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Genetic Polymorphism in Gynecological Cancer

Research Project

Project/Area Number 18591851
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionOsaka Medical College

Principal Investigator

UEDA Masatsugu  Osaka Medical College, 医学部, 非常勤講師 (50223467)

Co-Investigator(Kenkyū-buntansha) TERAI Yoshito  大阪医科大学, 医学部, 講師 (90278531)
TAKEHARA Mikio  大阪医科大学, 医学部, 非常勤講師 (40298766)
KANEMURA Masanori  大阪医科大学, 医学部, 講師 (40298782)
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,060,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥660,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2006: ¥1,200,000 (Direct Cost: ¥1,200,000)
Keywords婦人科癌 / 遺伝子多型 / 発癌 / 浸潤・転移 / アポトーシス / フポトーシス
Research Abstract

癌は生まれながらの体質(遺伝素因)と病原体や生活習慣などの影響(環境因子)の両者が複雑に絡み合って生じる疾患である。我々は、婦人科癌患者から同意を得て採取した血液や細胞病理標本を用いて、癌の発症に関連する様々な遺伝子の個人差や発現異常を解析してきた。その結果、環境発癌物質解毒酵素や細胞増殖あるいは細胞死に関連する遺伝子の特定のタイプ(遺伝素因)が子宮癌や卵巣癌の発症に密接に関連することが判明した。

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (43 results)

All 2009 2008 2007 2006 Other

All Journal Article (26 results) (of which Peer Reviewed: 19 results) Presentation (11 results) Book (5 results) Remarks (1 results)

  • [Journal Article] Murine double-minute 2 homolog single nucleotide polymorphism 309 and the risk of gynecologic cancer2009

    • Author(s)
      Ueda M, Yamamoto M, Nunobiki O, et.al.
    • Journal Title

      Hum Cell 22

      Pages: 49-54

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Murine double-minute 2 homolog single nucleotide polymorphism 309 and the risk of gynecologic cancer2009

    • Author(s)
      Masatsugu Ueda, et al
    • Journal Title

      Human Cell 22

      Pages: 49-54

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Germline polymorphism of cancer susceptibility genes in gynecological cancer2008

    • Author(s)
      Ueda M, Toji E, Nunobiki O, et.al.
    • Journal Title

      Hum Cell 21

      Pages: 95-104

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Alterations of the K-ras and p53 genes in tamoxifen-associated endometrial carcinoma2008

    • Author(s)
      Fujiwara K, Enomoto T, Fujita M, et.al.
    • Journal Title

      Oncol Rep 19

      Pages: 1293-1298

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mutational analysis of the BRAF gene in human tumor cells2008

    • Author(s)
      Ueda M, Toji E, Nunobiki O, et.al.
    • Journal Title

      Hum Cell 21

      Pages: 13-17

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mutational analysis of the BRAF gene in human tumor cells2008

    • Author(s)
      Masatsugu Ueda, et al
    • Journal Title

      Human Cell 21

      Pages: 13-17

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alterations of the K-ras and p53 genes in tamoxiifen-associate dendometrial carcinoma2008

    • Author(s)
      Kazuko Fujiwara, et al
    • Journal Title

      Oncology Report 19

      Pages: 1293-1298

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Germline polymorphism of cancer susceptibility genes in gynecologic cancer2008

    • Author(s)
      Masatsugu Ueda, et al
    • Journal Title

      Human Cell 21

      Pages: 95-104

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transcriptional expression of survivin and its splice variants in cervical carcinomas2007

    • Author(s)
      Futakuchi H, Ueda M, Kanda K, et.al.
    • Journal Title

      Int J Gynecol Cancer 17

      Pages: 1092-1098

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Germ line and somatic mutations of BRAF V599E in ovarian carcinoma2007

    • Author(s)
      Ueda M, Toji E, Noda S
    • Journal Title

      Int J Gynecol Cancer 17

      Pages: 794-797

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Exemestane or tamoxifen? [Correspondence letter]2007

    • Author(s)
      Ueda M, Toji E, Noda S
    • Journal Title

      Lancet 369

      Pages: 1600-1600

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Germ line and somatic mutations of BRAF V599E in ovarian carcinoma2007

