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Systemic and molecular analysis on the pathology of newly-developed myopathic chronic pain models

Research Project

Project/Area Number 18613020
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pain science
Research InstitutionAichi Medical University

Principal Investigator

KUMAZAWA Takao  Aichi Medical University, School of Medicine, Department of Algesiology, Professor (20022775)

Co-Investigator(Kenkyū-buntansha) HONDA Takashi  Fukushima Medical University, School of Nursing, Professor (20165608)
OHISHI Hitoshi  Aichi Medical University, School of Medicine, Department of Anatomy, Associate Professor (00252461)
橋本 辰幸  愛知医科大学, 医学部, 助手 (80367763)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥4,060,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥360,000)
Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2006: ¥2,500,000 (Direct Cost: ¥2,500,000)
Keywordschronic pain / animal model / muscle damage / immunohistochemistry / molecular biology / autonomic nervous system / spinal cord / glia / 筋障害 / 痛み
Research Abstract

In this study, two types of chronic pain animal models (myo-nociceptive model, cast-immobilization model) we had developed were used. The characteristics of these models are: 1) direct nerve injuries are not given; 2) bilateral wide-spread long-lasting pain behaviors are developed. The purpose of this study is to clarify the chronic pain mechanisms of these models.
1. In the chronic pain phase of these models, the contralateral hyperalgesia in the hind-paw was not affected by the ipsilateral sciatic nerve block. This result suggests the implication of central plasticity.
2. In the L4 dorsal horn of the cast-immobilization model, the microglias at the early phase after cast-removal and the astrocytes at the chronic pain phase had activated. When the paw hyperalgesia tend to attenuate, the activation of both types of spinal glial cells reduced. In the coccygeal cord, the microglial activation appeared in retard of that in the L4. The implication of spinal glial cells is suggested in this model. As the preliminary examination, IL-6 and BDNF mRNA expressions in spinal cord and muscles were determined by PCR.
3. In the cast-immobilization model, the autonomic parameters (blood pressure, heart rate) were telemetrically recorded, The sympathetic activity was augmented during cast-immobilization period and then decreased below the normal level while persisting pain behavior continued. In the chronic pain condition, the autonomic reactivities to cold-exposure were higher than in normal. Autonomic dysfunction in the chronic pain patients (e.g. CRPS type-I) is reported, so this model may be a partial explanation for those pathogenic conditions.
4. In the myo-nociceptive model, the treatment to young-age was not produced chronic pain behaviors. It is suggested any factors as a trigger to chronic pain may be immature.
5. Both of the minocycline injection and the treadmill exercise tended to decrease pain behaviors, though reexamination should be required.

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (69 results)

All 2008 2007 2006 Other

All Journal Article (30 results) (of which Peer Reviewed: 1 results) Presentation (29 results) Book (9 results) Remarks (1 results)

  • [Journal Article] 痛みの病態生理と理学療法2008

    • Author(s)
      熊澤 孝朗
    • Journal Title

      理学療法ジャーナル 42

      Pages: 87-94

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 生理的な痛覚系:痛覚受容器〜脊髄(講座「痛みの病態生理学」第4回)2008

    • Author(s)
      吉本 隆彦, ら
    • Journal Title

      理学療法 25

      Pages: 580-587

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 痛みの生物学的理解2008

    • Author(s)
      熊澤 孝朗
    • Journal Title

      EB Nursing 8(in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] How to grasp thePain(in Japanese)2008

    • Author(s)
      Kumazawa T
    • Journal Title

      Journey of the Research, Clinical Medicine. Ishiyakushuppan, Tokyo (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Current situation of the healthcare cooperation for the treatments of chronic pain patients.(in Japanese)2008

    • Author(s)
      Yamaguchi Y, Kumazawa T
    • Journal Title

      Understanding of Chronic Pain and the Healthcare Cooperation. Shinkokoekiisho, Tokyo (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Pathophysiology of pain and physical therapy.(in Japanese)2008

