Lung cancer cells metastasize together with tumor-derived host cells

• Project/Area Number: 18599007
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: Keio University
• Principal Investigator: KOHNO Mitsutomo Keio University, 医学部, 助教 (10276272)
• Co-Investigator(Kenkyū-buntansha): KOBAYASHI Koichi 慶應義塾大学, 医学部, 名誉教授 (80051704) ; HORINOUCHI Hirohisa 慶應義塾大学, 医学部, 准教授 (60173647) ; WATANABE Masazumi 慶應義塾大学, 医学部, 講師 (90201227) ; IZUMI Yotaro 慶應義塾大学, 医学部, 助教 (90245506)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,600,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥600,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2006: ¥1,000,000 (Direct Cost: ¥1,000,000)
• Keywords: 肺癌 / がん転移 / ストローマ細胞 / 呼吸器外科学 / がん / 転移

Research Abstract

がん転移のメカニズムに関してはさまざまな研究がなされ、宿主-腫瘍間の相互作用の重要性が認識されてきている。原発腫瘍ががん細胞とストローマ細胞(間質細胞)とで構成された細胞集塊を血流に放出し、肺に到達したストローマ細胞はがん細胞とともに微小転移巣を形成することを明らかにした。実験的肺転移モデルではストローマ細胞を含む細胞集塊内のがん細胞はviability が高く、ストローマ細胞を含む細胞集塊の方が転移形成能が高いことが明らかとなった。増殖に適した微小環境を作り出す原発巣のストローマ細胞ががん細胞とともに転移先に到達し、がんが転移巣を形成出来る確率を高めていることが示唆された。

