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Analysis of gene networks that regulate the differentiation program of mesenchymal stem cells

Research Project

Project/Area Number 18592035
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Functional basic dentistry
Research InstitutionHiroshima University

Principal Investigator

KAWAMOTO Takeshi  Hiroshima University, Graduate School of Biomedical Sciences, Assistant Professor (50224861)

Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,890,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2006: ¥2,200,000 (Direct Cost: ¥2,200,000)
KeywordsMesenchymal stem cell / differentiation program / differentiation marker / gene regulation / DNA microarray / regenerative therapy / DEC2 / ノックアウトマウス / 変異マウス
Research Abstract

Mesenchymal stem cells (MSC) are characterized by multipotency, sternness, and self-renewal. MSC can be differentiated into various types of cells including osteoblasts, chondrocytes, and adipocytes. To identify the genes responsible for the characteristics of MSC, we performed DNA microarray analysis for undifferentiated and differentiated MSC and control fibroblasts and identified 180 genes expressed specifically in undifferentiated MSC. The specific expression of 30 genes out of 180 genes was confirmed by RT-PCR analysis. Since these include 9 genes for transcription factors, we transfected their siRNAs into MSC. Some of these siRNAs inhibited growth of MSC, and inhibited or accelerated osteogenic differentiated MSC. Furthermore, using numerous MSC lines from tibia, femur, ilium, and jaw, together with skin and gum fibroblasts, we identified molecular markers - LIF, IGFI, PRGI, MGP, BMP4, CTGF, KCTD12, IGFBP7, TRIB2, and DYNCIII - that were expressed at a higher level in these MSCs than in fibroblasts. The passage number markedly altered the expression levels of several markers, while donor age had little effect on them. Although their efficacy may depend upon the passage number or donor age, these markers common among various MSCs are probably useful in routine tests. These results suggest that some of these transcription factors and markers are essential for differentiation of MSC and maintenance of the properties of MSC.

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (63 results)

All 2008 2007 2006 Other

All Journal Article (32 results) (of which Peer Reviewed: 15 results) Presentation (31 results)

  • [Journal Article] Human mismatch repair gene, MLHl,is transcriptionally repressed by the hypoxia-inducible transcription factors, DEC1 and DEC22008

    • Author(s)
      Nakamura, H., et. al.
    • Journal Title

      Oncogene 27(in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] DEC1 modulates circadian phase of clock gene expression2008

    • Author(s)
      Nakashima, A., et. al.
    • Journal Title

      Mol. Cell. Biol. 28(in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Basic-helix-loop-helix (bHLH)transcription factor DEC2 negatively regulates vascular endothelial growth factor expression2008

    • Author(s)
      Sato, F., et. al.
    • Journal Title

      Genes Cells 13

      Pages: 131-144

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Basic-helix-loop-helix (bHLH) transcription factor DEC2 negatively regulates vascular endothelial growth factor expression2008

    • Author(s)
      Sato, F., Bhawal, U.K., Kawamoto, T., Fujimoto, K., Imaizumi, T., Imanaka, T., Kondo, J., Koyanagi, S., Noshiro, M., Yoshida, H., Kusumi, T., Kato, Y., Kijima, H
    • Journal Title

      Genes Cells 13

      Pages: 131-144

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Human mismatch repair gene, MLH1, is transcriptionally repressed by the hypoxia-inducible transcription factors, DECI and DEC22008

    • Author(s)
      Nakamura, H., Tanimoto, K., Yunokawa, M., Kawamoto, T., Kato, Y., Yoshiga, K., Hiyama, E., Poellinger, L., Hiyama, K., Nishiyama, M
    • Journal Title

      Oncogene 27(in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] DEC1 modulates circadian phase of clock gene expression2008

    • Author(s)
      Nakashima, A., Kawamoto, T., Honda, K.K., Ueshima, T., Noshiro, M., Iwata, T., Fujimoto, K., Kubo, H., Honma, S., Yorioka, N., Kohno, N., Kato, Y
    • Journal Title

      Mol. Cell. Biol 28(in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Human mismatch repair gene, MLH1, is transcriptionally repressed by the hypoxia-inducible transcription factors, DEC1 and DEC22008

    • Author(s)
      Nakamura, H., et. al.
    • Journal Title

      Oncogene 27(in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Basic-helix-loop-helix (bHLH) transcription factor DEC2 negatively regulates vascular endothelial growth factor expression2008