    • Author(s)
      Masatsugu Ueda, et. al.
    • Journal Title

      International Journal of Gynecological Cancer 17

      Pages: 794-797

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transcriptional expression of survivin and its splice variants incervical carcinomas2007

    • Author(s)
      Hikari Hutakuchi, et. al.
    • Journal Title

      International Journal of Gynecological Cancer 17

      Pages: 1092-1098

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 血管新生抑制を介した卵巣がん分子標的治療2007

    • Author(s)
      植田 政嗣, ほか
    • Journal Title

      今日の移植(マクファージフォーラム) 14

      Pages: 229-234

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Transcriptional expression of survivin and its splice variants in endometriosis2006

    • Author(s)
      Fujino K, Ueda M, Takehara M, et.al.
    • Journal Title

      Mol Hum Reprod 12

      Pages: 383-388

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Infection of human papillomavirus and overexpression of dihydrodiol dehydrogenase in uterine cervical cancer2006

    • Author(s)
      Ueda M, Hung YC, Chen JT, et.al.
    • Journal Title

      Gynecol Oncol 102

      Pages: 173-181

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] HER-2 codon 655 polymorphism in cervical carcinogenesis2006

    • Author(s)
      Ueda M, Hung YC, Terai Y, et.al.
    • Journal Title

      Int J Gynecol Cancer 16

      Pages: 325-328

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fas gene promoter-670 polymorphism in gynecological cancer2006

    • Author(s)
      Ueda M, Terai Y, Kanda K, et.al.
    • Journal Title

      Int J Gynecol Cancer 16

      Pages: 179-182

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comment on "Germline polymorphism of p53 codon 72 in ovarian cancer". [Letter to the editor]2006

    • Author(s)
      Ueda M, Terai Y, Ueki M
    • Journal Title

      Gynecol Oncol 101

      Pages: 373-373

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Germline polymorphism of p53 codon 72 in gynecological cancer2006

    • Author(s)
      Ueda M, Terai Y, Kanda K, et.al.
    • Journal Title

      Gynecol Oncol 100

      Pages: 173-178

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Germline polymorphism of p53 codon 72 in gynecological cancer2006

    • Author(s)
      Masatsugu Ueda
    • Journal Title

      Gynecologic Oncology 100・1

      Pages: 173-178

    • Related Report
      2006 Annual Research Report
  • [Journal Article] HER-2 codon 655 polymorphism in cervical carcinogenesis2006

    • Author(s)
      Masatsugu Ueda
    • Journal Title

      International Journal of Gynecological Cancer 16・1

      Pages: 325-328

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Fas gene promoter -670 polymorphism in gynecological cancer2006

    • Author(s)
      Masatsugu Ueda
    • Journal Title

      International Journal of Gynecological Cancer 16・Suppl 1

      Pages: 179-182

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Comment of "Germline polymorphism of p53 codon 72 in ovarian cancer"2006

    • Author(s)
      Masatsugu Ueda
    • Journal Title

      Gynecologic Oncology 101・2

      Pages: 372-373

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Infection of human papillomavirus and overexpression of dihydrodio dehydrogenase in uterine cervical cancer2006

    • Author(s)
      Masatsugu Ueda
    • Journal Title

      Gynecologic Oncology 102・2

      Pages: 173-181

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Transcriptional expression of survivin and its splice variants in endometriosis2006

    • Author(s)
      Kuniko Fujino
    • Journal Title

      Molecular Human Reproduction 12・6

      Pages: 383-388

    • Related Report
      2006 Annual Research Report
  • [Presentation] 婦人科癌とアポトーシス2008

    • Author(s)
      植田政嗣ほか
    • Organizer
      第49回日本臨床細胞学会総会(春期大会)
    • Place of Presentation
      東京
    • Year and Date
      2008-06-07
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 卵巣癌の発生とBRAF遺伝子変異2008

    • Author(s)
      植田政嗣ほか
    • Organizer
      第60回日本産科婦人科学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2008-04-12
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 卵巣癌の発生とBRAFV599E遺伝子変異2007

    • Author(s)
      植田政嗣ほか
    • Organizer
      第25回日本ヒト細胞学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2007-08-04
    • Related Report
      2008 Final Research Report
  • [Presentation] 卵巣癌の発生とBRAF V599E遺伝子変異2007

