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Role of the red nucleus on mastication, swallowing, feeding and drinking behavior

Research Project

Project/Area Number 18592148
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 補綴理工系歯学
Research InstitutionThe Nippon Dental University

Principal Investigator

SATOH Yoshihide  The Nippon Dental University, School of Life Dentistry at Niigata, Assistant Professor (20287775)

Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥4,060,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥660,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2006: ¥1,200,000 (Direct Cost: ¥1,200,000)
Keywordsmastication / swallowing / feeding / drinking / red nucleus
Research Abstract

1. We study whether the red nucleus (RN) lesion can modify rhythmic jaw movements. Rhythmic jaw movements were induced by repetitive electrical stimulation of the orofacial motor cortex or the insular cortex. Lesions made by applied electric current in the RN were found to influence the rhythmic jaw movements induced by stimulation of the orofacial motor cortex. The distance between the maximum and minimum jaw-opening positions was less after the lesions were induced. In contrast, lesions of the RN did not influence rhythmic jaw movements induced by stimulation of the insular cortex. Next, kainic acid (lesion group) or phosphate-buffered saline (control group) was injected into the left RN. Three days after injection, rhythmic jaw movements were induced by repetitive electrical stimulation of the orofacial motor cortex. The distance between the maximum and minimum jaw-opening positions in the lesion group was smaller than in the control group. These results suggest that the RN is involved in the modification of jaw movements induced by stimulation of the orofacial motor cortex.
2. We have examined the effect of a unilateral lesion of the RN on mastication, feeding and drinking. Kainic acid (lesion group) or phosphate-buffered saline (control group) was injected into the left RN. The mean number of pellets ingested in the lesion group was significantly less on the first and second days after surgery. Spillage of food increased greatly in the lesion group after surgery. The lesion group would grasp a pellet and put it into their mouth, but they sometimes bit a pellet several times, then spilled it. The mean number of drops of water ingested by the lesion group was significantly reduced on the first day after surgery. Our study suggests that the RN lesion group can not masticate food well, and ingestion of food then decreases.

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (8 results)

All 2008 2007 Other

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (4 results) Remarks (2 results)

  • [Journal Article] Changes in cortically induced rhythmic jaw movements after lesioning of the red nucleus in rats2007

    • Author(s)
      Satoh Y., Ishizuka K., Murakami T.
    • Journal Title

      Brain Research 1165

      Pages: 60-70

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Changes in cortically induced rhythmic jaw movements after lesioning of the red nucleus in rats2007

    • Author(s)
      Satoh, Y., Ishizuka, K., Murakami, T
    • Journal Title

      Brain Research 1165

      Pages: 60-70

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Effects of lesions of the red nucleus on the feeding and drinking behavior in rats2008

    • Author(s)
      Satoh Y, Ishizuka K, Murakami T
    • Organizer
      第85回日本生理学会大会
    • Place of Presentation
      東京
    • Year and Date
      2008-03-25
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Effects of lesions of the red nucleus on the feeding and drinking behavior in rats2008

    • Author(s)
      Satoh, Y., Ishizuka, K., Murakami, T
    • Organizer
      The 85th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Tokyo
    • Year and Date
      2008-03-25
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Effect of lesions of the red nucleus on the cortically induced rhythmical jaw movements2007

    • Author(s)
      Satoh Y, Ishizuka K, Murakami T
    • Organizer
      第84回日本生理学会大会
    • Place of Presentation
      大阪
    • Year and Date
      2007-03-21
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Effect of lesions of the red nucleus on the cortically induced rhythmical jaw movements2007

    • Author(s)
      Satoh, Y., Ishizuka, K., Murakami, T
    • Organizer
      The 84th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Osaka
    • Year and Date
      2007-03-21
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Remarks] 「研究成果報告書概要(和文)」より

    • URL

      http://www.ngt.ndu.ac.jp/guide/kouza/kiso03.html

    • Related Report
      2007 Final Research Report Summary
  • [Remarks]

    • URL

      http://www.ngt.ndu.ac.jp/guide/kouza/kiso03.html

    • Related Report
      2007 Annual Research Report

URL: 

Published: 2006-04-01   Modified: 2016-04-21  

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