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Development of biological new titanium alloy

Research Project

Project/Area Number 18592145
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 補綴理工系歯学
Research InstitutionNihon University

Principal Investigator

KOBAYASHI Kihei  Nihon University, 松戸歯学部, 研究所教授 (90050046)

Co-Investigator(Kenkyū-buntansha) SAKAE Toshiro  日本大学, 松戸歯学部, 准教授 (20112948)
KATO Takao  日本大学, 松戸歯学部, 准教授 (80147719)
KUWAHARA Katsuhisa  日本大学, 松戸歯学部, 講師 (30147714)
NAKADA Hiroshi  日本大学, 松戸歯学部, 講師 (10349970)
Co-Investigator(Renkei-kenkyūsha) SUWA Taketoshi  日本大学, 松戸歯学部, 大学院生
NUMATA Yasuko  日本大学, 松戸歯学部, 大学院生
LEGEROS Racquel Z.  New York University College of Dentistry, Department of Biomaterials & Biomimetics, Professor
LEGEROS John P.  New York University College of Dentistry, Department of Biomaterials & Biomimetics, Professor
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,060,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥660,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2006: ¥1,200,000 (Direct Cost: ¥1,200,000)
Keywordsインプラント / チタン合金 / 動物実験 / 骨 / 結晶
Research Abstract

本研究は生体内環境を重視し、AlやV以外の細胞毒性が指摘されていない元素(Zr, Nb, Ta)をチタンに添加し、長期予後を考慮したより高い生物学的安全性および機械的性質を有するTi-15Zr-4Nb-4Ta合金(以下 ; Ti-15-4-4)について、生体用インプラント材料としての適応を目指すべく研究・開発を行う

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (37 results)

All 2008 2007 2006 Other

All Journal Article (24 results) (of which Peer Reviewed: 21 results) Presentation (13 results)

  • [Journal Article] Qualitative study of the New Bone formation Surrounding the Ti-implant by FTIR and Polarizing Microscope2008

    • Author(s)
      Yasuko Numata, Hiroshi Nakada, Toshiro Sakae, Hiromi Kimura-Suda, Racquel Z. LeGeros, Kihei Kobayashi and Masaharu Makimura
    • Journal Title

      J. Hard Tissue Biology 17

      Pages: 131-140

    • NAID

      110007081295

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of Bone Mineral Density and Area of Newly formed Bone around Ti-15%Zr-4%Nb-4%Ta Alloy and Ti-6%Al-4%V Alloy Implants2008

    • Author(s)
      Hiroshi Nakada, Yasuko Numata, Toshiro Sakae, Yoshimitsu Okazaki, Yasuhiro Tanimoto, Hiroyuki Tamaki, Takao Kato, Atsushi Ookubo, Kihei Kobayashi and Racquel Z. LeGeros
    • Journal Title

      J. Hard Tissue Biology 17

      Pages: 99-108

    • NAID

      110007081305

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] インプラント周囲に形成された新生骨をX-ray Photoelectron Spectroscopy分析により骨質評価を行った基礎的研究2008

    • Author(s)
      中田浩史, 沼田靖子, 寒河江登志朗, 諏訪武利, 佐伯啓行, 谷本安浩, 加藤仁夫, 河相安彦, 金澤英作, 小林喜平, Racquel Z. LeGeros
    • Journal Title

      日大口腔科学 34巻2号

      Pages: 52-62

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Qualitative and quantitative evaluation of bone and synthetic calcium phosphates using Raman Spectroscopy2008

    • Author(s)
      Yasuko Numata, Toshiro Sakae, Taketoshi Suwa, Hiroshi Nakada, Racquel Z. LeGeros and Kihei Kobayashi
    • Journal Title

      Key Engineering Materials 361-363

      Pages: 135-138

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Newly formed bone around implanted new titanium alloy : Ti-15%Zr-4%Nb-4%Ta2008

    • Author(s)
      Hiroshi Nakada, Yasuko Numata, Taketoshi Suwa, Yoshimitsu Okazaki, Racquel Z. LeGeros, Toshiro Sakae, Takao Kato, Katsuhisa Kuwahara, and Kihei Kobayashi
    • Journal Title

      Key Engineering Materials 361-363

      Pages: 661-664

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Newly formed bone around implanted new titanium alloy : Ti-15%Zr-4%Nb-4%Ta2008

