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Effect of Mucosal Vaccine for the Aspiration Pneumonia in the Experimental Model

Research Project

Project/Area Number 18592072
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionNihon University

Principal Investigator

MEGA Junichi  Nihon University, 松戸歯学部, 教授 (40190946)

Co-Investigator(Kenkyū-buntansha) TANAKA Yoko  日本大学, 松戸歯学部, 講師 (50349974)
Co-Investigator(Renkei-kenkyūsha) FUJIHASHI Kohtaro  アラバマ大学, 歯学部, 教授
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,930,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥630,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2006: ¥1,200,000 (Direct Cost: ¥1,200,000)
Keywords免疫 / 感染 / 炎症 / 粘膜ワクチン / 口腔細菌 / 誤嚥性肺炎
Research Abstract

口腔細菌Candida albicans(C.albicans)によるマウス誤嚥性肺炎モデルを確立するために行った実験では, 妥当と思われる感染モデルが見いだされた。また, cholera toxin(CT)とカンジダ抗原を併用し経鼻免疫した結果, 抗体価の上昇が認められ, 感染モデルの誤嚥性肺炎発症の予防に有効であることが示唆された

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (16 results)

All 2008 2007 2006

All Journal Article (7 results) (of which Peer Reviewed: 3 results) Presentation (9 results)

  • [Journal Article] 口腔ケアに対する歯科医療職関与の必要度に関する研究-介護老人福祉施設における検討-2008

    • Author(s)
      高橋賢晃, 菊谷武, (その他9名), 妻鹿純一
    • Journal Title

      障歯誌 29

      Pages: 78-83

    • NAID

      10024180645

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cytological Diagnosis for the Dependent Elderly by Using Oral Smear -For the Method to Evaluate Oral Mucosa2007

    • Author(s)
      Endoh M, Okada H, Yamamoto H, Mega J
    • Journal Title

      Dentistry in Japan 43

      Pages: 158-161

    • NAID

      10021953693

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 摂食・嚥下リハビリテーション-臨床の現場から地域連携まで-〈その1〉2007

    • Author(s)
      野本たかと, 妻鹿純一
    • Journal Title

      日本歯科医師会雑誌 60(7)

      Pages: 649-656

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 摂食・嚥下リハビリテーション-臨床の現場から地域連携まで-〈その2〉2007

    • Author(s)
      野本たかと, 妻鹿純一
    • Journal Title

      日本歯科医師会雑誌 60(8)

      Pages: 621-627

    • Related Report
      2008 Final Research Report
  • [Journal Article] Cytological Diagnosis for the Dependent Elderly by Using Oral Smear-For the Method to Evaluate Oral Mucosa-2007

    • Author(s)
      Mami Endoh
    • Journal Title

      Dentistry in Japan 43

      Pages: 158-161

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 摂食・嚥下リハビリテーション-臨床の現場から地域連携まで-<その1>2007

    • Author(s)
      野本たかと
    • Journal Title

      日本歯科医師会雑誌 60

      Pages: 649-656

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 摂食・嚥下リハビリテーション-臨床の現場から地域連携まで-<その2>2007

    • Author(s)
      野本たかと
    • Journal Title

      日本歯科医師会雑誌 60

      Pages: 621-627

    • Related Report
      2007 Annual Research Report
  • [Presentation] Cytological Diagnosis for the Patients with Mental Illness by Using Oral Smear Cytology2008

    • Author(s)
      ENDOH M, OKADA H, YAMAMOTO H, MEGA J
    • Organizer
      19th IADH
    • Place of Presentation
      Santos
    • Related Report
      2008 Final Research Report
  • [Presentation] 高齢者における擦過細胞診を使用した口腔粘膜の評価2008

    • Author(s)
      遠藤眞美, 岡田裕之, 松本敬, 山本浩嗣, 妻鹿純一
    • Organizer
      第17回日本口腔粘膜学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] Cytological Diagnosis for the Patients with Mental Illness by Using Oral Smear Cytology2008

    • Author(s)
      Endoh M, Okada H, Yamamoto H, Mega J
    • Organizer
      19th IADH
    • Place of Presentation
      Santos (Brazil)
    • Related Report
      2008 Annual Research Report
  • [Presentation] GeneExpression of IL-1・and TLR2 in Gingival Fibroblasts from Down Syndrome2007

    • Author(s)
      TANAKA Y, ABIKO Y, MEGA J
    • Organizer
      International Conference of Oral Care for People with Disabilities
    • Place of Presentation
      Taipei
    • Year and Date
      2007-12-16
    • Related Report
      2008 Final Research Report
  • [Presentation] Gene Expression of IL-1β and TLR2 in Gingival Fibroblasts from Down Syndrome2007

    • Author(s)
      Yoko Tanaka
    • Organizer
      International Conference of Oral Care for People with Disabilities
    • Place of Presentation
      Taipei
    • Year and Date
      2007-12-16
    • Related Report
      2007 Annual Research Report
  • [Presentation] Down症歯肉由来線維芽細胞におけるLPSレセプターの応答性2007

    • Author(s)
      田中陽子
    • Organizer
      第24回日本障害者歯科学会
    • Place of Presentation
      長崎
    • Year and Date
      2007-11-24
    • Related Report
      2007 Annual Research Report
  • [Presentation] 精神科入院患者に対する口腔粘膜の検討-口腔擦過細胞診を使用して-2006

    • Author(s)
      遠藤眞美, 岡田裕之, 林龍介, 山本浩嗣, 妻鹿純一
    • Organizer
      第23回日本障害者歯科学会
    • Place of Presentation
      仙台
    • Year and Date
      2006-10-20
    • Related Report
      2008 Final Research Report
  • [Presentation] Porphyromonas gingivalis Enhanced IL-1・and IL-6 in Alveolar Epithelial Cell2006

    • Author(s)
      YO TANAKA, T NOMOTO, T FUJITA Y ABIKO, and J MEGA
    • Organizer
      84th IADR General Session & Exhibition
    • Place of Presentation
      Brisbane
    • Year and Date
      2006-06-30
    • Related Report
      2008 Final Research Report
  • [Presentation] Smear Cytology for Oral Mucosa of Dependent Elderly-Effect of Professional Oral Health Care2006

    • Author(s)
      ENDOH M, OKADA H, MATSUMOTO T, YAMAMOTO H, MEGA J
    • Organizer
      18th Congress of the International Association for Disability and Oral Health
    • Place of Presentation
      Goteborg
    • Related Report
      2008 Final Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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