| Project/Area Number |
18592250
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Kagoshima University |
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Principal Investigator |
OHMURE Haruhito Kagoshima University, Graduate School of Medical and Dental Sciences, Assistant Professor (00404484)
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| Co-Investigator(Kenkyū-buntansha) |
MIYAWAKI Shouichi Kagoshima University, Graduate School of Medical and Dental Sciences, Professor (80295807)
TSUBOUCHI Hirohito Kagoshima University, Graduate School of Medical and Dental Sciences, Professor (60145480)
NAGATA Junko Kagoshima University, Graduate School of Medical and Dental Sciences, Assistant Professor (50264429)
瀬戸口 尚志 鹿児島大学, 大学院医歯学総合研究科, 助教授 (60206646)
小椋 幹記 鹿児島大学, 大学院医歯学総合研究科, 講師 (40194526)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥3,910,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2006: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | gastro-oesonhaeeal reflux / sleep bruxism / Helicobacter pylori / eradication / duodenogastro-esophageal reflux / DGOR / 歯周病 / 口臭 |
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| Research Abstract |
The purpose of this study was to investigate the effect of Helicobacter pylori infection on the periodontal disease, oral malodor and general health status.
One hundred and five adults were recruited from the patient who visited Kagoshima University Hospital. As the purpose of the present study, subjects were divided into two groups according to the presence or absence of gastro-oesophageal reflux (GERD) manifestations. Gastro-oesophageal manifestations were evaluated using the Carlsson-Dent self-administered questionnaire (QUEST) and frequency scale for the symptoms of GERD (FSSG).General and oral conditions were compared between the groups. As the result, 25.7% of subjects were diagnosed as a GERD positive. The prevalence of respiratory symptoms, back pain, numbness of hand, urological manifestations and sleep disorder in the GERD positive group were greater than that in the GERD negative group. Subjective QOL determined by WHO QOL 24 in the GERD positive group were lower than that in the GERD negative group.
The infection of Helicobacter pylori ware determined by 13C-urea breath test. Three of 15 subjects had an infection of Helicobacter pylori. As the result of polysomnography and pH monitoring in the oesophagus and stomach, sleep bruxism episode occurred during the decrease of intro-oesophageal pH and increase of intra-gastric pH.
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