Role of the red nucleus on mastication, swallowing, feeding and drinking behavior
| Project/Area Number |
18592148
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
補綴理工系歯学
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| Research Institution | The Nippon Dental University |
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Principal Investigator |
SATOH Yoshihide The Nippon Dental University, School of Life Dentistry at Niigata, Assistant Professor (20287775)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥4,060,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥660,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2006: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | mastication / swallowing / feeding / drinking / red nucleus |
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| Research Abstract |
1. We study whether the red nucleus (RN) lesion can modify rhythmic jaw movements. Rhythmic jaw movements were induced by repetitive electrical stimulation of the orofacial motor cortex or the insular cortex. Lesions made by applied electric current in the RN were found to influence the rhythmic jaw movements induced by stimulation of the orofacial motor cortex. The distance between the maximum and minimum jaw-opening positions was less after the lesions were induced. In contrast, lesions of the RN did not influence rhythmic jaw movements induced by stimulation of the insular cortex. Next, kainic acid (lesion group) or phosphate-buffered saline (control group) was injected into the left RN. Three days after injection, rhythmic jaw movements were induced by repetitive electrical stimulation of the orofacial motor cortex. The distance between the maximum and minimum jaw-opening positions in the lesion group was smaller than in the control group. These results suggest that the RN is involved in the modification of jaw movements induced by stimulation of the orofacial motor cortex.
2. We have examined the effect of a unilateral lesion of the RN on mastication, feeding and drinking. Kainic acid (lesion group) or phosphate-buffered saline (control group) was injected into the left RN. The mean number of pellets ingested in the lesion group was significantly less on the first and second days after surgery. Spillage of food increased greatly in the lesion group after surgery. The lesion group would grasp a pellet and put it into their mouth, but they sometimes bit a pellet several times, then spilled it. The mean number of drops of water ingested by the lesion group was significantly reduced on the first day after surgery. Our study suggests that the RN lesion group can not masticate food well, and ingestion of food then decreases.
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Report
(3 results)
Research Products
(8 results)