    • Author(s)
      Hiroshi Nakada, Yasuko Numata, K. Kobayashi, 他6名
    • Journal Title

      Key Engineering Materials 361-363

      Pages: 661-664

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Qualitative and quantitative evaluation of bone and synthetic calcium phosphates us ing Raman Spectroscopy2008

    • Author(s)
      Y. Numata, T. Sakae, T. Suwa, K. Kobayashi, 他2名
    • Journal Title

      Key Engineering Materials 361-363

      Pages: 135-138

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] インプラント周囲に形成された新生骨をX-ray Photoelectron Spectroscopy (XPS)分析により骨質評価を行った基礎的研究2008

    • Author(s)
      中田浩史, 沼田靖子, 寒河江登志朗, 小林喜平, 他7名
    • Journal Title

      日大口腔科学 34

      Pages: 52-62

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of Bone Mineral Density and Area of Newly formed Bone around Ti-15%Zr-4%Nb-4%Ta Alloy and Ti-6%Al-4%V Alloy lmpla2008

    • Author(s)
      Hiroshi Nakada, Yasuko Numata, Kihei Kobayashi, 他7名
    • Journal Title

      Journal of Hard Tissue Biology 17

      Pages: 99-108

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Qualitative study of the New Bone formation Surrounding the Ti-implant by FTIR and Polarizing Microscope2008

    • Author(s)
      Yasuko Numata, Hi roshi Nakada, Kihei Kobayashi, 他4名
    • Journal Title

      Journal of Hard Tissue Biology 17

      Pages: 131-140

    • NAID

      110007081295

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 硬組織の質的評価にMicro FT-Raman を使用した基礎的研究2007

    • Author(s)
      沼田靖子, 寒河江登志朗, 中田浩史, 諏訪武利, 小林喜平, 佐藤勇
    • Journal Title

      Journal of Hard Tissue Biology 16(4)

      Pages: 209-213

    • NAID

      110006570660

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Micro-CT Analysis of Rabbit Cancellous Bone Around Implants2007

    • Author(s)
      Yasuko Numata, Toshiro Sakae, Hiroshi Nakada, Taketoshi Suwa, Racquel Z. LeGeros, Yoshimitsu Okazaki and Kihei Kobayashi
    • Journal Title

      J. Hard Tissue Biology 16

      Pages: 91-93

    • NAID

      110006401728

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] ウサギ脛骨における炭酸カルシウム結晶の検出-微小部X 線回析法による研究-2007

    • Author(s)
      諏訪武利, 寒河江登志朗, 中田浩史, 小林喜平
    • Journal Title

      Journal of Hard Tissue Biology 16(4)

      Pages: 195-198

    • NAID

      110006570657

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Early Tissue Response to Modified Implant Surfaces Using Back Scattered Imaging2007

    • Author(s)
      Hiroshi Nakada, Toshiro Sakae, Racquel Z. LeGeros, John P. LeGeros, Taketoshi Suwa, Yasuko Numata, Kihei Kobayashi
    • Journal Title

      Implant Dentistry 16(3)

      Pages: 281-289

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of bone mineral density and bone area of newly formed bone around implants using micro-CT after pull-out tests2007

    • Author(s)
      Hiroshi Nakada, Taketoshi Suwa, Yasuko Numata, Yoshimitsu Okazaki, Toshiro Sakae, Tohru Hayakawa, Masataka Kato, Takashi Kaneda, Raquel Z. LeGeros, Takao Kato, Atsuko Gunji, Katsuhisa Kuwahara and Kihei Kobayashi
    • Journal Title

      Int J Oral-Med Sci 5

      Pages: 97-106

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of bone mineral density and bone area of newly formed bone around implants using micro-CT after pull-out tests2007

    • Author(s)
      H. Nakada, T. Suwa, Y. Numata, Y. Okazaki, T. Sakae, T. Hayakawa, M. Kato, T. Kaneda, R. Z. LeGeros, T. Kato, A. Gunji, K. Kuwahara, K. Kobayashi
    • Journal Title

      International Journal of Oral-Medical Sciences 5

      Pages: 97-106

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Micro-CT Analysis of Rabbit Cancellous Bone Around Implants2007

