Genetic Polymorphism in Gynecological Cancer

• Project/Area Number: 18591851
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Osaka Medical College
• Principal Investigator: UEDA Masatsugu Osaka Medical College, 医学部, 非常勤講師 (50223467)
• Co-Investigator(Kenkyū-buntansha): TERAI Yoshito 大阪医科大学, 医学部, 講師 (90278531) ; TAKEHARA Mikio 大阪医科大学, 医学部, 非常勤講師 (40298766) ; KANEMURA Masanori 大阪医科大学, 医学部, 講師 (40298782)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,060,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥660,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2007: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2006: ¥1,200,000 (Direct Cost: ¥1,200,000)
• Keywords: 婦人科癌 / 遺伝子多型 / 発癌 / 浸潤・転移 / アポトーシス / フポトーシス

Research Abstract

癌は生まれながらの体質(遺伝素因)と病原体や生活習慣などの影響(環境因子)の両者が複雑に絡み合って生じる疾患である。我々は、婦人科癌患者から同意を得て採取した血液や細胞病理標本を用いて、癌の発症に関連する様々な遺伝子の個人差や発現異常を解析してきた。その結果、環境発癌物質解毒酵素や細胞増殖あるいは細胞死に関連する遺伝子の特定のタイプ(遺伝素因)が子宮癌や卵巣癌の発症に密接に関連することが判明した。

