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Genetic analysis of monoamine transporter and relation to the frequency of the nocturnal bruxism.

Research Project

Project/Area Number 18592122
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 補綴理工系歯学
Research InstitutionOkayama University

Principal Investigator

MINAKUCHI Hajime  Okayama University, graduate Schools, Oral rehabilitation and regenerative medicine, Assistant Professor (30325097)

Co-Investigator(Kenkyū-buntansha) MAEKAWA Kenji  Okayama University, Hospital, Prosthodontics, Senior Assistant Professor (20304313)
KUBOKI Takuo  Okayama university, graduate school, Dental pharmacology, Chair and Professor (00225195)
KITAYAMA Shigeo  Okayama university, graduate school, Oral rehabilitation and regenerative medicine, Chair and Professor (80177873)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,920,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2006: ¥2,100,000 (Direct Cost: ¥2,100,000)
KeywordsNocturnal bruxism / Temporomandibular disorders / Orofacial pain / Electromyography / Adolescent population / Epidemiological study / 慢性筋痛 / 診断精度 / 日差変動 / 筋電計 / 咀嚼筋痛 / 簡易型筋電計 / オッズ比
Research Abstract

RESEARCH #1
Purpose: The relationship between sleep bruxism (SB) and temporomandibular disorders (TMDs) is unclear. This study aimed to estimate SB prevalence in an adolescent population and investigate the relationship between SB frequency and prevalence of the TMD signs/symptoms. Materials and Methods: First year high school students were recruited, and 195 subjects responded in this study. The subjects were divided into severe and non-severe SB groups with SB frequency and were received clinical examinations and interview. The odd-ratio (OR) were calculated to test the relationship between SB frequency gender difference and presence of the TMD signs/symptoms by multiple regression analysis. Results: Severe SB was significantly related to the presence of TMJ click (OR: 3.74, P= 02), while gender(male) was not related to that In contrast, severe SB was not related to headache, while gender (male)was significantly related to headache(OR: 2.52, P= 04). Conclusion: These results suggested … More that the presence of a TMJ click was closely related to the severe SB in an adolescent population.
RESEARCH #2
Objective: Novel miniature EMG analyzer (BiteStripR, S.L.P. Israel) occasionally showed error message when applied in Asian subjects. In response, the version-up model has been developed, and this study verified this modification. Methods: Six severe bruxism volunteers who had been diagnosed by portable electromyography and video recording participated this continuous 5-nights BiteStrip recording. The incidence rates of error message were compared. Results: The incidence of error message in the version-up systems (1/30, 3.3%) was significantly lower than that in the conventional system (14/30, 46.7%, p<0.01, Chi-square test). Conclusion: This modification was able to reduce the incidence of the error message.
RESEARCH #3
Objective: No research has been achieved regarding to the validity of bruxism assessment considering the daily fluctuation. This study aimed to verify the 1-night, 2-night and 3-night assessment of bruxism compared to the result of 10-straght night assessment. Methods: Fifteen TMD clinic patients were asked to measure individual bruxism level by means of using BiteStrip for 10 straight nights. The mode value of the result of 10-straight night was set as gold standard. The validity of 1-night test, 2-night test and 3-night test was calculated compared to prior gold standard. Result and summary: Totally 8 patients participated this study. The sensitivity, specificity and validity of 1-night test were 0.87-0.90, 0.74-0.80 and 0.82-0.88, respectively. This indicated the 1-night test could demonstrate the moderated diagnostic accuracy. Less

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (36 results)

All 2007 2006 Other

All Journal Article (15 results) (of which Peer Reviewed: 3 results) Presentation (18 results) Book (3 results)

  • [Journal Article] 貼付型ブラキシズム診断装置「BiteStrip^<[○!R]>」について2006

    • Author(s)
      水口 一, 窪木拓男
    • Journal Title

      日本歯科評論 66(6)

      Pages: 113-116

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 歯ぎしりセンサーの評価と使い方2006

    • Author(s)
      水口 一, 窪木拓男
    • Journal Title

      補綴臨床 39(5)