    • Author(s)
      Y. Numata, T. Sakae, H. Nakada, T. Suwa, R. Z. LeGeros, Y. Okazaki, K. Kobayashi
    • Journal Title

      Journal of Hard Tissue Biology 16

      Pages: 91-93

    • NAID

      110006401728

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Early Tissue Response to Modified Implant Surfaces Using Back Scattered Imaging2007

    • Author(s)
      Hiroshi Nakada, Toshiro Sakae, Racquel Z. LeGeros, John P. LeGeros, Taketoshi Suwa, Yasuko Numata, Kihei Kobayashi
    • Journal Title

      Implant Dentistry 16

      Pages: 281-289

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ウサギ脛骨における炭酸カルシウム結晶の検出-微小部X線回析法による研究-2007

    • Author(s)
      諏訪武利, 寒河江登志朗, 中田浩史, 小林喜平
    • Journal Title

      Journal of Hard Tissue Biology 16

      Pages: 195-198

    • NAID

      110006570657

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 硬組織の質的評価にMicro FT-Ramanを使用した基礎的研究2007

    • Author(s)
      沼田靖子, 寒河江登志朗, 中田浩史, 諏訪武利, 小林喜平, 佐藤勇
    • Journal Title

      Journal of Hard Tissue Biology 16

      Pages: 209-213

    • NAID

      110006570660

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] アパタイトブラスト処理インプラント周囲における新生骨の結晶性の評価2006

    • Author(s)
      諏訪武利, 寒河江登志朗, 中田浩史, 加藤仁夫, 小林喜平
    • Journal Title

      日本口腔インプラント学会誌 19巻4号

      Pages: 453-460

    • NAID

      10018693209

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] アパタイトブラスト処理インプラント周囲における新生骨の結晶性の評価2006

    • Author(s)
      諏訪武利
    • Journal Title

      日本口腔インプラント学会雑誌 19(4)

      Pages: 43-50

    • NAID

      10018693209

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Analysis of bone mineral density and bone area of newly formed bone around implants micro-CT after pull-out tests.

    • Author(s)
      H.Nakada
    • Journal Title

      International Journal of Oral-Medical Sciences (印刷中)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] ウサギ脛骨における炭酸カルシウム結晶の検出-微小部X線回析法による研究-

    • Author(s)
      諏訪武利
    • Journal Title

      Journal of Hard Tissue Biology (印刷中)

    • NAID

      110006570657

    • Related Report
      2006 Annual Research Report
  • [Presentation] Usefulness of implant-surrounding newly formed bone quality evaluation method using micro-CT2008

    • Author(s)
      Hiroshi Nakada, Yasuko Numata, Toshiro Sakae, Yoshimitsu Okazaki, Kihei Kobayashi
    • Organizer
      第1回再生補綴医学研究会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-11-28
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Observation of the biocompatibility of surface-treated Ti-15%Zr-4%Nb-4%Ta alloy, and measurement of bone mineral density2008

    • Author(s)
      Yasuko Numata, Hiroshi Nakada, Toshiro Sakae, Taketoshi Suwa, Yoshimitsu Okazaki, Kihei Kobayashi, John P. LeGeros, and Racquel Z. LeGeros
    • Organizer
      The 4^<th> International Symposium on Apatite and Correlative Biomaterials
    • Place of Presentation
      Manila
    • Year and Date
      2008-09-14
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Basic study on micro-CT-measurement of the bone mineral density and serial observation of the maturation degree of newly formed bone around implants2008

    • Author(s)
      Hiroshi Nakad, Yasuko Numata, Toshiro Sakae, Taketoshi Suwa, Hiroyuki Tamaki, Takao Kato, Kiyoshi Arai, Takahide Maeda, Kihei Kobayashi, and Racquel Z. LeGeros
    • Organizer
      The 4^<th> International Symposium on Apatite and Correlative Biomaterials
    • Place of Presentation
      Manila
    • Year and Date
      2008-09-14
    • Related Report
      2008 Final Research Report
  • [Presentation] Basic study on micro-CT-measurement of the bone mineral density and serial observation of the maturation degree of newly for med bone around implants2008

