| Project/Area Number |
18592197
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Meikai University |
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Principal Investigator |
MURAKAMI Yukio Meikai University, 歯学部, 准教授 (00286014)
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| Project Period (FY) |
2006 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥3,670,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥570,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2006: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | 口腔外科学一般(含病態検査学) / メトキシフェノール化合物 / 転写因子 / 天然植物性フェノール / COX-2 / フェノール作用 / P. gingivalis線毛 / bi-phenol / melatonin / メトキシフェノール / 抗酸化作用 / 抗炎症作用 / 炎症性サイトカイン / P.gingivalis線毛 / o-Vanillin / curcumin / ο-Vanillin / フェノール化合物 / Ferulic Acid / Natural products / BHA / OH基解離エンタルピー |
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| Research Abstract |
We investigated the regulatory effects of methoxyphenols such as BHA, bis-BHA, o-vanillin, guaiacol, curcumin, tetrahydrocurcumin, phenol and biphenol, on the transcription factor activation stimulated by LPS or other stimulants in mammalian cells. Methoxyphenols which hardly abstracted an H atom from the phenolic OH group inhibited a transcriptional activity of redox-sensitive transcription factors, and suppressed COX-2 and cytokine expression. These observations suggested that methoxyphenol compounds possessed a therapeutic potential against chronic inflammation and mutagenesis by its phenol function.
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