| Project/Area Number |
18592112
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
補綴理工系歯学
|
|---|
| Research Institution | Niigata University |
|---|
Principal Investigator |
TOMIZUKA Ken Niigata University, Institute of Medicine and Dentistry, Associate Professor (80251297)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OGASAWARA Toru The University of Tokyo Hospital, 医学部附属病院, Lecturer (20359623)
MORO Toru The University of Tokyo Hospital, Specially Appointed, Associate Professor (20302698)
IWASAKI Yasuhiko Tokyo Medical and Dental University, 生体材料工学研究所, Associate Professor (90280990)
ISHIHARA Kazuhiko University of Tokyo, Faculty of Engineering, Professor (90193341)
|
|---|
| Project Period (FY) |
2006 – 2007
|
| Project Status |
Completed (Fiscal Year 2007)
|
| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2006: ¥2,200,000 (Direct Cost: ¥2,200,000)
|
|---|
| Keywords | biocompatibility / MPC polymer / titanium / cell adhesion / チタン合金 |
|---|
| Research Abstract |
It is clarified that MPC polymer, that has the phosphorus lipid polarity radical, coated to the surface of material control the cell and the protein adhesion. As a result, the biocompatibility and the blood compatibility of the device for the medical treatment can be rapidly improved. The possibility of the application of MPC Polymer to the dental implant body is examined aiming to control the cellular adhesiveness to the implant body, and to be longer-term and to make the implant function in vivo surely. The kind of MPC Polymer necessary to obstruct the cellular adhesion to the titanium plate surface first of all and the density was examined.
First of all, the GFP tendency was made introducing the GFP gene by using the vector of the retrovirus for leaf system stem cell stock C3H10T1/2:] with stability and the appearing cell strain was made. As a result, it turned out PMB and PMS that the cellular adhesion was equally obstructed, and PMD was low the in hibition effect of the cellular adhesion. It was assumed that the plate of the same titanium alloy as the material of the implant body that had already been sold as aproduct was used because the appearance that the cell bonded was observed by the state etc. of grinding on the surface of the titanium plate, and however, Polymer adopted PMB and did a similar experiment. As a result, the effect of the cell bonding obstruction on the titanium alloy was admitted.
|
