| Project/Area Number |
18591859
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Chiba University |
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Principal Investigator |
NAKAZAWA Ken Chiba University, Graduate School of Medicine, Assistant Professor (10312943)
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| Co-Investigator(Kenkyū-buntansha) |
UMEZAKI Toshiro Kyushu University, University Hospital, Assistant Professor (80223600)
SHIMOYAMA Ichiro Research Center for Frontier Medical Engineering, フロンティアメディカル工学研究開発センター, Professor (60115483)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥3,870,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2006: ¥2,700,000 (Direct Cost: ¥2,700,000)
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| Keywords | larynx / swallowing |
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| Research Abstract |
The larynx serves various behaviors including vocalization, breathing and airway protection reflexes such as swallowing and conghing. To elucidate the neural mechanism generating laryngeal motor patterns during the behaviors, the membrane potential trajectories of expiratory (ELMs) and inspiratory (ILMs) laryngeal motoneurons were recorded during fictive breathing and swallowing in decerebrated and paralyzed cats. ELMs were hyperpolarized during the inspiratory phase of breathing and at the onset of the pharyngeal stage of swallowing, whereas ILMs were hyperpolarized during the post-inspiratory phase of breathing and during the whole pharyngeal stage of swallowing. Such hyperpolarized membrane potentials observed during the initial part of pharyngeal stage in ELMs and during the whole pharyngeal stage in ILMs were reversed by intracellular injection of chloride ions and depolarized by extracellular injection of GABA antagonist. These results suggest that chloride-dependent, GABAergic inhibitory inputs to ELMs and ILMs are involved in the temporal organization of the laryngeal motor sequence during the behaviors.
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