Strategy for treatment of septic shock by poly (ADP-ribose) synthetase inhibitor

• Project/Area Number: 18591978
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: MITAKA Chieko Tokyo Medical and Dental University, 医歯学総合研究科, 准教授 (20126254)
• Project Period (FY): 2006 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,280,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥780,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2006: ¥900,000 (Direct Cost: ¥900,000)
• Keywords: 敗血症性ショック / エンドトキシンショック / Poly (ADP-ribose) synthetase / 炎症性サイトカイン / Poly(ADP-ribose)synthetase / 3-aminobenzamide / ポリ(ADP-リボース)シンセターゼ / ARDS / 代謝性アシドーシス / ポリ(ADP-リポース)シンターゼ / 一酸化窒素 / 多臓器障害

Research Abstract

To investigate a strategy for treatment of septic shock, we administered 3-aminobenzamide, poly (ADP-ribose) synthetase inhibitor, in rat endotoxic shock model. 3-aminobenzamide reduced systemic inflammatory response and improved hemodynamics. These findings suggest that poly (ADP-ribose) synthetase plays an important role in mechanism of septic shock.

Research Products

• [Journal Article] A longer duration of polymyxin B immobilized fiber column hemoperfusion improves pulmonary oxygenation in patients with septic shock (2009)
  • Author(s): Mitaka C, Tsuchida N, Kawada K, Nakajima Y.
  • Journal Title: Shock 32 Pages: 478-483
• [Journal Article] A longer duration of polymyxin-B-immobilized fiber column hemoperfusion improves pulmonary oxygenation in patients with septic shock (2009)
  • Author(s): Chieko Mitaka, et al.
  • Journal Title: Shock 32 Pages: 478-483
  • Peer Reviewed
• [Journal Article] Effect of human natriuretic peptide on renal function in patients undergoing abdominal aortic aneurysm repair (2008)
  • Author(s): Mitaka C, Kudo T, Jibiki M, Sugano N, Inoue Y, Makita K, Imai T.
  • Journal Title: Crit Care Med 30 Pages: 745-751
• [Journal Article] Effects of human atria lnatriuretic peptide on renal function in patients under going abdominal aortic aneurysm repair (2008)
  • Author(s): Mitakac, Kudo T, Jibiki M, Sugano N, Inoue Y, Makita K, Imai T
  • Journal Title: Crit Care Med 36 Pages: 745-751
  • Peer Reviewed
• [Journal Article] Nitric oxide production is more prominent in off-pump than in on-pump coronary artery bypass surgery (2007)
  • Author(s): Mitaka C, Yokoyama K, Imai T.
  • Journal Title: Anaesth Intensive Care 35 Pages: 505-509
• [Journal Article] Nitric oxide production is more prominent in off-pump than in on-pump coronary artery bypass surgery. (2007)
  • Author(s): Mitaka C, Yokoyama K, Imai T.
  • Journal Title: Anaesth Intensive Care 35 Pages: 505-509
  • Peer Reviewed
• [Presentation] (2009)
  • Organizer: 22^<th> Annual Congress of European Society of Intensive Care Medicine
  • Place of Presentation: Vienna Austria
  • Year and Date: 2009-10-13
• [Presentation] (2008)
  • Organizer: 21^<th> Annual Congress of European Society of Intensive Care Medicine
  • Place of Presentation: Lisbon, Portugal
  • Year and Date: 2008-09-23
• [Presentation] Polynyxin B-immobilized fiber column hemoperfusion has the possibility to reduce endothelial activation in patients with septic shock. Effect of endotoxin adsorption therapy on hemodynamics, procaicitonin and C-reactive protein in patients with septic shock. (2008)
  • Author(s): Mitaka C, Fuji Y, Nakajma Y, Kawada K, lmai T Mitaka C, Tsuchiya K, Kawada K, Nakajima Y, Imai T
  • Organizer: 21^<th> Annual Congress of European Society of Intensive Care Medicine
  • Place of Presentation: Lisbon, Portugal
  • Year and Date: 2008-09-23
• [Presentation] (2008)
  • Organizer: 37^<th> Critical Care Congress of Society of Critical Care Medicine
  • Place of Presentation: Hawai, USA
  • Year and Date: 2008-02-19
• [Presentation] (2007)
  • Organizer: 20^<th> Annual Congress European Society of Intensive Care Medicine
  • Place of Presentation: Berlin, Germany
  • Year and Date: 2007-10-07
• [Presentation] Beneficial effects of human atrial natriuretic peptide on renal function in patients undergoing abdominal aortic aneurysm repair. (2007)
  • Author(s): Chieko Mitaka
  • Organizer: 20th Annual Congress, European Society of Intensive care medicine
  • Place of Presentation: Berlin, Germany
  • Year and Date: 2007-10-07