| Project/Area Number |
18591879
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
|
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
NAKAI Shigeru Kyoto Prefectural University of Medicine, Otolaryngology-Head and Neck Surgery, Lecturer (30295654)
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| Project Period (FY) |
2006 – 2007
|
| Project Status |
Completed (Fiscal Year 2007)
|
| Budget Amount *help |
¥3,740,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2006: ¥2,700,000 (Direct Cost: ¥2,700,000)
|
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| Keywords | Aggrus / Platelet aggregation factor / lung metastasis / head and neck cancer / lymphangiogenesis growth factor / VEGF-C / VEGFR3 / 下咽頭癌 / 癌 |
|---|
| Research Abstract |
Aggrus was recently determined to posse the ability of including platelet aggregation. Aggrus expression might be associated with tumor induced platelet aggregation and tumor metastasis. We hypothesize that the expression of Aggrus in head and neck cancer with lung metast asis is higher than the expression without metastasis. Aggrus protein expression in hypopharyngeal carcinoma was estimated using innunohistochemical staining The positive Aggrrus signals were detected in cytoplama Aggrus positive cell rate was 20%-100% (mean 68%) in hypopharyngeal cancer with lung metastasis, and was 0%-80% (means 28%) without lung metastasis. There was a significancy between Aggrus sigals and susceptibility to lung metastasis.
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