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Analgesic effect of histamine at spinal synaptic level

Research Project

Project/Area Number 18613025
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pain science
Research InstitutionKumamoto Health Science University

Principal Investigator

AKAIKE Norio  Kumamoto Health Science University, 保健科学部, 教授 (30040182)

Co-Investigator(Kenkyū-buntansha) SHODAI Kiyomitu  熊本保健科学大学, 保健科学部, 講師 (90290650)
NONAKA Kiku  熊本保健科学大学, 保健科学部, 講師 (70259745)
MAEDA Megumi  熊本保健科学大学, 保健科学部, 助教 (10369126)
OGAWA Satie  熊本保健科学大学, 保健科学部, 助教 (40380563)
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,170,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥570,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2006: ¥1,700,000 (Direct Cost: ¥1,700,000)
Keywords痛み / シナプス / GABA応答 / グリシン応答 / ヒスタミン / 修飾作用 / 脊髄ニューロン / 内因性鎮痛物質 / 鎮痛作用 / 脊髄 / ニューロン / 神経終末
Research Abstract

ヒスタミン(HA)と選択的H2受容体アゴニストはH1KO マウスの新線状態ニューロンに内向き電流を発生させた。HAと選択的H1受容体アゴニストはH2KO マウスニューロンで内向き電流を発生した。H1とH2のダブルKO マウスのニューロンではHA、H1やH2受容体アゴニストは共に無効であった。この内向き電流はK チャネルの抑制によってもたらされた。以上のことから、HAのH1とH2受容体は中枢におけるHA の興奮惹起作用に関与することを明らかにした。

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (42 results)

All 2009 2008 2007 2006 Other

All Journal Article (16 results) (of which Peer Reviewed: 14 results) Presentation (25 results) Remarks (1 results)

  • [Journal Article] Gastric relaxation induced by electrical and chemical stimulation of the area postrema in the rat2009

    • Author(s)
      M. Kawachi, N. Hori, M. Takei, T. Kurimoto, N. Akaike, Y. Ito
    • Journal Title

      Gen Physiol Biophys 27(4)

      Pages: 243-252

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Histamine responses of large neostriatal interneurons in histamine H1 and H2 receptor knock-out mice2009

    • Author(s)
      S. Ogawa, K. Yanai, T. Watanabe, ZM. Wang, H. Akaike, Y. Ito, N. Akaike
    • Journal Title

      Brain Res. 16 78(4-5)

      Pages: 189-194

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differential effects of divalent cations on spontaneous and evoked glycine release from spinal interneurons2009

    • Author(s)
      M. Maeda, E. Tanaka, K. Shoudai, K. Nonaka, N. Murayama, Y. Ito, N. Akaike
    • Journal Title

      J Neurophysiol 101(2)

      Pages: 1103-1113

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Histamine responses large neostriatal interneurons in histamine H_1 and H_2 receptor knock-out mice2009

    • Author(s)
      Ogawa, et al.
    • Journal Title

      Brain Res. Bull. 78

      Pages: 189-194

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential effect of divalent cations on spontaneous and evoked glycine release from spinal interneurons2009

    • Author(s)
      Maeda, et al.
    • Journal Title

      J. Neurophysol. 101

      Pages: 1103-1113

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A selective T-type Ca2+ channel blocker R(-) efonidipine2008

    • Author(s)
      MC. Shin, CJ. Kim, BI. Min, S. Ogawa, E. Tanaka, N. Akaike
    • Journal Title

      Naunyn Schmiedebergs Arch Pharmaco 377(4-6)

      Pages: 411-421

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative analysis of toxin extracts from various tissues of wild and cultured puffer fish by an electrophysiological method2008

    • Author(s)
      K. Sasaki, Y. Takayama, T. Tahara, K. Anraku, Y. Ito, N. Akaike
    • Journal Title

      Toxicon 51(4)

      Pages: 606-614

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Influence of Purinergic modulators on eEPSCs in rat CA3 hippocampal neurons: Contribution of ionotropic ATP receptors2008

    • Author(s)
      E.Kondratskaya, K. Nonaka, N. Akaike
    • Journal Title

      Neurophysiology 40

      Pages: 21-29

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of various K+ channel blockers on spontaneous glycine release at rat spinal neurons2007

