Strategy for treatment of septic shock by poly (ADP-ribose) synthetase inhibitor
Project/Area Number |
18591978
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Emergency medicine
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Research Institution | Tokyo Medical and Dental University |
Principal Investigator |
MITAKA Chieko Tokyo Medical and Dental University, 医歯学総合研究科, 准教授 (20126254)
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Project Period (FY) |
2006 – 2009
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Project Status |
Completed (Fiscal Year 2009)
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Budget Amount *help |
¥4,280,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥780,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2006: ¥900,000 (Direct Cost: ¥900,000)
|
Keywords | 敗血症性ショック / エンドトキシンショック / Poly (ADP-ribose) synthetase / 炎症性サイトカイン / Poly(ADP-ribose)synthetase / 3-aminobenzamide / ポリ(ADP-リボース)シンセターゼ / ARDS / 代謝性アシドーシス / ポリ(ADP-リポース)シンターゼ / 一酸化窒素 / 多臓器障害 |
Research Abstract |
To investigate a strategy for treatment of septic shock, we administered 3-aminobenzamide, poly (ADP-ribose) synthetase inhibitor, in rat endotoxic shock model. 3-aminobenzamide reduced systemic inflammatory response and improved hemodynamics. These findings suggest that poly (ADP-ribose) synthetase plays an important role in mechanism of septic shock.
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Report
(6 results)
Research Products
(12 results)
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[Presentation] Polynyxin B-immobilized fiber column hemoperfusion has the possibility to reduce endothelial activation in patients with septic shock. Effect of endotoxin adsorption therapy on hemodynamics, procaicitonin and C-reactive protein in patients with septic shock.2008
Author(s)
Mitaka C, Fuji Y, Nakajma Y, Kawada K, lmai T Mitaka C, Tsuchiya K, Kawada K, Nakajima Y, Imai T
Organizer
21^<th> Annual Congress of European Society of Intensive Care Medicine
Place of Presentation
Lisbon, Portugal
Year and Date
2008-09-23
Related Report
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