    • Author(s)
      Sato, F., et. al.
    • Journal Title

      Genes Cells 13

      Pages: 131-144

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential regulation of DEC2 among hypoxia-inducible genes in endometrial carcinomas2007

    • Author(s)
      Yunokawa, M., et. al.
    • Journal Title

      Oncol. Rep. 17

      Pages: 871-878

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Collocational Analysis of Life Science English (4)-Lists of common collocates of common collocates of affinity, aim, difference, growth, importance, knowledge, observation, understanding-2007

    • Author(s)
      Ohtake, H., et. al.
    • Journal Title

      Humana et Naturalia 41

      Pages: 67-108

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Multiple mechanisms regulate circadian expression of the gene for choles terol 7alpha-hydroxylase (Cyp7a), a key enzyme in hepatic bile acid biosynthesis2007

    • Author(s)
      Noshiro, M., et. al.
    • Journal Title

      J. Biol. Rhythms 22

      Pages: 299-311

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Selection of Common Markers for Bone Marrow Stromal Cells from Various Bones Using Real-Time RT-PCR: Effects of Passage Number and Donor Age2007

    • Author(s)
      Igarashi, A., et. al.
    • Journal Title

      Tissue Eng. 13

      Pages: 2405-2417

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Transcriptional repression by the basic helix-loop-helix protein Dec2: multiple mechanisms through E-box elements2007

    • Author(s)
      Fujimoto, K., et. al.
    • Journal Title

      Int. J. Mol. Med. 19

      Pages: 925-932

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 生体時計に関与する転写因子の機能制御とタンパク質間相互作用2007

    • Author(s)
      河本健, 他
    • Journal Title

      生体の科学 58

      Pages: 468-470

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Journal Article] Transcriptional repression by the basic helix-loop-helix protein. Dec2 : multiple mechanisms through E-box elements2007

    • Author(s)
      Fujimoto, K., Hamaguchi, H., Hashiba, T., Nakamura, T., Kawamoto, T., Sato, F., Noshiro, M., Bhawal, U.K., Suardita, K., Kato, Y
    • Journal Title

      Int. J. Mol. Med 19

      Pages: 925-932

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Selection of common markers for bone marrow stromal cells from various bones using real-time RT-PCR : effects of passage number and donor age2007

    • Author(s)
      Igarashi, A., Segoshi, K., Sakai, Y., Pan, H., Kanawa, M., Higashi, Y., Sugiyama, M., Nakamura, K., Kurihara, H., Yamaguchi, S., Tsuji, K., Kawamoto, T., Kato, Y
    • Journal Title

      Tissue Eng 13

      Pages: 2405-2417

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Multiple mechanisms regulate circadian expression of the gene for cholesterol 7alpha-hydroxylase (Cyp7a), a key enzyme in hepatic bile acid biosynthesis2007

    • Author(s)
      Noshiro, M., Usui, E., Kawamoto, T., Kubo, H., Fujimoto, K., Furukawa, M., Honma, S., Makishima, M., Honma, K., Kato, Y
    • Journal Title

      J. Biol. Rhythms 22

      Pages: 299-311

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Differential regulation of DEC2 among hypoxia-inducible genes in endometrial carcinomas2007

    • Author(s)
      Yunokawa, M., Tanimoto, K., Nakamura, H., Nagai, N., Kudo, Y., Kawamoto, T., Kato, Y., Hiyama, E., Hiyama, K., Nishiyama, M
    • Journal Title

      Oncol. Rep 17

      Pages: 871-878

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Collocational Analysis of Life Science English (4) - Lists of common collocates of common collocates of affinity, aim, difference, growth, importance, knowledge, observation, understanding -2007

    • Author(s)
      Ohtake, H., Fujita, N., Kaneko, S., Morren, B., Kawamoto, T
    • Journal Title

      Studia Humana et Naturalia 41

      Pages: 67-108

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Collocational Analysis of Life Science English (4) -Lists of common collocates of common collocates of affinity, aim, difference, growth, importance, knowledge, observation, understanding-2007

    • Author(s)
      Ohtake, H., et. al.
    • Journal Title

      Humana et Naturalia 41

      Pages: 67-108

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multiple mechanisms regulate circadian expression of the gene for cholesterol 7alpha-hydroxylase (Cyp7a), a key enzyme in hepatic bile acid biosynthesis2007

