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A study for the involvement of IL-22 in the pathogenesis of periodontal diseases

Research Project

Project/Area Number 18592274
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Periodontal dentistry
Research InstitutionHyogo College of Medicine

Principal Investigator

OHYAMA Hideki  Hyogo College of Medicine, Faculty of Medicine, Assistant Professor (90280685)

Co-Investigator(Kenkyū-buntansha) TERADA Nobuyuki  Hyogo College of Medicine, Faculty of Medicine, Professor (50150339)
NAKASHO Keiji  Hyogo College of Medicine, Faculty of Medicine, Assistant Professor (00217712)
YAMADA Naoko  Hyogo College of Medicine, Faculty of Medicine, Assistant Professor (10319858)
NISHIMURA Fusanori  Hiroshima University, Graduate School of Biomedical Sciences, Professor (80208222)
HASHITANI Susumu  Hyogo College of Medicine, Faculty of Medicine, Instructor (00330449)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥4,010,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2006: ¥1,800,000 (Direct Cost: ¥1,800,000)
KeywordsIL-22 / periodontitis / β-defensin / T cells / keratinocytes / β-ディフェンシン2,3
Research Abstract

Interleukin (IL)-22, which is one of cytokines produced from activated helper T cells, plays an important role in the host defence against the bacterial infection by inducing the expression of β-defensin from keratinocytes. In contrast, since IL-22 is mostly produced from Th17 cells, which are implicated in the cell-mediated tissue damage, it is also likely that IL-22 is one of possible cytokines involved in the progression of the disease. In order to assess the involvement of IL-22 in periodontal diseases, we evaluated the expression level of IL-22 and IL-22 receptors in the periodontal lesions and the production level of IL-22 of peripheral blood T cells specific to periodontal antigens. Firstly, gene expression of IL22 and IL22RA were evaluated in the lesional sites and their control sites in each gingival biopsy sample. As a result, we could detect IL22RA expression in almost all gingival biopsy samples; however, the expression of IL22 could be detected in only a few samples. When compared between lesional sites and control sites, the gene expression levels of IL22RA in lesional sites were significantly higher than control sites. Next, we evaluated the IL-22 production of Th cell clones specific to Ag53 of P. gingivalis, which were derived from PBMCs. As a result, we could detect the IL-22 production in many T cell clones established in this study. Most of Th cell clones also had potential to produce IL-13 and IFN-γ, however, we could not find the correlations between IL-22 productivities and the production of these cytokines. From these findings, it might be implicated in the pathogenesis of the periodontal diseases that there are few numbers of Th cell producing IL-22 in periodontal lesions as compared with the numbers of IL-22 producing cells in the peripheral blood Th cells responding specific to the periodontal bacterial antigens.

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (68 results)

All 2008 2007 2006

All Journal Article (34 results) (of which Peer Reviewed: 20 results) Presentation (32 results) Book (2 results)

  • [Journal Article] Enhanced suppression of pulmonary metastasis of malignant melanoma cells by combined administration of alpha-galactosylceramide and interleukin-182008

    • Author(s)
      Shoji Nishio
    • Journal Title

      Cancer Science 99(1)

      Pages: 113-120

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Histochemical demonstration of aluminum and iron deposition in pulmonary bony tissues in three cases of diffuse pulmonary ossification2008

    • Author(s)
      Yuji Ohtsuki
    • Journal Title

      Histology and Histopathology 23(2)

      Pages: 137-141

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Role of human non-invariant NKT lymphocytes in the maintenance of type 2 T helper environment during pregnancy2008

    • Author(s)
      Yasushi Uemura
    • Journal Title

      International Immunology 20(3)

      Pages: 405-412

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Polymorphisms in the 5'flanking region of IL12RB2 are associated with susceptibility to periodontal diseases in the Japanese population2008

    • Author(s)
      Hideki Ohyama
    • Journal Title

      Journal of Clinical Periodontology 35(4)

      Pages: 317-323

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Distinct subsets of human invariant NKT cells differentially regulate Thelper responses via dendritic cells2008

