Development of new therapy for vitreoretinal disorders with enzymatic vitreolysis

• Project/Area Number: 18599005
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Saga University
• Principal Investigator: HIRATA Akira Saga University, Department of Ophthalmology, Associate Professor (60295144)
• Project Period (FY): 2006 – 2007
• Project Status: Completed (Fiscal Year 2007)
• Budget Amount: ¥3,790,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2006: ¥2,100,000 (Direct Cost: ¥2,100,000)
• Keywords: plasmin / vitrectomv / 網膜 / 硝子体 / プラスミン

Research Abstract

Establishment of vitreous surgery with plasmin: After institutional review board approval, vitrectomy with using plasmin was performed for 6 eyes of 4 patients. All eyes treated with autologous plasmin required significantly less surgical time. Also, we published our data regarding beneficial results in the surgical management of proliferative diabetic retinopathy and retinopathy of prematurity usefulness. All eyes showed visual
Effect of bevacizumab on choriocapillaris : We presented that bevacizumab injected into the vitreous cavity caused decrease of the number of fenestrae in choriocapillaris
Effect of retinal sealant with enzymatic vitreolysis : We are still investigating the effect of retinal sealant with enzymatic vitreolysis on experimental retinal detachment in rabbit eye.

Research Products

• [Journal Article] Y-27632, a Rho-associated protein kinase inhibitor, attenuates neuronal cell death after transient retinal ischemia (2008)
  • Author(s): Hirata, A., Inatani, M., Inomata, Y., Yonemura, N., Kawaji, T., Honjo, M., anihara, TH
  • Journal Title: Graefes Arch Clin Exp Ophthalmol 246 Pages: 51-59
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Y-27632,a Rho-associated protein kinase inhibitor, attenuates neuronal cell death after transient retinal ischemia (2008)
  • Author(s): Hirata A, Inatani M, Inomata Y, Yonemura N, Kawaji T, Honjo M, Tanihara H.
  • Journal Title: Graefes Arch Clin Exp Ophthalmol. 246 Pages: 51-59
  • Peer Reviewed
• [Journal Article] Plasmin-assisted vitrectomy for management of proliferative membrane in prolifbrative diabetic retinopathy (2007)
  • Author(s): Hirata A, Takano A, Inomata Y, Yonemura N, Sagara N, Tanihara H.
  • Journal Title: Retina 27 Pages: 139-141
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Autologous plasmin assisted vitrectomy for stage 5 retinopathy of prematurity (2007)
  • Author(s): Tsukahara Y, Honda S, Imai H, Kondo N, Fujii S, Yokoyama N, Hirata A, Kawaji T, Fukushima M, Tanihara H, Negi A.
  • Journal Title: Am.J.Ophthalmol. 144 Pages: 139-141
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] プラスミン注入後の空気タンポナーデによる実験的後部硝子体剥離作製 (2007)
  • Author(s): 下村 由起子, 平田 憲, 沖波 聡
  • Journal Title: 眼科臨床医報 Pages: 853-855
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Plasmin-assisted vitrectomy for management of proliferative membrane in proliferative diabetic retinopathy. (2007)
  • Author(s): Hirata, A., Talcano, A., Inomata, Y., Yonemura, N., Sagara, N., Tanihara, H
  • Journal Title: Retina 27 Pages: 1074-1078
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Autologous plasmin assisted vitrectomy for stage 5 retinopathy of prematurity (2007)
  • Author(s): Tsukahara, Y., Honda, S., Imai, H., Kondo, N., Fujii, S., Yokoyama, N., Hirata, A., Kawaji, T., Fukushima, M., Tanihara, H., Negi, A
  • Journal Title: Am. J. Ophthalmol 144 Pages: 139-141
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Plasmin-assisted vitrectomy for management of proliferative membrane in proliferative diabetic retinopathy (2007)
  • Author(s): Hirata A, Takano A, Inomata Y, Yonemura N, Sagara N, Tanihara H.
  • Journal Title: Retina 27 Pages: 1074-1078
  • Peer Reviewed
• [Journal Article] Autologous plasmin assisted vitrectomy for stage 5 retinopathy of prematurity (2007)
  • Author(s): Tsukahara Y, Honda S, Imai H, Kondo N, Fujii S, Yokoyama N, Hirata A, Kawaji T, Fukushima M, Tanihara H, Negi A.
  • Journal Title: Am.J.Ophthalmol. 144 Pages: 139-141
  • Peer Reviewed
• [Journal Article] プラスミン注入後の空気タンポナーデによる実験的後部硝子体剥離作製. (2007)
  • Author(s): 下村 由起子, 平田 憲, 沖波 聡
  • Journal Title: 眼科臨床医報 Pages: 853-855
  • Peer Reviewed
• [Journal Article] Plasmin-assisted vitrectomy for management of proliferative membrane in proliferative diabetic retinopathy
  • Author(s): Hirata, Takano, Inomata, Yonemura, Tanihara
  • Journal Title: Retina