Relation between the molecular structure of functional monomers and their interaction on apatite surface

• Project/Area Number: 18592088
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Conservative dentistry
• Research Institution: Okayama University
• Principal Investigator: OGAWA Tatsuyuki (OGAWA Tatuyuki) Okayama University, 大学院・医歯薬学総合研究科, 助手 (10346421)
• Co-Investigator(Kenkyū-buntansha): YOSHIDA Yasuhiro 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (90281162) ; SUZUKI Kazuomi 岡山大学, 大学院・医歯薬学総合研究科, 教授 (30050058)
• Project Period (FY): 2006 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,220,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥720,000); Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2007: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2006: ¥1,100,000 (Direct Cost: ¥1,100,000)
• Keywords: 機能性モノマー / 4-MET / 10-MDP / Phenyl-P / アパタイト / 硬組織 / NMR / XRD / XPS / 歯学 / 接着

Research Abstract

Although decayed/fractured teeth can be reconstructed minimally invasively and nearly invisibly using adhesive technology, the clinical longevity of dental composite restorations is still too short. Water sorption is thought to be the principal cause of destabilization of the biomaterial-tooth bond. However, the actual mechanisms of interfacial degradation are far from understood. In this study, the interaction of three monomers (4-MET/10-MDP/Phenyl-P) with hydroxyapatite (HAp), and for an experimental 10-MDP:EtOH:H_2O (15:45:40wt%) self-etch primer also with dentin/enamel, was characterized by XPS and XRD. The tensile bond strength (TBS) to enamel/dentin of the primer with and without 1wt% camphorquinone (CQ) added, was also measured. Regarding molecular interaction, the two extremes were Phenyl-P that rather "etched" and 10-MDP that rather "bonded" to HAp (with 4-MET behaving somewhat in between). XRD revealed a higher crystallite size/cristallinity for enamel, while nano-layering was more pronounced at dentin. The exp. primer needed CQ to obtain a TBS to dentin comparable to that of commercial material including 10-MDP, but not when bonded to enamel. It was indicated that adequate polymerization (by CQ) is needed to stabilize the formed nano-layer.

