    • Organizer
      第42回日本婦人科腫瘍学会学術集会
    • Place of Presentation
      東京都
    • Year and Date
      2007-06-29
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Paclitaxelとcarboplatinによる放射線併用化学療法を施行した子宮頚部glassy cell carcinomaの1例2007

    • Author(s)
      奈須 家栄
    • Organizer
      第42回日本婦人科腫瘍学会学術集会
    • Place of Presentation
      東京都
    • Year and Date
      2007-06-29
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 卵巣原発MMMTの1例2007

    • Author(s)
      西田 正和
    • Organizer
      第42回日本婦人科腫瘍学会学術集会
    • Place of Presentation
      東京都
    • Year and Date
      2007-06-29
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Erucylohotphocholine induce growth inhibition, cell cycle arrest and apoptosis in human endometrial cancer cells2007

    • Author(s)
      Noriyuki, Takai
    • Organizer
      42th Annual Meeting of the JSCO
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2007-06-29
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] A case pericarditis carcinomatosa arising torn cervical cancer2007

    • Author(s)
      Naoko, Kira
    • Organizer
      42th Annual Meeting of the JSCO
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2007-06-29
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] A case of glassy cell carcinoma in the uterine cervix2007

    • Author(s)
      Kaei, Nasu
    • Organizer
      42th Annual Meeting of the JSCO
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2007-06-29
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Acase ofMMMT in the ovary2007

    • Author(s)
      Masakazu, Nishida
    • Organizer
      42th Annual Meeting of the JSCO
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2007-06-29
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 子宮頸癌の転移による癌性心外膜炎の1例2007

    • Author(s)
      吉良 尚子
    • Organizer
      第42回日本婦人科腫瘍学会学術集会
    • Place of Presentation
      東京都
    • Year and Date
      2007-06-29
    • Related Report
      2007 Annual Research Report
  • [Presentation] Paclitaxelとcarboplatinによる放射線併用化学療法を施行した子宮頸部glassy cell carcinomaの1例2007

    • Author(s)
      奈須 家栄
    • Organizer
      第42回日本婦人科腫瘍学会学術集会
    • Place of Presentation
      東京都
    • Year and Date
      2007-06-29
    • Related Report
      2007 Annual Research Report
  • [Presentation] 婦人科癌の診断と治療2007

    • Author(s)
      高井 教行
    • Organizer
      第7回大分県病院薬剤師会オンコロジー研修会
    • Place of Presentation
      大分市
    • Year and Date
      2007-06-26
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Diagnosis and treatment of gynecological cancer2007

    • Author(s)
      Noriyuki, Takai
    • Organizer
      7th Meeting of the Pharmacologic Oncologist in Oita
    • Place of Presentation
      Oita, Japan
    • Year and Date
      2007-06-26
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 婦人科癌の診断と治療2007

    • Author(s)
      高井 教行
    • Organizer
      第7回大分県病院薬剤師会オンコロジー研修会
    • Place of Presentation
      大分県
    • Year and Date
      2007-06-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] 進行卵巣癌に対する拡大手術によるoptimal cytoreductionの達成と周術期合併症2007

    • Author(s)
      奈須 家栄
    • Organizer
      第57回日本産科婦人科学会大分地方部会、第58回大分県産婦人科医会総会
    • Place of Presentation
      大分市
    • Year and Date
      2007-06-17
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Optimal cytoreduction in ovarian cancer2007

    • Author(s)
      Kaei, Nasu
    • Organizer
      57th Annual Meeting of the JSOG in Oita
    • Place of Presentation
      Oita, Japan
    • Year and Date
      2007-06-17
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 進行卵巣癌に対する拡大手術によるoptimal cytoreductionの達成と周術期合併症2007

    • Author(s)
      奈須 家栄
    • Organizer
      第57回日本産科婦人科学会大分地方部会、第58回大分県産婦人科医会総会
    • Place of Presentation
      大分県
    • Year and Date
      2007-06-17
    • Related Report
      2007 Annual Research Report
  • [Presentation] 多発肺転移を伴ったbenign metastasizing leiomyomaの1例2007

    • Author(s)
      津野 晃寿
    • Organizer
      第64回日本産科婦人科学会九州連合地方部会、第58回日本産婦人科医会九州ブロック会学術講演会
    • Place of Presentation
      長崎市
    • Year and Date
      2007-05-27
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] A case of benign metastazing leiomyoma with multiple lung metasiases2007

    • Author(s)
      Akitoshi, Tsuno
    • Organizer
      64th Annual Meeting of the JSOG in Kyushu
    • Place of Presentation
      Nagasaki, Japan
    • Year and Date
      2007-05-27
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 多発肺転移を伴ったbenign metastasizing leiomyomaの1例2007

    • Author(s)
      津野 晃寿
    • Organizer
      第64回日本産科婦人科学会九州連合地方部会、第58回日本産婦人科医会九州ブロック会 学術講演会
    • Place of Presentation
      長崎県
    • Year and Date
      2007-05-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] β-Hydroxyisovalerylshikoninの卵巣癌に対する抗癌作用2007

