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Quantitative assessments of enamel remineralisation and salivarycariogenic bacteria in relation to caries risk

Research Project

Project/Area Number 18592083
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Conservative dentistry
Research InstitutionTokyo Medical and Dental University

Principal Investigator

KITASAKO Yuichi  Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 助教 (30361702)

Co-Investigator(Kenkyū-buntansha) 田上 順次  東京医科歯科大学, 大学院医歯学総合研究科, 教授 (50171567)
マティン カイルール (MATIN KHAIRUL)  東京医科歯科大学, 大学院・医歯学総合研究科, COE拠点形成特任講師 (00372433)
Co-Investigator(Renkei-kenkyūsha) マティンカイルール  東京医科歯科大学, 大学院・医歯学総合研究科, 特任講師
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,130,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥630,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2006: ¥1,400,000 (Direct Cost: ¥1,400,000)
Keywords初期う蝕 / う蝕リスク / エナメル質 / 再石灰化 / う蝕細菌 / PCR / pH / 唾液 / caries / pH censer / demineralization / streptococci / white spot lesion / remineralization / saliva / dimineralization / buffer capacity
Research Abstract

エナメル質初期むし歯を保有し、本研究参加に同意を得られた8名において、ホームケアによる再石灰化療法を試みた。来院時毎に、口腔内写真、むし歯表層pH測定、唾液緩検査を行い、むし歯リスクが再石灰化に及ぼす影響について検討を加えた。その結果、全症例において、観察1ヶ月後よりむし歯表層pH値の上昇を認めた。一方、カリエスリスクと再石灰化との関連性は認められず、再石灰化療法中の唾液中むし歯にも顕著な変化を認めなかった。

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (40 results)

All 2009 2008 2007 2006 Other

All Journal Article (26 results) (of which Peer Reviewed: 20 results) Presentation (10 results) Book (3 results) Remarks (1 results)

  • [Journal Article] Micro-shear bond strengths and etching efficacy of a two-step self-etching adhesive system to fluorosed and non-fluorosed enamel2009

    • Author(s)
      Shida K, Kitasako Y, Burrow MF and Tagami J
    • Journal Title

      European Journal of Oral Sciences 117

      Pages: 182-186

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Micro-shear bond strengths and etching efficacy of a two-step self-etching adhesive system to fluorosed and non-fluorosed enamel.2009

    • Author(s)
      Shida K, Kitasako Y, Burrow MF, Tagami J.
    • Journal Title

      European Journal of Oral Sciences 117

      Pages: 182-186

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of enamel and dentin microshear bond strengths of a two-step self-etchoing priming system with five all-in-one system2008

    • Author(s)
      Burrow MF, Kitasako Y, Thomas CD and Tagami J
    • Journal Title

      Operative Dentistry 33

      Pages: 456-460

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between quantitative assessments of salivary buffering capacity and ion activity product for hydroxyapatite in relation to cariogenic potential2008

    • Author(s)
      Aiuchi H, Kitasako Y, Fukuda Y, Nakashima S, Burrow MF and Tagami J
    • Journal Title

      Australian Dental Journal 53

      Pages: 67-171

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparative analysis of three commercial saliva testing kits with a standard saliva buffering test2008

    • Author(s)
      Kitasako Y, Burrow MF, Stacey M, Huq L, Reynolds EC and Tagami J
    • Journal Title

      Australian Dental Journal 53

      Pages: 140-144

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pulpalresponses to bacterial contaminationfollowing dentin bridging beneath hard-setting calcium hydroxide and self-etching adhesive resin system2008

    • Author(s)
      Kitasako Y, Ikeda M, Tgami J
    • Journal Title

      DentalTraumatology 24

      Pages: 201-206

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] A technique using resin composite with orthodontic wire to replacea missing tooth rapidly2008

    • Author(s)
      Kitasako Y, Ikeda M, Burrow MF and Tagami J
    • Journal Title

      Dental Traumatology 24

      Pages: 127-130

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Retrospective study of the 10-year clinical performance of direct resincomposite restorations placed with the acid-etch technique2008

    • Author(s)
      Nikaido T, Takada T, Kitasako Y, Ogata M, Shimada Y, Yoshikawa T, Nakajima M, Otsuki M, Tagami J and Burrow MF
    • Journal Title

      38

      Pages: 240-246

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of enamel and dentin microshear bond strengths of a two-step self-etchoing priming system with five all-in-one system.2008

    • Author(s)
      Burrow MF, Kitasako Y, Thomas CD, Tagami J.
    • Journal Title

      Operative Dentistry 33

      Pages: 456-460

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between quantitative assessments of salivary buffering capacity and ion activity product for hydroxyapatite in relation to cariogenic potential.2008

    • Author(s)
      Aiuchi H, Kitasako Y, Fukuda Y, Nakashima S, Burrow MF, Tagami J.
    • Journal Title