    • Author(s)
      Noshiro, M., et. al.
    • Journal Title

      J. Biol. Rhythms 22

      Pages: 299-311

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of fasting and re-feeding on the expression of Dec1, Per1, and other clock-related genes.2006

    • Author(s)
      Kawamoto, T., et. al.
    • Journal Title

      J. Biochem. (Tokyo) 140

      Pages: 401-408

    • NAID

      10018842326

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Effects of overexpression of basic helix-loop-helix transcription factor Dec1 onosteogenic and adipogenic differentiation of mesenchymal stem cells.2006

    • Author(s)
      Iwata, T, et. al.
    • Journal Title

      Eur. J. Cell Biol. 85

      Pages: 423-431

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 57Arg in the bHLH transcription factor DEC2 is essential for the suppression of CLOCK/BMAL2-mediated transactivation.2006

    • Author(s)
      Kondo, J., et. al.
    • Journal Title

      Int. J. Mol. Med. 17

      Pages: 1053-1056

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Effects of fasting and re-feeding on the expression of decl, per 1, and other clock-related genes2006

    • Author(s)
      Kawamoto, T., Noshiro, M., Furukawa, M., Honda, K.K., Nakashima, A., Ueshima, T., Usui, E., Katsura, Y., Fujimoto, K., Honma, S., Honma, K., Hamada, T., Kato, Y
    • Journal Title

      J. Biochem. (Tokyo) 140

      Pages: 401-408

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Effects of overexpression of basic helix-loop-helix transcription factor Decl on osteogenic and adipogenic differentiation of mesenchymal stem cells2006

    • Author(s)
      Iwata, T., Kawamoto, T., Sasabe, E., Miyazaki, K., Fujimoto, K., Noshiro, M., Kurihara, H., Kato, Y
    • Journal Title

      Eur. J. Cell Biol 85

      Pages: 423-431

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 57Arg in the bHLH transcription factor DEC2 is essential for the suppression of CLOCK/BMAL2-mediated transactivation2006

    • Author(s)
      Kondo, J., Sato, F., Fujimoto, K., Kusumi, T., Imanaka, T., Kawamoto, T., Bhawal, U.K., Noshiro, M., Kato, Y., Sato, T., Kijima, H
    • Journal Title

      Int. J. Mol. Med 17

      Pages: 1053-1056

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Collocational Analysis of Life Science English (3) - Lists of common collocates of common collocates of addition, analysis, hypothesis, identification, level, production, risk -2006

    • Author(s)
      Ohtake, H., Kawamoto, T., Fujita, N., Morren, B., Kaneko, S
    • Journal Title

      Studia Humana et Naturalia 40

      Pages: 23-59

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Effects of fasting and re-feeding on the expression of Dec1, Per1, and other clock-related genes.2006

    • Author(s)
      Kawamoto, T., et al.
    • Journal Title

      Journal of Biochemistry 140(3)

      Pages: 401-408

    • NAID

      10018842326

    • Related Report
      2006 Annual Research Report
  • [Journal Article] effects of over expression of basic helix-loop-helix transcription factor Decl on osteogenic and adipogenic differentiation of mesenchymal stem cells.2006

    • Author(s)
      Iwata, T., et al.
    • Journal Title

      European Journal of Cell Biology 85

      Pages: 423-431

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 57Arg in the bHLH transcription factor DEC2 is essential for the suppression of CLOCK/BMAL2-mediated transactivation.2006

    • Author(s)
      Kondo, J., et al.
    • Journal Title

      International Journal of Molecular Medicine 17(6)

      Pages: 1053-1056

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Transcriptional repression by the basic helix-loop-helix protein Dec2 : multiple mechanisms through E-box elements.