      Pages: 536-541

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Miniature Bruxism Detection Device -BiteStrip[○!R]-2006

    • Author(s)
      Hajime, Minakuchi, Takuo, Kuboki
    • Journal Title

      The Nippon Dental Review 66(6)

      Pages: 113-116

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Assessment and Usage of Bruxism Detection Device2006

    • Author(s)
      Hajime, Minakuchi, Takuo, Kuboki
    • Journal Title

      Practice in Prosthodontics 39(5)

      Pages: 536-541

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] An evidence-based approach to diagnosis and treatment2006

    • Author(s)
      Glenn, T., Clark, Hajime, Minakuchi
    • Journal Title

      Temporomandibular Disorders Quintessence Book

      Pages: 548-548

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 貼付型ブラキシズム測定装置により計測したブラキシズム頻度と頭頸背部の筋痛の関連性2006

    • Author(s)
      永松千代美, 水口 一, 前川賢治, 完山 学, 松香芳三, 窪木拓男, Glenn T.Clark
    • Journal Title

      日本補綴歯科学会雑誌 50・115回特別号

      Pages: 152-152

    • NAID

      10024183999

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 簡易貼付型睡眠時ブラキシズム測定装置のバージョンアップとその効果2006

    • Author(s)
      水口 一, 永松千代美, 前川賢治, 完山 学, 松香芳三, 窪木拓男, Glenn T.Clark
    • Journal Title

      日本補綴歯科学会雑誌 50・115回特別号

      Pages: 153-153

    • NAID

      10024184001

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Relationship between severity of sleep bruxism and prevalence of TMD signs and symptoms in an adolescent population.2006

    • Author(s)
      Nagamatsu C, Minakuchi H, Maekawa K, Kanyama M, Matsuka Y, Kuboki T
    • Journal Title

      The 1^<st> International and the 19^<th> Annual Meeting of the Japanese Society for the Temporomandibular Joint Program and Abstracts. 19・1

      Pages: 136-136

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Version-up of miniature bruxism detection device and its clinical effectiveness.2006

    • Author(s)
      Minakuchi H, Nagamatsu C, Maekawa K, Kanyama M, Matsuka Y, Kuboki T
    • Journal Title

      The 1^<st> International and the 19^<th> Annual Meeting of the Japanese Society for the Temporomandibular Joint Program and Abstracts. 19・1

      Pages: 135-135

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 簡易貼付型睡眠時ブラキシズム測定装置のバージョンアップとその効果2006

    • Author(s)
      水口 一, 永松千代美, 前川賢治, 完山 学, 松香芳三, 窪木拓男, Glenn T.Clark
    • Journal Title

      第20回日本顎頭蓋機能学会記念学術大会プログラム・抄録集 20・1

      Pages: 70-70

    • NAID

      10024184001

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 貼付型ブラキシズム診断装置「BiteStrip【○!R】」について2006

    • Author(s)
      水口 一, 窪木拓男
    • Journal Title

      日本歯科評論 66-6

      Pages: 113-116

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 歯ぎしりセンサーの評価と使い方2006

    • Author(s)
      水口 一, 窪木拓男
    • Journal Title

      補綴臨床 39-5

      Pages: 536-541

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Relationship between the frequency of sleep bruxism and the prevalence of signs and symptoms of temporomandibular disorders in an adolescent population.

    • Author(s)
      Chiyomi Nagamatsu-Sakaguchi, Hajime Minakuchi, Glenn T. Clark and Takuo Kuboki.
    • Journal Title

      INTERNATIONAL JOURNAL of PROSTHODONTICS (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Relationship between the frequency of sleep bruxism and the prevalence of signs and symptoms of temporomandibular disorders in an adolescent population

    • Author(s)
      Chiyomi, Nagamatsu-Sakaguchi, Hajime, Minakuchi, Glenn, T., Clark, Takuo, Kuboki
    • Journal Title

      INTERNATIONAL JOURNAL of PROSTHODONTICS (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Relationship between the frequency of sleep bruxism and the prevalence of signs and symptoms of temporomandibular disorders in an adolescent population.