    • Author(s)
      植田 政嗣, ほか
    • Organizer
      第25回日本ヒト細胞学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2007-08-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] 卵巣癌の発生とBRAFV599E遺伝子変異2007

    • Author(s)
      植田政嗣ほか
    • Organizer
      第48回日本臨床細胞学会総会(春期大会)
    • Place of Presentation
      千葉
    • Year and Date
      2007-06-08
    • Related Report
      2008 Final Research Report
  • [Presentation] 卵巣癌の発生とBRAF V599E遺伝子変異2007

    • Author(s)
      植田 政嗣, ほか
    • Organizer
      第48回日本臨床細胞学会総会(春期大会)
    • Place of Presentation
      千葉
    • Year and Date
      2007-06-08
    • Related Report
      2007 Annual Research Report
  • [Presentation] Transcriptional expression of survivin and its splice variants in cervical carcinomas2007

    • Author(s)
      Masatsugu Ueda, et.al.
    • Organizer
      The 59th Annual Meeting of Japan Society of Obstetrics and Gynecology
    • Place of Presentation
      Kyoto
    • Year and Date
      2007-04-16
    • Related Report
      2008 Final Research Report
  • [Presentation] Transcriptional expression of survivin and its splice variants in cervical carcinomas2007

    • Author(s)
      Masatsugu Ueda, et. al.
    • Organizer
      The 59th Annual Meeting of Japan Society of Obstetrics and Gynecology
    • Place of Presentation
      Kyoto,Japan
    • Year and Date
      2007-04-16
    • Related Report
      2007 Annual Research Report
  • [Presentation] 婦人科癌の悪性度と血管新生2006

    • Author(s)
      植田政嗣ほか
    • Organizer
      第45回日本臨床細胞学会(秋期大会)
    • Place of Presentation
      東京
    • Year and Date
      2006-11-11
    • Related Report
      2008 Final Research Report
  • [Presentation] 子宮頚癌発生と遺伝子多型2006

    • Author(s)
      植田政嗣ほか
    • Organizer
      第45回日本臨床細胞学会(秋期大会)
    • Place of Presentation
      東京
    • Year and Date
      2006-11-10
    • Related Report
      2008 Final Research Report
  • [Presentation] Transcriptional expression of survivin and its splice variants in cervical carcinomas2006

    • Author(s)
      Masatsugu Ueda, et.al.
    • Organizer
      The 24th Annual Meeting of Japan Human Cell Society
    • Place of Presentation
      Tokyo
    • Year and Date
      2006-07-31
    • Related Report
      2008 Final Research Report
  • [Book] Genetic polymorphism in gynecological cancer. In : Current research in cancer2008

    • Author(s)
      Ueda M, Toji E, Nunobiki O, Izuma S, Okamoto Y, Torii K, Noda S
    • Publisher
      Research Media, Kerala
    • Related Report
      2008 Final Research Report
  • [Book] よくわかる卵巣癌のすべて4分子生物学的特徴6)血管新生関連因子(安田允編)2008

    • Author(s)
      植田政嗣
    • Publisher
      永井書店
    • Related Report
      2008 Final Research Report
  • [Book] Genetic polymorphism in gynecological cancer In : Current research in cancer2008

    • Author(s)
      Masatsugu Ueda, et al
    • Total Pages
      141
    • Publisher
      Research Media, Kerala
    • Related Report
      2008 Annual Research Report
  • [Book] よくわかる卵巣癌のすべて4分子生物学的特徴6)血管新生関連因子2007

    • Author(s)
      植田 政嗣
    • Total Pages
      514
    • Publisher
      永井書店,東京
    • Related Report
      2007 Annual Research Report
  • [Book] 先端医療シリーズ39産科婦人科の最新医療-血管新生抑制を介した卵巣癌分子標的治療ー(武谷雄二、丸尾猛、吉村泰典編)2006

    • Author(s)
      植田政嗣
    • Publisher
      先端医療技術研究所
    • Related Report
      2008 Final Research Report
  • [Remarks] 植田政嗣 : 平成19年度日本臨床細胞学会賞受賞、平成20年6月8日、東京

    • Related Report
      2008 Final Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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