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Three-dimensional bone formation by octacalcium phosphate combined with collagen

Research Project

Project/Area Number 18592111
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 補綴理工系歯学
Research InstitutionTohoku University

Principal Investigator

KAWATA Tetsuo  Tohoku University, 大学院・歯学研究科, 大学院・非常勤講師 (80292225)

Co-Investigator(Kenkyū-buntansha) SASAKI Keiichi  東北大学, 大学院・歯学研究科, 教授 (30178644)
SUZUKI Osamu  東北大学, 大学院・歯学研究科, 教授 (60374948)
KAMAKURA Shinji  東北大学, 大学院・医工学研究科, 教授 (80224640)
KOYAMA Shigeto  東北大学, 病院, 准教授 (10225089)
KOHKI Hatori  東北大学, 大学院・歯学研究科, 助教 (40372320)
OGAWA Toru  東北大学, 病院, 助教 (50372321)
KUBO Kei  東北大学, 病院, 助教 (10431511)
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,860,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2007: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2006: ¥2,300,000 (Direct Cost: ¥2,300,000)
Keywords歯科補綴学一般 / リン酸オクタカルシウム / OCP-コラーゲン複合体 / 三次元的骨造成 / 骨再生材料 / 破骨細胞 / 形態付与性 / 骨造成
Research Abstract

病気や怪我で顎骨を失った場合や、抜歯後に歯槽骨が吸収されると、失われた歯を人工歯根(インプラント)や義歯で修復する際、歯槽骨や顎骨の再建が必要となる。必要な形態を附与しつつ早期に骨を作ることが望ましいが、現在使用されている骨再生材料では速度・量ともに十分であるとは言い難い。本研究では、骨や歯に含まれるリン酸オクタカルシウム(OCP)をコラーゲンと複合化し、骨表面に埋入し、これまで困難であった吸収顎堤の骨造成について検討した。その結果、骨のかさ上げが可能であることが判明した。

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (27 results)

All 2008 2007 2006

All Journal Article (21 results) (of which Peer Reviewed: 14 results) Presentation (6 results)

  • [Journal Article] Effects of a removable partial denture and its rest location on the forces exerted on an abutment tooth in vivo2008

    • Author(s)
      Kawata T, Kawaguchi T, Yoda N, Ogawa T, Kuriyagawa T, Sasaki K
    • Journal Title

      The International Journal of Prosthodontics 21

      Pages: 50-52

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Analysis of the Load Exerted on the Implants Supporting an Overdenture Based on In vivo Measurement2008

    • Author(s)
      Yoda N, Ogawa T, Gunji Y, Kawata T, Kuriyagawa T, Sasaki K
    • Journal Title

      Prothodont Res Pract 7

      Pages: 258-260

    • NAID

      10021955363

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bone regeneration by synthetic octacalcium phosphate and its role in biological mineralization2008

    • Author(s)
      Suzuki O, Imaizumi H, Kamakura S, Katagiri T
    • Journal Title

      Current Medical Chemistry 15

      Pages: 305-313

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Analysis of the Load Exerted on the Implants Supporting an Overdenture Based on In Vivo Measurement2008

    • Author(s)
      N. Yoda, T. Ogawa, Y. Gunji, T. Kawata, T. Kuriyagawa and K. Sasaki
    • Journal Title

      Prosthodont Res Pract 7

      Pages: 258-260

    • NAID

      10021955363

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bone regeneration by synthetic octacalcium phosphate and its role in biological mineralization2008

    • Author(s)
      Suzuki O, Imaizumi H, Kamakura S. Katagiri T
    • Journal Title

      Current Medical Chemistry 15

      Pages: 305-313

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of a removable partial denture and its rest location on the forces exerted on an abutment tooth in vivo2008

    • Author(s)
      T Kawata, T Kawaguchi, N Yoda, T Ogawa. T Kuriyagawa, K Sasaki
    • Journal Title

      The International Journal of Prosthodontics 21

      Pages: 50-52

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of a removable partial denture and its rest location on the forces exerted on an abutment tooth in vivo.2008

    • Author(s)
      T Kawata, T Kawaguchi, N Yoda, T Ogawa, T Kuriyagawa, K Sasaki
    • Journal Title

      The International Journal of Prosthodontics 21

      Pages: 50-52

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Osteoconductivity of Porous Titanium Having Young's Modulus Similar to Bone and Surface Modification by OCP2007

    • Author(s)
      Suzuki Y, Kamakura S, Sasaki K, Kokubun S, Suzuki O, et.al.
    • Journal Title

      Key Engineering Materials 330-332

      Pages: 951-954

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] オーバーデンチャー支台インプラントへの荷重解析-生体内測定に基づく2本支台と4本支台とのインプラント荷重の比較-2007

    • Author(s)
      依田信裕、重光竜二、小川徹、久保圭、末永華子、郡司良律、川田哲男、厨川常元、佐々木啓一
    • Journal Title

      日口腔インプラント誌 37

      Pages: 218-218

    • Related Report
      2008 Final Research Report
  • [Journal Article] Biological Response of Octacalcium Phosphate Combined with Collagen Implanted in Subperiosteal Region2007

    • Author(s)
      Suzuki Y, Kamakura S, Hatori K, Sasaki K, Honda Y, Anada T, Sasaki K, Suzuki O
    • Journal Title

      Interface Oral Health Science 2007

      Pages: 357-358

    • NAID

      130006961923

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Behaviors of three-dimensional compressive and tensile forces exerted on a tooth during function2007

    • Author(s)
      Kawata T, Yoda N, Kawaguchi T, Kuriyagawa T, Sasaki K
    • Journal Title

