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A fundamental study for application of nitric oxide to a diagnosis and treatments of the chronic pain

Research Project

Project/Area Number 18613023
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pain science
Research InstitutionKansai Medical University

Principal Investigator

ABE Tetsuya  Kansai Medical University, Faculty of Medicine, Assistant Professor (20411506)

Co-Investigator(Kenkyū-buntansha) MATSUMURA Shinji  Kansai Medical University, Faculty of Medicine, Assistant Professor (70276393)
FUKUNAGA Mikihiko  Kansai Medical University, Faculty of Medicine, Associate Professor (90257949)
NAKAI Yoshihide  Kansai Medical Univerity, Faculty of Medicine, Professor (00091281)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,910,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2006: ¥3,000,000 (Direct Cost: ¥3,000,000)
Keywordsnitric oxide / neuropathic pain / primary afferent / NMDA receptor / spinal cord / enzymohistochemistry / Imaging / mice / 神経因性痺痛 / ノシセプチン
Research Abstract

We established an ex vivo system to elucidate biochemical and molecular mechanisms for nNOS activation by the use of a combination of isolated intact spinal cord preparations and NADPH-diaphorase histochemistry.
Nociceptin/orphanin FQ (N/OFQ) was earlier shown to be involved in the maintenance of neuropathic pain by activating neuronal nitric oxide synthase (nNOS). We examined the N/OFQ signal pathways coupled to nNOS activation in the spinal cord by using this ex vivo system. N/OFQ enhanced nNOS activity in the superficial layer of the spinal cord, as assessed by NADPH-diaphorase histochemistry, in a time- and dose-dependent manner. The maximum effect was observed at 3-10 nM. The N/OFQ-stimulated nNOS activity was inhibited by NMDA receptor antagonists MK-801 and D-AP5, but not by the NR2B-selective antagonist; and the stimulated activity was observed in NR2D(-/-) mice, but not in NR2A(-/-) or NR2A(-/-)/NR2D(-/-) mice. N/OFQ receptor antagonists attenuated the nNOS activity stimulated … More by N/OFQ, but not that by NMDA. N/OFQ stimulated nNOS activity by a biochemical cascade initiated by activation of NMDA receptors containing NR2A.
To clarify whether NO itself affected nNOS activity in the spinal cord as a retrograde messenger, we examined the involvement of the NO/cGMP signaling pathway in the regulation of nNOS activity. NO-generating agents enhanced NADPH-diaphorase staining in the spinal cord 8-Br-cGMP also enhanced it similar to that by NO-generating agents, and 8-Br-cAMP and forskolin, an activator of adenylate cyclase, enhanced it moderately. NO-generating agents markedly increased the cGMP level in the spinal cord. Additionally, the nNOS activation was completely inhibited by NMDA antagonists MK-801 and d-AP5, partially by the NR2B-selective antagonist, and was attenuated in NR2A(-/-) and NR2A(-/-)/2D(-/-) mice. These results suggest that NO may regulate nNOS activity as a retrograde messenger in the spinal cord via activation of NMDA receptor containing NR2A and NR2B subunits. Less

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (61 results)

All 2008 2007 2006

All Journal Article (40 results) (of which Peer Reviewed: 12 results) Presentation (21 results)

  • [Journal Article] Involvement of stem cell factor and its receptor tyrosine kinase c-kit in pain regulation2008

    • Author(s)
      Takagi K, Okuda-Ashitaka E, Mabuchi T, Katano T, Ohnishi T, Matsumura S, Ohnaka M, Kaneko S, Abe T, Hirata T, Fujiwara S, Minami T and Ito S.
    • Journal Title

      Neuroscience (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Characterization of signaling pathway for the translocation of neuronal nitric oxide synthase to the plasma membrane by PACAP2008

    • Author(s)
      Ohnishi T, Okuda-Ashitaka E, Matsumura S, Katano T, Nishizawa M and Ito S
    • Journal Title

      J Neurochem (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 口腔内に含水することで症状が消失した呑気症の1例2008

    • Author(s)
      土井 麻里, 福永 幹彦, 阿部 哲也, 水野 泰行, 永岡 三穂, 中井 吉英
    • Journal Title

      心療内科 12

      Pages: 62-66

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 痛みにおけるNOの関与2008

    • Author(s)
      松村 伸治, 阿部 哲也, 芦高 恵美子, 伊藤 誠二
    • Journal Title

      BIO CLINICA 23

      Pages: 397-403

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Involvement of stem cell factor and its receptor tyrosine kinase c-kit in pain regulation2008

