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A new strategy of molecular targeting therapy for ovarian clear cell adenocinoma using transforming growth factor-betal(TGFβ1)

Research Project

Project/Area Number 18591850
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionFujita Health University

Principal Investigator

KOMIYAMA Shin-ichi  Fujita Health University, School of Medicine, Associate Professor (80256312)

Co-Investigator(Kenkyū-buntansha) HASEGAWA Kiyoshi  Fujita Health University, School of Medicine, Associate Professor (60208478)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,890,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2006: ¥2,200,000 (Direct Cost: ¥2,200,000)
KeywordsTGFβ1 / ovarian clear cell adenocarcinoma / molecular targeting therapy / anti tumor effect / RMG-1
Research Abstract

We studied a basic research for a new molecular targeting therapy for ovarian clear cell adenocarcinoma using transforming growth factor-beta 1 (TGFβ1). Several cell lines of human ovarian clear cell adenocarcinoma (RMG-1, RMG-2, and MO were demonstrated growth inhibition, G1 arrest, and invasion inhibition by TGFBI in vitro. RMG-1 expressed p57 mRNA and PAI-1 mRNA transcribed by TGFf31, dose-dependently. On the other hand, MIVIP2 protein expression was suppressed. Then xenograft models of RMG-1 were created in SCID mice, and tumor growth was assessed from the wet weight and the BrdU uptake. In tumor-bearing mice, the tumor weight and BrdU uptake were both lower when they were treated by TGFβ1. Furthermore, TGFβ1 combined several cytotoxic drugs (paclitaxel, SN-38, and CDDP) demonstrated growth inhibition additively for RMG-1 in vitro.

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (26 results)

All 2007 2006

All Journal Article (19 results) (of which Peer Reviewed: 6 results) Presentation (5 results) Book (2 results)

  • [Journal Article] Local activation of TGF-betal at endometriosis sites2007

    • Author(s)
      Shin-ichi Komiyama, et. al.
    • Journal Title

      The Journal of Reproductive Medicine 52

      Pages: 306-312

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] A heavily pretreated patient with recurrent clear cell adenocarcinoma ofthe ovary in whom carcinomatous peritonitis was controlled successfullyby salvage therapy with gemcitabine2007

    • Author(s)
      Shin-ichi Komiyama, et. al.
    • Journal Title

      Archives of Gynecology and Obstetrics Epub

      Pages: 1-4

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 合成ステロイドホルモン-抗ステロイドホルモン薬の臨床応用-2007

    • Author(s)
      小宮山 慎一, 他
    • Journal Title

      日本臨床 66

      Pages: 174-181

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Local activation of TGF-beta 1 at endometriosis sites.2007

    • Author(s)
      Komiyama S, et. al.
    • Journal Title

      J Reprod Med(reviewed) 52

      Pages: 306-12

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] A heavily pretreated patient with recurrent clear cell adenocarcinoma of the ovary in whom carcinomatous peritonitis was controlled successfully by salvage therapy with gemcitabine.2007

    • Author(s)
      Komiyama S, et. al.
    • Journal Title

      Arch Gynecol Obstet (Epub ahead of print)(reviewed)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Sanfujinka Senmon-I ni Kiku Saishin-no Rinsho(Suzuki/Yoshimura eds.)2007

    • Author(s)
      Komiyama S, et. al.
    • Journal Title

      Tyu-gai Igakusya

      Pages: 301-303

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Local activation of TGF-beta1 at endometriosis sites.2007

    • Author(s)
      Shin-ichi Komiyama, et. al.
    • Journal Title

      The Journal of Reproductive Medicine 52

      Pages: 306-312

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A heavily pretreated patient with recurrent clear cell adenocarcinoma of the ovary in whom carcinomatous peritonitis was controlled successfully by salvage therapy with gemcitabine.2007

    • Author(s)
      Shin-ichi Komiyama, et. al.
    • Journal Title

      Archives of Gynecology and Obstetrics (Epub)

      Pages: 1-4

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 合成ステロイドホルモン -抗ステロイドホルモン薬の臨床応用-2007

    • Author(s)
      小宮山 慎一、他
    • Journal Title

      日本臨床 66

      Pages: 174-181

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Proliferative activity of early ovarian clear cell adenocarcinoma depends on association with endometriosis2006

    • Author(s)
      Shin-ichi Komiyama, et. al.
    • Journal Title

      European journal of obstetrics, gynecology, and reproductive biology 127

      Pages: 130-136

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Papillary serous carcinoma of the peritoneum with paraaortic lymph node metastasis despite minimal intraperitoneal involvement:a case report2006