    • Author(s)
      Fujimoto K., et al.
    • Journal Title

      International Journal of Molecular Medicine (in press)

    • Related Report
      2006 Annual Research Report
  • [Presentation] Light-dark conditions control development and metabolism in permanent cartilage2008

    • Author(s)
      K. K., Honda, T., Kawamoto, A., Nakashimal, T., Ueshima, K., Fujimoto, M., Nishimura, M., Noshiro, Yukio, Kato
    • Organizer
      The 21st Anuual Meeting of the Japanese Society of Cartilage Metabolism
    • Place of Presentation
      Kyoto
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Novel clock-responsive elements and transcription factors involved in chondrocyte differntiation2008

    • Author(s)
      T., Ueshima, T., Kawamoto, K. K., Honda, M., Noshiro, K., Fujimoto, O., Gotoh, Y., Kato
    • Organizer
      The 21st Anuual Meeting of the Japanese Society of Cartilage Metabolism
    • Place of Presentation
      Kyoto
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 軟骨細胞分化の概日リズムを制御する新規配列の探索とそこに関与する転写因子の同定2007

    • Author(s)
      上嶋太一, 他
    • Organizer
      中四国骨代謝研究会
    • Place of Presentation
      岡山市
    • Year and Date
      2007-07-07
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 滑膜由来間葉系幹細胞の特徴2007

    • Author(s)
      坂井裕大, 他
    • Organizer
      中四国骨代謝研究会
    • Place of Presentation
      岡山市
    • Year and Date
      2007-07-07
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 間葉系幹細胞の骨分化に関わる転写因子の機能解析2007

    • Author(s)
      末廣史雄, 他
    • Organizer
      第40回広島大学歯学会総会
    • Place of Presentation
      広島市
    • Year and Date
      2007-06-16
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] DEC1による概日リズム調節の機構2007

    • Author(s)
      河本健, 他
    • Organizer
      第5回ながの遺伝子発現調節研究会
    • Place of Presentation
      長野県諏訪市
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] DEC1 modulates circadian phase of clock gene expression.2007

    • Author(s)
      Nakashima A., et. al.
    • Organizer
      2nd World Congress of Chronobiology
    • Place of Presentation
      東京都
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] The liver X receptors (LXRα and LXRβ) are potent regulators for hepatic Dec1 expression2007

    • Author(s)
      Noshiro M., et. al.
    • Organizer
      2nd World Congress of Chronobiology
    • Place of Presentation
      東京都
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] DEC1による概日リズム調節の機構2007

    • Author(s)
      河本健, 他
    • Organizer
      第49回歯科基礎医学会
    • Place of Presentation
      札幌市
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 間葉系幹細胞の生体内分布および未分化維持機構の解明2007

    • Author(s)
      清水正和, 他
    • Organizer
      第25回日本骨代謝学会学術集会
    • Place of Presentation
      大阪市
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 軟骨細胞の分化の概日リズムを制御する数種類の新規制御配列の同定とそこに関与する転写因子の探索(ポスター発表)2007

    • Author(s)
      上嶋太一, 他
    • Organizer
      第25回日本骨代謝学会学術集会
    • Place of Presentation
      大阪市
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 間葉系幹細胞の自己複製に関わる転写因子についての検討2007

    • Author(s)
      久保裕嗣, 他
    • Organizer
      第6回日本再生医療学会総会
    • Place of Presentation
      横浜市
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] DEC1 modulates circadian phase of clock gene expression2007

    • Author(s)
      A., Nakashima, T., Kawamoto, K. K., Honda, T., Ueshima, M., Noshiro, K., Fujimoto, H., Kubo, Y., Kato
    • Organizer
      2rd World Congress of Chronobiology
    • Place of Presentation
      Tokyo
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The liver X receptors (LXRa and LXRb) are potent regulators for hepatic Decl expression2007

    • Author(s)
      M., Noshiro, E., Usui, T., Kawamoto, F., Sato, A., Nakashima, M., Furukawa, T., Ueshima, K. K., Honda, K., Fujimoto, S., Honma, K., Honma, Y., Kato
    • Organizer
      2nd World Congress of Chronobiology
    • Place of Presentation
      Tokyo
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 間葉系幹細胞(MSC)と線維芽細胞(FB)のマトリックス分解系(MMP/TIMP):炎症刺激応答の検討2006

    • Author(s)
      瀬越和美, 他
    • Organizer
      第16回中国・四国骨代謝研究会
    • Place of Presentation
      岡山市
    • Year and Date
      2006-07-01
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 葉系幹細胞の蛋白マーカー 〜サイトカイン定量によるアプローチ〜2006

    • Author(s)
      瀬越和美, 他
    • Organizer
      第16回中国・四国骨代謝研究会
    • Place of Presentation
      岡山市
    • Year and Date
      2006-07-01
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ライフサイエンス辞書: 英語での研究論文作成を支援する辞書システム-第3報-2006