    • Author(s)
      Takagi K, Okuda-Ashitaka E, Mabuchi T, Katano T, Ohnishi I, Matsumura S. Ohnaka M, Kaneko S. Abe T, Hirata T, Fujiwara S, Minami T, Ito S.
    • Journal Title

      Neuroscience (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Characterization of signaling pathway for the translocation of neuronal nitric oxide synthase to the plasma membrane by PACAP2008

    • Author(s)
      Ohnishi T, Okuda-Ashitaka E, Matsumura S, Katano T, Nishizawa M, Ito S.
    • Journal Title

      J Neurochem (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 痛みにおけるNOの関寿2008

    • Author(s)
      松村 伸治
    • Journal Title

      バイオクリニカ 23

      Pages: 397-403

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Cytotoxicity of spermine on retinal pigment epithelial cells2007

    • Author(s)
      Kaneko, S., Ueda-Yamada, M., Ando, A., Matsumura, S., Okuda-Ashitaka, E., Matsumura, M., Uyama, M. and Ito, S.
    • Journal Title

      Investigative Ophthalmology and Visual Science 48

      Pages: 455-463

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Signal pathways coupled to activation of neuronal nitric oxide synthase in the spinal cord by nociceptin/orphanin FQ2007

    • Author(s)
      Xu, L., Okuda-Ashitaka, E., Matsumura, S., Mabuchi, T., Okamoto, S., Sakimura, K., Mishina, M., and Ito, S.
    • Journal Title

      Neuropharmacology 52

      Pages: 1318-1325

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Interleukin-1 is not essential for expression of inducible NOS in hepatocytes induced by lipopolysaccharide in vivo2007

    • Author(s)
      Takagi K, Matsumura S, Okuda-Ashitaka E, Okuda K, Watanabe J, Takahashi H, Iwakura Y and Ito S.
    • Journal Title

      Nitric Oxide 17

      Pages: 433-441

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Nitric oxide (NO) serves as a retrograde messenger to activate neuronal NO synthase in the spinal cord via NMDA receptors2007

    • Author(s)
      Xu L., Mabuchi T, Katano T, Matsumura S, Okuda-Ashitaka E, Sakimura K, Mishina M and Ito S
    • Journal Title

      Nitric Oxide 17

      Pages: 18-24

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 消化性潰瘍2007

    • Author(s)
      阿部 哲也, 福永 幹彦, 中井 吉英
    • Journal Title

      小児科 48

      Pages: 574-578

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 心療内科から見た消化管機能異常症2007

    • Author(s)
      阿部 哲也, 福永 幹彦, 中井 吉英
    • Journal Title

      クリニカルプラクティス 26

      Pages: 382-385

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 自律訓練法による胃運動機能の変化2007

    • Author(s)
      阿部 哲也, 福永 幹彦, 中井 吉英
    • Journal Title

      消化器心身医学 14

      Pages: 70-73

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 外在化技法を用いることで解決志向アプローチの有効性を高めた機能性消化管障害症例の検討2007

    • Author(s)
      蓮尾 英明, 阿部 哲也, 永岡 三穂, 福永 幹彦, 中井 吉英
    • Journal Title

      心療内科 11

      Pages: 350-354

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 痛みと闘う 各科の取り組み システム論的な見方による難治性疼痛の予防と治療2007

    • Author(s)
      中井 吉英, 水野 康行, 阿部 哲也
    • Journal Title

      医学のあゆみ 223

      Pages: 784-789

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 慢性腰痛に対する集学的アプローチII 心療内科の並場から2007

    • Author(s)
      水野 泰行, 阿部 哲也, 中井 吉英
    • Journal Title

      ペインクリニック 28

      Pages: 1589-1598

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 脊髄後角におけるNMDA受容体リン酸化と神経因性疼痛2007

    • Author(s)
      芦高 恵美子, 阿部 哲也, 松村 伸治, 伊藤 誠二
    • Journal Title

      慢性疼痛 26

      Pages: 41-47

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 日常診療におけるうつ病痛みとの関連2007

    • Author(s)
      阿部 哲也, 福永 幹彦, 神原 憲治, 水野 泰行, 永岡 三穂, 中井 吉英
    • Journal Title

      治療学 42

      Pages: 151-154

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Cytotoxic effect of spermine on retinal pigment epithelial cells.2007