      J Oral Rehabilitation 34

      Pages: 259-266

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] In vivo 3-dimensional measurement of the force exerted on a tooth during clenching2007

    • Author(s)
      Kawaguchi T, Kawata T, Kuriyagawa T, Sasaki K
    • Journal Title

      J Biomechanics 40

      Pages: 244-251

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] オーバーデンチャー支台インプラントへの荷重解析-生体内測定に基づく2本支台と4本支台とのインプラント荷重の比較-2007

    • Author(s)
      依田信裕, 重光竜二, 小川 徹, 久保 圭, 末永華子, 郡司良律, 川田哲男, 厨川常元, 佐々木啓一
    • Journal Title

      日口腔インプラント誌 37

      Pages: 320-320

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Biodegradable characteristics of octacalcium phosphate combined with collagen implanted in two bony sites2007

    • Author(s)
      Y Suzuki, S Kamakura, K Hatori, K Sasaki, Y Honda, T Anada, K Sasaki, O Suzuki
    • Journal Title

      Interface Oral Health Science 2007

      Pages: 357-358

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Behaviours of three-dimensional comressive and tensile forces exerted on a tooth during function2007

    • Author(s)
      T Kawata, N Yoda, T Kawaguchi, T Kuriyagawa, K Sasaki
    • Journal Title

      Journal of Oral Rehabilitation 34

      Pages: 259-266

    • Related Report
      2006 Annual Research Report
  • [Journal Article] In vivo 3-dimensional measurement of the force exerted on a tooth during clenching2007

    • Author(s)
      T Kawaguchi, T Kawata, T Kuriyagawa, K Sasaki
    • Journal Title

      Journal of Biomechanics 40

      Pages: 244-251

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Osteoconductivity of Porous Titanium Having Young's Modulus Similar to Bone and Surface Modification by OCP2007

    • Author(s)
      Y.Suzuki, S.Kamakura, K.Sasaki, S.Kokubun, O.Suzuki et al.
    • Journal Title

      Key Engineering Materials 330-332

      Pages: 951-954

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Bone formation enhanced by implanted octacalcium phosphate involving conversion into Ca-deficient hydroxyapatite2006

    • Author(s)
      Suzuki O, Kamakura S, Katagiri T, Nakamura M, Honda Y et.al.
    • Journal Title

      Biomaterials 27

      Pages: 2671-2681

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Octacalciom phosphate combined with collagen orthotopically enhanced bone regeneration2006

    • Author(s)
      Kamakura S, Sasaki K, Honda Y, Anada T, Suzuki O
    • Journal Title

      J Biomed Mater Res B Appl Bionmater 79

      Pages: 210-217

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bone formation enhanced by implanted octacalcium phosphate involving conversion into Ca-deficient hydroxyapatite2006

    • Author(s)
      Suzuki O, Kamakura S, Katagiri T, Nakamura M, Honda Y et al.
    • Journal Title

      Bioceramics 27

      Pages: 2671-2681

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Octacalcium phosphate combined with collagen orthotopically enhances bone regeneration2006

    • Author(s)
      Kamakura S, Sasaki K, Honda Y, Anada T, Suzuki O
    • Journal Title

      J Biomed Mater Res B Appl Biomater. 79

      Pages: 210-217

    • Related Report
      2006 Annual Research Report
  • [Presentation] 固定性上部構造支台インプラントに加わる荷重の生体内三次元解析2008

    • Author(s)
      依田信裕、川田哲男、佐々木啓一
    • Organizer
      第38回日本口腔インプラント学会・学術大会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] リン酸オクタカルシウム/コラーゲン複合体の骨膜下インプラントによる骨造成2008

    • Author(s)
      鈴木祐子、鎌倉慎治、羽鳥弘毅、本田義知、穴田貴久、鈴木治、佐々木啓一
    • Organizer
      第117回日本補綴歯科学会学術大会
    • Place of Presentation
      名古屋
    • Related Report
      2008 Final Research Report
  • [Presentation] リン酸オクタカルシウム/コラーゲン複合体の骨膜下インプラントによる骨造成2008

    • Author(s)
      鈴木祐子, 鎌倉慎治, 羽鳥弘毅, 本田義知, 穴田貴久, 鈴木治, 佐々木啓一
    • Organizer
      第117介日本補綴歯科学会学術大会
    • Place of Presentation
      名古屋
    • Related Report
      2008 Annual Research Report
  • [Presentation] Biological Response of Octacalcium Phosphate Combined with Collagen Implanted in Subperiosteal Region2007

    • Author(s)
      Suzuki Y, Kamakura S, Hatori K, Sasaki K, Honda Y, Anada T, Sasaki K, Suzuki O
    • Organizer
      International Dental Materials Congress 2007
    • Place of Presentation
      バンコク
    • Related Report
      2008 Final Research Report
  • [Presentation] Osteoconductivity of low Young's modulus porous titanium combined with OCP2007

    • Author(s)
      Suzuki Y, Nomura N, Hanada S, Kamakura S, Anada T, Fuji T, Honda Y, Masuda T, Sasaki K, Kokubun S, Suzuki O
    • Organizer
      第6回国際歯科チタンシンポジウム
    • Place of Presentation
      京都
    • Related Report
      2008 Final Research Report
  • [Presentation] Biological Response of Octacalcium Phosphate Combined with Collagen Implanted in Subperiosteal Region2007

    • Author(s)
      Suzuki Y, Kamakura S, Hatori K, Sasaki K, Honda Y, Anada T, Sasaki K, Suzuki O
    • Organizer
      International Dental Materials Congress 2007
    • Place of Presentation
      Bangkok (Thailand)
    • Related Report
      2007 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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