    • Author(s)
      Chiyomi Nagamatsu-Sakaguchi, Hajime Minakuchi, Glenn T. Clark and Takuo Kuboki.
    • Journal Title

      INTERNATIONAL JOURNAL of PROSTHODONTICS (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 顎関節内障と筋痛患者の就寝時ブラキシズム頻度の比較2007

    • Author(s)
      水口 一, 永松千代美, 川上 彩, 窪木拓男
    • Organizer
      第21回日本顎頭蓋機能学会学術大会
    • Place of Presentation
      大阪
    • Year and Date
      2007-09-22
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Comparison of nocturnal bruxism frequency between TMD internal derangement and myofascial pain patients. -Daily fluctuation of bruxism and optimum measurement protocol-2007

    • Author(s)
      Hajime, Minakuchi, Chiyomi, Nagamatsu-Sakaguchi, Aya, Kawakami, Takuo, Kuboki
    • Organizer
      20th Annual convocation of the Japan Association of Cranio-Mandibular Orthopedics
    • Place of Presentation
      Osaka
    • Year and Date
      2007-09-22
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 簡易貼付型ブラキシズム測定装置の現状と今後2007

    • Author(s)
      水口 一
    • Organizer
      補綴歯科学会サマースクール2007鳴門
    • Place of Presentation
      鳴門
    • Year and Date
      2007-08-31
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Current and future direction of miniature bruxism detection device2007

    • Author(s)
      Hajime, Minakuchi
    • Organizer
      1st Summer School of Prosthodontic Dentistry 2007 in Naruto
    • Place of Presentation
      Naruto
    • Year and Date
      2007-08-31
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 被験者の自覚や家族の指摘のみで睡眠時ブラキシズムは診断できるか?2007

    • Author(s)
      永松千代美, 水口 一, GT Clark, 窪木拓男
    • Organizer
      第28回岡山歯学会総会・学術大会
    • Place of Presentation
      岡山
    • Year and Date
      2007-08-19
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] The Validity of Self-administered assessment of Sleep Bruxism in adolescent population2007

    • Author(s)
      Chiyomi, Nagamatsu, Hajime, Minakuchi, Glenn, T., Clark
    • Organizer
      28th Annual convocation of Okayama Dental Society
    • Place of Presentation
      Okayama
    • Year and Date
      2007-08-19
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 被験者の自覚や家族の指摘のみで睡眠時ブラキシズムは診断できるか?2007

    • Author(s)
      永松千代美, 水口 一, GT Clark, 窪木拓男
    • Organizer
      日本補綴歯科学会第116回学術大会第5回アジア補綴歯科学会
    • Place of Presentation
      神戸
    • Year and Date
      2007-05-19
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] The Validity of Self-administered assessment of Sleep Bruxism in adolescent population2007

    • Author(s)
      Chiyomi, Nagamatsu, Hajime, Minakuchi, Glenn, T., Clark
    • Organizer
      116th Scientific meeting of Japan Prosthodontic Society
    • Place of Presentation
      Kobe
    • Year and Date
      2007-05-19
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 簡易貼付型睡眠時ブラキシズム測定装置のバージョンアップとその効果2006

    • Author(s)
      水口 一, 永松千代美, 前川賢治, 完山 学, 松香芳三, 窪木拓男, GT Clark.
    • Organizer
      第20回日本顎頭蓋機能学会記念学術大会
    • Place of Presentation
      岡山
    • Year and Date
      2006-09-23
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Version upgrade of miniature bruxism detection device and its assessment2006

    • Author(s)
      Hajime, Minakuchi, Chiyomi, Nagamatsu, Kenji, Maekawa, Manabu, Kanyama, Yoshizo, Matsuka, Takuo, Kuboki, Glenn, T., Clark
    • Organizer
      20th Annual convocation of the Japan Association of Cranio-Mandibular Orthopedics
    • Place of Presentation
      Okayama
    • Year and Date
      2006-09-23
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Version-up of miniature bruxism detection device and its clinical effectiveness.2006