    • Author(s)
      Tian-Yi Liu
    • Journal Title

      European Journal of Immunology 38(4)

      Pages: 1012-1023

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Differential effects of polymorphisms in the 5' flanking region of IL12RB2 on NK and T cell activity2008

    • Author(s)
      Hideki Ohyama
    • Journal Title

      Journal of Interferon & Cytokine Research (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] HLA-II-induced cytokines from human gingical fibroblasts promotes proliferation of human umbilical vein endothelial(HUVEC)cells:potential association with enhanced angiogenesis in chronic periodontal inflammation2008

    • Author(s)
      Yuka Okada
    • Journal Title

      Journal of Periodontal Research (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Histochemical demonstration of aluminum and iron deposition in pulmonayr bony tissues in three cases of diffuse pulmonary ossification.2008

    • Author(s)
      Yuji Ohtsuki
    • Journal Title

      Histology and Histopathology 23(2)

      Pages: 137-141

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Role of human non-invariant NKT lymphocytes in the maintenance of type 2 T helper environment during pregnancy.2008

    • Author(s)
      Yasushi Uemura
    • Journal Title

      International Immunology 20(3)

      Pages: 405-412

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Polymorphisms in the 5'flanking region of IL12RB2 are associated with susceptibility to periodontal diseases in the Japanese population.2008

    • Author(s)
      Hideki Ohyama
    • Journal Title

      Journal of Periodontal Research 35(4)

      Pages: 317-323

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Distinct subsets of human invariant NKt cells defferentially regulate T helper responses via dendritic cells.2008

    • Author(s)
      Tian-Yi Liu
    • Journal Title

      European Journal of Immunology 38(4)

      Pages: 1012-1023

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Differential effects of polymorphisms in the 5' flanking region of IL12RB2 on NK and T cell activity.2008

    • Author(s)
      Hideki Ohyama
    • Journal Title

      Journal of Interferon & Cytokine Research (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] HLA-II-induced cytokines from human gingical fibroblasts prmotes proliferation of human umbilical vein endothelial(HUVEC) cells : potential association with enhanced angiogenesis in chronic peridontal infalmmation.2008

    • Author(s)
      Yuka Okada
    • Journal Title

      Journal of Periodontal Research (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Polymorphisms in the 5' flanking region of IL12RB2 are associated with susceptibility to periodontal diseases in the Japanese population2008

    • Author(s)
      Kazu Takeuchi-Hatanaka
    • Journal Title

      Journal of Clinical Periodontology 35

      Pages: 317-323

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential effects of polymorplusms in the 5' flanking region of IL12RB2 on,NK and T cell activity2008

    • Author(s)
      Hideki Ohyama
    • Journal Title

      Journal of Interferon&Cytokine Research (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Distinct subsets of human invariant NKT cells differentially regulate T helper responses via dendridc cells2008

    • Author(s)
      Tian-Yi Liu
    • Journal Title

      European Journal of Immunology 38

      Pages: 1012-1023

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of human non-invariant NKT lymphocytes in the maintenance of type 2 Thelper environment during pregnancy2008

    • Author(s)
      Yasushi Uemura
    • Journal Title

      International Immunology 20

      Pages: 405-412

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Focal adhesion kinase mediates human leukocyte histocompatibility antigen class II-induced signaling in gingival fibroblasts2007

    • Author(s)
      Sayuri Yoshizawa
    • Journal Title

      Journal of Periodontal Research 42(6)

      Pages: 572-579

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Inflammatory malignant fibrous histiocytoma originating from the infrat emporal fossa and extruding into the external auditory meatus2007

    • Author(s)
      Koji Yamanegi
    • Journal Title

      Pathology 39(3)

      Pages: 371-373

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Epithelial-myoepithelial carcinoma arising in the nasal cavity2007

    • Author(s)
      Koji Yamanegi
    • Journal Title

      Auris Nasus Larynx (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Female adnexal tumor of probable wolffian origin(FATPWO)の1症例2007

