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The mechanism of abnormal secretion of saliva in patients with Sjogren's syndrome.

Research Project

Project/Area Number 18592186
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionKyushu University

Principal Investigator

OHYAMA Yukiko  Kyushu University, 歯学研究院, 助教 (70294957)

Co-Investigator(Kenkyū-buntansha) NAKAMUA Seiji  九州大学, 大学院・歯学研究院, 教授 (60189040)
FUJII Jun  九州大学, 大学院・歯学研究院, 准教授 (60271441)
SHIRASUNA Kanemitsu  九州大学, 大学院・歯学研究院, 名誉教授 (30093420)
Project Period (FY) 2006 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥3,370,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥570,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2006: ¥900,000 (Direct Cost: ¥900,000)
Keywordsシェーグレン症候群 / 唾液分泌異常 / ドライマウス / 塩酸セビメリン
Research Abstract

Treatment with cevimeline hydrochloride in patients with Sjogren's syndrome is significantly effective to patients who had mild destruction of salivary glands. "nzm-1858", an anti salivary glands monoclonal antibody established from model mice of SS, reacts to human salivary ductal cells, and cevimeline hydrochloride is more effective to salivary glands which have positive reaction to nzm-1858 in immunohistchemical staining. Antigen to nzm-1858 is 69kDa protein and we are analyzing this protein.

Report

(5 results)
  • 2009 Final Research Report ( PDF )
  • 2008 Annual Research Report   Self-evaluation Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (13 results)

All 2008 2007 2006 Other

All Journal Article (13 results) (of which Peer Reviewed: 2 results)

  • [Journal Article] Inflammatory stimuli accelerate Sjogren's syndrome-like disease in (NZB x NZW)F(1) mice.2008

    • Author(s)
      Deshmukh US, Ohyama Y, Bagavant H, Guo X, Gaskin F, Fu SM.
    • Journal Title

      Arthritis Rheum. 58(5)

      Pages: 1318-1323

    • Related Report
      2009 Final Research Report
  • [Journal Article] Inflammatory stimuli accelerate Sjogren's syndrome-like disease in(NZB x NZW)F(1) mice2008

    • Author(s)
      Deshmukh US, Ohyama Y, Bagavant H, Guo X, Gaskin F, Fu SM.
    • Journal Title

      Arthritis Rheum 58(5)

      Pages: 1318-1323

    • Related Report
      2008 Self-evaluation Report
  • [Journal Article] Sonographic diagnosis of Sjogren's syndrome : evaluation of parotid gland vascularity as a diagnostic tool2008

    • Author(s)
      Shimizu M, Okamura K, Yoshiura K, Ohyama Y, Nakamura S.
    • Journal Title

      Oral Surg Oral Med Oral Pathol Oral Radiol Endod 106(4)

      Pages: 567-594

    • Related Report
      2008 Self-evaluation Report
  • [Journal Article] Inflammatory stimuli accelerate Sjogren's syndrome -like disease in (NZM x NZW)F1 mice2008

    • Author(s)
      Deshmukh US, Ohyama Y, et. al
    • Journal Title

      Arthritis and Rheunatism 58

      Pages: 1318-1323

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sonographic diagnosis of S jogren syndrome: evaluation of parotid gland vascularitity as a diagnostic tool2008

    • Author(s)
      Shimizu M, Okamura K, Yoshiura K, Ohyama Y, Nakamura S.
    • Journal Title

      Oral Surg Oral Med Oral Pathol Oral Radiol Endod. (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] シェーグレン症候群患者に対する塩酸セビメリンを用いた内服治療の検討2007

    • Author(s)
      大山順子, 中村誠司, 宮田弘毅, 佐々木匡理, 川村英司, 熊丸渉, 林田淳之將, 豊嶋健史, 森山雅文, 白砂兼光
    • Journal Title

      日口外誌 53(4)

      Pages: 220-227

    • Related Report
      2009 Final Research Report
  • [Journal Article] シェーグレン症候群患者に対する塩酸セビメリンを用いた内服治療の検討2007

    • Author(s)
      大山順子、中村誠司、宮田弘毅、佐々木匡理、川村英司、熊丸渉、林田淳之將、豊嶋健史、森山雅文、白砂兼光
    • Journal Title

      日口外誌 53(4)

      Pages: 220-227

    • Related Report
      2008 Self-evaluation Report
  • [Journal Article] シェーグレン症候群患者に対する塩酸セビメリン内服治療の検討2007

    • Author(s)
      大山順子, 中村誠司, 宮田弘毅, 佐々木匡理, 川村英司, 熊丸 渉, 林田淳之將, 豊嶋健史, 森山雅文, 白砂兼光
    • Journal Title

      日本口腔外科学会雑誌 53・4

      Pages: 220-227

    • NAID

      10019576079

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Severe focal sialadenitis and dacryoadenitis in NZM2328 mice induced by MCMV: a novel model for human Sjogren's syndrome.2006

    • Author(s)
      Ohyama Y, Carroll VA, Deshmukh U, Gaskin F, Brown MG, Fu SM.
    • Journal Title

      J Immunol 177(10)

      Pages: 7391-7

    • Related Report
      2009 Final Research Report
  • [Journal Article] Sonographic diagnostic criteria for screening Sjogren's syndrome2006

    • Author(s)
      Shimizu M, Okamura K, Yoshiura K, Ohyama Y, Nakamura S, Kinukawa N.
    • Journal Title

      Oral Surg Oral Med Oral Pathol Oral Radiol Endod 102(1)

      Pages: 85-93

    • Related Report
      2008 Self-evaluation Report
  • [Journal Article] Severe focal sialadenitis and dacryoadenitis in NZM2328 mice induced by MCMV : a novel model for human Sjogren's syndrome2006

    • Author(s)
      Ohyama Y, Carroll VA, Deshmukh U, Gaskin F, Brown MG, Fu SM.
    • Journal Title

      J Immunol 177(10)

      Pages: 7391-7

    • Related Report
      2008 Self-evaluation Report
  • [Journal Article] Severe focal sialadenitis and dacryoadenitis in NZM2328 mice induced by MCMV : a novel model for human Sjogren's syndrome.2006

    • Author(s)
      Ohyama Y, Carroll VA, Deshmukh U, Gaskin F, Brown MG, Fu SM.
    • Journal Title

      Journal of Immunology 177・10

      Pages: 7391-7397

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Sonographic diagnosis of Sjogren's syndrome: evaluation of parotid gland vascularity as a diagnostic tool.

    • Author(s)
      Shimizu M, Okamura K, Yoshiura K, Ohyama Y, Nakamura S.
    • Journal Title

      Oral Surg Oral Med Oral Pathol Oral Radiol Endod 106(4)

      Pages: 567-594

    • Related Report
      2009 Final Research Report

URL: 

Published: 2006-04-01   Modified: 2016-04-21  

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