    • Author(s)
      河本健, 他
    • Organizer
      第39回広島大学歯学会総会
    • Place of Presentation
      広島市
    • Year and Date
      2006-06-10
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] DNAマイクロアレーを用いた成長板軟骨における概日リズム遺伝子の解析2006

    • Author(s)
      本田清昌, 他
    • Organizer
      第13回日本時間生物学会学術大会
    • Place of Presentation
      東京都
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Dec1は時計遺伝子の概日リズム位相を制御する2006

    • Author(s)
      中島歩他
    • Organizer
      第13回日本時間生物学会学術大会
    • Place of Presentation
      東京都
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] マウス肝臓ステロール代謝酵素の概日リズムと分子時計2006

    • Author(s)
      能城光秀, 他
    • Organizer
      第13回日本時間生物学会学術大会
    • Place of Presentation
      東京都
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 時計遺伝子発現に及ぼす食餌条件の影響2006

    • Author(s)
      河本健他
    • Organizer
      第13回日本時間生物学会学術大会
    • Place of Presentation
      東京都
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ライフサイエンス英語類語使い分け辞典-その作成意図と意義2006

    • Author(s)
      河本健他
    • Organizer
      日本医学英語教育学会第9回総会
    • Place of Presentation
      金沢市
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 間葉系幹細胞システムにおける基本的デザインの追究2006

    • Author(s)
      清水正和, 他
    • Organizer
      第24回日本骨代謝学会
    • Place of Presentation
      東京都
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Dec1による間葉系幹細胞の概日リズム発振および24時間周期の維持2006

    • Author(s)
      中島歩他
    • Organizer
      第24回日本骨代謝学会
    • Place of Presentation
      東京都
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 軟骨分化の時間的制御:概日リズム機構の解析2006

    • Author(s)
      本田清昌, 他
    • Organizer
      第24回日本骨代謝学会
    • Place of Presentation
      東京都
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Mutation analysis of the bHLH transcription factor DEC1 and DEC2 in circadian regulation2006

    • Author(s)
      Sato, F., et. al.
    • Organizer
      the 20th IUBMB International Congress of Biochemistry and Molecular Biology and the 11th FAOBMB Congress
    • Place of Presentation
      京都市
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Life Science Dictionary: Statistical and Collocational Analyses of Life Science English2006

    • Author(s)
      Kawamoto, T., et. al.
    • Organizer
      the 20th IUBMB International Congress of Biochemistry and Molecular Biology and the 11th FAOBMB Congress
    • Place of Presentation
      京都市
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Molecular mechanisms involved in circadian rhythms in cartilage2006

    • Author(s)
      Honda, k. k., et. al.
    • Organizer
      the 20th IUBMB International Congress of Biochemistry and Molecular Biology and the 11th FAOBMB Congress
    • Place of Presentation
      京都市
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Life Science Dictionary : Statistical and Collocational Analyses of Life Science English2006

    • Author(s)
      T., Kawamoto, H., Ohtake, N., Fujita, M., Takekoshi, Y., Ugawa, H., Takeuchi, S., Kaneko
    • Organizer
      the 20th IUBMB International Congress of Biochemistry and Molecular Biology and the 11th FAOBMB Congress
    • Place of Presentation
      Kyoto
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Molecular mechanisms involved in circadian rhythms in cartilage2006

    • Author(s)
      K. K., Honda, T., Kawamoto, R., Yamada, H. R., Ueda, M., Noshiro, K., Fujimoto, A., Nakashima, T., Ueshima, T., Ogawa, S., Hashimoto, Y., Kato
    • Organizer
      the 20th IUBMB International Congress of Biochemistry and Molecular Biology and the 11th FAOBMB Congress
    • Place of Presentation
      Kyoto
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Mutation analysis of the bHLH transcription factor DEC1 and DEC2 in circadian regulation2006

    • Author(s)
      F., Sato, T., Kawamoto, Ujjal, K., Bhawal, K., Fujimoto, J., Kondo, T., Imanaka, M., Noshiro, T., Kutsumi, T., Sato, S., Honma, K., Honma, Y., Kato, H., Kijima
    • Organizer
      the 20th IUBMB International Congress of Biochemistry and Molecular Biology and the 11th FAOBMB Congress
    • Place of Presentation
      Kyoto
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2006-04-01   Modified: 2016-04-21  

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