| Project/Area Number |
18591940
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Aichi Medical University |
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Principal Investigator |
ZAKO Masahiro Aichi Medical University, Ophthalmology, Professor (80298596)
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| Co-Investigator(Kenkyū-buntansha) |
YONEDA Masahiro Aichi Prefectural College of Nursing and Health, Biochemistry, Professor (80201086)
IWAKI Masayoshi Aichi Medical University, Ophthalmology, Professor (10093163)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥4,010,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2006: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | SPACR / SPACRCAN / hyaluronan / interphotoreceptor matrix / FiVerHy versican / FiVerHy / バーシカン / 網膜接着 / 網膜分化 / versican / プロテオグリカン |
|---|
| Research Abstract |
We previously showed that chicken SPACR expression increased with developmental age in interphotoreceptor matrix, paralleling the adhesion between neural retina and retinal pigment epithelium (Zako, et al., 2002). As we hypothesized that an appropriate usage of the molecules in interphotoreceptor matrix may assist physiological recovery from retinal detachment, we tried to analyze other molecules there. Here we newly characterized chicken SPACRCAN in interphotoreceptor matrix. Furthermore, we fortunately clarified FiVerHy complex in ciliary body as a result of investigations for the origin of ocular hyaluronan. We also found the degradation of versican, a key molecule for FiVerHy, in chicken vitreous body and in human dermal samples from solar elastosis. In conclusion, we need more information about molecules in interphotoreceptor matrix to utilize these molecules for the treatment of retinal detachment.
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