    • Author(s)
      Kumazawa T
    • Journal Title

      The Japanese Journal of Physical Therapy. 42

      Pages: 87-94

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Physiological pain system : from receptor to spinal cord and Pathophysiology of pain.(in Japanese)2008

    • Author(s)
      Yoshimoto T, Kumazawa T
    • Journal Title

      Journal of Physical Therapy 25

      Pages: 580-587

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Biological understanding of pain.(in Japanese)2008

    • Author(s)
      Kumazawa T
    • Journal Title

      EB Nursing 8(in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 特集「痛みの病態生理と理学療法」2008

    • Author(s)
      熊澤孝朗
    • Journal Title

      理学療法ジャーナル 42

      Pages: 87-94

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 痛みの病態生理学第4回「生理的な痛覚系(痛覚受容器〜脊髄)」2008

    • Author(s)
      吉本隆彦, 熊澤孝朗
    • Journal Title

      理学療法 25

      Pages: 580-587

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 慢性痛では何が起こっているか?そしてどう取り組むべきか2007

    • Author(s)
      熊澤 孝朗
    • Journal Title

      MB Orthopaedics 20

      Pages: 1-8

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 特集「リハビリテーションにおける疼痛コントロール」(編集)2007

    • Author(s)
      熊澤 孝朗
    • Journal Title

      MB Medical Rehabilitation 79

      Pages: 80-80

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 痛みについて:序論(講座「痛みの病態生理学」第1回)2007

    • Author(s)
      熊澤 孝朗
    • Journal Title

      理学療法 24

      Pages: 1485-1490

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 痛みについて:痛みの特性(講座「痛みの病態生理学」第2回)2007

    • Author(s)
      熊澤 孝朗
    • Journal Title

      理学療法 24

      Pages: 1597-1605

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Pain : Autonomic nervous system and biological warning system.(in Japanese)2007

    • Author(s)
      Kumazawa T
    • Journal Title

      Autonomic Nervous System Current Version.(ed. Uono K, Iriki M) Shinkoigakusha, Tokyo

      Pages: 94-103

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Knowledge of Pain.(in Japanese)2007

    • Author(s)
      Kumazawa T
    • Journal Title

      Tohoshuppan

      Pages: 180-180

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Chronic pain mechanisms : How should we address chronic pain?(in Japanese)2007

    • Author(s)
      Kumazawa T
    • Journal Title

      MB Orthopaedics 20

      Pages: 1-8

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Pain control on rehabilitation.(in Japanese)2007

    • Author(s)
      Kumazawa T, (editor)
    • Journal Title

      MB Medical Rehabilitation 79

      Pages: 1-80

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Pain : the introduction, Pathophysiology of pain.(in Japanese)2007

    • Author(s)
      Kumazawa T
    • Journal Title

      Journal of Physical Therapy 24

      Pages: 1485-1490

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Pain : the characteristics of pain, Pathophysiology of pain.(in Japanese)2007

    • Author(s)
      Kumazawa T
    • Journal Title

      Journal of Physical Therapy 24

      Pages: 1597-1605

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 痛みの病態生理学第1回「痛みについて:序論」2007

    • Author(s)
      熊澤孝朗
    • Journal Title

      理学療法 24

      Pages: 1485-1490

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 痛みの病態生理学第2回「痛みについて:痛みの特性」2007

    • Author(s)
      熊澤孝朗
    • Journal Title

      理学療法 24

      Pages: 1597-1605

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 慢性通では何が起こっているか?そしてどう取り組むべきか?2007

    • Author(s)
      熊澤孝朗
    • Journal Title

      Monthly Book Orthopaedics 20

      Pages: 1-8

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Molecular cloning of prostaglandin EP3 receptor from canine sensory ganglia and their facilitatory action on bradykinin-induced mobilization of intracellular calcium.2007

    • Author(s)
      Kozaki, Y.
    • Journal Title

      Journal of Neurochemistry 100

      Pages: 1636-1647

    • Related Report
      2006 Annual Research Report
  • [Journal Article] リハビリテーションと痛みのコントロール2007

    • Author(s)
      熊澤孝朗
    • Journal Title

      Monthly Book Medical Rehabilitation (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 腓腹筋障害により生じたラット足底部の慢性的痛み行動に関する検討2006