    • Author(s)
      Shin-ichi Komiyama, et. al.
    • Journal Title

      Acta cytologica 50

      Pages: 323-326

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 転移性生殖器癌-性器外原発転移性生殖器腫瘍を中心に-2006

    • Author(s)
      小宮山 慎一, 他
    • Journal Title

      臨床婦人科産科 60

      Pages: 1106-1109

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Proliferative activity of early ovarian clear cell adenocarcinoma depends on association with endometriosis.2006

    • Author(s)
      Komiyama S, et. al.
    • Journal Title

      Eur J Obstet Gynecol Reprod Biol(reviewed) 127

      Pages: 130-6

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Papillary serous carcinoma of the peritoneum with paraaortic lymph node metastasis despite minimal intraperitoneal involvement : a case report.2006

    • Author(s)
      Komiyama S, et. al.
    • Journal Title

      Acta Cytol(reviewed) 50

      Pages: 323-6

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Metastatic gynecologic cancer -extra genital origin-2006

    • Author(s)
      Komiyama S, et. al.
    • Journal Title

      Rinsho Fujinka Sanka(not reviewed) 60

      Pages: 1106-9

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Anti-steroid hormones for uterine cancer2006

    • Author(s)
      Komiyama S, et. al.
    • Journal Title

      Nippon Rinsho(not reviewd) 66

      Pages: 174-81

    • NAID

      40015772119

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Proliferative activity of early ovarian clear cell adenocarcinoma depends on association with endometriosis.2006

    • Author(s)
      Shin-ichi Komiyama et al.
    • Journal Title

      European journalof obstetrics, gynecology, and reproductive biology 127・1

      Pages: 130-136

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Papillary serous carcinoma of the peritoneum with paraaortic lymph node metastasis despite minimal intraperitoneal involvement : a case report.2006

    • Author(s)
      Shin-ichi Komiyama et al.
    • Journal Title

      Acta cytologica 50・3

      Pages: 323-326

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 転移性生殖器癌-性器外原発転移性生殖器腫瘍を中心に-2006

    • Author(s)
      小宮山慎一, 他
    • Journal Title

      臨床婦人科産科 60・8

      Pages: 1106-1109

    • Related Report
      2006 Annual Research Report
  • [Presentation] 進行上皮性卵巣癌におけるTGFβ発現は生物学的悪性度や薬剤感受性を推定する新たなbiomarkerになりうるか2007

    • Author(s)
      小宮山 慎一, 他
    • Organizer
      第59回日本産科婦人科学会総会学術集会 一般講演
    • Place of Presentation
      京都 国立京都国際会館
    • Year and Date
      2007-04-17
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 進行上皮性卵巣癌におけるTGFβ発現は生物学的悪性度や薬剤感受性を推定する新たなbiomarkerになりうるか?2007

    • Author(s)
      小宮山 慎一、他
    • Organizer
      第59回日本産科婦人科学会総会学術集会
    • Place of Presentation
      京都 国立京都国際会館
    • Year and Date
      2007-04-17
    • Related Report
      2007 Annual Research Report
  • [Presentation] Is mRNA expression of TGFβ1 is related with the biological significance and drug sensitivity of anti-cancer agents in advanced ovarian cancer?2007

    • Author(s)
      Komiyama S, et. al.
    • Organizer
      The 59th Meeting of Japanese Society of Obstetrics and Gynecology
    • Place of Presentation
      Kyoto International Conference Center, Kyoto
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] TGFβ1とそのレセプターの発現は上皮性卵巣癌、卵管癌、腹膜原発癌の生物学的特性および薬剤感受性と関連がある2006

    • Author(s)
      小宮山 慎一, 他
    • Organizer
      第44回日本癌治療学会総会 シンポジウム
    • Place of Presentation
      東京 京王プラザホテル
    • Year and Date
      2006-10-20
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Expression of TGFβ1 and its receptors in Mullerian cancers are related with the biological significance and drug sensitivity of anti-cancer agents2006

    • Author(s)
      Komiyama S, et. al.
    • Organizer
      The 44th Meeting of Japanese Society of Clinical Oncology
    • Place of Presentation
      KEIO Plaza Hotel, Tokyo
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 産婦人科専門医に聞く最新の臨床2007

    • Author(s)
      小宮山 慎一, 他
    • Total Pages
      441
    • Publisher
      中外医学社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 産婦人科 専門医に聞く最新の臨床2007

    • Author(s)
      小宮山 慎一、他
    • Total Pages
      441
    • Publisher
      中外医学社
    • Related Report
      2007 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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