    • Author(s)
      Hiroshi Nakada, Yasuko Numata, Kihei Kobayashi, 他7名
    • Organizer
      The 4^<th> International Symposium on Apatite and Correlative Biomaterials
    • Place of Presentation
      Manila
    • Year and Date
      2008-09-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] Micro-CTを利用してインプラント周囲新生骨の骨塩量をカラーマッピング表示した経時的変化について2008

    • Author(s)
      中田浩史, 沼田靖子, 寒河江登志朗, 小林喜平, 他8名
    • Organizer
      第8回日本大学口腔科学会
    • Place of Presentation
      千葉
    • Year and Date
      2008-09-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] 表面処理を施した生体用Ti-15%Zr-4%Nb-4%Ta合金の生体適合性の観察2008

    • Author(s)
      沼田靖子, 中田浩史, 寒河江登志朗、 諏訪武利, 岡崎義光, 小林喜平, John P. LeGeros、and Racquel Z. LeGeros
    • Organizer
      第17回硬組織再生生物学会
    • Place of Presentation
      徳島
    • Year and Date
      2008-08-30
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] インプラント周囲における新生骨の石灰化についてLEBRA-PXRを用いた基礎的研究2008

    • Author(s)
      中田浩史、諏訪武利、寒河江登志朗、沼田靖子、小林喜平、佐藤勇
    • Organizer
      日本大学量子化学研究所 学術フロンティア成果発表会
    • Place of Presentation
      千葉
    • Year and Date
      2008-03-14
    • Related Report
      2007 Annual Research Report
  • [Presentation] Qualitative and quantitative evaluation of bone and synthetic calcium phosphates using Raman Spectroscopy2007

    • Author(s)
      Yasuko Numata, Toshiro Sakae, Taketoshi Suwa, Hiroshi Nakada, Racquel Z. LeGeros and Kihei Kobayashi
    • Organizer
      20^<th> International Symposium of Ceramics in Medicine
    • Place of Presentation
      France-Nantes
    • Year and Date
      2007-10-24
    • Related Report
      2008 Final Research Report
  • [Presentation] Newly formed bone around implanted new titanium alloy : Ti-15%Zr-4%Nb-4%Ta2007

    • Author(s)
      Hiroshi Nakada, Yasuko Numata, Taketoshi Suwa, Y. Okazaki, Racquel Z. LeGeros, Toshiro Sakae, Takao Kato, Katsuhisa Kuwahara, Kobayashi Kobayashi
    • Organizer
      20^<th> International Symposium of Ceramics in Medicine
    • Place of Presentation
      France-Nantes
    • Year and Date
      2007-10-24
    • Related Report
      2008 Final Research Report
  • [Presentation] Qualitative and quantitative evaluation of bone and synthetic calcium phosphates using Raman Spectroscopy2007

    • Author(s)
      Y. Numata, T. Sakae, T. Suwa, H. Nakada, R. Z. LeGeros and K. Kobayashi
    • Organizer
      20th International Symposium of Ceramics in Medicine
    • Place of Presentation
      France- Nantes
    • Year and Date
      2007-10-24
    • Related Report
      2007 Annual Research Report
  • [Presentation] インプラント周囲における新生骨の石灰化度の二次元的解析2007

    • Author(s)
      諏訪武利、寒河江登志朗、中田浩史、沼田靖子、佐藤勇
    • Organizer
      第16回硬組織再生生物学会
    • Place of Presentation
      松本
    • Year and Date
      2007-09-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] Micro-CT Analysis of Rabbit Cancellous Bone around Implants2006

    • Author(s)
      Yasuko Numata, Toshiro Sakae, Taketoshi Suwa, Hiroshi Nakada, Racquel Z. LeGeros, Katsuhisa Kuwahara and Kihei Kobayashi
    • Organizer
      6 th Asian Bioceramics symposium, Thailand
    • Year and Date
      2006-11-08
    • Related Report
      2008 Final Research Report
  • [Presentation] Quantitative Radiographic Study of New Bone Formed around the Implant Using a Newly Developed Parametric X-Ray Method2006

    • Author(s)
      Toshiro Sakae, Taketoshi Suwa, Yasuko Numata, Hiroshi Nakada, I. Sato and Racquel Z. LeGeros
    • Organizer
      6 th Asian Bioceramics symposium
    • Place of Presentation
      Thailand
    • Year and Date
      2006-11-08
    • Related Report
      2008 Final Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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