    • Author(s)
      橋本 辰幸, ら
    • Journal Title

      全日本鍼灸学会雑誌 56

      Pages: 809-814

    • NAID

      10031188571

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] The change of the pain concept, the treatments.(in Japanese)2006

    • Author(s)
      Kumzawa T
    • Journal Title

      Management of Pain : The Approaches for Chronic Pain, Cancer Pain.(ed. Kumazawa T) Shorinsha, Tokyo

      Pages: 2-24

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] The points to consider for the chronic pain patients.(in Japanese)2006

    • Author(s)
      Yamaguchi Y, Kumzawa T
    • Journal Title

      Management of Pain : The Approaches for Chronic Pain, Cancer Pain.(ed. Kumazawa T) Shorinsha, Tokyo

      Pages: 38-44

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Chronic pain and the complementary and alternative medicine.(in Japanese)2006

    • Author(s)
      Hashimoto T, Kumzawa T
    • Journal Title

      Management of Pain : The Approaches for Chronic Pain, Cancer Pain.(ed. Kumazawa T) Shorinsha, Tokyo

      Pages: 178-188

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Assessment of chronic pain-like behaviors in rats induced by muscle lesion.(in Japanese)2006

    • Author(s)
      Hashimoto T, Kumazawa T
    • Journal Title

      Journal of the Japan Society of Acupuncture and Moxibustion 56

      Pages: 809-814

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 下肢不動化慢性痛症モデル動物における覚醒下交感神経系機能の解析2008

    • Author(s)
      吉本 隆彦, ら
    • Organizer
      第85回日本生理学会大会
    • Place of Presentation
      東京
    • Year and Date
      2008-03-26
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] ラットにおける2週間の下肢不動化は脊髄グリア細胞の変化を起こす2008

    • Author(s)
      大道 裕介, ら
    • Organizer
      第85回日本生理学会大会
    • Place of Presentation
      東京
    • Year and Date
      2008-03-26
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Functional analysis of sympathetic nervous system under the free moving in the limb-immobilization chronic pain model.2008

    • Author(s)
      Yoshimoto T, et. al.
    • Organizer
      The 85th Annual Meeting of Physiological Society of Japan
    • Place of Presentation
      Tokyo
    • Year and Date
      2008-03-26
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Two weeks hindlimb immobilization causes spinal glial changes in rats.2008

    • Author(s)
      Ohmichi Y, et. al.
    • Organizer
      The 85th Annual Meeting of Physiological Society of Japan
    • Place of Presentation
      Tokyo
    • Year and Date
      2008-03-26
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 下肢不動化は慢性的な痛みと脊髄変化を引き起こす2008

    • Author(s)
      大道 裕介, ら
    • Organizer
      平成19年度愛知医科大学運動療育センター研究発表会
    • Place of Presentation
      長久手
    • Year and Date
      2008-01-17
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 慢性的な痛みを起こす下肢不動化では自律系にも異常きたす2008

    • Author(s)
      吉本 隆彦, ら
    • Organizer
      平成19年度愛知医科大学運動療育センター研究発表会
    • Place of Presentation
      長久手
    • Year and Date
      2008-01-17
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Developmental changes of the chronic pain behaviors in rats induced by myopathic treatment.2008

    • Author(s)
      Sakurai H, et. al.
    • Organizer
      The 3rd Asian Pain Symposium
    • Place of Presentation
      Fukuoka
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Changes in pain behavior associated with the spinal glial activations in the chronic pain model by plaster-immobilization.2008

    • Author(s)
      Ohmichi Y, et. al.
    • Organizer
      The 3rd Asian Pain Symposium
    • Place of Presentation
      Fukuoka
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Dysfunction of autonomic nervous system on the chronic pain animal model by plaster-immobilization.2008

    • Author(s)
      Yoshimoto T, et. al.
    • Organizer
      The 30th Annua. Meeting of Japanese Association for the Study of Pain
    • Place of Presentation
      Fukuoka
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Sympathetic dysfunction in the cast-immobilization chronic pain model.2008