Research Products

• [Journal Article] Murine double-minute 2 homolog single nucleotide polymorphism 309 and the risk of gynecologic cancer (2009)
  • Author(s): Ueda M, Yamamoto M, Nunobiki O, et.al.
  • Journal Title: Hum Cell 22 Pages: 49-54
  • Peer Reviewed
• [Journal Article] Murine double-minute 2 homolog single nucleotide polymorphism 309 and the risk of gynecologic cancer (2009)
  • Author(s): Masatsugu Ueda, et al
  • Journal Title: Human Cell 22 Pages: 49-54
  • Peer Reviewed
• [Journal Article] Germline polymorphism of cancer susceptibility genes in gynecological cancer (2008)
  • Author(s): Ueda M, Toji E, Nunobiki O, et.al.
  • Journal Title: Hum Cell 21 Pages: 95-104
  • Peer Reviewed
• [Journal Article] Alterations of the K-ras and p53 genes in tamoxifen-associated endometrial carcinoma (2008)
  • Author(s): Fujiwara K, Enomoto T, Fujita M, et.al.
  • Journal Title: Oncol Rep 19 Pages: 1293-1298
  • Peer Reviewed
• [Journal Article] Mutational analysis of the BRAF gene in human tumor cells (2008)
  • Author(s): Ueda M, Toji E, Nunobiki O, et.al.
  • Journal Title: Hum Cell 21 Pages: 13-17
  • Peer Reviewed
• [Journal Article] Mutational analysis of the BRAF gene in human tumor cells (2008)
  • Author(s): Masatsugu Ueda, et al
  • Journal Title: Human Cell 21 Pages: 13-17
  • Peer Reviewed
• [Journal Article] Alterations of the K-ras and p53 genes in tamoxiifen-associate dendometrial carcinoma (2008)
  • Author(s): Kazuko Fujiwara, et al
  • Journal Title: Oncology Report 19 Pages: 1293-1298
  • Peer Reviewed
• [Journal Article] Germline polymorphism of cancer susceptibility genes in gynecologic cancer (2008)
  • Author(s): Masatsugu Ueda, et al
  • Journal Title: Human Cell 21 Pages: 95-104
  • Peer Reviewed
• [Journal Article] Transcriptional expression of survivin and its splice variants in cervical carcinomas (2007)
  • Author(s): Futakuchi H, Ueda M, Kanda K, et.al.
  • Journal Title: Int J Gynecol Cancer 17 Pages: 1092-1098
  • Peer Reviewed
• [Journal Article] Germ line and somatic mutations of BRAF V599E in ovarian carcinoma (2007)
  • Author(s): Ueda M, Toji E, Noda S
  • Journal Title: Int J Gynecol Cancer 17 Pages: 794-797
  • Peer Reviewed
• [Journal Article] Exemestane or tamoxifen? [Correspondence letter] (2007)
  • Author(s): Ueda M, Toji E, Noda S
  • Journal Title: Lancet 369 Pages: 1600-1600
  • Peer Reviewed
• [Journal Article] Germ line and somatic mutations of BRAF V599E in ovarian carcinoma (2007)
  • Author(s): Masatsugu Ueda, et. al.
  • Journal Title: International Journal of Gynecological Cancer 17 Pages: 794-797
  • Peer Reviewed
• [Journal Article] Transcriptional expression of survivin and its splice variants incervical carcinomas (2007)
  • Author(s): Hikari Hutakuchi, et. al.
  • Journal Title: International Journal of Gynecological Cancer 17 Pages: 1092-1098
  • Peer Reviewed
• [Journal Article] 血管新生抑制を介した卵巣がん分子標的治療 (2007)
  • Author(s): 植田 政嗣, ほか
  • Journal Title: 今日の移植(マクファージフォーラム) 14 Pages: 229-234
• [Journal Article] Transcriptional expression of survivin and its splice variants in endometriosis (2006)
  • Author(s): Fujino K, Ueda M, Takehara M, et.al.
  • Journal Title: Mol Hum Reprod 12 Pages: 383-388
  • Peer Reviewed
• [Journal Article] Infection of human papillomavirus and overexpression of dihydrodiol dehydrogenase in uterine cervical cancer (2006)
  • Author(s): Ueda M, Hung YC, Chen JT, et.al.
  • Journal Title: Gynecol Oncol 102 Pages: 173-181
  • Peer Reviewed
• [Journal Article] HER-2 codon 655 polymorphism in cervical carcinogenesis (2006)
  • Author(s): Ueda M, Hung YC, Terai Y, et.al.
  • Journal Title: Int J Gynecol Cancer 16 Pages: 325-328
  • Peer Reviewed
• [Journal Article] Fas gene promoter-670 polymorphism in gynecological cancer (2006)
  • Author(s): Ueda M, Terai Y, Kanda K, et.al.
  • Journal Title: Int J Gynecol Cancer 16 Pages: 179-182
  • Peer Reviewed
• [Journal Article] Comment on "Germline polymorphism of p53 codon 72 in ovarian cancer". [Letter to the editor] (2006)
  • Author(s): Ueda M, Terai Y, Ueki M
  • Journal Title: Gynecol Oncol 101 Pages: 373-373
  • Peer Reviewed
• [Journal Article] Germline polymorphism of p53 codon 72 in gynecological cancer (2006)