    • Author(s)
      Kaneko S, Ueda-Yamada M, Ando A, Matsumura S, Okuda-Ashitaka E, Matsumura M, Uyama M, Ito S.
    • Journal Title

      Invest Ophthalmol Vis Sci. 48

      Pages: 455-463

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Signal pathways coupled to activation of neuronal nitric oxide synthase in the spinal cord by nociceptinlorphanin FQ2007

    • Author(s)
      Xu L, Okuda-Ashitaka E, Matsumura S. Mabuchi T, Okamoto S, Sakimura K, Mishina M and Ito S.
    • Journal Title

      Neuropharmacology 52

      Pages: 1318-1325

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Interleukin-1 is not essential for expression of inducible NOS in hepatocytes induced by lipopolysaccharide in vivo2007

    • Author(s)
      Takagi K, Matsumura S. Okuda-Ashitaka E, Okuda K, Watanabe J, Takahashi H, Iwakura Y , Ito S.
    • Journal Title

      Nitric Qxide. 16

      Pages: 433-441

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Nitric oxide(NO) serves as a retrograde messenger to activate neuronal NO synthase in the spinal cord via NMDA receptors2007

    • Author(s)
      Xu L, Mabuchi T, Katano T, Matsumura S. Okuda-Ashitaka E, Sakimura k, Mishina M, Ito S.
    • Journal Title

      Nitric Oxide 17

      Pages: 18-24

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Oytotoxic effect of spermine on retinal pigment epithelial cells2007

    • Author(s)
      Kaneko S
    • Journal Title

      Invest Ophthalmol Vis Sci 48

      Pages: 455-463

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Signal pathways coupled to activation ofneuronal nitric oxide synthase in the spinacord by nocicentin/orphanin FQ2007

    • Author(s)
      Xu L
    • Journal Title

      Neuropharmacology 52

      Pages: 1318-1325

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-1 is not essential for expression ofinducible NOS in hepatocytes induced by lipopolysaccharide in vivo2007

    • Author(s)
      Takagi K
    • Journal Title

      Nitric Oxide 16

      Pages: 433-441

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nitric oxide(NO)serves as a retrograde messenger to activate neuronal NO synthase inthe spinal cord via NMDA receptors2007

    • Author(s)
      Xu L
    • Journal Title

      Nitric Oxide 17

      Pages: 18-24

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cytotoxicity of spermine on retinal pigment epithelial cells.2007

    • Author(s)
      Kaneko, S, Ueda- Yamada, M, Ando, A, Matsumura, S, Okuda-Ashitaka, E, Matsumura, M, Uyama, M, Ito, S.
    • Journal Title

      Investigative Ophthalmology and Visual Sciece 48・1

      Pages: 455-463

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Signal pathways coupled to activation of neuronal nitric oxide synthase in the spinal cord by nociceptin/orphanin FQ.2007

    • Author(s)
      Xu, L, Okuda-Ashitaka, E, Matsumura, S, Mabuchi, T, Okamoto, S, Sakimura, K, Mishina, M, Ito, S.
    • Journal Title

      Neuropharmacology 52・5

      Pages: 1318-1325

    • Related Report
      2006 Annual Research Report
  • [Journal Article] In situ measurement of neuronal nitric oxide synthase activity in the spinal cord by NADPH-disphorase histochemistry2006

    • Author(s)
      Xu, L., Matsumura S., Mabuchi, T., Takagi, K., Abe, T. and Ito, S.
    • Journal Title

      Journal of Neuroscience Methods 150

      Pages: 174-184

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] The opioid peptide nociceptin/orphanin FQ mediates prostaglandin E_2-induced allodynia,tactile pain associated with nerve injury2006

    • Author(s)
      Okuda-Ashitaka, E., Minami, T., Matsumura, S., Takeshima, H., Reinscheid RK, Civelli, O and Ito S.
    • Journal Title

      European Journal of Neuroscience 23

      Pages: 995-1004

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 痛みの臨床心理学2006

    • Author(s)
      阿部 哲也, 中井 吉英
    • Journal Title

      理学療法 23

      Pages: 23-27

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 消化器内科と「うつ」2006

    • Author(s)
      阿部 哲也, 福永 幹彦, 中井 吉英
    • Journal Title

      臨床精神医学 35

      Pages: 951-956

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 卒前・卒後教育に果たす心身医学の役割 全人的医療の教育を目指して チュートリアルにおける全人医療教育 心療内科の存在が与える影響について2006