    • Author(s)
      Yoshimoto T, et. al.
    • Organizer
      12th World Congress on Pain
    • Place of Presentation
      Glasgow
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Temporal and spatial changes of spinal glial cells in chronic pain model induced by the cast-immobilization.2008

    • Author(s)
      Ohmichi M, et. al.
    • Organizer
      12th World Congress on Pain
    • Place of Presentation
      Glasgow
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ギプス固定慢性痛症モデルにおける痛みの出現と脊髄グリア細胞の変化2007

    • Author(s)
      大道 美香, ら
    • Organizer
      平成19年度生理学研究所研究会「筋・骨格系と内臓の痛み研究会」
    • Place of Presentation
      岡崎
    • Year and Date
      2007-12-06
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 下肢不動化モデルにおける脊髄グリア細胞の変化2007

    • Author(s)
      大道 美香, ら
    • Organizer
      第29回日本疼痛学会
    • Place of Presentation
      横浜
    • Year and Date
      2007-07-07
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Changes of spinal glial cells on the chronic pain animal model by the plaster-immobilization.2007

    • Author(s)
      Ohmichi M, et. al.
    • Organizer
      The 29th Annual Meeting of Japanese Association for the Study of Pain
    • Place of Presentation
      Yokohama
    • Year and Date
      2007-07-07
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 筋障害性慢性痛症モデル動物の慢性痛には障害筋からの直接的なシグナルは関与しない2007

    • Author(s)
      松原 貴子, ら
    • Organizer
      第42回日本理学療法学術大会
    • Place of Presentation
      新潟
    • Year and Date
      2007-05-24
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 運動療法の新たな可能性を探る-慢性痛症に及ぼす運動の影響-2007

    • Author(s)
      橋本 辰幸, ら
    • Organizer
      平成18年度愛知医科大学運動療育センター研究発表会
    • Place of Presentation
      長久手
    • Year and Date
      2007-01-25
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 筋障害性慢性痛症モデル動物における筋の組織像2006

    • Author(s)
      松原 貴子, ら
    • Organizer
      平成18年度生理学研究所研究会「痛みの分子機構と治療戦略研究会」
    • Place of Presentation
      岡崎
    • Year and Date
      2006-11-16
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ギプス固定による慢性痛症モデル動物の自律神経機能は?〜血圧変動の周波数解析から〜2006

    • Author(s)
      吉本 隆彦, ら
    • Organizer
      第53回中部日本生理学会
    • Place of Presentation
      甲府
    • Year and Date
      2006-09-27
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The function of autonomic nervous system of the chronic pain animal model by the plaster-immobilization.2006

    • Author(s)
      Yoshimoto T, et. al.
    • Organizer
      The 53th Annual Meeting of Physiological Society of central Japan
    • Place of Presentation
      Kofu
    • Year and Date
      2006-09-27
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ギプス固定による慢性痛症モデル動物における検討I:Minocyclineは慢性期の痛み行動を抑制した2006

    • Author(s)
      高畑 成雄, ら
    • Organizer
      第28回日本疼痛学会
    • Place of Presentation
      神戸
    • Year and Date
      2006-07-14
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ギプス固定による慢性痛症モデル動物における検討II:急性期の坐骨神経プロックは慢性期の痛み行動を抑制した2006

    • Author(s)
      大道 裕介, ら
    • Organizer
      第28回日本疼痛学会
    • Place of Presentation
      神戸
    • Year and Date
      2006-07-14
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 筋障害による慢性痛症モデル動物における検討I:慢性痛症の誘発要因を探る2006

    • Author(s)
      橋本 辰幸, ら
    • Organizer
      第28回日本疼痛学会
    • Place of Presentation
      神戸
    • Year and Date
      2006-07-14
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 筋障害による慢性痛症モデル動物における検討II:若齢時の処置では慢性痛症を発症しなかった2006