Research Products

• [Journal Article] Occult injury in the residual lung after pneumonectomy in mice (2008)
  • Author(s): Tajima A, Kohno M, Watanabe M, Izumi Y, Tasaka S, Maruyama I, Miyasho T, Kobayashi K.
  • Journal Title: Interact Cardiovasc Thorac Surg.(Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Systemic Administration of Hemoglobin Vesicle Elevates Tumor Tissue Oxygen Tension and Modifies Tumor Response to Irradiation (2008)
  • Author(s): Yamamoto M, Izumi Y, Horinouchi H, Teramura Y, Sakai H, Kohno M, Watanabe M, Kawamura M, Adachi T, Ikeda E, Takeoka S, Tsuchida E, Kobayashi K.
  • Journal Title: JSurg Res 2008(Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Histopathological changes of rat brain after direct injection of Hb-vesicles (artificial oxygen carriers) and neurological impact in an intracerebral hemorrhage model (2008)
  • Author(s): Sakai H, Okamoto M, Ikeda E, Horinouchi H, Kobayashi K, Tsuchida E.
  • Journal Title: J Biomed Mater Res A.(Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Structure, photophysical property, and cytotoxicity of human serum albumin complexed with tris(dicarboxymethylene)[60]fullerene (2008)
  • Author(s): Qu X, Komatsu T, Sato T, Glatter O, Horinouchi H, Kobayashi K, Tsuchida E.
  • Journal Title: Bioconjug Chem.(Epub 2008 Jul 22) 19(8) Pages: 1556-1560
  • Peer Reviewed
• [Journal Article] Histopathological features and prognostic significance of the micropapillary pattern in lung adenocarcinoma (2008)
  • Author(s): Kamiya K, Hayashi Y, Douguchi J, Hashiguchi A, Yamada T, Izumi Y, Watanabe M, Kawamura M, Horinouchi H, Shimada N, Kobayashi K, Sakamoto M.
  • Journal Title: Mod Pathol.(Epub 2008 May 30) 21(8) Pages: 992-1001
  • Peer Reviewed
• [Journal Article] Enhanced radiation response of a solid tumor with the artificial oxygen carrier 'albumin-heme' (2008)
  • Author(s): Horinouchi H, Yamamoto H, Komatsu T, Huang Y, Tsuchida E, Kobayashi K.
  • Journal Title: Cancer Sci.(Epub 2008 Apr 21) 99(6) Pages: 1274-1278
  • NAID: 10024007807
  • Peer Reviewed
• [Journal Article] Syndrome of inappropriate secretion of antidiuretic hormone after chemotherapy with vinorelbine (2008)
  • Author(s): Kuroda H, Kawamura M, Hato T, Kamiya K, Kawakubo M, Izumi Y, Watanabe M, Horinouchi H, Kobayashi K, Nakayama M.
  • Journal Title: Cancer Chemother Pharmacol 62(2) Pages: 331-333
  • Peer Reviewed
• [Journal Article] Exacerbation of bleomycin-induced injury and fibros is bypneumonectomy in the residual lung of mice (2008)
  • Author(s): Kakizaki T, Kohno M, Watanabe M, Tajima A, Izumi Y, Miyasho T, Tasaka S, Fukunaga K, Maruyama I, Ishizaka A, Kobayashi K.
  • Journal Title: Journal of Surgical Research (E-pub ahead)
  • Peer Reviewed
• [Journal Article] Occult injury in the residual lung after pneumonectomy in mice. (2008)
  • Author(s): Tajima A, Kohno M, Watanabe M, Izumi Y, Tasaka s, Maruyama I, Miyasho T, Kobayashi K.
  • Journal Title: Interact Cardiovasc Thorac Surg 7(6) Pages: 1114-1120
  • Peer Reviewed
• [Journal Article] 術前化学療法後に外科的切除し得た前縦隔原発Germ cell tumor with somatic typemalignancy の1 例 (2007)
  • Author(s): 高橋祐介, 池田達彦, 河野光智, 堀之内宏久, 林雄一郎, 小林紘一, 仁木利郎
  • Journal Title: 肺癌 47巻6号 Pages: 793-794
  • NAID: 110006475037
  • Peer Reviewed
• [Journal Article] 縦隔へ向かって発育を示した鎖骨原発軟骨肉腫の1例 (2007)
  • Author(s): 江間俊哉, 江口圭介, 井澤菜緒子, 高橋祐介, 池田達彦, 朝倉啓介, 塚田紀理, 河野光智, 泉陽太郎, 渡辺真純, 堀之内宏久, 川村雅文, 小林紘一
  • Journal Title: 日本呼吸器外科学会雑誌 21巻6号 Pages: 850-853
  • NAID: 110006452377
  • Peer Reviewed
• [Journal Article] Hemostatic efficacy of a recombinant thrombin-coated polyglycolic acid sheet coupled with liquid fibrinogen, evaluated in a canine model of pulmonary arterial hemorrhage (2007)
  • Author(s): Izumi Y, Gika M, Shinya N, Miyabashira S, Imamura T, Nozaki C, Kawamura M, Kobayashi K.
  • Journal Title: J Trauma.(discussion 787) 63(4) Pages: 783-787
  • Peer Reviewed
• [Journal Article] The short-term efficacy of fibrin glue combined with absorptive sheet material in visceral pleural defect repair (2007)