    • Author(s)
      高井 教行
    • Organizer
      第59回日本産科婦人科学会総会・学術講演会
    • Place of Presentation
      京都府
    • Year and Date
      2007-04-16
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Bufalinによる子宮内膜症細胞のG0/G1 arrestおよびapoptosisの誘導2007

    • Author(s)
      井上 智恵子
    • Organizer
      第59回日本産科婦人科学会総会・学術講演会
    • Place of Presentation
      京都府
    • Year and Date
      2007-04-16
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] β-HydroxyisovalerylshSkonin(紫根)により引き起こされる子宮内膜症のアポトーシスの検討-子宮内膜症治療薬としての可能性2007

    • Author(s)
      西田 正和
    • Organizer
      第59回日本産科婦人科学会総会・学術講演会
    • Place of Presentation
      京都府
    • Year and Date
      2007-04-16
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Beta-HIVS induce growth inhibition, cell cycle arrest and apoptosis in human ovarian cancer cells2007

    • Author(s)
      Noriyuki, Takai
    • Organizer
      59th Annual Meeting of the JSOG
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2007-04-16
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Bufalin induce growth inhibition, cell cycle arrest and apoptosis in human endometriotic cells2007

    • Author(s)
      Chieko, Inoue
    • Organizer
      59th Annual Meeting of the JSOG
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2007-04-16
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Beta-HIVS induce growth inhibition, cell cycle arrest and apoptosis in human endometriotic cells2007

    • Author(s)
      Masakazu, Nishida
    • Organizer
      59th Annual Meeting of the JSOG
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2007-04-16
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] β-Hydroxyisovalerylshikonin(紫根)により引き起こされる子宮内膜症のアポトーシスの検討-子宮内膜症治療薬としての可能性-2007

    • Author(s)
      西田 正和
    • Organizer
      第59回日本産科婦人科学会総会・学術講演会
    • Place of Presentation
      京都府
    • Year and Date
      2007-04-16
    • Related Report
      2007 Annual Research Report
  • [Presentation] Discovery of epigenetioally silenced tumor suppressor gene in endometrial cancer.2007

    • Author(s)
      Noriyuki, Takai
    • Organizer
      60th Annual Meeting of the JSOG
    • Place of Presentation
      Yokohama, Jauan
    • Year and Date
      2007-04-14
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] A case of benign metastazing leiomyoma with multiple lung metasiases2007

    • Author(s)
      Akitoshi, Tsuno
    • Organizer
      60th Annual Meeting of the JSOG
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2007-04-14
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Application of the nuclear factor-kB inhibitor, BAY ll-7085, for the treatment of endometriosis2007

    • Author(s)
      Kaei, Nasu
    • Organizer
      60th Annual Meeting of the JSOG
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2007-04-14
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 腔壁に発生したGlassy cell carcinomaの1例2007

    • Author(s)
      井上 智恵子
    • Organizer
      第16回大分婦人科悪性腫瘍研究会
    • Place of Presentation
      大分市
    • Year and Date
      2007-03-09
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] A case of glassy cell carcinoma in the Vagina2007

    • Author(s)
      Chieko, Inoue
    • Organizer
      16th Annual Meeting of the Gynecologic Oncologyin Oita
    • Place of Presentation
      Oita, Jarpan
    • Year and Date
      2007-03-09
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 子宮内膜症に対する治療薬としての選択的nuclear factor-κB阻害剤BAY11-7085の有用性2007

    • Author(s)
      奈須 家栄
    • Organizer
      第28回エンドメトリオーシス研究会
    • Place of Presentation
      和歌山市
    • Year and Date
      2007-01-20
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Application of the nuclear faotor-iB inhibitor, BAY 11-7085, for the treatment of endometriosis2007

    • Author(s)
      Kaei, Nasu
    • Organizer
      28th Annual Meeting of the Japanese Society of Endometriosis
    • Place of Presentation
      Wakayama, Japan
    • Year and Date
      2007-01-20
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Histone deacetylase inhibitorを用いた子宮体癌の治療2006

    • Author(s)
      高井 教行
    • Organizer
      第44回日本癌治療学会総会
    • Place of Presentation
      東京都
    • Year and Date
      2006-10-20
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Histone deacetylase inhibitors induce growth inhibition, cell cycle arrest and apoptosis in human endometrial cancer cells.2006

    • Author(s)
      Noriyuki, Takai
    • Organizer
      44th Annual Meeting of the JSCO
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2006-10-20
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 子宮体癌の新しい癌抑制遺伝子の検索(エピジェネティックスからのアプローチ)2006

    • Author(s)
      高井 教行
    • Organizer
      第5回日本婦人科がん分子標的研究会学術集会
    • Place of Presentation
      東京都
    • Year and Date
      2006-08-06
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Discovery of epigeneticaUy silenced tumor suppressor gene in endometrial cancer2006

    • Author(s)
      Noriyuki, Takai
    • Organizer
      5th Annual Meeting of the Molecular Target Therapy
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2006-08-06
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 子宮筋腫に対する薬物療法2006

