Pathogenesis and Treatment of Eosinophilic Inflammation in the Upper Respiratory Tract
| Project/Area Number |
18591887
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Jichi Medical University |
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Principal Investigator |
IINO Yukiko Jichi Medical University, School of Medicine, Professor (30108534)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥3,930,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2006: ¥2,500,000 (Direct Cost: ¥2,500,000)
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| Keywords | eosinophilic otitis media / IL-5 / Eosinophil cationic protein (ECP) / IgE / bone conduction hearing level / PGE2 / patulous eustachian tube / triamcinolone acetonide / 好酸球 / サイトカイン / ケモカイン / 真菌 / 内耳障害 |
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| Research Abstract |
Eosinophilic otitis media (EOM) is an intractable otitis media characterized by the presence of a highly viscous yellow effusion containing eosinophils It mainly occurs in patients with bronchial asthma and is resistant to conventional treatments for otitis media. We obtained the following results in patients with eosinophilic otitis media. 1) Eosinophil chemoattractants such as IL-5, ecalectin and RANTES were expressed and produced in the middle ear mucosa. 2) High concentration of IgE was detected in middle ear effusion and IgE may relate to the local immune responses. 3) High tone loss is more frequently found and more severe in the patients than in control patients. 4) High tone loss is closely related with the concentrations of IgE and ECP in the middle ear effusion. 5) The expression of m-PGES-1, a PGE2 symthese, was significantly down-regulated in the middle ear mucosa. 6) The Eustachian tube function using sonotubometry clarified that the tubal opening duration in EOM patients was significantly longer than that in the control groups, indicating the presence of patulous eustachian tubes in EOM patients. 7) The instillation of triamcinolone acetonide, a suspension of steroids, into the middle ear is very effective for the control of eosinophilic inflammation.
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Report
(3 results)
Research Products
(30 results)