  • Author(s): Ueda M, Terai Y, Kanda K, et.al.
  • Journal Title: Gynecol Oncol 100 Pages: 173-178
  • Peer Reviewed
• [Journal Article] Germline polymorphism of p53 codon 72 in gynecological cancer (2006)
  • Author(s): Masatsugu Ueda
  • Journal Title: Gynecologic Oncology 100・1 Pages: 173-178
• [Journal Article] HER-2 codon 655 polymorphism in cervical carcinogenesis (2006)
  • Author(s): Masatsugu Ueda
  • Journal Title: International Journal of Gynecological Cancer 16・1 Pages: 325-328
• [Journal Article] Fas gene promoter -670 polymorphism in gynecological cancer (2006)
  • Author(s): Masatsugu Ueda
  • Journal Title: International Journal of Gynecological Cancer 16・Suppl 1 Pages: 179-182
• [Journal Article] Comment of "Germline polymorphism of p53 codon 72 in ovarian cancer" (2006)
  • Author(s): Masatsugu Ueda
  • Journal Title: Gynecologic Oncology 101・2 Pages: 372-373
• [Journal Article] Infection of human papillomavirus and overexpression of dihydrodio dehydrogenase in uterine cervical cancer (2006)
  • Author(s): Masatsugu Ueda
  • Journal Title: Gynecologic Oncology 102・2 Pages: 173-181
• [Journal Article] Transcriptional expression of survivin and its splice variants in endometriosis (2006)
  • Author(s): Kuniko Fujino
  • Journal Title: Molecular Human Reproduction 12・6 Pages: 383-388
• [Presentation] 婦人科癌とアポトーシス (2008)
  • Author(s): 植田政嗣ほか
  • Organizer: 第49回日本臨床細胞学会総会(春期大会)
  • Place of Presentation: 東京
  • Year and Date: 2008-06-07
• [Presentation] 卵巣癌の発生とBRAF遺伝子変異 (2008)
  • Author(s): 植田政嗣ほか
  • Organizer: 第60回日本産科婦人科学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2008-04-12
• [Presentation] 卵巣癌の発生とBRAFV599E遺伝子変異 (2007)
  • Author(s): 植田政嗣ほか
  • Organizer: 第25回日本ヒト細胞学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2007-08-04
• [Presentation] 卵巣癌の発生とBRAF V599E遺伝子変異 (2007)
  • Author(s): 植田 政嗣, ほか
  • Organizer: 第25回日本ヒト細胞学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2007-08-04
• [Presentation] 卵巣癌の発生とBRAFV599E遺伝子変異 (2007)
  • Author(s): 植田政嗣ほか
  • Organizer: 第48回日本臨床細胞学会総会(春期大会)
  • Place of Presentation: 千葉
  • Year and Date: 2007-06-08
• [Presentation] 卵巣癌の発生とBRAF V599E遺伝子変異 (2007)
  • Author(s): 植田 政嗣, ほか
  • Organizer: 第48回日本臨床細胞学会総会(春期大会)
  • Place of Presentation: 千葉
  • Year and Date: 2007-06-08
• [Presentation] Transcriptional expression of survivin and its splice variants in cervical carcinomas (2007)
  • Author(s): Masatsugu Ueda, et.al.
  • Organizer: The 59th Annual Meeting of Japan Society of Obstetrics and Gynecology
  • Place of Presentation: Kyoto
  • Year and Date: 2007-04-16
• [Presentation] Transcriptional expression of survivin and its splice variants in cervical carcinomas (2007)
  • Author(s): Masatsugu Ueda, et. al.
  • Organizer: The 59th Annual Meeting of Japan Society of Obstetrics and Gynecology
  • Place of Presentation: Kyoto,Japan
  • Year and Date: 2007-04-16
• [Presentation] 婦人科癌の悪性度と血管新生 (2006)
  • Author(s): 植田政嗣ほか
  • Organizer: 第45回日本臨床細胞学会(秋期大会)
  • Place of Presentation: 東京
  • Year and Date: 2006-11-11
• [Presentation] 子宮頚癌発生と遺伝子多型 (2006)
  • Author(s): 植田政嗣ほか
  • Organizer: 第45回日本臨床細胞学会(秋期大会)
  • Place of Presentation: 東京
  • Year and Date: 2006-11-10
• [Presentation] Transcriptional expression of survivin and its splice variants in cervical carcinomas (2006)
  • Author(s): Masatsugu Ueda, et.al.
  • Organizer: The 24th Annual Meeting of Japan Human Cell Society
  • Place of Presentation: Tokyo
  • Year and Date: 2006-07-31
• [Book] Genetic polymorphism in gynecological cancer. In : Current research in cancer (2008)
  • Author(s): Ueda M, Toji E, Nunobiki O, Izuma S, Okamoto Y, Torii K, Noda S
  • Publisher: Research Media, Kerala
• [Book] よくわかる卵巣癌のすべて4分子生物学的特徴6)血管新生関連因子(安田允編) (2008)
  • Author(s): 植田政嗣
  • Publisher: 永井書店
• [Book] Genetic polymorphism in gynecological cancer In : Current research in cancer (2008)
  • Author(s): Masatsugu Ueda, et al
  • Total Pages: 141
  • Publisher: Research Media, Kerala
• [Book] よくわかる卵巣癌のすべて4分子生物学的特徴6)血管新生関連因子 (2007)
  • Author(s): 植田 政嗣
  • Total Pages: 514
  • Publisher: 永井書店,東京
• [Book] 先端医療シリーズ39産科婦人科の最新医療-血管新生抑制を介した卵巣癌分子標的治療ー(武谷雄二、丸尾猛、吉村泰典編) (2006)
  • Author(s): 植田政嗣
  • Publisher: 先端医療技術研究所
• [Remarks] 植田政嗣 : 平成19年度日本臨床細胞学会賞受賞、平成20年6月8日、東京