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感染症に対する抵抗力を反映する新規指標の開発

Research Project

Project/Area Number 18650189
Research Category

Grant-in-Aid for Exploratory Research

Allocation TypeSingle-year Grants
Research Field Sports science
Research InstitutionThe University of Tokyo (2007)
Waseda University (2006)

Principal Investigator

秋本 崇之  The University of Tokyo, 大学院・医学系研究科, 講師 (00323460)

Co-Investigator(Kenkyū-buntansha) 河野 一郎  筑波大学, 人間総合科学研究科, 教授 (00132994)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2007: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2006: ¥1,700,000 (Direct Cost: ¥1,700,000)
KeywordsEBウィルス / アスリート / 易感染性
Research Abstract

本研究は,すでに感染し,身体に潜在しているウィルスDNAを指標として個体全体の免疫機能を定量化し,感染症との関係を明らかにしようとする研究である.本研究では以下の3つの目的を設定している:
1.潜在性ウィルスの再活性化と他の免疫学的指標の関連性の検討
2.健常者を対象にウィルス再活性化と感染症罹患リスクとの関係の検討
3.実際のフィールドでスポーツ選手のウィルス再活性化を指標として感染症罹患リスクをモニタリングし,コンディショニングへの応用の可能性を探る
平成19年度は上記の2と3に関する検討を行った.
健常人を対象としたウィルスDNAの変化と他の免疫学的指標の関連の検討では,ウィルスDNAの変化と唾液中SIgA濃度などの免疫学的指標の関連について相関解析を行い,それらの関連性について検討し,論文を本年度3編発表した.また,投稿準備中の論文が2編ある.
全体統括
平成18-19年度に本研究を行った.全体期間を通じて,英文論文5編,和文論文1編を発表した.また投稿準備中の論文が2編あり,2年間の萌芽研究の成果としては十分なものだったと考えられる.今後は本研究で確立したウィルスDNAを唾液から検出する手法をスポーツ競技現場,中高齢者のヘルスケアの現場に応用することで,一層の研究の展開を計りたい.

Report

(2 results)
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (10 results)

All 2008 2007 2006

All Journal Article (6 results) (of which Peer Reviewed: 3 results) Presentation (4 results)

  • [Journal Article] A rat modei of saliva secretory immunbglobulin; a suppression caused by intense exercise.2008

    • Author(s)
      F. Kimura, K. Aizawa, K. Tanabe〓
    • Journal Title

      Scand J Med Sci Sports (印刷中)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 日常生活における高レベルの身体活動が中高齢者の免疫機能に及ぼす影響.2008

    • Author(s)
      清水和弘, 木村文律, 田辺匠, 小林大祐,
    • Journal Title

      スポーツ科学研究 (印刷中)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of moderate exercise training, gender and aging on salivary secretory immunoglobulin A in〓2007

    • Author(s)
      K. Shimizu, F. Kimura, T. Akimoto, T. A
    • Journal Title

      Exerc Immunol Rev, 13

      Pages: 55-66

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of free-living daily physical activity on salivary secretors IgA in elderly.2007

    • Author(s)
      K.Shimizu, F.Kimura, T.Akimoto, T.Akama, S.Kuno, I.Kono
    • Journal Title

      Med Sci Snorts Exerc (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Daily changes in secretion rate of salivary secretory immunoglobulin A correlate with appearance of upper respiratory symptoms during physical training.2006

    • Author(s)
      D.Nakamura, T.Akimoto, S.Suzuki, I.Kono
    • Journal Title

      J Sports Med Phys Fitness 46(1)

      Pages: 152-157

    • Related Report
      2006 Annual Research Report
  • [Journal Article] The effects of walking exercise training on immune response in elderly subjects.2006

    • Author(s)
      F.Kimura, K.Shimizu, T.Akimoto, T.Akama, I.Kono
    • Journal Title

      Int J Snort Health Sci 4

      Pages: 504-508

    • NAID

      130000069812

    • Related Report
      2006 Annual Research Report
  • [Presentation] The relationship between Epstein-Barr virus reactivation and upper respiratory infection during sum2007

    • Author(s)
      R. Yamauchi, F. Kimura, K. Suzuki, T. A
    • Organizer
      8th symposium of International Society of Exercise and Immunology
    • Place of Presentation
      Sendai, Japan
    • Year and Date
      2007-10-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] Effects of exercise, age and gender on SIgA in elderly2007

    • Author(s)
      K. Shimizu, F. Kimura, T. Akimoto, T. A
    • Organizer
      8th symposium of International Society of Exercise and Immunology
    • Place of Presentation
      Sendai, Japan
    • Year and Date
      2007-10-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] A rat model of saliva secretory immunoglobulin; a suppression caused by intense exercise2007

    • Author(s)
      F. Kimura, K. Aizawa, K. Tanabe〓
    • Organizer
      8th symposium of International Society of Exercise and Immunology
    • Place of Presentation
      Sendai, Japan
    • Year and Date
      2007-10-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] Exercise and secretary Immunoglobulin A2007

    • Author(s)
      T. Akimoto.
    • Organizer
      7th (Biospace) International Symposium on Human & Sport Science: Obesity, Aging
    • Place of Presentation
      Daegu, Korea
    • Related Report
      2007 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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