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Development of positron-emitting arsenic tracer by means of new generator system

Research Project

Project/Area Number 18602005
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 食の安全
Research InstitutionJapan Atomic Energy Agency

Principal Investigator

ISHIOKA Noriko  Japan Atomic Energy Agency, Quantum Beam Science Directorate, Assistant Principal Researcher (30354963)

Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥4,060,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥360,000)
Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2006: ¥2,500,000 (Direct Cost: ¥2,500,000)
KeywordsAs-73 / As-74 / tracer / production / cyclotron / GeO_2 / BAS / PETIS / As-72 / Se-72 / ジェネレーター / ヒ素 / ファイトレメディエーション
Research Abstract

Arsenic (As) is one of the most serious pollutants for soil and foods in Japan. The aim of this research project is to elucidate the dynamics of As on the absorption into / the transport inside plant individuals, using the positron emitting tracer imaging system (PETIS) and radioactive As tracer. We have developed a new method which is the separation of carrier-free ^<73>As and ^<74>As from bulk amount of germanium oxide (GeO2). ^<73,74>As has been produced through the reaction ^<nat>Ge(p, xn)^<73,74>As with 18 MeV protons obtained from TIARA AVF Cyclotron, JAEA. The separation is performed by the precipitation method of Ge compounds with NaOH and KCl. In the tracer solution we could find no detectable radionuclides besides ^<73,74>As. The ^<73,74>As tracers were fed to root of Soybean for 4 days. After that, we obtained images of distribution of ^<73,74>As tracers using autoradiography. As a conclusion, it is suggested that ^<73,74>As tracers are expected to obtain serial images of As transport inside living plant individuals.

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (25 results)

All 2009 2008 2007 2006 Other

All Journal Article (21 results) (of which Peer Reviewed: 8 results) Presentation (4 results)

  • [Journal Article] Production of no-carrier-added 64^<Cu> and applications to molecular imaging by PET and PETIS as a biomedical tracer2009

    • Author(s)
      Sh. Watanabe
    • Journal Title

      J. Radioanal. Nucl. Chem. 280

      Pages: 199-205

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Production of no-carrier-added ^<64>Cu and applications to molecular imaging by PET and PETIS as a biomedical tracer2009

    • Author(s)
      Sh. Watanabe
    • Journal Title

      J. Radioanal. Nucl. Chem. 280

      Pages: 199-205

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Cyclotron Production of PET Radionuclide : No-carrier-added Bromine-76 with Protons on Natural SeO_2 and KBr Targets2008

    • Author(s)
      N. S. Ishioka
    • Journal Title

      JAERI-Review 2007-060

      Pages: 127-127

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Production of Radioisotopes for Nuclear Medicine Using Ion-beam Technology and Its Utilization for Both Therapeutic and Diagnostic Application in Cancer2008

    • Author(s)
      Y. Iida
    • Journal Title

      JAERI-Review 2007-060

      Pages: 128-128

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 土壌中からのカドミウムの除去技術(ファイトレメディエーション)の実用化を目指した研究におけるポジトロンイメージング技術の貢献2008

    • Author(s)
      中村進一
    • Journal Title

      放射線と産業 117

      Pages: 9-13

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Cyclotron Production of PET Radionuclide: No-carrier-added Bromine-76 with Protons on Natural SeO_2 and KBr Targets2008

    • Author(s)
      N. S. Ishioka
    • Journal Title

      JAEA Takasaki Annual Report 2006, JAERI-Review 2007-060

      Pages: 127-127

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Production of Radioisotopes for Nuclear Medicine Using Ion-beam Technology and Its Utilization for Both Therapeutic and Diagnostic Application in Cancer2008

    • Author(s)
      Y. Iida
    • Journal Title

      JAEA Takasaki Annual Report 2006, JAERI-Review 2007-060

      Pages: 128-128

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Contribution of the positron imaging methods to studies on decontamination of cadmium from soil.2008

    • Author(s)
      Nakamura S
    • Journal Title

      Radiation & Industries 117

      Pages: 9-13

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] ^<76>Br- or ^<64>Cu-labeled antibody for immuno-PET in quantitative evaluation of radioimmunotherapy2007