  • Author(s): Gika M, Kawamura M, Izumi Y, Kobayashi K.
  • Journal Title: Interact Cardiovasc Thorac Surg 6(1) Pages: 12-15
  • Peer Reviewed
• [Journal Article] Prediction of anti-tumour effect of thermochemotherapy with in vitro thermochemosensitivity testing for non-small cell lung cancer (2007)
  • Author(s): Abiko T, Kawamura M, Izumi Y, Oyama T, Saito Y, Kobayashi K.
  • Journal Title: Int J Hyperthermia. 23(3) Pages: 267-275
  • Peer Reviewed
• [Journal Article] Cross-linked poly (gamma-glutamic acid) attenuates peritoneal adhesion in arat model (2007)
  • Author(s): Izumi Y, Yamamoto M, Kawamura M, Adachi T, Kobayashi K.
  • Journal Title: Surgery 141(5) Pages: 678-681
  • Peer Reviewed
• [Journal Article] Hyperthermia-enhanced tumor accumulation and antitumor efficacy of a doxorubicin-conjugate with a novel macromolecular carrier system in mice with non-small cell lung cancer (2007)
  • Author(s): Oyama T, Kawamura M, Abiko T, Izumi Y, Watanabe M, Kumazawa E, Kuga H, Shiose Y, Kobayashi K.
  • Journal Title: Oncol Rep. 17(3) Pages: 653-659
  • Peer Reviewed
• [Journal Article] Phase II trial of gemcitabine and docetaxel in patients with completely resected stage IIA-IIIA non-small-cell lung cancer (2007)
  • Author(s): Kawamura M, Eguchi K, Izumi Y, Yamato Y, Koike T, Sakaguchi H, Hada E, Kobayashi K.
  • Journal Title: Cancer Chemother Pharmacol 60(4) Pages: 495-501
  • Peer Reviewed
• [Journal Article] 術前化学療法後に外科的切除し得た前縦隔原発Germ cell tumor with somatic type mahgnancyの1例 (2007)
  • Author(s): 高橋 祐介, 池田 達彦, 河野 光智, 堀之内 宏久, 林雄 一郎, 小林 紘一, 仁木 利郎
  • Journal Title: 肺癌 47 Pages: 793-794
  • Peer Reviewed
• [Journal Article] 縦隔へ向かって発育を示した鎖骨原発軟骨肉腫の1例 (2007)
  • Author(s): 江間 俊哉, 江口 圭介, 井澤 菜緒子, 高橋 祐介, 池田 達彦, 朝倉 啓介, 塚田 紀理, 河野 光智, 泉 陽太郎, 渡辺 真純, 堀之内 宏久, 川村 雅文, 小林 紘一
  • Journal Title: 日本呼吸器外科学会雑誌 21 Pages: 850-853
  • NAID: 110006452377
  • Peer Reviewed
• [Journal Article] Hyperthermia-enhanced tumor accumulation and antitumor efficacy of a doxorubicin-conjugate with a novel macromolecular carrier system in mice with non-small cell lung cancer. (2007)
  • Author(s): Oyama T, Kawamura M, Abiko T, Izumi Y, Watanabe M, Kumazawa E, Kuga H, Shiose Y, Kobayashi K
  • Journal Title: Oncol Rep. 17(3) Pages: 653-659
• [Journal Article] Effects of initial passage of endotoxin through the liver on the extent of acute lung injury in a rat model (2006)
  • Author(s): Shimada H, Hasegawa N, Koh H, Tasaka S, Shimizu M, Yamada W, Nishimura T, Amakawa K, Kohno M, Sawafuji M, Nakamura K, Fujishima S, Yamaguchi K
  • Journal Title: Ishizaka A Shock 26(3) Pages: 311-315
  • Peer Reviewed
• [Journal Article] Early pulmonary resection for Mycobacterium avium complex lung disease treated with macrolides and quinolones (2006)
  • Author(s): Watanabe M, Hasegawa N, Ishizaka A, Asakura K, Izumi Y, Eguchi K, Kawamura M, Horinouchi H, Kobayashi K.
  • Journal Title: Ann Thorac Surg 81(6) Pages: 2026-2030
  • Peer Reviewed
• [Journal Article] Prognosis of surgically treated thymic epithelial tumors (2006)
  • Author(s): Horinouchi H, Asakura K, Kimura Y, Takeuchi K, Kawamura M, Watanabe M, Eguchi K, Kobayashi K
  • Journal Title: Nippon Geka Gakkai Zasshi 107(6) Pages: 262-267
  • NAID: 110004852494
• [Journal Article] Large chondrosarcoma of the rib invading the mediastinum an the spine. (2006)
  • Author(s): Morioka H, Yabe H, Kaneko S, Takaishi H, Ueda T, Watanabe M, Kobayashi K, Toyama Y
  • Journal Title: J Thorac Cardiovasc Surg. 132(4) Pages: 986-987
• [Journal Article] Exacerbation of bleomycin-induced injury and fibrosis by pneumonectomy in the residual lung of mice
  • Author(s): Kakizaki T, Kohno M, Watanabe M, Tajima A, Izumi Y, Miyasho T, Tasaka S, Fukunaga K, Maruyama I, Ishizaka A, Kobayashi K.
  • Journal Title: J Surg Res. (in press)
  • Peer Reviewed
• [Presentation] 実験的胸膜播種モデルにおける原発巣由来ストローマ細胞の関与についての検討 (2007)
  • Author(s): 河野 光智, 羽藤 泰, 泉 陽太郎, 渡辺 真純, 川村 雅文, 堀之内 宏久, 小林 紘一
  • Organizer: 第48回 日本肺癌学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2007-11-08