| Project/Area Number |
18613015
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pain science
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| Research Institution | Tohoku Pharmaceutical University |
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Principal Investigator |
WATANABE Chizuko Tohoku Pharmaceutical University, 薬学部, 助教 (90296020)
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| Co-Investigator(Kenkyū-buntansha) |
櫻田 忍 (桜田 忍) 東北薬科大学, 薬学部, 教授 (30075816)
溝口 広一 東北薬科大学, 薬学部, 准教授 (30360069)
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| Project Period (FY) |
2006 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥690,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2006: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | ノシセプチン / 疼痛伝達 / 鎮痛作用 / 神経制御 / 脊髄 / 神経性御 |
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| Research Abstract |
The involvement of various neurotransmitters on spinal pain transmission was investigated in this project. As the results, it was found that nociceptin, hemokinin, histamine, endogenous cannabinoid, endogenous polyamine, as well as substance P and glutamate, participated on spinal pain transmission, and the spinal pain transmission was regulated by the mutual control of these neurotransmitter-containing neurons. In addition, it was also found that the supersensitivity of these neurotransmitters was occurred at the stage of the neuropathic pain to increase the pain sensation.
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