    • Author(s)
      脇本 栄子
    • Journal Title

      産科と婦人科 74(3)

      Pages: 362-365

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 転移性肝平滑筋肉腫切除および動注化学療法後の区域胆肝壊死の1剖検例2007

    • Author(s)
      中正 恵二
    • Journal Title

      診断病理 24(1)

      Pages: 77-82

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 免疫組織化学的にアポクリン細胞および神経内分泌細胞への分化を伴った乳腺glycogen-rich clear cell carcinomaの1例2007

    • Author(s)
      中正 恵二
    • Journal Title

      診断病理 24(3)

      Pages: 311-320

    • NAID

      10019729091

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Focal adhesion kinase mediates human leukocyte histocompatibility antigen class II-indecued signaling in gingival fibroblasts.2007

    • Author(s)
      Sayuri Yoshizawa
    • Journal Title

      Journal of Periodontal Research 42(6)

      Pages: 572-579

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Inflammatory malignant fibrous hisitiocytoma originating from the infratemporal fossa and extruding into the external additory meatus.2007

    • Author(s)
      Koji Yamanegi
    • Journal Title

      Pathology 39(3)

      Pages: 371-373

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Epithelial-myoepthelial carcinoma arising in the nasal cavity.2007

    • Author(s)
      Koji Yamanegi
    • Journal Title

      Auris Nasus Larynx (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Focal adhesion kinase(FAK)mediates human leukocyte histocompatibility antigen(HLA) CLASS II-induced signaling in gingival fibroblasts.2007

    • Author(s)
      Sayuri Yoshizawa
    • Journal Title

      Journal of Periodontal Research (In press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Effect of interleukin-18 on metastasis of mouse osteosarcoma cells2006

    • Author(s)
      Yoshiteru Nakamura
    • Journal Title

      Cancer Immunology, Immunotherapy. 55(9)

      Pages: 1151-1158

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Oncocytic non-functioning endocrine tumor of the pancreas2006

    • Author(s)
      Ayako Sugihara
    • Journal Title

      Pathology International 56(12)

      Pages: 755-759

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] ハンセン病に対する感受性および病型形成に関わる免疫遺伝学的背景2006

    • Author(s)
      大山 秀樹
    • Journal Title

      化学療法の領域 22(9)

      Pages: 71-77

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] びまん性肺骨形成(diffuse puhnonary ossification;DPO)の一例2006

    • Author(s)
      大山 秀樹
    • Journal Title

      診断病理 23(4)

      Pages: 266-270

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Effect of interleukin-18 on metastasis of mouse osteosarcoma cells2006

    • Author(s)
      Yoshiteru Nakamura
    • Journal Title

      Cancer Immunology, Immunotherapy 55(9)

      Pages: 1151-1158

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Oncocytic non-functioning endocrine tumor of the pancreas.2006

    • Author(s)
      Ayako Sugihara
    • Journal Title

      Pathology International 56(12)

      Pages: 755-759

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] ハンセン病に対する感受性および病型形成に関わる免疫遺伝学的背景2006

    • Author(s)
      大山 秀樹
    • Journal Title

      化学療法の領域 22

      Pages: 71-77

    • Related Report
      2006 Annual Research Report
  • [Presentation] FAK mediates HLA class II-induced signaling in gingival fibroblasts2007

    • Author(s)
      Michio Meguro
    • Organizer
      日本免疫学会総会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-22
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Effects of HLA-II-induced CXC chemokines from human gingival fibroblasts on the proliferation of HUVEC cells2007

    • Author(s)
      Yuka Okada
    • Organizer
      日本免疫学会総会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-22
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 歯周炎感受性に関する免疫遺伝学的アプローチーハンセン病を疾患モデルとして捉えた研究-2007

    • Author(s)
      大山 秀樹
    • Organizer
      日本口腔病理学会総会・学術大会
    • Place of Presentation
      岐阜
    • Year and Date
      2007-08-11
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 歯周炎感受性に関する免疫遺伝学的アプローチ2007