    • Author(s)
      櫻井 博紀, ら
    • Organizer
      第28回日本疼痛学会
    • Place of Presentation
      神戸
    • Year and Date
      2006-07-14
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Chronic pain animal model by the plaster-immobilization : I. The pain behaviors on chronic phase were inhibited by the injection of minocycline.2006

    • Author(s)
      Takahata S, et. al.
    • Organizer
      The 28th Annual Meeting of Japanese Association for the Study of Pain
    • Place of Presentation
      Kobe
    • Year and Date
      2006-07-14
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Chronic pain animal model by the plaster-immobilization : II. The pain behaviors on chronic phase were inhibited by the sciatic nerve block at acute phase.2006

    • Author(s)
      Ohmichi Y, et. al.
    • Organizer
      The 28th Annual Meeting of Japanese Association for the Study of Pain
    • Place of Presentation
      Kobe
    • Year and Date
      2006-07-14
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Chronic pain animal model caused by myopathic treatment. I. Exploration of the trigger for chronic pain behaviors of this model.2006

    • Author(s)
      Hashimoto T, et. al.
    • Organizer
      The 28th Annual Meeting of Japanese Association for the Study of Pain
    • Place of Presentation
      Kobe
    • Year and Date
      2006-07-14
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Chronic pain animal model caused by myopathic treatment. II. The treatment to young rats did not develop chronic pain.2006

    • Author(s)
      Sakurai H, et. al.
    • Organizer
      The 28th Annual Meeting of Japanese Association for the Study of Pain
    • Place of Presentation
      Kobe
    • Year and Date
      2006-07-14
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 起炎物質の作用から運動器の慢性痛症のメカニズムを探る2006

    • Author(s)
      橋本 辰幸, ら
    • Organizer
      第55回(社)全日本鍼灸学会学術大会
    • Place of Presentation
      金沢
    • Year and Date
      2006-06-16
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Exploration of chronic pain mechanisms based on results of the inflammatory substance effects.2006

    • Author(s)
      Hashimoto T, Kumazawa T
    • Organizer
      The 55th Meeting of the Japan Society of Acupuncture and Moxibustion
    • Place of Presentation
      Kanazawa
    • Year and Date
      2006-06-16
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 医師50年 研究と臨床の軌跡(「痛み」をどう捉えるか?)2008

    • Author(s)
      熊澤 孝朗
    • Publisher
      医歯薬出版(in press)
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 最新自律神経学(自律神経系と痛み・生体警告系)2007

    • Author(s)
      熊澤 孝朗
    • Publisher
      新興医学出版社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 痛みを知る2007

    • Author(s)
      熊澤 孝朗
    • Total Pages
      180
    • Publisher
      東方出版
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 最新自立神経学(自立神経系と痛み・生体警告系)2007

    • Author(s)
      熊澤孝朗
    • Publisher
      新興医学出版社
    • Related Report
      2006 Annual Research Report
  • [Book] 痛みのケア:慢性痛、がん性疼痛へのアプローチ2006

    • Author(s)
      熊澤 孝朗(監修・編集)
    • Total Pages
      247
    • Publisher
      照林社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 痛みのケア:慢性痛、がん性疼痛へのアプローチ(痛みの概念の変革とその治療)2006

    • Author(s)
      熊澤 孝朗
    • Publisher
      照林社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 痛みのケア:慢性痛、がん性疼痛へのアプローチ(慢性の痛みをもつ患者さんが来られたら)2006

    • Author(s)
      山口 佳子, ら
    • Publisher
      照林社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 痛みのケア:慢性痛、がん性疼痛へのアプローチ(慢性痛症と補完・代替医療)2006

    • Author(s)
      橋本 辰幸, ら
    • Publisher
      照林社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 痛みのケア : 慢性通、がん性疼痛へのアプローチ2006

    • Author(s)
      熊澤孝朗
    • Total Pages
      247
    • Publisher
      照林社
    • Related Report
      2006 Annual Research Report
  • [Remarks] 「研究成果報告書概要(和文)」より

    • URL

      http://www.aichi-med-u.ac.jp/pain/

    • Related Report
      2007 Final Research Report Summary

URL: 

Published: 2006-04-01   Modified: 2016-04-21  

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