    • Author(s)
      福永 幹彦, 阿部 哲也, 水野 泰行, 永岡 三穂, 中井 吉英
    • Journal Title

      心身医学 46

      Pages: 745-751

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] ポータブル電図言によるバイオフィードバックを用いた筋弛緩法が有用であった慢性疼痛の症例2006

    • Author(s)
      松田 能宣, 神原 憲治, 堀 裕典, 阿部 哲也, 北村 香奈, 福永 幹彦, 中井 吉英
    • Journal Title

      心療内科 10

      Pages: 279-285

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 上部消化管ビデオ透視検査の機能性胃腸症への応用の試み2006

    • Author(s)
      阿部 哲也, 福永 幹彦, 四宮 敏章, 中井 吉英
    • Journal Title

      日本心療内科学会誌 10

      Pages: 152-156

    • NAID

      10019285347

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] In situmeasurement of neuronal nitric oxide synthase activity in the spinal cord by NADPH-disphorase histochemistry.2006

    • Author(s)
      Xu, L., Matsumura S., Mabuchi, T., Takagi, K., Abe, T., Ito, S.
    • Journal Title

      Journal of Neuroscience Methods 150

      Pages: 174-184

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] The opioid peptide nociceptin/orphanin FQ mediates prostaglandin E2-induced allodynia, tactile pain associated with nerve injury.2006

    • Author(s)
      Okuda-Ashitaka E, Minami T, Matsumura S, Takeshima H. Reinscheid RK, Civelli O, Ito S.
    • Journal Title

      Eur J Neurosci. 23

      Pages: 995-1004

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] In situ measurement of neuronal nitric oxide synthase activity in the spinal cord by NADPH-disphorase histochemistry.2006

    • Author(s)
      Xu, L, Matsumura S, Mabuchi, T, Takagi, K, Abe, T, Ito, S.
    • Journal Title

      Journal of Neuroscience Methods 150・2

      Pages: 174-184

    • Related Report
      2006 Annual Research Report
  • [Journal Article] The opioid peptide nociceptin/rphanin FQ mediates prostaglandin E_2 induced allodynia, tactile pain associated with nerve injury.2006

    • Author(s)
      Okuda-Ashitaka, E, Minami, T, Matsumura, S, Takeshima, H, Reinscheid RK, Civelli, O, Ito S.
    • Journal Title

      European Journal of Neuroscience 23・4

      Pages: 995-1004

    • Related Report
      2006 Annual Research Report
  • [Presentation] 機能性胃腸症における胃蠕動運動リズム異常の他疾患との比較2008

    • Author(s)
      阿部 哲也, 福永 幹彦, 中井 吉英
    • Organizer
      第70回消化器心身医学研究会
    • Place of Presentation
      福岡
    • Year and Date
      2008-05-10
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 機能性胃腸症における胃運動リズム異常の検討2007

    • Author(s)
      阿部 哲也, 福永 幹彦, 中井 吉英
    • Organizer
      第12阿日本心療内科学会学術大会
    • Place of Presentation
      大阪
    • Year and Date
      2007-12-01
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Signal pathways coupled to activation of neuronal nitric oxide synthase in the spinal cord by nociceptin/orphanin FQ2007

    • Author(s)
      Okuda-Ashitaka E, Xu L, Matsumura S, Mabuchi T, Sakimura K, Mishina M and Ito S.
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego,USA
    • Year and Date
      2007-11-04
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Differentiation and migration of progenitor cells for maitenance of neuropathic pain in the model using nestin promoter-GFP transgenic mice2007

    • Author(s)
      Matsumura S, Tkagi K, Okuda-Ashitaka E, Yamaguchi M and Ito S.
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego,USA
    • Year and Date
      2007-11-04
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Nitric oxide is involved in activation of neuronal nitric oxide synthase as a retrograde messenger in the spinal cord2007

    • Author(s)
      Ito S, Xu L, Mabuchi T, Katano T, Matsumura S, Okuda-Ashitaka E, Sakimura K and Mishina M
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego,USA
    • Year and Date
      2007-11-04
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Molecular mechanism for the translocation of nNOS to the plasma membrane by PACAP2007