    • Author(s)
      K. Shoudai, K. Nonaka, M. Maeda, W ZM. ang, HJ. Jeong, H. Higashi, Murayama, N. Akaike
    • Journal Title

      Brain Res 1157

      Pages: 11-22

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Activation of mu-opioid receptor selectively potentiates NMDA-induced outward currents in rat locus coeruleus neurons2007

    • Author(s)
      S.Koyama, N. Akaike
    • Journal Title

      Neurosci Res 60(1)

      Pages: 22-28

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Excitaory effect of ATP on rat area postrema neurons2006

    • Author(s)
      M. Sorimachi, M. Wakamori, N. Akaike
    • Journal Title

      Purinergic Signalling 2

      Pages: 545-557

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Altered emotional behavioral responses in mice lacking brain-type fatty acid-binding protein gene2006

    • Author(s)
      Owada, SA. Abdelwahab, N, Kitanaka,H. Sakagami, H. Takano, Y. Sugitani, M. Sugawara, H. Kawashima, Y. Kiso, JI. Mobarakeh, K. Yanai, K. Kaneko, H. Sasaki, H. Kato, S. Saino-Saito, N. Matsumoto, N.Akaike, T. Noda, H. Kondo
    • Journal Title

      Eur J Neurosci 24(1)

      Pages: 175-187

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Presynaptic GABAA receptors facilitate spontaneous glutamate release from presynaptic terminals on mechanically dissociated rat CA3 pyramidal neurons2006

    • Author(s)
      IS. Jang, M. Nakamura, Y. Ito, N. Akaike
    • Journal Title

      Neuroscience 138(1)

      Pages: 25-35

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Na(+)/H(+) exchanger is a major pH regulator in GABAergic presynaptic nerve terminals synapsing onto rat CA3 pyramidal neurons2006

    • Author(s)
      IS. Jang, MS. Brodwick, ZM. Wang, HJ. Jeong, BJ.Choi, N. Akaike
    • Journal Title

      J Neurochem 99(4)

      Pages: 1224-1236

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Na(+)/H(+) exchanger is a major pH regulator in GABAergic presynaptic nerve terminals synapsing onto rat CA3 phramidal neurons.2006

    • Author(s)
      Jang IS
    • Journal Title

      J Neurochem Nov;99(4)

      Pages: 1224-36

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Presynaptic GABAA receptors facilitate spontaneous glutamate release from presynaptic terminals on mechanically dissociated rat CA3 pyramidal neurons.2006

    • Author(s)
      Jang IS
    • Journal Title

      Neuroscience 138(1)

      Pages: 25-35

    • Related Report
      2006 Annual Research Report
  • [Presentation] Effects of novel neurotoxin, A2-NTX, on the excitatory and inhibitory CNS transmission2009

    • Author(s)
      N. Akaike, Y. Ito, MC. Shin, M. Maeda, K. Nonaka, T. Harakawa A. Ginnaga
    • Organizer
      The 8th Japan-Korea Joint Symposium of Brain Science, and Cardiac and SmoothMuscles
    • Place of Presentation
      Pusan/Korea
    • Related Report
      2008 Final Research Report
  • [Presentation] Modulation of Glycine release at a singlesynapse by Ca2+, Sr2+ and Ba2+2009

    • Author(s)
      M. Maeda, K. Shoudai, K. Nonaka, N, Akaike, Y. Ito
    • Organizer
      The 8th Japan-Korea Joint Symposium of Brain Sciences, and Cardiac and Smooth Muscles
    • Place of Presentation
      Pusan/Korea
    • Related Report
      2008 Final Research Report
  • [Presentation] Both P- and R-Type Ca2+ channels regulate mainly glycine release in rat spinal cord2009

    • Author(s)
      K. Nonaka, M. Maeda, k. Shoudai, T.Yamaga, N. Akaike
    • Organizer
      The 8th Japan-Korea Joint Symposium ofBrain Sciences, and Cardiac and Smooth Muscles
    • Place of Presentation
      Pusan/Korea
    • Related Report
      2008 Final Research Report
  • [Presentation] Effects of Z-338on the action of excitatory and inhibitory neurotransmitters on neurons in area postrema2009

