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Strategy for treatment of septic shock by poly (ADP-ribose) synthetase inhibitor

Research Project

Project/Area Number 18591978
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Emergency medicine
Research InstitutionTokyo Medical and Dental University

Principal Investigator

MITAKA Chieko  Tokyo Medical and Dental University, 医歯学総合研究科, 准教授 (20126254)

Project Period (FY) 2006 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,280,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥780,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2006: ¥900,000 (Direct Cost: ¥900,000)
Keywords敗血症性ショック / エンドトキシンショック / Poly (ADP-ribose) synthetase / 炎症性サイトカイン / Poly(ADP-ribose)synthetase / 3-aminobenzamide / ポリ(ADP-リボース)シンセターゼ / ARDS / 代謝性アシドーシス / ポリ(ADP-リポース)シンターゼ / 一酸化窒素 / 多臓器障害
Research Abstract

To investigate a strategy for treatment of septic shock, we administered 3-aminobenzamide, poly (ADP-ribose) synthetase inhibitor, in rat endotoxic shock model. 3-aminobenzamide reduced systemic inflammatory response and improved hemodynamics. These findings suggest that poly (ADP-ribose) synthetase plays an important role in mechanism of septic shock.

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report   Self-evaluation Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (12 results)

All 2009 2008 2007

All Journal Article (6 results) (of which Peer Reviewed: 3 results) Presentation (6 results)

  • [Journal Article] A longer duration of polymyxin B immobilized fiber column hemoperfusion improves pulmonary oxygenation in patients with septic shock2009

    • Author(s)
      Mitaka C, Tsuchida N, Kawada K, Nakajima Y.
    • Journal Title

      Shock 32

      Pages: 478-483

    • Related Report
      2009 Final Research Report
  • [Journal Article] A longer duration of polymyxin-B-immobilized fiber column hemoperfusion improves pulmonary oxygenation in patients with septic shock2009

    • Author(s)
      Chieko Mitaka, et al.
    • Journal Title

      Shock 32

      Pages: 478-483

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of human natriuretic peptide on renal function in patients undergoing abdominal aortic aneurysm repair2008

    • Author(s)
      Mitaka C, Kudo T, Jibiki M, Sugano N, Inoue Y, Makita K, Imai T.
    • Journal Title

      Crit Care Med 30

      Pages: 745-751

    • Related Report
      2009 Final Research Report
  • [Journal Article] Effects of human atria lnatriuretic peptide on renal function in patients under going abdominal aortic aneurysm repair2008

    • Author(s)
      Mitakac, Kudo T, Jibiki M, Sugano N, Inoue Y, Makita K, Imai T
    • Journal Title

      Crit Care Med 36

      Pages: 745-751

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nitric oxide production is more prominent in off-pump than in on-pump coronary artery bypass surgery2007

    • Author(s)
      Mitaka C, Yokoyama K, Imai T.
    • Journal Title

      Anaesth Intensive Care 35

      Pages: 505-509

    • Related Report
      2009 Final Research Report
  • [Journal Article] Nitric oxide production is more prominent in off-pump than in on-pump coronary artery bypass surgery.2007

    • Author(s)
      Mitaka C, Yokoyama K, Imai T.
    • Journal Title

      Anaesth Intensive Care 35

      Pages: 505-509

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation]2009

    • Organizer
      22^<th> Annual Congress of European Society of Intensive Care Medicine
    • Place of Presentation
      Vienna Austria
    • Year and Date
      2009-10-13
    • Related Report
      2009 Final Research Report
  • [Presentation]2008

    • Organizer
      21^<th> Annual Congress of European Society of Intensive Care Medicine
    • Place of Presentation
      Lisbon, Portugal
    • Year and Date
      2008-09-23
    • Related Report
      2009 Final Research Report
  • [Presentation] Polynyxin B-immobilized fiber column hemoperfusion has the possibility to reduce endothelial activation in patients with septic shock. Effect of endotoxin adsorption therapy on hemodynamics, procaicitonin and C-reactive protein in patients with septic shock.2008

    • Author(s)
      Mitaka C, Fuji Y, Nakajma Y, Kawada K, lmai T Mitaka C, Tsuchiya K, Kawada K, Nakajima Y, Imai T
    • Organizer
      21^<th> Annual Congress of European Society of Intensive Care Medicine
    • Place of Presentation
      Lisbon, Portugal
    • Year and Date
      2008-09-23
    • Related Report
      2008 Annual Research Report
  • [Presentation]2008

    • Organizer
      37^<th> Critical Care Congress of Society of Critical Care Medicine
    • Place of Presentation
      Hawai, USA
    • Year and Date
      2008-02-19
    • Related Report
      2009 Final Research Report
  • [Presentation]2007

    • Organizer
      20^<th> Annual Congress European Society of Intensive Care Medicine
    • Place of Presentation
      Berlin, Germany
    • Year and Date
      2007-10-07
    • Related Report
      2009 Final Research Report
  • [Presentation] Beneficial effects of human atrial natriuretic peptide on renal function in patients undergoing abdominal aortic aneurysm repair.2007

    • Author(s)
      Chieko Mitaka
    • Organizer
      20th Annual Congress, European Society of Intensive care medicine
    • Place of Presentation
      Berlin, Germany
    • Year and Date
      2007-10-07
    • Related Report
      2007 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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