    • Author(s)
      Ohnishi T, Okuda-Ashitaka E, Matsumura S and Ito S
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego,USA
    • Year and Date
      2007-11-04
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Signal pathways coupled to activation of neuronal nitric oxide synthase in the spinal cord by nociceptin/orphanin FQ.2007

    • Author(s)
      Okuda-Ashitaka E, Xu L, Matsumura S, Mabuchi T, Sakimura K, Mishina M, Ito S.
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2007-11-04
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Differentiation and migration of progenitor cells for maitenance of neuropathic pain in the model using nestin promoter-GFP transgenic mice2007

    • Author(s)
      Matsumura S, Tkagi K, Okuda-Ashitaka E, Yamaguchi M and Ito S.
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2007-11-04
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Nitric oxide is involved in activation of neuronal nitric oxide synthase as a retrograde messenger in the spinal cord2007

    • Author(s)
      Ito S, Xu L, Mabuchi T, Katano T, Matsumura S, Okuda-Ashitaka E, Sakimura K, Mishina M.
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2007-11-04
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Molecular mechanism for the translocation of nNOS to the plasma membrane by PACAP2007

    • Author(s)
      Ohnishi T, Okuda-Ashitaka E, Matsumura S, Ito S
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2007-11-04
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Signal pathways coupled to activation ofneuronal nitric oxide synthase in the spinal cord by nociceptin/orphanin FQ2007

    • Author(s)
      Okuda-Ashitaka E
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego,USA
    • Year and Date
      2007-11-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] Differentiation and migration ofprogenitor cells for maitenance ofneuropathic pain in the model using nestin promoter-GFP transgenic mice2007

    • Author(s)
      Matsumura S
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego,USA
    • Year and Date
      2007-11-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] Nitric oxide is involved in activation ofneuronal nitric oxide synthase as a retrograde messenger in the spinal cord2007

    • Author(s)
      Ito S
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego,USA
    • Year and Date
      2007-11-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] 上部消化管ビデオ透視検査を用いた機能性胃腸症の胃運動機能評価2007

    • Author(s)
      阿部 哲也, 福永 幹彦, 中井 吉英
    • Organizer
      第48回日本心身医学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2007-05-25
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 胃運動機能への自律訓練法の短期的効果について2006

    • Author(s)
      阿部 哲也, 福永 幹彦, 中井 吉英
    • Organizer
      第11回日本心療内科学会学術大会
    • Place of Presentation
      大阪
    • Year and Date
      2006-12-02
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Establishment of in situ analysis system of neuronal nitric oxide synthase activity in the spinal cord2006

    • Author(s)
      Ito S, Xu L, Matsumura S, Mabuchi T, Katano T, Lu J and Okuda-Ashitaka E
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Atlanta,USA
    • Year and Date
      2006-10-17
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Mediation by the opioid peptide nociceptin/orphanin FQ of prostaglandin E2-induced allodynia,tactile pain associated with nerve injury2006

    • Author(s)
      Okuda-Ashitaka E, Minami T, Matsumura S, Takeshima H, Reinscheid RK, Civelli O and Ito S
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Atlanta,USA
    • Year and Date
      2006-10-17
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Establishment of in situ analysis system of neuronal nitric oxide synthase activity in the spinal cord2006

    • Author(s)
      Ito S, Xu L, Matsumura S, Mabuchi T, Katano T, Lu J, Okuda-Ashitaka E
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Atlanta, USA
    • Year and Date
      2006-10-17
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Mediation by the opioid peptide nociceptiniorphanin FQ of prostaglandin E2-induced allodynia, tactile pain associated with nerve injury2006

    • Author(s)
      Okuda-Ashitaka E, Minami T, Matsumura S, Takeshima H, Reinscheid RK, Civelli O, Ito S.
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Atlanta, USA
    • Year and Date
      2006-10-17
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 慢性疼痛への脊髄NMDA受容体の関与2006

    • Author(s)
      阿部 哲也, 中井 吉英
    • Organizer
      第47回日本心身医学会総会
    • Place of Presentation
      東京
    • Year and Date
      2006-05-30
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 自律訓練法による胃運動機能の変化2006

    • Author(s)
      阿部 哲也, 福永 幹彦, 中井 吉英
    • Organizer
      第66回消化器心身医学研究会
    • Place of Presentation
      小倉
    • Year and Date
      2006-04-22
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2006-04-01   Modified: 2016-04-21  

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