Studies on the regenerative medicine utilizing the plasticity of dental pulp stem cells

• Project/Area Number: 18592211
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Osaka Dental University
• Principal Investigator: NOZAKI Tadashige Osaka Dental University, 歯学部, 講師 (90281683)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,010,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥510,000); Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2006: ¥1,800,000 (Direct Cost: ¥1,800,000)
• Keywords: 歯髄 / 幹細胞 / 細胞分化 / 分化誘導 / 再生医学 / 分化転換

Research Abstract

:分化ポテンシャルの高い幹細胞を利用して、自己の生体組織を再生修復する新しい治療法が試みられている。これら幹細胞を用いた再生医療は移植に代わる治療法として社会的なニーズがある。本研究課題では、幹細胞のソースとして歯髄に存在する幹細胞に着目し、幹細胞の多分化能を分子レベルで解析した。歯髄に存在する幹細胞の有用性を明らかにし、その可塑性を利用した再生医療のための基礎となる研究を展開した。

Research Products

• [Journal Article] 多能性幹細胞による歯の再生 (2008)
  • Author(s): 野崎中成
  • Journal Title: 生物工学会誌 86(5) Pages: 240-240
  • NAID: 110006687320
• [Journal Article] Analysis of gene expression during differentiation induction of normal human periodontal ligament cells into an osteoblast lineage (2008)
  • Author(s): Nagata, S., Nozaki, T., Ohura, K.,Daito, M
  • Journal Title: Journal of Oral Tissue Engeering 6(2) Pages: 88-96
  • NAID: 110007043751
  • Peer Reviewed
• [Journal Article] Analysis of gene expression during differentiation induction of normal human periodontal ligament cells into an osteoblast lineage (2008)
  • Author(s): Nagata, S., Nozaki. T., Ohura, K., Daito, M.
  • Journal Title: Journal of Oral Tissue Engeering 6(2) Pages: 88-96
  • NAID: 110007043751
  • Peer Reviewed
• [Journal Article] 多能性幹細胞による歯の再生 (2008)
  • Author(s): 野崎 中成
  • Journal Title: 生物工学会誌 86(5) Pages: 240-240
  • NAID: 110006687320
• [Journal Article] Differentiation of dental pulp stem cells into a neural lineage (2006)
  • Author(s): Takeyasu, M., Nozaki, T., Daito, M
  • Journal Title: Pediatric Dental Journal 16(2) Pages: 154-162
  • NAID: 10018252827
  • Peer Reviewed
• [Journal Article] Differentiation of dental pulp stem cells into a neural lineage (2006)
  • Author(s): Takeyasu, M., Nozaki, T., Daito, M.
  • Journal Title: Pediatric Dental Journal 16(2) Pages: 154-162
  • NAID: 10018252827
• [Presentation] Gene expression profile in the adipogenesis induction of dental pulp cells (2008)
  • Author(s): Nozaki, T., Ohura, K
  • Organizer: The American Society for Cell Biology, 48th Annual Meeting
  • Place of Presentation: San Francisco, U.S.A.
  • Year and Date: 2008-12-17
• [Presentation] Gene expression profile in the adipogenesis induction of dental pulp cells (2008)
  • Author(s): Nozaki, T., Ohura, K.
  • Organizer: The American Society for Cell Biology, 48th Annual Meeting
  • Place of Presentation: San Francisco, U. S. A
  • Year and Date: 2008-12-17
• [Presentation] 歯髄細胞の脂肪細胞系譜への分化における遺伝子発現変動の網羅的解析 (2007)
  • Author(s): 野崎中成
  • Organizer: BMB2007 第30 回日本分子生物学会第80 回日本生化学会大会合同大会
  • Place of Presentation: 横浜市
  • Year and Date: 2007-12-11
• [Presentation] 歯髄細胞の脂肪細胞系譜への分化における遺伝子発現変動の網羅的解析 (2007)
  • Author(s): 野崎 中成
  • Organizer: BMB2007第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
  • Place of Presentation: 横浜市パシフィコ横浜
  • Year and Date: 2007-12-11