Research Project
Grant-in-Aid for Scientific Research (C)
The objectives of the study was to investigate characteristics of restless legs syndrome (RLS) among a large sample taken from the general population of Japan. The presence of RLS was established by asking the subjects if they experienced a crawling sensation in their legs after going to bed. The survey was performed in June 2000, targeting a sample that was randomly selected from 300 communities throughout Japan. The questionnaire contained questions focusing on health consciousness, mental health, and sleep. A total of 26 705 participants completed the questionnaire. The prevalence of RLS was 3.0%, with a significant predominance in women. The prevalence of RLS increased significantly with advancing age. Multiple logistic regression analysis revealed that RLS was significantly associated with difficulty initiating sleep (odds ratio, OR = 2.58), excessive daytime sleepiness (OR = 2.28), difficulty maintaining sleep (OR = 1.71), non-restorative sleep (OR = 1.51), subjective insufficient sleep (OR = 1.36), and early morning awakening (OR = 1.21). These results suggest that the prevalence of RLS in Japan is lower than in northern European populations and that RLS is strongly associated with difficulty initiating sleep and excessive daytime sleepiness. As for the relation between RLS and other psycho-somatic complaints, Multiple logistic regression analysis revealed that RLS was significantly associated with palpitation/shortness of breath (OR=1.81), fragility (OR=1.55), backache (OR=1.50), constipation/diarrhea (OR=1.38), concern about health (OR=1.30), tenseness (OR=1.29), epigastric discomfort (OR=1.24) and stiff neck/shoulder (OR=1.24) in descending order of OR. These findings suggest that RLS involves not only deteriorated nocturnal sleep but also various somatic and psychological symptoms in the daytime.
All 2008 2007 2006
All Journal Article (29 results) (of which Peer Reviewed: 11 results)
Curr Med Res Opin 24
Pages: 307-17
Sleep Med Rev 11
Pages: 485-96
Sleep 30
Pages: 1155-61
Sleep Med 8
Pages: 723-32
J Am Geriatr Soc 55
Pages: 95-101
J Neurophysiol 95
Pages: 2293-2303
Sleep and Biological Rhythms 4
Pages: 153-159
精神科治療学 21・(増刊)
Pages: 378-381
臨床研修プラクティス 3
Pages: 34-40
医学のあゆみ 219
Pages: 1075-1079
精神神経学雑誌 108
Pages: 1230-1236
10020333791
Pages: 55-62
Pages: 2293-303
J Clin Psychiatry 67
Pages: 196-203
Sleep and Bilolgical Rhythms 4
精神科治療学 21・増刊
臨床研修プラクティス 3・12
医学のあゆみ 219・13
精神神経学雑誌 108・11
