| Project/Area Number |
18591844
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
|
|---|
| Research Institution | Jichi Medical University |
|---|
Principal Investigator |
FUJIWARA Hiroyuki Jichi Medical University, 医学部, 准教授 (50316535)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KONNO Ryo 自治医科大学, 医学部, 教授 (70271905)
SUZUKI Mitsuaki 自治医科大学, 医学部, 教授 (50110870)
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|---|
| Project Period (FY) |
2006 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,070,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥570,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2006: ¥1,600,000 (Direct Cost: ¥1,600,000)
|
|---|
| Keywords | 子宮内膜症 / 月経困難症 / 慢性炎症性増殖性疾患 / 免疫学 / 病理学 / マイクロアレイ / 薬剤反応性 / 生理活性 |
|---|
| Research Abstract |
One aspect of endometriosis is its chronic inflammatory proliferative disease nature and we believe an immunologic mechanism is associated with the development and extension. From this hypothesis, we carried out several studies to find a treatment target. Using rat endometriosis model, we identified two factors (osteopontin (OPN) and L-selectin) associated with pathogenesis of endometriosis. In clinical studies, we proved the possibility that a leukotriene receptor antagonist which has anti-inflammatory effects was effective in treatment of endometriosis and dysmenorrhea by a prospective, double-blind, randomized, placebo-controlled study.
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