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Influence of loss of posterior occlusal support on Stress Hormone and Immunoglobulin in Saliva

Research Project

Project/Area Number 18592161
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 補綴理工系歯学
Research InstitutionOsaka Dental University

Principal Investigator

MAEDA Teruta  Osaka Dental University, Dentistry, associate professor (10103110)

Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,830,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2006: ¥2,400,000 (Direct Cost: ¥2,400,000)
KeywordsOcclusal support / Saliva / Cortisol / Salivary α-amylase / Immunoglobulin A / psychological stress / physiological stress / クロモグラニンA / コルチソール
Research Abstract

The purpose of this study is to elucidated influences of loss of posterior occlusal support and restored support by removable partial dentures (RPD) on stress and immune system in human.
First, nineteen healthy subjects were included in this study. We quantified the degree of discomfort induced by plates of different thicknesses placed under an experimental acrylic plate (exp-plate) covering the palatal mucosa in an attempt to model ill-fitting dentures.
Next, Twenty-one patients whose unilateral or bilateral molar teeth were missing (Eichner B2-B4, C1) were participated in this study. They were treated their denture by 3 dentists. The stages of saliva collection were just before treatment at first visit, and at each subsequent visit. All of them filled out the State-Trait Anxiety Inventory.
A cotton roll (salivette) was to collect their saliva sample. Cortisol, α-amylase and immunoglobulin A were measured by ELISA kit. The data were analyzed using an ANOVA with repeated measures.
The concentrations of cortisol and salivary α-amylase activity were significantly greater with exp-plate than without exp-plate (p<0.01). The immunoglobulin was greater with exp. plate than without exp-plate, which was not shown statistic significant. Subjects who feel anxious tend to increase their salivary α-amylase activity levels. These results suggest that the pain and discomfort from an ill-fitting denture can be the source of stress.
When the patients were provided the RPD and satisfied with their RPD, the concentration of salivary cortisol, α-amylase and immunoglobulin A decreased significantly compare with those at the other visits.
The present data suggest that loss of posterior occlusal support was a factor for a source of stress and that treatment of RPD should reduce the stress. However, as these results might involve many other factors (individual characteristics, their life style, etc.), a new experimental model should be required for the analysis.

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (11 results)

All 2008 2007 2006

All Journal Article (5 results) (of which Peer Reviewed: 2 results) Presentation (6 results)

  • [Journal Article] Influence of Uncomfortable Removable Partial Dentures on Stress Hormone in Saliva2008

    • Author(s)
      Jigen KOHNO, et al
    • Journal Title

      顎頭蓋機能1学会雑誌 21

      Pages: 1-6

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Influence of Uncomfortable Removable Partial Dentures on Stress Hormone in Saliva2008

    • Author(s)
      Jigen KOHNO, Teruta Maeda, Hiroshi Inoue
    • Journal Title

      J. Jpn. Assoc. Craniomandib. Orthoped. 21-1

      Pages: 1-6

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Functional maxillary denture model for rats-investigations based on masticatory performance and masseter electromyography-2007

    • Author(s)
      MATSUNO A
    • Journal Title

      J Osaka Dent Univ 41

      Pages: 161-167

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ラットの上顎義歯モデル確立へのチヤレンジ-装着義歯は咀嚼機能を発揮するか-2006

    • Author(s)
      松野彰仁 ほか
    • Journal Title

      日本補綴歯科学会雑誌 50巻115回特別号

      Pages: 107-107

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 実験的咬合干渉が心拍数変動に及ぼす影響2006

    • Author(s)
      畦崎靖男ほか
    • Journal Title

      日本補綴歯科学会雑誌 50巻115回特別号

      Pages: 147-147

    • Related Report
      2006 Annual Research Report
  • [Presentation] 局部床義歯による不快症状が唾液中のストレスホルモンに及ぼす影響2008

    • Author(s)
      河野慈元ら
    • Organizer
      日本補綴歯科学会関西支部 学術大会
    • Place of Presentation
      大阪市
    • Year and Date
      2008-01-27
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Influence of Uncomfortable Removable Partial Dentures on Stress Hormone in Saliva2008

    • Author(s)
      Jigen KOHNO, Teruta MAEDA, Hiroshi INOUE
    • Organizer
      Annual meeting of Japan Prosthodontic Society, Kansai Chapter
    • Place of Presentation
      Osaka
    • Year and Date
      2008-01-27
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 局部床義歯による不快症状が唾液中のストレスホルモンに及ぼす影響2008

    • Author(s)
      河野 慈元, ら
    • Organizer
      日本補綴歯科学会関西支部学術大会
    • Place of Presentation
      大阪市
    • Year and Date
      2008-01-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] 実験的口蓋床による不快刺激が唾液中ストレス反応物質に及ぼす影響2007

    • Author(s)
      伊藤秀高ら
    • Organizer
      第21回日本顎頭蓋機能学会
    • Place of Presentation
      大阪府枚方市
    • Year and Date
      2007-09-23
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Influence of offensive stimulus under experimental acrylic palatal plate on stress-reacting substance in saliva2007

    • Author(s)
      Hidetaka ITO, Teruta MAEDA, Hiroshi INOUE
    • Organizer
      21 meeting of Jpn. Assoc. Craniomandib. Orthoped
    • Place of Presentation
      Hirakata-shi Osaka-fu
    • Year and Date
      2007-09-23
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 臼歯喪失がラットの学習・記憶に及ぼす影響-回避実験と脳内グルタミン酸の同時分析-2007

    • Author(s)
      松野 彰仁, ら
    • Organizer
      日本補綴歯科学会第116回大会
    • Place of Presentation
      神戸市
    • Year and Date
      2007-05-19
    • Related Report
      2007 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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