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Neural mechanisms which induce blood pressure fluctuation during REM sleep

Research Project

Project/Area Number 18603007
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 睡眠学
Research InstitutionFukushima Medical University

Principal Investigator

KAYAMA Yukihiko  Fukushima Medical University, School of Medicine, Professor (30035224)

Co-Investigator(Kenkyū-buntansha) KOYAMA Yoshimasa  Fukushima Univ., Dept of Science and Technology, Professor (80183812)
TAKAHASHI Kazumi  Fukushima Medical Univ., Scholl of Medicine, Lecturer (90325952)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥4,090,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2006: ¥2,400,000 (Direct Cost: ¥2,400,000)
KeywordsHypothalamus / Laterodorsal tegmental nucleus / Acetylcholine / Blood pressure / REM sleep / Autonomic nervous system / 外側視床下部 / ラット / ムスカリン性受容体
Research Abstract

During REM sleep, the homeostasis system does not show normal performance and large fluctuations of autonomic nervous systems appear. Little is known on the mechanisms how this fluctuation is generated and on the physiological significance of this fluctuation. In this study, the experiments were performed to elucidate the relationship of the hypothalamus and the brainstem for the regulation of blood pressure fluctuation during REM sleep, and we got the following results ;
1. The hypothalamus of urethane anesthetized rats was electrically stimulated every 200-400 μm through a carbon fiber electrode which was moved by oil-pressure manipulator. Blood pressure increase was induced after the stimulation to the lateral hypothalamus (LHA) and its surroundings, while posterior to this effective area, blood pressure decrease was induced.
2. Neuronal activity was recorded from unanesthetized head-restrained rats simultaneously with blood pressure. Some of the LHA neurons show close correlation with blood pressure increase during REM sleep.
3.Last year, we found that the cholinergic neurons in the laterodorsal tegmental nucleus (LDT) showed the correlation with blood pressure increase during REM sleep. So, this year, we performed simultaneous recording from the LHA and LDT and found that when the blood pressure increase during REM sleep, the activity of the LDT neurons preceded that of the LHA neurons.
These results suggest that for blood pressure fluctuation during REM sleep, the excitatory input from the LDT to the LHA have a crucial role.

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (16 results)

All 2008 2007 2006

All Journal Article (14 results) (of which Peer Reviewed: 4 results) Presentation (2 results)

  • [Journal Article] Penile erection and micturition events triggered by electrical stimulation of the mesopontine tegmental area2008

    • Author(s)
      Juan C. Toledo, H. Iwasaki, E., Jodo, M. H. Schmidt, A. Kawauchi, T. Miki, Y. Kayama, M. Otsuki, Y. Koyama
    • Journal Title

      American Journal of Physiology 292

      Pages: 102-111

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Penile erection and micturition events triggered by electrical stimulation of the mesopontine tegmental area2008

    • Author(s)
      Juan, C., Toledo, H., Iwasaki, E., Jodo, M., H., Schmidt, A., Kawauchi, T., Miki, Y., Kayama, M., Otsuki, Y., Koyama
    • Journal Title

      American Journal of Physiology 292

      Pages: 102-111

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Penile erection and micturition events triggered by electrical stimulation of the mesopontine tegmental area2008

    • Author(s)
      Juan C. Toledo, H. Iwasaki, E. Jodo, M. H. Schmidt, A. Kawauchi, T. Miki, Y. Kayama. M. Otsuki, Y. Koyama
    • Journal Title

      American Journal of Physiology 292

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acupuncture stimulation to the sacral segment affects the state of vigilance in rats2007

    • Author(s)
      Hui Wang, Yoshiyuki Tanaka, Eiich Jodo, Yukihiko Kayama, Akibiro Kawauchi, Tsuneharu Miki, Manabu Otsuki, Yoshimasa Koyama
    • Journal Title

      Neuroscience Research 57

      Pages: 531-537

    • NAID

      10024413906

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 脳幹網様体賦活系の各種神経細胞と覚醒機構2007

    • Author(s)
      小山 純正, 高橋 和巳
    • Journal Title

      Clinical Neuroscience 25

      Pages: 388-390

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Acupuncture stimulation to the sacral segment affects the state of vigilance in rats2007

    • Author(s)
      Hui, Wang, Yoshiyuki, Tanaka, Eiich, Jodo, Yukihiko, Kayama, Akihiro, Kawauchi, Tsuneharu, Miki, Manabu, Otsuki, Yoshimasa, Koyama
    • Journal Title

      Neuroscience Research 57

      Pages: 531-537

    • NAID

      10024413906

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Neuron groups in the activation system in the brainstem reticular formation2007

    • Author(s)
      Yoshimasa, Koyama, Kazumi, Takahashi
    • Journal Title

      Clinical Neuroscience 25

      Pages: 388-390

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Acupuncture stimulation to the sacral segment affects the state of vigilance in rats.2007

    • Author(s)
      Hui Wang, Yoshiyuki Tanaka, Eiich Jodo, Yukihiko Kayama, Akihiro Kawauchi, Tsuneharu Miki, Manabu
    • Journal Title

      Neuroscience Research 57: 531-537, 2007. 57

      Pages: 531-537

    • NAID

      10024413906

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 脳幹網様体賦活系の各種神経細胞と覚醒機構2007

    • Author(s)
      小山純正 高橋和巳
    • Journal Title

      Clinical Neuroscience 25

      Pages: 388-390

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Nitric oxide from the laterodorsal tegmental neurons : Its possible retrograde modulation on norepinephrine release from the axon terminal of the locus coeruleus neurons.2006

    • Author(s)
      Kodama T., Koyama Y.
    • Journal Title

      Neuroscience 138

      Pages: 245-256

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A Quartet Neural System Model Orchestrating Sleep and Wakefulness Mechanisms2006

    • Author(s)
      Tamakawa Y., Karashima A., Koyama Y., et al.
    • Journal Title

      J Neurophysiol 95 :, 2006. 95

      Pages: 2055-2069

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Neurobiological basis of state-dependent control of motor behaviors.2006

    • Author(s)
      Takakusaki K., Saito K., Nonaka T., Okumura T., Miyokawa N., Koyama Y.
    • Journal Title

      Sleep Biol Rhythms 4 : 87-104. 2006 4

      Pages: 87-104

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Requirement of tryptophan hydroxylase during development for maturation of sensorimotor gating2006

    • Author(s)
      Nakamura K., Koyama Y., Takahashi K., et al.
    • Journal Title

      J Mol Biol 363

      Pages: 345-354

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Suppressive effect of acupuncture stimulation to the sacral segment on the state of vigilance and the brainstem cholinergic neurons.2006

    • Author(s)
      Wang H., Koyama Y., Jodo E, Kayama Y.
    • Journal Title

      Fukushima Med J 52

      Pages: 125-134

    • NAID

      10026160003

    • Related Report
      2006 Annual Research Report
  • [Presentation] レム睡眠中の血圧変動に対する視床下部と脳幹の役割2007

    • Author(s)
      小山 純正、高橋 和巳、 香山 雪彦
    • Organizer
      日本睡眠学会第32回定期学術集会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-09
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] A role of the hypothalamus and brainstem in blood pressure fluctuation during REM sleep2007

    • Author(s)
      Yoshimasa, Koyama, Kazumi, Takahashi, Yukihiko, Kayama
    • Organizer
      The 32nd annual meeting of the Japanese Sleep Research Society
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-11-09
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2006-04-01   Modified: 2016-04-21  

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