      Australian Dental Journal 53

      Pages: 167-171

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparative analysis of three commercial saliva testing kits with a standard saliva buffering test.2008

    • Author(s)
      Kitasako Y, Burrow MF, Stacey M, Huq L, Reynolds EC, Tagami J.
    • Journal Title

      Australian Dental Journal 53

      Pages: 140-144

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pulpal responses to bacterial contamination following dentin bridging beneath hard-setting calcium hydroxide and self-etching adhesive resin system2008

    • Author(s)
      Kitasako Y, lkeda M, Tgami J.
    • Journal Title

      Dental Traumatology 24

      Pages: 201-206

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A technique using resin composite with orthodontic wire to replace a missing tooth rapidly2008

    • Author(s)
      Kitasako Y, lkeda M, Burrow MF, Tagami J
    • Journal Title

      Dental Traumatology 24

      Pages: 127-130

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Retrospective study of the 10-year clinical performance of direct resin composite restorations placed with the acid-etch technique2008

    • Author(s)
      Nikaido T, Takada T, Kitasako Y, Ogata M, Shimada Y, Yoshikawa T, Nakajima M, Otsuki M, Tagami J, Burrow MF
    • Journal Title

      Quintessence International 38

      Pages: 240-246

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oral health status in relation to stimulated saliva buffering capacityamong Japanese adults above or below 35 years of age2006

    • Author(s)
      Kitasako Y, Ikeda M, Burrow MF and Tagami J
    • Journal Title

      Journal of Medical and Dental Sciences 53

      Pages: 75-180

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Migration and particle clearance from har d-setting Ca(OH)2 and self-etching adhesive resin following direct pulp capping2006

    • Author(s)
      Kitasako Y, Shibata S and Tagami J
    • Journal Title

      American Journal of Dentistry 19

      Pages: 370-375

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative assessment for stimulated saliva flow rate and buffering capacity inrelation to different ages2006

    • Author(s)
      Moritsuka M, Kitasako Y, Ikeda M, Burrow MF, Tagami J and Nomura S
    • Journal Title

      ournal of Dentistry 34

      Pages: 716-720

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The pH changeafter HCl titration into resting and stimulated saliva for a buffering capacity test2006

    • Author(s)
      Moritsuka M, Kitasako Y, Ikeda M, Burrow MF and Tagami J
    • Journal Title

      Australian Dental Journal 51

      Pages: 170-174

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of oral streptococci in the pH-dependent cariousdentin.2006

    • Author(s)
      Maeda T, Kitasako Y, Senpuku H, Burrow MF and Tagami J
    • Journal Title

      Journal of Medical and DentalSciences 53

      Pages: 159-166

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] In vitro pH analysis of active and arrested dentinal caries in extracted human teeth using a micro pH sensor2006

    • Author(s)
      Murakami K, Kitasako Y, Burrow MF and Tagami J
    • Journal Title

      25

      Pages: 423-429

    • NAID

      110004810963

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oral health status in relation to stimulated saliva buffering capacity among Japanese adults above or below 35 years of age2006

    • Author(s)
      Kitasako Y, Ikeda M, Burrow MF, Tagami J
    • Journal Title

      Journal of Medical and Dental Sciences 53(4)

      Pages: 175-180

    • NAID

      110006318493

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Migration and particle clearance from hard-setting Ca(OH)_2 and self-etching adhesive resin following direct pulp capping2006

    • Author(s)
      Kitasako Y, Shibara S, Tagami J
    • Journal Title

      American Journal of Dentistry 19(6)

      Pages: 370-375

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Quantitative assessment for stimulated saliva flow rate and buffering capacity in relation to different ages.2006

    • Author(s)
      Moritsuka M, Kitasako Y, Ikeda M, Burrow MF, Tagami J, Nomura S
    • Journal Title

      Journal of Dentistry 34(9)

      Pages: 716-720

    • Related Report
      2006 Annual Research Report
  • [Journal Article] The pH change after HCI titration into resting and stimulated saliva for a buffering capacity test2006

    • Author(s)
      Moritsuka M, Kitasako Y, Ikeda M, Burrow MF, Tagami J.
    • Journal Title

      Australian Dental Journal 51(2)

      Pages: 170-174

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Role of oral streptococci in the pH-dependent carious dentin2006

    • Author(s)
      Maeda T, Kitasako Y, Senpuku H, Burrow MF, Tagami J
    • Journal Title

      Journal of Medical and Dental Sciences 53(3)

      Pages: 159-166

    • NAID

      110006318485

    • Related Report
      2006 Annual Research Report
  • [Journal Article] In vitro pH analysis of active and arrested dentinal caries in extracted human teeth using a micro pH sensor2006

    • Author(s)
      Murakami K, Kitasako Y, Burrow MF, Tagami J
    • Journal Title

      Dental Material Journal 25(3)