    • Author(s)
      H. Akaike, IIS. Jang, N. Hori, S. Ogawa, N. Akaike, Y. Ito
    • Organizer
      The 8th Japan-Korea Joint Symposium of Brain Sciences, and Cardiac andSmooth Muscles
    • Place of Presentation
      Pusan/Korea
    • Related Report
      2008 Final Research Report
  • [Presentation] Effects of volatile anesthetics on GABAergic pre- and post-synaptic membranes2009

    • Author(s)
      S. Ogawa, MC. Shin, E. Tanaka, N. Kotani, N. Akaike
    • Organizer
      The 8th Japan-Korea Joint Symposium of Brain Sciences, and Cardiac and Smooth Muscles
    • Place of Presentation
      Pusan/Korea
    • Related Report
      2008 Final Research Report
  • [Presentation] Both P-and R-type Ca channels regulate mainly glycine release in rat spinal cord2009

    • Author(s)
      Nonaka, et al.
    • Organizer
      81th Japan-Korea Joint Symposium
    • Place of Presentation
      Pusan/Korea
    • Related Report
      2008 Annual Research Report
  • [Presentation] Analysis of toxin extracts from various tissues of wild and cultured puffer fish2008

    • Author(s)
      N. Akaike, S. Ogawa, Y. Takayama
    • Organizer
      The Japanese Journal of Physiology
    • Related Report
      2008 Final Research Report
  • [Presentation] In vivo パッチクランプ記録法を用いたラット一次体性感覚野における痛覚応答の解析2008

    • Author(s)
      古賀浩平, 水口洋子, 古江秀昌, 赤池紀生, 吉村恵
    • Organizer
      第59 回西日本生理学会
    • Place of Presentation
      熊本
    • Related Report
      2008 Final Research Report
  • [Presentation] 単一グリシン作動性神経終末部にみられる高閾値Caチャネルの分布2008

    • Author(s)
      野中喜久, 前田恵, 山鹿敏臣, 田中永一郎, 村山伸樹
    • Organizer
      第59回西日本生理学会
    • Place of Presentation
      熊本
    • Related Report
      2008 Final Research Report
  • [Presentation] 単一シナプス前終末からのグリシン遊離に及ぼす2価陽イオンの効果2007

    • Author(s)
      前田 恵, 田中永一郎,正代清光, 村山伸樹, 赤池紀生
    • Organizer
      第9 回応用薬理シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2007-09-10
    • Related Report
      2008 Final Research Report
  • [Presentation] 中枢神経終末部における伝達物質放出のメカニズム解明2007

    • Author(s)
      野中喜久, 村山伸樹, 赤池紀生
    • Organizer
      第9回応用薬理シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2007-09-10
    • Related Report
      2008 Final Research Report
  • [Presentation] T型 Ca2+チャネル阻害剤'R(-)エホニジピン2007

    • Author(s)
      申 敏哲, 小川幸恵, 田中永一郎, 赤池紀生
    • Organizer
      第58 回西日本生理学会
    • Place of Presentation
      福岡
    • Related Report
      2008 Final Research Report
  • [Presentation] Novel insight on the purinergic signalling in rat hippocampus with single bouton stimulation techniwue2007

    • Author(s)
      E. Kondratskaya, K. Shoudai, N. Akaike
    • Organizer
      IBRO World Congress of Neuroscience
    • Place of Presentation
      Melbourne, Australia
    • Related Report
      2008 Final Research Report
  • [Presentation] Neurotransmission at mammalian single synapse2007

    • Author(s)
      K. Nonaka, N. Murayama, N. Akaike
    • Organizer
      IBRO World Congress of Neuroscience
    • Place of Presentation
      Melbourne, Australia
    • Related Report
      2008 Final Research Report
  • [Presentation] Functional studies at a single excitatory or inhibitory brain sysnapse2007

    • Author(s)
      N. Akaike
    • Organizer
      IBROWorld Congress of Neuroscience
    • Place of Presentation
      Melbourne, Australia
    • Related Report
      2008 Final Research Report
  • [Presentation] A selective T-type Ca2+ channels blcoker2007