    • Author(s)
      Y. Iida
    • Journal Title

      J. of Label. Compd. Radiopharm. 5O(S1)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Improved Separation of Cadmium-107 from Silver Cyclotron Targets by Precipitation Method2007

    • Author(s)
      N. S. Ishioka
    • Journal Title

      JAEA-Review 2006-042

      Pages: 162-162

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Production of positron-emitting Cadmium Tracer for Plant study2007

    • Author(s)
      N. S. Ishioka
    • Journal Title

      JAEA-Review 2006-042

      Pages: 127-127

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] ^<76>Br- or ^<64>Cu-labeled antibody for immuno-PET in quantitative evaluation of radioimmunotherapy2007

    • Author(s)
      Y. Iida
    • Journal Title

      J. of Label. Compd. Radiopharm. 50, S1

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Improved Separation of Cadmium-107 from Silver Cyclotron Targets by Precipitation Method2007

    • Author(s)
      N. S. Ishioka
    • Journal Title

      JAEA Takasaki Annual Report 2005, JAEA-Review 2006-042

      Pages: 162-162

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Non-Invasive Imaging of Cadmium Transport in Crop Plants2007

    • Author(s)
      S. Fujimaki
    • Journal Title

      JAEA Takasaki Annual Report 2005, JAEA-Review 2006-042

      Pages: 127-127

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 生命科学分野における放射性核種の有効利用2006

    • Author(s)
      石岡典子
    • Journal Title

      電機 10月号

      Pages: 10-15

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Production of positron-emitting Cadmium Tracer for Plant Study2006

    • Author(s)
      N. S. Ishioka
    • Journal Title

      JAEA-Review 2005-001

      Pages: 177-179

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Non-Invasive Imaging of Cadmium Transport in Crop Plants2006

    • Author(s)
      S. Fujimaki
    • Journal Title

      JAEA-Review 2005-001

      Pages: 177-179

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Effective Use of Radioisotopes in the Life Sciences2006

    • Author(s)
      N. S. Ishioka
    • Journal Title

      DENKI, The Japan Electrical Manufacturers Association

      Pages: 10-15

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Production of Positron-emitting Cadmium Tracer for Plant Study2006

    • Author(s)
      N. S. Ishioka
    • Journal Title

      TIARA Annual Report 2004, JAEA-Review 2005-001

      Pages: 277-179

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Chelationg ion-exchange methods or the preparation ofno-carrier-added ^<64>Cu

    • Author(s)
      Sh. Watanabe
    • Journal Title

      J. Nucl. Med. Bio. in press

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Novel Production Technique of No-carrier-added Cu-64 by using the Chelate-exchange Method

    • Author(s)
      Sh. Watanabe
    • Journal Title

      J. Nucl. Med. Bio. (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 医療ライフサイエンスへの応用を目指した放射性同位元素の開発2008

    • Author(s)
      石岡典子
    • Organizer
      H20年度若手研究者研究発表会(主催 : 日本原子力学会関東甲越支部)(招待講演)
    • Place of Presentation
      東京
    • Year and Date
      2008-10-24
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Effective Use of Radioisotopes in the Life Sciences2008

    • Author(s)
      N. S. Ishioka
    • Organizer
      7th Symposium on advanced atomic energy and radiation research for young researcher, Atomic Energy Society og Japan Invited speech
    • Place of Presentation
      Tokyo, JAPAN
    • Year and Date
      2008-10-24
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Br-76 or Cu-64 labeled antibody for immuno-PET in quantitative evaluation of radioimmunotherapy.2007

    • Author(s)
      Iida Y.
    • Organizer
      17th International Symposium on Radiopharmaceutical Sciences
    • Place of Presentation
      Aachen, Germany
    • Year and Date
      2007-05-02
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Br-76 or Cu-64 labeled antibody for immuno-PET in quantitative evaluation of radioimmunotherapy2007

    • Author(s)
      Iida Y
    • Organizer
      17th International Symposium on Radiopharmaceutical Sciences
    • Place of Presentation
      Aachen, Germany
    • Year and Date
      2007-05-02
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2006-04-01   Modified: 2016-04-21  

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