| Project/Area Number |
18592193
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Nara Medical University |
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Principal Investigator |
AOKI Kumiko (2007) Nara Medical University, Department of Oral and Maxillofacial Surgery, Research associate (40448767)
大儀 和彦 (2006) 奈良県立医科大学, 医学部, 助手 (70347566)
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| Co-Investigator(Kenkyū-buntansha) |
ISHITANI Akiko Nara Medical University, Department of Legal Medicine, Assistant professor (40112544)
青木 久美子 奈良県立医科大学, 医学部, 医員 (40448767)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥3,920,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2006: ¥2,100,000 (Direct Cost: ¥2,100,000)
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| Keywords | Oral squamous cell carcinoma / Gene / 口腔扁平上皮癌 |
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| Research Abstract |
Recently, a new polymorphic gene family called the major histocompatibility complex class I chain-related gene A (MICA) was discovered about 40 kb centromeric to HLA-B gene. The MICA protein, expressed on epithelial cells and many kinds of tumor cells, serves to regulate immune function. The MICA protein is thought to activate immune function on mucosal tissue by binding to NKG2D which is expressed on most natural killer cells, CD8 positive T cells, and gamma delta T cells. An association between MICA gene polymorphisms and the development of oral squamous cell carcinoma (OSCC) has also been reported.
This study was designed to test this association in Japanese patients with OSCC.
The (GCT)n polymorphisms of the MICA gene was investigated in OSCC patients and normal controls using polymerase chain reaction amplification and denaturing polyacrylamide gel electrophoresis.
Five alleles, namely A4, A5, A6, A9, and A5.1, were found in both groups. The MICA-A5.1 allele was significantly higher in patients with OSCC when compared with normal controls These results suggest that the MICAA5.1 allele may be associated with an increased susceptibility
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