    • Author(s)
      大山 秀樹
    • Organizer
      日本口腔病理学会総会・学術大会
    • Place of Presentation
      岐阜
    • Year and Date
      2007-08-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] HLA-DR分子を介した刺激によってヒト歯肉線維芽細胞から産生されるCXCケモカインの膀帯静脈内皮細胞の増殖への影響2007

    • Author(s)
      岡田 祐佳
    • Organizer
      第126回日本歯科保存学会春季学術大会
    • Place of Presentation
      埼玉
    • Year and Date
      2007-06-07
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] PGE2 produced from fibroblasts via HLA-II stimulation regulates Th1/Th2 polarization2007

    • Author(s)
      Hideki Ohyama
    • Organizer
      85th International Association for Dental Research
    • Place of Presentation
      New Orleans(USA)
    • Year and Date
      2007-03-22
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] PGE2 produced from fibroblasts via HLA-II stimulation regulates Thl/Th2 polarization.2007

    • Author(s)
      Hideki Ohyama
    • Organizer
      85th International Association for Dental Research.
    • Place of Presentation
      New Orleans(USA)
    • Year and Date
      2007-03-22
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] カポジ肉腫ウィルスK8βはK8α(K-bZIP)の生物学的機能をコントロールしている2007

    • Author(s)
      山根木 康嗣
    • Organizer
      第96回日本病理学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2007-03-15
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 胆嚢mucin-producing carcinomaの1例2007

    • Author(s)
      杉原 綾子
    • Organizer
      第96回日本病理学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2007-03-14
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 胆嚢Hepatoid adenccrcinomaの1症例2007

    • Author(s)
      中正 恵二
    • Organizer
      第96回日本病理学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2007-03-14
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 自己免疫性肝炎に非アルコール性脂肪性肝炎の合併が示唆された1例2007

    • Author(s)
      中正 恵二
    • Organizer
      第96回日本病理学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2007-03-14
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 非アルコール性脂肪性肝炎を伴なう肝細胞癌の3症例2007

    • Author(s)
      中正 恵二
    • Organizer
      第96回日本病理学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2007-03-14
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] クラスII HLA分子を介した刺激を受けた歯肉線維芽細胞によるTh1/Th2応答性の制御2007

    • Author(s)
      大山 秀樹
    • Organizer
      第96回日本病理学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2007-03-14
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 骨髄移植患者に発症したアスペルギルス症から肺梗塞を伴ない死亡に至った症例2007

    • Author(s)
      堀内 日佐世
    • Organizer
      第96回日本病理学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2007-03-13
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] IL-18とα・ガラクトシルセラミドの併用による癌の肺転移抑制の機構2007

    • Author(s)
      西尾 祥史
    • Organizer
      第96回日本病理学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2007-03-13
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Role of non-invariant NKT cells in the maintenance of uterine Th2 environment during pregnancy2006

    • Author(s)
      Motoharu Suzuki
    • Organizer
      第36回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2006-12-13
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Dendritic cell-mediated Th deviation controlled by functionally distinct subsets of NKT cells2006

    • Author(s)
      Tianyi Liu
    • Organizer
      第36回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2006-12-13
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 左鼻腔腫瘍の一例2006

    • Author(s)
      山根木 康嗣
    • Organizer
      第35回日本病理学会近畿支部学術集会
    • Place of Presentation
      京都
    • Year and Date
      2006-12-09
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 歯肉線維芽細胞内のサイトカイン産生に関わるHLA-II分子を介した刺激伝達へのFAKの関与2006

    • Author(s)
      吉澤 さゆり
    • Organizer
      第125回日本歯科保存学会秋季学術大会
    • Place of Presentation
      鹿児島
    • Year and Date
      2006-11-09
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 歯周組織におけるクラスII HLA分子が関わる免疫防御機構2006

