Mechanism of photomutagenicity of UV-irradiated food additives and pesticides

• Project/Area Number: 18602003
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 食の安全
• Research Institution: Tokyo University of Pharmacy and Life Science
• Principal Investigator: OHTA Toshihiro Tokyo University of Pharmacy and Life Science, 生命科学部, 教授 (10266893)
• Project Period (FY): 2006 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,380,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥780,000); Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2006: ¥1,000,000 (Direct Cost: ¥1,000,000)
• Keywords: 光遺伝毒性 / 変異原性 / 紫外線 / 食品添加物 / 農薬 / マルトール / 複合作用 / チアベンダゾール / 8-OHdG

Research Abstract

Maltol are used as a flavor enhancer in breads and cakes. It became mutagenic to bacteria, when the solution was irradiated with UV. Formaldehyde was detected in a crude fraction containing mutagenic photoproduct from UVC-irradiated maltol. However, formaldehyde contributed less than 10% of mutagenicity of the mutagenic fraction.

Research Products

• [Journal Article] Photomutagenic property of a flavoring maltol following UV-irradiation in S. (2007)
  • Author(s): Watanabe-Akanuma M, Inaba Y, Ohta T
  • Journal Title: typhimurium. Mutagenesis 22 Pages: 43-47
• [Journal Article] Additive mutagenic effects of DNA damages induced by multiple mutagens at virtually non-mutagenic dose level of each. (2007)
  • Author(s): Ohta, T.
  • Journal Title: Genes Environ 29 Pages: 141-145
  • NAID: 110006474278
• [Journal Article] Mutagenicity of UV-irradiated maltol in Salmonella typhimurium (2007)
  • Author(s): Watanabe-Akanuma, M., Y, Inaba, and T. Ohta
  • Journal Title: Mutagenesis 22 Pages: 43-47
  • Peer Reviewed
• [Journal Article] Additive mutagenic effects of DNA damages induced by multiple mutagens at virtually non-mutagenic dose level of each. (2007)
  • Author(s): Ohta, T.
  • Journal Title: Genes Environ. 29 Pages: 141-145
  • NAID: 110006474278
  • Peer Reviewed
• [Journal Article] Mutagenicity of UV-irradiated maltol in Salmonella typhimurium (2007)
  • Author(s): Watanabe-Akanuma, M.
  • Journal Title: Mutagenesis 22 Pages: 43-47
  • Peer Reviewed
• [Journal Article] Analysis of photomutagenicity of thiaben-dazole with UVA irradiation: absence of 8-hydroxyguanosine formation. (2006)
  • Author(s): Watanabe-Akanuma, M., Y, Inaba, T. Ohta
  • Journal Title: Genes Environ 28 Pages: 103-107
  • NAID: 110004793040
• [Journal Article] Mutagenic activity of a mixture of heterocyclic amines at doses below the biological threshold level of each. (2006)
  • Author(s): Ohta, T.
  • Journal Title: Genes Environ 28 Pages: 181-184
  • NAID: 110005717029
• [Journal Article] Analysis of photomutagenicity of thiabendazole with UVA irradiation : Absence of 8-hydroxy-guanosine formation (2006)
  • Author(s): Watanabe-Akanuma, M., Y, Inaba, and T. Ohta
  • Journal Title: Genes Environ 28 Pages: 103-107
  • Peer Reviewed
• [Journal Article] Analysis of photomutagenicity of thiabendazole with UVA irradiation : absence of 8-hydroxyguanosine formation (2006)
  • Author(s): Watanabe-Akanuma, M.
  • Journal Title: Genes and Environment 28 Pages: 103-107
• [Presentation] マルトールおよびエチルマルトール溶液へのUV照射によるホルムアルデヒドの生成 (2009)
  • Author(s): 赤沼三恵, 中島大介, 稲葉洋平, 内山茂久, 太田敏博
  • Organizer: 日本環境変異原学会第38回大会
  • Place of Presentation: 清水
  • Year and Date: 2009-11-26
• [Presentation] Photomutagenicity of sidestream smoke condensate of cigarette with UVA- irradiation (2009)
  • Author(s): 越田英史、荒井理沙、稲葉洋平、太田敏博
  • Organizer: 第38回日本環境変異原学会
  • Place of Presentation: 清水
• [Presentation] Formation of formalde- hyde from UV-irradiated maltol and ethylmaltol solution (2009)
  • Author(s): 赤沼三恵、中島大介、稲葉洋平、内山茂久、太田敏博
  • Organizer: 第38回日本環境変異原学会
  • Place of Presentation: 清水
• [Presentation] Formation of formaldehyde from UVirradiated maltol and ethylmaltol solution (2009)
  • Author(s): Ohta, T., Watanabe-Akanuma, M., Nakajima, D., Inaba, Y., Uchiyama, S.
  • Organizer: 10th International Conference on Environmental Mutagens
  • Place of Presentation: Firenze, Italy
• [Presentation] MaltolおよびEthylmaltol水溶液へのUV照射で生成する変異原の解析 (2008)
  • Author(s): 赤沼三恵、中島大介、山田樹里、角田真澄、太田敏博
  • Organizer: 日本環境変異原学会
  • Place of Presentation: 沖縄
  • Year and Date: 2008-12-05
• [Presentation] MaltolおよびEthylmaltol水溶液へのUV照射で生成する変異原の解析 (2008)
  • Author(s): 赤沼三恵、中島大介、山田樹里、角田真澄、太田敏博
  • Organizer: 第37回日本環境変異原学会大会
  • Place of Presentation: 沖縄
• [Presentation] Additive mutagenic effects of DNA damages formed by multiple mutagens at virtually non-mutagenic dose level of each. (2008)
  • Author(s): Ohta, T.
  • Organizer: International Symposium on Genotoxic and Carcinogenic Thresholds
  • Place of Presentation: Tokyo, Japan
• [Presentation] Mechanism of Photomutagenicity of UV-irradiated maltol solution (2007)
  • Author(s): Watanabe-Akanuma, M., Takagi, R., Hirai, K., and Ohta, T.
  • Organizer: 1st Asian Conference on Environmental Mutagens
  • Place of Presentation: Kokura, Japan
  • Year and Date: 2007-11-29
• [Presentation] Mechanism of Photomutage- nicity of UV-irradiated maltol solution. (2007)
  • Author(s): Watanabe-Akanuma, M., Takagi, R., Hirai, K., Ohta, T.
  • Organizer: 1st Asian Conference on Environmental Mutagens
  • Place of Presentation: Kokura, Japan
• [Presentation] マルトールのUV照射により生成する変異原物質の分離 (2006)
  • Author(s): 坂平昌英、太田敏博、山形秀夫、貝瀬利一、角田真澄、中島大介、後藤純雄、赤沼三恵
  • Organizer: 日本環境変異原学会
  • Place of Presentation: 堺
• [Presentation] マルトールおよびその構造類似体のUVAあるいはUVC照射による変異原性の発現 (2006)
  • Author(s): 赤沼三恵、太田敏博、角田真澄、中島大介、後藤純雄
  • Organizer: 日本環境変異原学会
  • Place of Presentation: 堺
• [Remarks]
  • URL: http://www.ls.toyaku.ac.jp/~lemb-5/