Research Products

• [Journal Article] TEM characterization of a silorane composite bonded to enamel/dentin. (2010)
  • Author(s): Mine, A., De Munck, J., Van Ende, A., Vivan Cardoso, M., Kuboki, T., Yoshida, Y., Van Meerbeek, B.
  • Journal Title: Dental Materials 26 Pages: 524-532
  • Peer Reviewed
• [Journal Article] Bonding effectiveness of two contemporary self-etch adhesives to enamel and dentin. (2009)
  • Author(s): Mine, A., De Munck, J., Cardoso, M.V., Van Landuyt, K.L., Poitevin, A., Kuboki, T., Yoshida, Y., Suzuki, K., Lambrechts, P., Van Meerbeek, B.
  • Journal Title: Journal of Dentistry 37 Pages: 872-883
  • Peer Reviewed
• [Journal Article] 表面・界面研究が明日の歯科医療を創る. 今月の表紙. (2009)
  • Author(s): 吉田靖弘, 鈴木一臣
  • Journal Title: 日本歯科評論 69 Pages: 39-40
• [Journal Article] 最新の接着技術を駆使した「G-ボンドプラス」の接着メカニズムと性能. (2009)
  • Author(s): 鈴木一臣, 吉田靖弘, 吉原久美子, 皆木省吾
  • Journal Title: GC CIRCLE No.130 Pages: 26-29
• [Journal Article] Influence of the chemical structure of functional monomers on their adhesive performance. (2008)
  • Author(s): Van Landuyt, K.L., Yoshida, Y., Hirata, I., Snauwaert, J., De Munck, J., Okazaki, M., Suzuki, K., Lambrechts, P., Van Meerbeek, B.
  • Journal Title: Journal of Dental Research 87 Pages: 757-761
  • Peer Reviewed
• [Journal Article] Bonding effectiveness and interfacial characterization of a HEMA/TEGDMA-free three-step etch&rinse adhesive. (2008)
  • Author(s): Mine, A., De Munck, J., Van Landuyt, K.L., Poitevin, A., Kuboki, T., Yoshida, Y., Suzuki, K., Lambrechts, P., Van Meerbeek, B.
  • Journal Title: Journal of Dentistry 36 Pages: 767-773
  • Peer Reviewed
• [Journal Article] Ultrasonic Cleaning Influences Silica Coated Zirconia Bond Strength (2008)
  • Author(s): Nishigawa, G., Maruo, Y., Irie, M., Oka, M., Yoshihara, K., Minagi, S., Nagaoka, N., Yoshida, Y., Suzuki, K.
  • Journal Title: Dental Materials Journal 27 Pages: 842-848
  • Peer Reviewed
• [Journal Article] Influence of the chemical structure of functional monomers on their adhesive performance (2008)
  • Author(s): Van Landuyt, K.L., Yoshida, Y., Hirata, I., Snauwaert, J., De Munck, J., Okazaki, M., Suzuki, K., Lambrechts, P., Van Meerbeek, B.
  • Journal Title: Journal of Dental Research 87 Pages: 757-761
• [Journal Article] Systematic review of the chemical composition of contemporary dental adhesives. (2007)
  • Author(s): Van Landuyt, K.L., Snauwaert, J., De Munck, J., Peumans, M., Yoshida, Y., Coutinho, E., Poitevin, A., Suzuki, K., Lambrechts, P., Van Meerbeek, B.
  • Journal Title: Biomaterials 28 Pages: 3757-3785
  • Peer Reviewed
• [Journal Article] Restoring cervical lesions with flexible composites. (2007)
  • Author(s): Peumans, M., De Munck, J., Van Landuyt, K.L., Kanumilli, P., Yoshida, Y., Inoue, S., Lambrechts, P., Van Meerbeek, B.
  • Journal Title: Dental Materials 23 Pages: 749-754
  • Peer Reviewed
• [Journal Article] Origin of interfacial droplets with one-step self-etch adhesives (2007)
  • Author(s): Van Landuyt, K.L., Snauwaert, J., De Munck, J., Coutinho, E., Poitevin, A., Yoshida, Y., Suzuzki, K., Lambrechts, P., Van Meerbeek. B.
  • Journal Title: Journal of Dental Research 86 Pages: 739-744
• [Journal Article] Study on chemical interaction between 4-MET and hydroxyapatite using XPS. (2006)
  • Author(s): Nagakane, K., Yoshida, Y., Hirata, I., Fukuda, R., Nakayama, Y., Shirai, K., Ogawa, T., Suzuki, K., Van Meerbeek, B., Okazaki, M.
  • Journal Title: Dental Materials Journal 25 Pages: 645-649
  • Peer Reviewed
• [Journal Article] Chemical interaction of phosphoric acid ester with hydroxyapatite. (2006)
  • Author(s): Fukegawa, D., Hayakawa, S., Yoshida, Y., Suzuki, K., Osaka, A., Van Meerbeek, B.
  • Journal Title: Journal of Dental Research 85 Pages: 941-944
  • Peer Reviewed
• [Journal Article] Effect of water storage on the bonding effectiveness of 6 adhesives to Class I cavity dentin. (2006)