    • Author(s)
      大山 秀樹
    • Organizer
      大阪大学大学院歯学研究科21世紀COEシンポジウム2006「歯周組織のバイオロジー, 基礎から臨床まで」
    • Place of Presentation
      大阪
    • Year and Date
      2006-10-22
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The effects of 5'flanking region gene polymorphism of IL12RB2 on NK cell activity2006

    • Author(s)
      Hideki Ohyama
    • Organizer
      Forty-first Tuberculosis and Leprosy Research Conference, US-Japan Cooperative Medical Science Program
    • Place of Presentation
      Kagoshima(Japan)
    • Year and Date
      2006-07-19
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The effects of 5'flanking region gene polymorphism of IL12RB2 on NK cell activity.2006

    • Author(s)
      Hideki Ohyama
    • Organizer
      Forty-first Tuberculosis and Leprosy Research Conference, US-Japan Cooperative Medical Science Program.
    • Place of Presentation
      Kagoshima(Japan)
    • Year and Date
      2006-07-19
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] FAK mediates HLA-II-induced signaling in gingival fibroblasts2006

    • Author(s)
      Sayuri Yoshizawa
    • Organizer
      84th International Association for Dental Research
    • Place of Presentation
      Brisbane(Australia)
    • Year and Date
      2006-06-28
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] FAK mediates HLA-II-induced signaling in gingival fibroblasts.2006

    • Author(s)
      Sayuri Yoshizawa
    • Organizer
      84th International Association for Dental Research.
    • Place of Presentation
      Brisbane(Australia)
    • Year and Date
      2006-06-08
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] HLA-DR分子を介した刺激によってヒト歯肉線維芽細胞はGRO(growth-related oncogene)を産生する2006

    • Author(s)
      目黒 道生
    • Organizer
      第124回日本歯科保存学会春季学術大会
    • Place of Presentation
      横浜
    • Year and Date
      2006-05-28
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 肝Nodular Regenerative Hyperplasia(NRH)の2剖検例2006

    • Author(s)
      中正 恵二
    • Organizer
      第95回日本病理学会総会
    • Place of Presentation
      東京
    • Year and Date
      2006-05-01
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 胆嚢原発のhepatoid adenocarcinomaの1切除例2006

    • Author(s)
      杉原 綾子
    • Organizer
      第95回日本病理学会総会
    • Place of Presentation
      東京
    • Year and Date
      2006-05-01
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 肝炎症性偽腫瘍の1例2006

    • Author(s)
      大山 秀樹
    • Organizer
      第95回日本病理学会総会
    • Place of Presentation
      東京
    • Year and Date
      2006-05-01
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 混合型肝癌を合併した原発性胆汁性肝硬変(PBC)の1剖検例2006

    • Author(s)
      中正 恵二
    • Organizer
      第95回日本病理学会総会
    • Place of Presentation
      東京
    • Year and Date
      2006-05-01
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Non-alcoholic steatohepatitisを背景に伴う肝細胞癌"clear cell type"の1例2006

    • Author(s)
      平野 博嗣
    • Organizer
      第95回日本病理学会総会
    • Place of Presentation
      東京
    • Year and Date
      2006-05-01
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 脾炎症性偽腫瘍の1例2006

    • Author(s)
      寺田 信行
    • Organizer
      第95回日本病理学会総会
    • Place of Presentation
      東京
    • Year and Date
      2006-05-01
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 早期発症型歯周炎患者におけるP.gingivalis由来53kDa外膜蛋白に対するT細胞応答性2006

    • Author(s)
      大山 秀樹
    • Organizer
      第95回日本病理学会総会
    • Place of Presentation
      東京
    • Year and Date
      2006-05-01
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 「総説現代ハンセン病医学」:第1部 基礎医学の進歩 第4章 ハンセン病の免疫遺伝学2007

    • Author(s)
      大山 秀樹, 大谷 藤郎監修
    • Total Pages
      471
    • Publisher
      東海大学出版会(神奈川)
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 総説現代ハンセン病医学2007

    • Author(s)
      大谷藤郎
    • Total Pages
      468
    • Publisher
      東海大学出版会
    • Related Report
      2006 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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