    • Author(s)
      Minakuchi H, Nagamatsu C, Maekawa K, Kanyama M, Matsuka Y, Kuboki T.
    • Organizer
      The 1st International and the 19th Annual Meeting of the Japanese Society for the Temporomandibular Joint.
    • Place of Presentation
      Nagoya
    • Year and Date
      2006-07-19
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Relationship between severity of sleep bruxism and prevalence of TMD signs and symptoms in an adolescent population.2006

    • Author(s)
      Nagamatsu C, Minakuchi H, Maekawa K, Kanyama M, Matsuka Y, Kuboki T.
    • Organizer
      The 1st International and the 19th Annual Meeting of the Japanese Society for the Temporomandibular Joint.
    • Place of Presentation
      Nagoya
    • Year and Date
      2006-07-19
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Version-up of miniature bruxism detection device and its clinical effectiveness2006

    • Author(s)
      Hajime, Minakuchi, Chiyomi, Nagamatsu, Kenji, Maekawa, Manabu, Kanyama, Yoshizo, Matsuka, Takuo, Kuboki
    • Organizer
      The 1st International and the 19th Annual Meeting of the Japanese Society for the Temporomandibular Joint
    • Place of Presentation
      Nagoya
    • Year and Date
      2006-07-19
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Relationship between severity of sleep bruxism and prevalence of TMD signs and symptoms in an adolescent population2006

    • Author(s)
      Nagamatsu, C., Minakuchi, H., Maekawa, K., Kanyama, M., Matsuka, Y., Kuboki, T
    • Organizer
      The 1st International and the 19th Annual Meeting of the Japanese Society for the Temporomandibular Joint
    • Place of Presentation
      Nagoya
    • Year and Date
      2006-07-19
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 貼付型ブラキシズム測定装置により計測したブラキシズム頻度と頭頚背部の筋痛の関連性2006

    • Author(s)
      永松千代美, 水口 一, 前川賢治, 完山 学, 松香芳三, 窪木拓男, GT Clark.
    • Organizer
      日本補綴歯科学会第115回学術大会
    • Place of Presentation
      札幌
    • Year and Date
      2006-07-09
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Prevalence of sleep bruxism investigated by a miniature bruxism detection device in two adolescent samples and its relation with orofacial and cervical muscle pain2006

    • Author(s)
      Chiyomi, Nagamatsu, Hajime, Minakuchi, Kenji, Maekawa, Manabu, Kanyama, Yoshizo, Matsuka, Takuo, Kuboki, GT., Clark
    • Organizer
      115th Scientific meeting of Japan Prosthodontic Society
    • Place of Presentation
      Sapporo
    • Year and Date
      2006-07-09
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 簡易貼付型睡眠時ブラキシズム測定装置のバージョンアップとその効果2006

    • Author(s)
      水口 一, 永松千代美, 前川賢治, 完山 学, 松香芳三, 窪木拓男, GT Clark.
    • Organizer
      日本補綴歯科学会第115回学術大会
    • Place of Presentation
      札幌
    • Year and Date
      2006-07-08
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Version upgrade of miniature bruxism detection device and its quantitative assessment2006

    • Author(s)
      Hajime, Minakuchi, Chiyomi, Nagamatsu, Kenji, Maekawa, Manabu, Kanyama, Yoshizo, Matsuka, Takuo, Kuboki, GT., Clark
    • Organizer
      115th Scientific meeting of Japan Prosthodontic Society
    • Place of Presentation
      Sapporo
    • Year and Date
      2006-07-08
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] Temporomandibular disorders: An evidence-based approach to diagnosis and treatment2006

    • Author(s)
      Clark GT and Minakuchi H
    • Total Pages
      548
    • Publisher
      Quintessence Book
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] Temporomandibular Disorders : An Evidence-Based Approach to Diagnosis and Treatment2006

    • Author(s)
      Minakuchi H, Clark GT
    • Publisher
      Quintessence books, US
    • Related Report
      2006 Annual Research Report
  • [Book] Management of temporomandibular Disorders and Occlusion2006

    • Author(s)
      窪木拓男, 水口 一
    • Publisher
      医歯薬出版
    • Related Report
      2006 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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