    • Author(s)
      高井 教行
    • Organizer
      第63回日本産科婦人科学会九州連合地方部会、第57回日本産婦人科医会九州ブロック会学術講演会
    • Place of Presentation
      北九州市
    • Year and Date
      2006-06-04
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Medical treatment for the uterine leiomyotna2006

    • Author(s)
      Noriyuki, Takai
    • Organizer
      63th Annual Meeting of the JSOG in Kyushu
    • Place of Presentation
      Kitakyushu, Japan
    • Year and Date
      2006-06-04
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Benzodiazepine受容体のHgand PK11195の卵巣癌に対する抗癌作用2006

    • Author(s)
      高井 教行
    • Organizer
      第58回日本産科婦人科学会学術講演会
    • Place of Presentation
      横浜市
    • Year and Date
      2006-04-24
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 皮膚筋炎合併卵巣癌の1症例2006

    • Author(s)
      上田 多美
    • Organizer
      第58回日本産科婦人科学会学術講演会
    • Place of Presentation
      横浜市
    • Year and Date
      2006-04-24
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Interferon-γにより誘導されるapoptosisに対する子宮内膜症細胞の耐性獲得機序2006

    • Author(s)
      奈須 家栄
    • Organizer
      第58回日本産科婦人科学会学術講演会
    • Place of Presentation
      横浜市
    • Year and Date
      2006-04-24
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 子宮内膜症細胞におけるIL-1 receptorの減少およびCXC chemokineの発現異常2006

    • Author(s)
      西田 正和
    • Organizer
      第58回日本産科婦人科学会学術講演会
    • Place of Presentation
      横浜市
    • Year and Date
      2006-04-24
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] PK11195 induce growth inhibition, cell cycle arrest and apoptosis in human ovarian cancer cells.2006

    • Author(s)
      Noriyuki, Takai
    • Organizer
      58th Annual Meeting of the JSOG
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2006-04-24
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] A case of dermatomyositis with ovarian cancer.2006

    • Author(s)
      Tami, Ueda
    • Organizer
      58th Annual Meeting of the JSOG
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2006-04-24
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Appiication of the nuclear factorkB inhibitor, BAY 11-7085, for the treatment of endometrio sis2006

    • Author(s)
      Kaei, Nasu
    • Organizer
      58th Annual Meeting of the JSOG
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2006-04-24
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Expression of IL-1 receptor and CXC chemokine in endometnosxs.2006

    • Author(s)
      Masakazu, Nishida
    • Organizer
      58th Annual Meeting of the JSOG
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2006-04-24
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Glassy cell carcinomaの1症例2006

    • Author(s)
      上田 多美
    • Organizer
      第15回大分婦人科悪性腫瘍研究会
    • Place of Presentation
      大分市
    • Year and Date
      2006-02-24
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] A case of glassy cell carcinoma in the cervix2006

    • Author(s)
      Tami, Ueda
    • Organizer
      15th Annual Meeting of the Gynecologic Oncologyin Oita
    • Place of Presentation
      Oita, Japan
    • Year and Date
      2006-02-24
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Bufalinは子宮内膜症細胞のG0/G1 arrestとapoptosisを誘導する2006

    • Author(s)
      奈須 家栄
    • Organizer
      第27回エンドメトリオージス研究会
    • Place of Presentation
      東京都
    • Year and Date
      2006-01-21
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Bufalinduce growth inhibition, cell cycle arrest and apoptosis in human endometriotic cells2006

    • Author(s)
      Kaei, Nasu
    • Organizer
      27th Annual Meeting of the Japanese Society of Endometriosis
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2006-01-21
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] Handbook of immunohistochemistry and in situ hybridization of human carcinomas. Vol 4.Edited by MA Hayat.Role of Elf-1 in epithelial ovarian carcinoma:Immunohistochemistry2006

    • Author(s)
      Noriyuki Takai
    • Total Pages
      6
    • Publisher
      Elsevier(USA)
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] New Consensus新撰産婦人科診療編集:石塚文平, 金山尚裕, 鈴木秋悦, 安田允絨毛癌診断スコア2006

    • Author(s)
      高井 教行
    • Total Pages
      3
    • Publisher
      永井書店
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 看護のための最新医学講座[第2版]第16巻婦人科疾患編集:神崎秀陽性機能の生理2006

    • Author(s)
      高井 教行
    • Total Pages
      14
    • Publisher
      中山書店
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] The score diagnosing choriocarcinoma.(Japanese)New consensus in Obstet Gynecol. Edited by Isbiz, et. al.2006

    • Author(s)
      Noriyuki, Takai
    • Publisher
      Nagai shoten
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] The physiology of sexual function.(Japanese)New medical lecture for nurse. Vol 16. Edited by Kanzaki H.2006

    • Author(s)
      Noriyuki, Takai
    • Publisher
      Nakayama shoten
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] Handbook of immunohistochemistry and in situ hybridization of human carcinomas. Vol 4.2006

    • Author(s)
      Noriyuki Takai
    • Total Pages
      6
    • Publisher
      Elsevier (USA)
    • Related Report
      2006 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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