  • Author(s): De Munck, J., Shirai, K., Yoshida, Y., Inoue, S., Van Landuyt, K., Lambrechts, P., Suzuki, K., Shintani, H., Van Meerbeek, B.
  • Journal Title: Operative Dentistry 31 Pages: 456-465
  • Peer Reviewed
• [Journal Article] Spectroscopic characterization of enamel surfaces irradiated with Er:YAG laser. (2006)
  • Author(s): Mine, A., Yoshida, Y., Suzuki, K., Nakayama, Y., Yatani, H., Kuboki, T.
  • Journal Title: Dental Materials Journal 25 Pages: 214-218
  • NAID: 110004757969
  • Peer Reviewed
• [Journal Article] Development of a Self-Etch Adheseve for Resin-Modified Glass-Ionomers. (2006)
  • Author(s): Couinho, E., Van Landuyt, K., De Munck, J., Poitevin, A., Yoshida, Y., Inoue, S., Peumans, M., Suzuki, K., Lambrechts, P., Van Meerbeek, B.
  • Journal Title: Journal of Dental Research 85 Pages: 349-353
  • Peer Reviewed
• [Journal Article] Study on chemical interaction between 4-MET and hydroxyapatite using XPS (2006)
  • Author(s): Nagakane, K., Yoshida, Y., Hirata, I., Fukuda, R., Nakayama, Y., Shirai, K., Ogawa, T., Suzuki, K., Van Meerbeek, B., Okazaki, M.
  • Journal Title: Dental Materials Journal 25 Pages: 645-649
• [Journal Article] Chemical interaction of phosphoric acid ester with hydroxyapatite (2006)
  • Author(s): Fukegawa, D., Hayakawa, S., Yoshida, Y., Suzuki, K., Osaka, A., Van Meerbeek, B.
  • Journal Title: Journal of Dental Research 85 Pages: 941-944
• [Journal Article] Analysis of Chemical Interaction of 4-MET with Hydroxyapatite Using XPS (2006)
  • Author(s): Kouji Nagakane, Yasuhiro Yoshida, Isao Hirata, Ryuichi Fukuda, Youichi Nakayama, Kenichi Shirai, Tatsuyuki Ogawa, Jazuomi Suzuki, Bart Van Meerbeek, Masayuki Okazaki
  • Journal Title: DENTAK MATERIALS JOURNAL 25.4 Pages: 645-649
  • NAID: 110006151612
• [Journal Article] Nano-controlled molecular interaction at adhesive interfaces for hard-tissue reconstruction.
  • Author(s): Yoshihara, K., Yoshida, Y., Nagaoka, N., Fukegawa, D., Hayakawa, S., Mine, A., Nakamura, M., Minagi, S., Osaka, A., Suzuki, K., Van Meerbeek, B.
  • Journal Title: Acta Biomaterialia (in press)
  • Peer Reviewed
• [Journal Article] Hydrolytic stability of one-step self-etch adhesives bonded to dentin.
  • Author(s): Fukuoka, A., Koshiro, K., Inoue, S., Yoshida, Y., Tanaka, T., Ikeda, T., Suzuki, K., Sano, H., Van Meerbeek, B.
  • Journal Title: Journal of Adhesive Dentistry (in press)
  • Peer Reviewed
• [Journal Article] The quasi-3D marginal leakage of full-coverage crowns: resin coating method vs sodium hypochlorite treatment.
  • Author(s): Kawahara, D., Mine, A., De Munck, J., Kuboki, T. Yoshida, Y., Suzuki, K., Van Meerbeek, B., Yatani, H.
  • Journal Title: International Journal of Prosthodontics (in press)
  • Peer Reviewed
• [Journal Article] 歯質接着における化学分析の応用.
  • Author(s): 吉田靖弘, 中山陽一, 吉原久美子, 英將生, 峯篤史, 井上哲, 鈴木一臣, Van Meerbeek, B.
  • Journal Title: 接着歯学 (in press)
  • NAID: 10026425396
• [Journal Article] Origin of interfacial droplets with one-step self-etch adhesives.
  • Author(s): Van Landuyt, K.L., Snauwaert, J., De Munck, J., Coutinho, E., Poitevin, A., Yoshida, Y., Suzuki, K., Lambrechts, P., Van Meerbeek. B.
  • Journal Title: Journal of DentalResearch 86 Pages: 739-74
  • Peer Reviewed
• [Book] Adhesion to tooth enamel and dentin-A view on the latest technology and future perspectives: In Statements: Diagnostics and therapy in dental medicine today and in the future. (Roulet, J. F., Kappert, H. F. Ed.) (2009)
  • Author(s): Cardoso, M. V., Yoshida, Y., Van Meerbeek, B.
  • Publisher: Quintessence Publishing Co, Ltd., London, UK
• [Book] 象牙質への接着～化学的接着の見地から. 日本歯科評論別冊/接着性コンポジットレジン修復の基礎と臨床(山田敏元編) (2007)
  • Author(s): 吉田靖弘, 鈴木一臣, 宮崎真至
  • Publisher: ヒョーロン・パブリッシャーズ, 東京
• [Book] 歯質への化学的接着を科学する. 歯界展望別冊/臨床に役立つ接着修復のすべて(宮崎真至編) (2006)
  • Author(s): 吉田靖弘, 鈴木一臣
  • Publisher: 医歯薬出版, 東京