Next-generation dental resins which scavenge and immobilize endocrine disruptors by themselves
| Project/Area Number |
18592113
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
補綴理工系歯学
|
|---|
| Research Institution | Tokyo Medical and Dental University |
|---|
Principal Investigator |
KADOMA Yoshinori Tokyo Medical and Dental University, Institute of Biomaterials, Associate Professor and Bioengineering (00092403)
|
|---|
| Project Period (FY) |
2006 – 2007
|
| Project Status |
Completed (Fiscal Year 2007)
|
| Budget Amount *help |
¥3,710,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2006: ¥2,800,000 (Direct Cost: ¥2,800,000)
|
|---|
| Keywords | Bis-GMA / Bisphenol A / Radical |
|---|
| Research Abstract |
The aim of the present investigation was to invent next-generation dental resins which contain Bis-GMA and is absolutely safe. The fundamental techniques to suppress the bisphenol A elution by mixing activated alumina fillers with high bisphenol A-scavenging activity were presented.
1. Various commercial Bis-GMA monomers were analyzed by HPLC. Bis-GMA content of the monomers was about 50 % and approximately 25 % of Iso-Bis-GMA, an isomer of Bis-GMA, was present. Therefore, it was found that commercial Bis-GMA monomers contained about 80 % of Bis-GMA including isomers. Pure Bis-GMA main component was obtained in 20 to 30 % yield by silica gel column chromatography treatment of commercial Bis-GMA using chloroform as mobile phase.
2. Chemical-curing and visible-light-curing resins were prepared by combining pure Bis-GMA with comonomer initiator, and filler. Various properties of cured resins revealed that it is quite helpful to scavenge and immobilize impurities such as bisphenolA in a Bis-GMA composite.
3. In order to evaluate self-scavenging and self-immobilizing performance for bisphenol A of activated alumina fillers, a lot of experimental visible-light-curing composite resins with different composition were prepared. Bisphenol A was effectively scavenged and immobilized by introducing 50 wt% of basic activated alumina into Bis-GMA composites. Based on the measurements of various properties of cured resins, the introduction of activated alumina was proved effective, although there is some room for further improvement.
|
Report
(3 results)
Research Products
(15 results)