    • Author(s)
      MC. Shin, S. Ogawa, K. Nonaka, Y. Ito, N. Akaike
    • Organizer
      The 7Th Japan-Korea join symposium of brain sciences, and cardiac and smooth muscles
    • Place of Presentation
      仙台
    • Related Report
      2008 Final Research Report
  • [Presentation] Effect of volatile and intravenous anesthetics on the transmitter release in a single CNS synapse2007

    • Author(s)
      S. Ogawa, MC. Shin, K. Nonaka, Y. Ito, N. Akaike
    • Organizer
      The 7Th Japan-Korea join symposium of brain sciences, and cardiac and smooth muscles
    • Place of Presentation
      仙台
    • Related Report
      2008 Final Research Report
  • [Presentation] A selective T-type Ca2+ channels blcoker2007

    • Author(s)
      MC. Shin, K. Nonaka, N. Akaike
    • Organizer
      5Th international symposium on receptor mechanism, signal transduction and drug effects
    • Place of Presentation
      静岡
    • Related Report
      2008 Final Research Report
  • [Presentation] Analysis of excitatory postsynaptic current components in the rat hippocampal neurons2006

    • Author(s)
      E... Kondratskay, N. Akaike
    • Organizer
      The 6th Congress of the Federation of Asian and Oceanian Physiological Societies Program & Abstracts
    • Place of Presentation
      Seoul/Korea
    • Year and Date
      2006-10-18
    • Related Report
      2008 Final Research Report
  • [Presentation] Effects of divalent cations on glycinergic IPSCs elicited at A single synapse2006

    • Author(s)
      K. Nonaka, M. Maeda, K. Shoudai, H. Higashi, N. Murayama, N. Akaike
    • Organizer
      The 6th Congress of the Federation of Asian and Oceanian Physiological Societies Program & Abstracts
    • Place of Presentation
      Seoul/Korea
    • Year and Date
      2006-10-18
    • Related Report
      2008 Final Research Report
  • [Presentation] Effects of Ca2+ channel blockers on evoked glycinergic IPSC s in the rat spinal neurons2006

    • Author(s)
      K. Shoudai, K. Nonaka,M. Maeda, H. Higashi, N. Murayama, N. Akaike
    • Organizer
      The 6th Congress of the Federation of Asian and Oceanian Physiological Societies Program & Abstracts
    • Place of Presentation
      Seoul/Korea
    • Year and Date
      2006-10-18
    • Related Report
      2008 Final Research Report
  • [Presentation] Effect of selenium on contraction mechanism of the bovine tracheal smooth muscle sells2006

    • Author(s)
      S. Ogawa, H. Higashi, Y. Ito, N. Akaike
    • Organizer
      The 6th Congress of the Federation of Asian and Oceanian Physiological Societies Program & Abstracts
    • Place of Presentation
      Seoul/Korea
    • Year and Date
      2006-10-18
    • Related Report
      2008 Final Research Report
  • [Presentation] Functional interactions between P2X receptors and GABA- or Glycine-receptor in rat area postrema neurons2006

    • Author(s)
      M. Sorimachi, N. Akaike, M. Wakamori
    • Organizer
      The Japanese Journal of Physiology
    • Place of Presentation
      群馬
    • Related Report
      2008 Final Research Report
  • [Presentation] 単一シナプスからのグリシン遊離に及ぼす2価陽イオンの効果2006

    • Author(s)
      野中喜久, 正代清光, 前田 惠, 東英穂, 村山伸樹, 赤池紀生
    • Organizer
      第57回西日本生理学会
    • Place of Presentation
      日.宮崎
    • Related Report
      2008 Final Research Report
  • [Presentation] A selective T-Type Ca2+ channel blocker, R(-) efonidipine effect of a novel T-Type Ca channel blocker of the rat hippocampal neurons

    • Author(s)
      MC. Shin, BII. Min, CJ. Kim, K. Shoudai, S. Ogawa, N. Akaike
    • Organizer
      The 6th Congress of the Federation of Asian and Oceanian Physiological Societies Program & Abstracts
    • Related Report
      2008 Final Research Report
  • [Remarks]

    • URL

      http://www.kumamoto-hsu.ac.jp

    • Related Report
      2008 Final Research Report

URL: 

Published: 2006-04-01   Modified: 2016-04-21  

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