      Pages: 423-429

    • NAID

      110004810963

    • Related Report
      2006 Annual Research Report
  • [Presentation] Effects of CPP-ACP onenamel pH and salivary cariogenic bacteria2009

    • Author(s)
      Kitasako Y, Shida K, Matin K, IkedaM and Tagami J
    • Organizer
      88th International Academy ofDental Research General Session
    • Place of Presentation
      Maiami、USA
    • Year and Date
      2009-04-03
    • Related Report
      2008 Final Research Report
  • [Presentation] Intraoral pH Measurement of Caries and Quantification of Cariogenic Bacteria.2009

    • Author(s)
      Shida K, Kitasako Y, Matin K, IkedaM and Tagami J
    • Organizer
      88th International Academy of Dental Research General Session
    • Place of Presentation
      Maiami、USA
    • Year and Date
      2009-04-02
    • Related Report
      2008 Final Research Report
  • [Presentation] 各種飲み物に浸漬した牛歯エナメル質の表面性状2009

    • Author(s)
      藤井美恵、北迫勇一、田上順次
    • Organizer
      第27回日本接着歯学会
    • Place of Presentation
      仙台
    • Year and Date
      2009-02-22
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] MMA系レジンセメントの象牙質に対する10年後の接着耐久性2009

    • Author(s)
      青木香那子、北迫勇一、有吉芽生、二階堂徹、田上順次
    • Organizer
      第27回日本接着歯学会
    • Place of Presentation
      仙台
    • Year and Date
      2009-02-21
    • Related Report
      2008 Final Research Report
  • [Presentation] 臨床用微小pHセンサーによるう蝕活動性診断とう蝕細菌叢2007

    • Author(s)
      北迫勇一
    • Organizer
      COE国際シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2007-12-02
    • Related Report
      2008 Final Research Report
  • [Presentation] 人工バイオフィルムを用いた二次う蝕invitroモデルの確2007

    • Author(s)
      Hayati Fahimeh, Matin Khairul, MalekShirin, 岡田彩子、北迫勇一、田上順次
    • Organizer
      JADR
    • Place of Presentation
      鶴見
    • Year and Date
      2007-11-18
    • Related Report
      2008 Final Research Report
  • [Presentation] 臨床用微小pHセンサーによるう蝕活動性診断とう蝕細菌叢遺伝子分析2007

    • Author(s)
      北迫勇一、志田嘉奈子、二階堂徹、マティンカイルール、田上順次
    • Organizer
      日本歯科保存学会
    • Place of Presentation
      岡山
    • Year and Date
      2007-11-09
    • Related Report
      2008 Final Research Report
  • [Presentation] セルフエッチングシステムの日本人とオーストラリア人の歯に対する接着性とpH変化2007

    • Author(s)
      志田嘉奈子、北迫勇一、池田正臣、田上順次
    • Organizer
      日本歯科保存学会
    • Place of Presentation
      岡山
    • Year and Date
      2007-11-09
    • Related Report
      2008 Final Research Report
  • [Presentation] 唾液緩衝能によるう蝕リスク評価酸緩衝能と唾液のミネラルイオンに由来する脱灰ポテンシャルとの関連性2007

    • Author(s)
      相内紘子、北迫勇一、福田康、田上順次
    • Organizer
      日本歯科保存学会
    • Place of Presentation
      大宮
    • Year and Date
      2007-06-08
    • Related Report
      2008 Final Research Report
  • [Presentation] 臨床用微小pHセンサーによるう蝕活動性診断とう蝕細菌叢遺伝子分析2007

    • Author(s)
      北迫勇一、志田嘉奈子、二階堂徹、マティンカイルール、田上順次
    • Organizer
      日本歯科保存学会
    • Place of Presentation
      岡山コンベンションセンター
    • Related Report
      2007 Annual Research Report
  • [Book] 永末書店2008

    • Author(s)
      田上順次、花田信弘、桃井保子、北迫勇一
    • Total Pages
      256
    • Publisher
      ほか、う蝕学-チェアサイドの予防と回復のプログラム
    • Related Report
      2008 Final Research Report
  • [Book] ヒョーロン・パブリッシャーズ(鴨井久一, 花田信弘監修)2008

    • Author(s)
      北迫勇一
    • Total Pages
      51
    • Publisher
      CheckbufRセット私はこう使ってます唾液検査ハンドブック
    • Related Report
      2008 Final Research Report
  • [Book] う蝕学-チェアサイドの予防と回復のプログラム2008

    • Author(s)
      編集 田上順次、花田信弘、桃井保子分担 北迫勇一, ほか
    • Total Pages
      256
    • Publisher
      永末書店
    • Related Report
      2007 Annual Research Report
  • [Remarks] TV報道北迫勇一, 田上順次、NHKためしてガッテン2008年11月5日放送

    • Related Report
      2008 Final Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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