Role of PPAR-mediated pathway on induction of anoikis in squamous cell carcinoma
| Project/Area Number |
18592028
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
WADA Koichiro Osaka University, 大学院・歯学研究科, 准教授 (90263467)
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| Co-Investigator(Kenkyū-buntansha) |
KAMISAKI Yoshinori 大阪大学, 大学院・歯学研究科, 教授 (40116017)
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| Project Period (FY) |
2006 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥4,100,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥600,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2006: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | 核内受容体 / PPAR / 扁平上皮癌 / アノイキス / 浸潤 / Apoptosis / 細胞増殖 / PPARgamma / 高脂肪 / 生活習慣病 / エストロゲン / 扇平上皮癌 |
|---|
| Research Abstract |
扁平上皮癌における核内受容体PPAR を介した転写制御系の役割を検討したところ、核内受容体PPAR が高発現していること、このPPAR を阻害したところアノイキスとよばれる接着阻害による細胞死がおこり癌細胞の浸潤が有意に抑制されることが明らかになった。この核内受容体PPARを介した転写制御系の下流には様々な細胞機能制御系の分子群が存在することも明らかになった。核内受容体PPAR を制御することにより癌細胞の増殖・浸潤を抑制できることが示唆された。
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Report
(4 results)
Research Products
(71 results)
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[Journal Article] Adiponectin inhibits colorectal cancer cell growth through theAMPK/mTOR pathway.2009
Author(s)
Sugiyama M, Takahashi H, Hosono K, Endo H, Kato s, Yoneda K, Nozaki Y, Fujita K, Yoneda M, Wada K, et al
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Journal Title
Int. J. Oncol. 34
Pages: 339-344
Related Report
Peer Reviewed
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[Journal Article] Upregulation of S100 calcium-binding protein A9 is required for induction of smooth musde cell proliferation by a periodontal pathogen.2009
Author(s)
Inaba H, Hokamura K, Nakano K, Nomura R, Katayama K, Nakajima A, Yoshioka H, Taniguchi K, Kamisaki Y, Ooshima T, Umemura K, Murad F, Wada K, Amano A.
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Journal Title
FEBS Letters 583
Pages: 128-134
Related Report
Peer Reviewed
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[Journal Article] Association of visceral fat accumulation and plasma adiponectin with rectal dysplastic aberrant crypt foci in a clinical population.2009
Author(s)
Takahashi H, Takayama T, Yoneda K, Endo H, Iida H, Sugiyama M, Fujita K, Yoneda M, Iramori M, Abe Y, Saito S, Wada K, et al.
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Journal Title
Cancer Science 100
Pages: 29-32
NAID
Related Report
Peer Reviewed
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[Journal Article] Inhibition of peroxisome proliferator-activated receptor gamma activity suppresses pancreatic cancer cell motility.2008
Author(s)
Nakajima A, Tomimoto A, Takahashi H, Ikeda I, Hosono K, Endo H, Yoneda K, Kubota K, Nakajima N, Wada K, et al.
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Journal Title
Cancer Science 99
Pages: 1892-1890
Related Report
Peer Reviewed
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[Journal Article] Expression of adiponectin receptors, AdipoRl and AdipoR2, in normal colon epithelium and colon cancer tissue.2008
Author(s)
Yoneda K, Tornimoto A, Endo H, Iida H, Sugiyama M, Takahashi H, Mawatari H, Nozaki Y, Fujita K, Yoneda M, Inamori M, Nakajima N, Wada K, et al
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Journal Title
Oncol. Rep. 20
Pages: 479-483
Related Report
Peer Reviewed
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